Bis(4-chlorophenyl)acetic acid (BioDeep_00000006251)

 

Secondary id: BioDeep_00001868737

human metabolite blood metabolite


代谢物信息卡片


Bis(p-chlorophenyl)acetic acid, potassium salt

化学式: C14H10Cl2O2 (280.0058)
中文名称: 双(4-氯苯基)乙酸
谱图信息: 最多检出来源 Homo sapiens(blood) 15.95%

分子结构信息

SMILES: C1=CC(=CC=C1C(C2=CC=C(C=C2)Cl)C(=O)O)Cl
InChI: InChI=1S/C14H10Cl2O2/c15-11-5-1-9(2-6-11)13(14(17)18)10-3-7-12(16)8-4-10/h1-8,13H,(H,17,18)

描述信息

D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D050258 - Mitosis Modulators > D008934 - Mitogens

同义名列表

22 个代谢物同义名

Bis(p-chlorophenyl)acetic acid, potassium salt; Bis(p-chlorophenyl)acetic acid, 14C-labeled; Bis(p-chlorophenyl)acetic acid, sodium salt; 2,2-Bis(4-chlorophenyl)acetic acid; 2,2-Bis(p-chlorophenyl)acetic acid; p,P-dichlorodiphenylacetic acid; 2,2-Bis(4-chlorophenyl)acetate; Bis(4-chlorophenyl)acetic acid; 2,2-Bis(p-chlorophenyl)acetate; Bis(p-chlorophenyl)acetic acid; Di(p-chlorophenyl)acetic acid; Bis(p-chlorphenyl)essigsaeure; p,P-dichlorodiphenylacetate; Dichlorodiphenylacetic acid; Bis(p-chlorophenyl)acetate; Bis(4-chlorophenyl)acetate; Di(p-chlorophenyl)acetate; Dichlorodiphenylacetate; p,p-DDA; 4,4-DDA; DDA; Bis(4'-chlorophenyl)acetate



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lei Xin, Rui Qiao, Xin Chen, Hieu Tran, Shengying Pan, Sahar Rabinoviz, Haibo Bian, Xianliang He, Brenton Morse, Baozhen Shan, Ming Li. A streamlined platform for analyzing tera-scale DDA and DIA mass spectrometry data enables highly sensitive immunopeptidomics. Nature communications. 2022 06; 13(1):3108. doi: 10.1038/s41467-022-30867-7. [PMID: 35672356]
  • Simone Putzke, Elisabeth Feldhues, Iris Heep, Thomas Ilg, Alf Lamprecht. Cationic lipid/pDNA complex formation as potential generic method to generate specific IRF pathway stimulators. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2020 Oct; 155(?):112-121. doi: 10.1016/j.ejpb.2020.08.010. [PMID: 32798666]
  • Wenjing Qu, Na Li, Rui Yu, Wenbao Zuo, Tingting Fu, Wenling Fei, Yanhui Hou, Yanhua Liu, Jianhong Yang. Cationic DDA/TDB liposome as a mucosal vaccine adjuvant for uptake by dendritic cells in vitro induces potent humoural immunity. Artificial cells, nanomedicine, and biotechnology. 2018; 46(sup1):852-860. doi: 10.1080/21691401.2018.1438450. [PMID: 29447484]
  • Hongpo Wu, Mark Kwaaitaal, Roxana Strugala, Ulrich Schaffrath, Paweł Bednarek, Ralph Panstruga. Chemical suppressors of mlo-mediated powdery mildew resistance. Bioscience reports. 2017 Dec; 37(6):. doi: 10.1042/bsr20171389. [PMID: 29127104]
  • Zhenshan Chen, Francois Maartens, Helen Vega, Simon Kunene, Jonathan Gumede, Robert I Krieger. 2,2-bis(4-Chlorophenyl)acetic acid (DDA), a water-soluble urine biomarker of DDT metabolism in humans. International journal of toxicology. 2009 Nov; 28(6):528-33. doi: 10.1177/1091581809349862. [PMID: 19966144]
  • H Cai, X Tian, X D Hu, S X Li, D H Yu, Y X Zhu. Combined DNA vaccines formulated either in DDA or in saline protect cattle from Mycobacterium bovis infection. Vaccine. 2005 Jun; 23(30):3887-95. doi: 10.1016/j.vaccine.2005.03.025. [PMID: 15917109]
  • Daniel E Frigo, Matthew E Burow, Kamron A Mitchell, Tung-Chin Chiang, John A McLachlan. DDT and its metabolites alter gene expression in human uterine cell lines through estrogen receptor-independent mechanisms. Environmental health perspectives. 2002 Dec; 110(12):1239-45. doi: 10.1289/ehp.021101239. [PMID: 12460804]
  • L Brandt, M Elhay, I Rosenkrands, E B Lindblad, P Andersen. ESAT-6 subunit vaccination against Mycobacterium tuberculosis. Infection and immunity. 2000 Feb; 68(2):791-5. doi: 10.1128/iai.68.2.791-795.2000. [PMID: 10639447]
  • R K Dubey, D G Gillespie, Z Mi, M Rosselli, P J Keller, E K Jackson. Estradiol inhibits smooth muscle cell growth in part by activating the cAMP-adenosine pathway. Hypertension (Dallas, Tex. : 1979). 2000 Jan; 35(1 Pt 2):262-6. doi: 10.1161/01.hyp.35.1.262. [PMID: 10642308]
  • R J Bosch, P Rojo-Linares, G Torrecillas-Casamayor, M C Iglesias-Cruz, D Rodríguez-Puyol, M Rodríguez-Puyol. Effects of parathyroid hormone-related protein on human mesangial cells in culture. The American journal of physiology. 1999 12; 277(6):E990-5. doi: 10.1152/ajpendo.1999.277.6.e990. [PMID: 10600786]
  • M A Dawson, J L Renfro. Interaction of structurally similar pesticides with organic anion transport by primary cultures of winter flounder renal proximal tubule. The Journal of pharmacology and experimental therapeutics. 1993 Aug; 266(2):673-7. doi: . [PMID: 7689103]
  • B D Banerjee. Development of an enzyme-linked immunosorbent assay for the quantification of DDA (2,2-bis(p-chlorophenyl) acetic acid) in urine. Bulletin of environmental contamination and toxicology. 1987 May; 38(5):798-804. doi: 10.1007/bf01616704. [PMID: 3580596]
  • W L Henrich, W B Campbell. Importance of calcium in renal renin release. The American journal of physiology. 1986 Jul; 251(1 Pt 1):E98-103. doi: 10.1152/ajpendo.1986.251.1.e98. [PMID: 3014894]
  • J Guilford, E Eugere, G Mitra, D Ghosh. The effect of lead on insecticide metabolism. Drug and chemical toxicology. 1986; 9(3-4):239-52. doi: 10.3109/01480548608998278. [PMID: 3816614]
  • J P Klerx, H Van Dijk, E A Kouwenberg, W J Van der Maaden, J M Willers. Effects of immunological adjuvants on the mouse complement system--II. Anti-complementary effects of surface-active compounds. International journal of immunopharmacology. 1986; 8(1):47-52. doi: 10.1016/0192-0561(86)90072-x. [PMID: 3957505]
  • M Ramachandran, S S Zaidi, B D Banerjee, Q Z Hussain. Urinary excretion of DDA: 2, 2-bis (4-chlorophenyl) acetic acid as an index of DDT exposure in men. The Indian journal of medical research. 1984 Oct; 80(?):483-6. doi: NULL. [PMID: 6532960]
  • S S Zaidi, B D Banerjee, M Ramachandran, Q Z Hussain. Colorimetric assay of 2,2-bis(4-chlorophenyl)acetic acid (DDA) in urine. Analytical biochemistry. 1984 Jan; 136(1):185-6. doi: 10.1016/0003-2697(84)90322-1. [PMID: 6711805]
  • B Gold, G Brunk. Metabolism of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane in the mouse. Chemico-biological interactions. 1982 Sep; 41(3):327-39. doi: 10.1016/0009-2797(82)90109-0. [PMID: 7105253]
  • K Furuya, S Urasawa. Chromatographic analysis of the hydrophobic interactions of rabbit IgG immunoglobulins and their papain-digested fragments by bis-(p-chlorophenyl)-acetic acid coupled to aminohexyl sepharose. Molecular immunology. 1982 May; 19(5):705-17. doi: 10.1016/0161-5890(82)90372-8. [PMID: 7110142]
  • J B Pritchard, A R Krall, S U Silverthorn. Effects of anionic xenobiotics on rat kidney. I--Tissue and mitochondrial respiration. Biochemical pharmacology. 1982 Jan; 31(2):149-55. doi: 10.1016/0006-2952(82)90204-0. [PMID: 7059358]
  • P W Ferguson, C R Clark, S J Gee, R I Krieger. Phenobarbital treatments lower DDT body burden in rhesus monkeys. Archives of environmental contamination and toxicology. 1981; 10(3):263-70. doi: 10.1007/bf01055627. [PMID: 7259297]
  • F J Koschier, P J Gigliotti, S K Hong. The effect of bis(p-chlorophenyl) acetic acid on the renal function of the rat. Journal of environmental pathology and toxicology. 1980 Nov; 4(5-6):209-17. doi: . [PMID: 7217846]
  • F J Koschier, M F Stokols, P J Cattrall, W D Conway, M Acara, S K Hong. Renal tubular transport and nephrotoxicity of DDA. Journal of environmental pathology and toxicology. 1980 Jun; 3(5-6):513-27. doi: . [PMID: 6255051]
  • H D Fiorentina, J de Graeve, M Grogna, F de Wiest. Improved assay for the rapid determination of bis(p-chlorophenyl)acetic acid in human urine. Journal of chromatography. 1978 Sep; 157(?):421-6. doi: 10.1016/s0021-9673(00)92365-3. [PMID: 701448]
  • J B Pritchard. Kinetic analysis of the renal handling of 2,2-bis(p-chlorophenyl) acetic acid by the rat. The Journal of pharmacology and experimental therapeutics. 1978 Apr; 205(1):9-18. doi: . [PMID: 633091]
  • J B Pritchard. In vitro analysis of 2,2-bis(p-chloropheny) acetic acid (DDA) handling by rat kidney and liver. Toxicology and applied pharmacology. 1976 Dec; 38(3):621-30. doi: 10.1016/0041-008x(76)90192-7. [PMID: 1014016]
  • W F DURHAM, J F ARMSTRONG, G E QUINBY. DDA EXCRETION LEVELS. STUDIES IN PERSONS WITH DIFFERENT DEGREES OF EXPOSURE TO DDT. Archives of environmental health. 1965 Jul; 11(?):76-9. doi: 10.1080/00039896.1965.10664172. [PMID: 14312392]
  • E F STOHLMAN, M I SMITH. The isolation of di (p-chlorophenyl) acetic acid (DDA) from the urine of rabbits poisoned with 2,2 bis (p-chlorophenyl) 1,1,1 trichloroethane (DDT). The Journal of pharmacology and experimental therapeutics. 1945 Aug; 84(?):375-9. doi: NULL. [PMID: 21004432]