Fenoprofen (BioDeep_00000002721)

 

Secondary id: BioDeep_00000408875

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


calcium(-1) anion; 2-(3-phenoxyphenyl)propanoate

化学式: C15H14O3 (242.0943)
中文名称: 菲诺洛芬
谱图信息: 最多检出来源 Homo sapiens(blood) 18.63%

分子结构信息

SMILES: CC(C(=O)O)c1cccc(Oc2ccccc2)c1
InChI: InChI=1S/C15H14O3/c1-11(15(16)17)12-6-5-9-14(10-12)18-13-7-3-2-4-8-13/h2-11H,1H3,(H,16,17)

描述信息

Fenoprofen is only found in individuals that have used or taken this drug. It is an anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding. [PubChem]Fenoprofens exact mode of action is unknown, but it is thought that prostaglandin synthetase inhibition is involved. Fenoprofen has been shown to inhibit prostaglandin synthetase isolated from bovine seminal vesicles.
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AE - Propionic acid derivatives
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors

同义名列表

35 个代谢物同义名

calcium(-1) anion; 2-(3-phenoxyphenyl)propanoate; alpha-Methyl-3-phenoxybenzeneacetic acid; (+-)-2-(3-Phenoxyphenyl)propionic acid; alpha-(m-Phenoxyphenyl)propionic acid; alpha-Methyl-3-phenoxybenzeneacetate; Α-methyl-3-phenoxybenzeneacetic acid; a-Methyl-3-phenoxybenzeneacetic acid; Fenoprofen, anhydrous, calcium salt; Fenoprofen dihydrate, calcium salt; (+-)-2-(3-Phenoxyphenyl)propionate; Α-(m-phenoxyphenyl)propionic acid; alpha-(m-Phenoxyphenyl)propionate; Feneprofen calcium salt dihydrate; 2-(3-Phenoxyphenyl)propionic acid; a-(m-Phenoxyphenyl)propionic acid; 2-(3-phenoxyphenyl)propanoic acid; 2-(m-Phenoxyphenyl)propionic acid; Α-methyl-3-phenoxybenzeneacetate; a-Methyl-3-phenoxybenzeneacetate; (+-)-m-Phenoxyhydratropic acid; 2-(m-Phenoxyphenyl)propionate; a-(m-Phenoxyphenyl)propionate; Α-(m-phenoxyphenyl)propionate; 2-(3-Phenoxyphenyl)propionate; (+-)-m-Phenoxyhydratropate; Fenoprofen calcium hydrate; Calcium, fenoprofen; Fenoprofen Calcium; Fenoprofenum; Fenoprofeno; Fenoprofene; fenoprofen; Nalgesic; Nalfon; Fenoprofen



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ALB, CAT, CYP2C9, MC1R, POMC, PRPH, PTGS1, PTGS2
Peripheral membrane protein 4 CRAT, PTGS1, PTGS2, SLC27A2
Endoplasmic reticulum membrane 6 CYP2C9, FAAH, PTGS1, PTGS2, SLC27A2, UGT2B7
Nucleus 1 ALB
cytosol 6 ACOX1, ALB, CAT, CRAT, HEATR5B, SLC27A2
centrosome 1 ALB
Cell membrane 5 ADRB3, GPRC5A, MC1R, SLC27A2, TNFRSF1A
Cell projection, axon 1 PRPH
Multi-pass membrane protein 6 ADRB3, FAAH, GPRC5A, MC1R, PRPH, SLC27A2
Golgi apparatus membrane 1 TNFRSF1A
cell surface 2 C3, TNFRSF1A
glutamatergic synapse 1 FAAH
Golgi apparatus 2 ALB, PTGS1
Golgi membrane 1 TNFRSF1A
mitochondrial inner membrane 1 CRAT
postsynapse 1 FAAH
Presynapse 1 FAAH
plasma membrane 9 ADRB3, C3, CYP2C9, GPRC5A, IGHE, MC1R, PRPH, SLC27A2, TNFRSF1A
Membrane 9 ACOX1, CAT, FAAH, HEATR5B, MC1R, PRPH, SLC27A2, TNFRSF1A, UGT2B7
axon 1 PRPH
caveola 1 PTGS2
extracellular exosome 7 ALB, C3, CAT, GPRC5A, PRPH, PTGS1, SLC27A2
endoplasmic reticulum 4 ALB, CRAT, FAAH, PTGS2
extracellular space 5 ALB, C3, IGHE, POMC, TNFRSF1A
perinuclear region of cytoplasm 1 HEATR5B
mitochondrion 2 CAT, CRAT
protein-containing complex 4 ALB, C3, CAT, PTGS2
intracellular membrane-bounded organelle 5 CAT, CYP2C9, GPRC5A, HEATR5B, PTGS1
Microsome membrane 4 CYP2C9, FAAH, PTGS1, PTGS2
Single-pass type I membrane protein 2 IGHE, TNFRSF1A
Secreted 5 ALB, C3, POMC, TNFRSF1A, VIP
extracellular region 7 ALB, C3, CAT, IGHE, POMC, TNFRSF1A, VIP
Single-pass membrane protein 2 FAAH, UGT2B7
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
photoreceptor inner segment 1 PRPH
photoreceptor outer segment 2 PRPH, PTGS1
perikaryon 1 PRPH
nucleolus 1 GPRC5A
vesicle 1 GPRC5A
Cytoplasm, perinuclear region 1 HEATR5B
Mitochondrion inner membrane 1 CRAT
Matrix side 1 CRAT
Membrane raft 1 TNFRSF1A
Cytoplasm, cytoskeleton 2 FAAH, PRPH
focal adhesion 1 CAT
Peroxisome 3 ACOX1, CAT, CRAT
Peroxisome matrix 1 CAT
peroxisomal matrix 3 ACOX1, CAT, CRAT
peroxisomal membrane 3 ACOX1, CAT, SLC27A2
secretory granule 1 POMC
intermediate filament 1 PRPH
nuclear speck 1 HEATR5B
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 3 ADRB3, GPRC5A, TNFRSF1A
neuron projection 3 PTGS1, PTGS2, VIP
ciliary basal body 1 ALB
IgE immunoglobulin complex 1 IGHE
cytoskeleton 1 FAAH
centriole 1 ALB
Cell projection, cilium, photoreceptor outer segment 1 PRPH
[Isoform 1]: Mitochondrion 1 CRAT
spindle pole 1 ALB
blood microparticle 2 ALB, C3
[Isoform 2]: Cell membrane 1 IGHE
organelle membrane 1 FAAH
Endomembrane system 2 FAAH, PTGS1
Cytoplasmic vesicle membrane 1 GPRC5A
specific granule membrane 1 SLC27A2
Peroxisome membrane 1 SLC27A2
clathrin-coated vesicle 1 HEATR5B
Microsome 1 SLC27A2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 3 C3, CAT, POMC
endoplasmic reticulum lumen 4 ALB, C3, PTGS2, SLC27A2
platelet alpha granule lumen 1 ALB
Cytoplasmic vesicle, clathrin-coated vesicle 1 HEATR5B
endocytic vesicle 1 HEATR5B
azurophil granule lumen 1 C3
[Isoform 3]: Cell membrane 1 IGHE
type III intermediate filament 1 PRPH
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
catalase complex 1 CAT
tumor necrosis factor receptor superfamily complex 1 TNFRSF1A
[Isoform 2]: Peroxisome 1 CRAT
ciliary transition fiber 1 ALB


文献列表

  • Pooja Prasanthan, Nand Kishore. Unusual human serum albumin fibrillation inhibition by ketoprofen and fenoprofen: Mechanistic insights. Journal of molecular recognition : JMR. 2021 12; 34(12):e2937. doi: 10.1002/jmr.2937. [PMID: 34505308]
  • Georgios Malis, Elena Geromichalou, George D Geromichalos, Antonios G Hatzidimitriou, George Psomas. Copper(II) complexes with non-steroidal anti-inflammatory drugs: Structural characterization, in vitro and in silico biological profile. Journal of inorganic biochemistry. 2021 11; 224(?):111563. doi: 10.1016/j.jinorgbio.2021.111563. [PMID: 34399232]
  • Kirtikumar D Bharwad, Priyanka A Shah, Pranav S Shrivastav, Vinay S Sharma, Puran Singhal. Quantification of fenoprofen in human plasma using UHPLC-tandem mass spectrometry for pharmacokinetic study in healthy subjects. Biomedical chromatography : BMC. 2020 Jan; 34(1):e4708. doi: 10.1002/bmc.4708. [PMID: 31630419]
  • Satoshi Endo, Namiki Miyagi, Toshiyuki Matsunaga, Akira Ikari. Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity, different from human DHRS11. Chemico-biological interactions. 2019 May; 305(?):12-20. doi: 10.1016/j.cbi.2019.03.026. [PMID: 30926317]
  • Nan Wang, Feng Wang, Yu Meng, Guo-Hui Yang, Ju-Wu Chen, Jia-Xiang Wang. Albumin Supplement Affects the Metabolism and Metabolism-Related Drug-Drug Interaction of Fenoprofen Enantiomers. Chirality. 2015 Jul; 27(7):436-40. doi: 10.1002/chir.22462. [PMID: 26037509]
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  • Deia Abd El-Hady, Ahmed K Youssef. Hyphenation of ionic liquid albumin glassy carbon biosensor or protein label-free sensor with differential pulse stripping voltammetry for interaction studies of human serum albumin with fenoprofen enantiomers. Analytica chimica acta. 2013 Apr; 772(?):68-74. doi: 10.1016/j.aca.2013.02.018. [PMID: 23540249]
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