Dobutamine (BioDeep_00000001951)

 

Secondary id: BioDeep_00000398425

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine

化学式: C18H23NO3 (301.1678)
中文名称: 多巴酚丁胺
谱图信息: 最多检出来源 Homo sapiens(blood) 8.03%

分子结构信息

SMILES: CC(CCC1=CC=C(C=C1)O)NCCC2=CC(=C(C=C2)O)O
InChI: InChI=1S/C18H23NO3/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15/h4-9,12-13,19-22H,2-3,10-11H2,1H3

描述信息

Dobutamine is only found in individuals that have used or taken this drug. It is a beta-2 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. [PubChem]Dobutamine directly stimulates beta-1 receptors of the heart to increase myocardial contractility and stroke volume, resulting in increased cardiac output.
C - Cardiovascular system > C01 - Cardiac therapy > C01C - Cardiac stimulants excl. cardiac glycosides > C01CA - Adrenergic and dopaminergic agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
C78274 - Agent Affecting Cardiovascular System > C78322 - Cardiotonic Agent
D020011 - Protective Agents > D002316 - Cardiotonic Agents
D002317 - Cardiovascular Agents
KEIO_ID D185; [MS2] KO008933
KEIO_ID D185

同义名列表

53 个代谢物同义名

3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine; 4-{2-[3-(4-hydroxy-phenyl)-1-methyl-propylamino]-ethyl}-benzene-1,2-diol; (+-)-4-(2-((3-(p-Hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol; 3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenylethylamine; 3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-b-phenylethylamine; 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol; Boehringer ingelheim brand OF dobutamine hydrochloride; Dobutamine tartrate (1:1), (R-(r*,r*))-isomer; Dobutamine tartrate (1:1), (S-(r*,r*))-isomer; Ratiopharm brand OF dobutamine hydrochloride; Dobutamine, phosphate (1:1) salt (+)-isomer; Eli lilly brand OF dobutamine hydrochloride; Dobutamine phosphate (1:1) salt, (-)-isomer; Irisfarma brand OF dobutamine hydrochloride; Fresenius brand OF dobutamine hydrochloride; Kendrick brand OF dobutamine hydrochloride; Inibsa brand OF dobutamine hydrochloride; Solvay brand OF dobutamine hydrochloride; Hexal brand OF dobutamine hydrochloride; Lilly brand OF dobutamine hydrochloride; Juste brand OF dobutamine hydrochloride; Rovi brand OF dobutamine hydrochloride; Pisa brand OF dobutamine hydrochloride; Hydrochloride, dobutamine; Lactobionate, dobutamine; Hydrobromide, dobutamine; Dobutamine hydrochloride; Dobutamine lactobionate; Dobutamine hydrobromide; Dobutamine, (-)-isomer; Dobutamine (+)-isomer; Dobutamin-ratiopharm; Dobutamin ratiopharm; Tartrate, dobutamine; Dobutamin fresenius; Dobutamine tartrate; Racemic-dobutamine; Dobutamina inibsa; Dobutamin solvay; Dobutamin hexal; Dobutamina rovi; rac-Dobutamine; DL-Dobutamine; Dobutaminum; Lilly 81929; dobutamine; Dobutamina; Posiject; Dobuject; Dobutrex; Dobucor; Oxiken; Dobutamine



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ACE, AXIN2, EDN1, MPI, MYLK
Endosome membrane 1 ADRB2
Endoplasmic reticulum membrane 1 PLN
Mitochondrion membrane 1 PLN
Nucleus 2 ADRB2, AXIN2
cytosol 6 AVP, AXIN2, MPI, MYLK, TNNI3, VPS51
dendrite 1 AVP
mitochondrial membrane 1 PLN
centrosome 1 AXIN2
Cell membrane 4 ACE, ADRB1, ADRB2, ADRB3
Cleavage furrow 1 MYLK
lamellipodium 1 MYLK
Multi-pass membrane protein 5 ADRB1, ADRB2, ADRB3, CACNA1I, UCP1
Synapse 1 MYLK
Golgi apparatus 2 ADRB2, VPS51
Golgi membrane 1 INS
mitochondrial inner membrane 1 UCP1
Lysosome 2 ACE, ADRB2
endosome 2 ACE, ADRB2
plasma membrane 9 ACE, ADRB1, ADRB2, ADRB3, AXIN2, CACNA1I, GCG, MYLK, REN
Membrane 6 ACE, ADRB2, CACNA1I, PLN, REN, VPS51
apical plasma membrane 1 ADRB2
extracellular exosome 2 ACE, MPI
endoplasmic reticulum 1 PLN
extracellular space 8 ACE, AVP, CRP, EDN1, GCG, IL6, INS, REN
perinuclear region of cytoplasm 1 PLN
Schaffer collateral - CA1 synapse 1 ADRB1
mitochondrion 3 PLN, SARS2, UCP1
intracellular membrane-bounded organelle 1 VPS51
Single-pass type I membrane protein 1 ACE
Secreted 8 ACE, AVP, CRP, EDN1, GCG, IL6, INS, REN
extracellular region 8 ACE, AVP, CRP, EDN1, GCG, IL6, INS, REN
Single-pass membrane protein 1 PLN
basal part of cell 1 EDN1
Mitochondrion matrix 1 SARS2
mitochondrial matrix 1 SARS2
external side of plasma membrane 1 ACE
actin cytoskeleton 1 MYLK
beta-catenin destruction complex 1 AXIN2
nucleolus 1 VPS51
Early endosome 2 ADRB1, ADRB2
apical part of cell 1 REN
recycling endosome 1 VPS51
Cell projection, lamellipodium 1 MYLK
Mitochondrion inner membrane 1 UCP1
sarcoplasmic reticulum 1 PLN
secretory granule 1 AVP
sarcomere 1 TNNI3
receptor complex 2 ADRB2, ADRB3
brush border membrane 1 ACE
Golgi apparatus, trans-Golgi network 1 VPS51
sperm midpiece 1 ACE
endosome lumen 1 INS
stress fiber 1 MYLK
basal plasma membrane 1 ACE
trans-Golgi network membrane 1 VPS51
secretory granule lumen 2 GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 GCG, IL6, INS
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 2 EDN1, INS
Sarcoplasmic reticulum membrane 1 PLN
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 3 ADRB1, ADRB2, AVP
clathrin-coated endocytic vesicle membrane 2 ADRB2, AVP
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
[Glucagon-like peptide 1]: Secreted 1 GCG
cardiac myofibril 1 TNNI3
troponin complex 1 TNNI3
rough endoplasmic reticulum lumen 1 EDN1
Weibel-Palade body 1 EDN1
interleukin-6 receptor complex 1 IL6
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
calcium ion-transporting ATPase complex 1 PLN
cardiac Troponin complex 1 TNNI3
EARP complex 1 VPS51
GARP complex 1 VPS51


文献列表

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  • Anastasia Vamvakidou, Mohamed-Salah Annabi, Phillipe Pibarot, Edyta Plonska-Gosciniak, Ana G Almeida, Ezequiel Guzzetti, Abdellaziz Dahou, Ian G Burwash, Matthias Koschutnik, Philipp E Bartko, Jutta Bergler-Klein, Julia Mascherbauer, Stefan Orwat, Helmut Baumgartner, Joao Cavalcante, Fausto Pinto, Tomasz Kukulski, Jaroslaw D Kasprzak, Marie-Annick Clavel, Frank A Flachskampf, Roxy Senior. Clinical Value of Stress Transaortic Flow Rate During Dobutamine Echocardiography in Reduced Left Ventricular Ejection Fraction, Low-Gradient Aortic Stenosis: A Multicenter Study. Circulation. Cardiovascular imaging. 2021 11; 14(11):e012809. doi: 10.1161/circimaging.121.012809. [PMID: 34743529]
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  • Basil John, Mariya Babu, Sandramol Shaji, Suja Abraham, Jabir Abdullakutty. Clinical outcomes of levosimendan versus dobutamine in patients with acute decompensated heart failure with reduced ejection fraction and impaired renal function. Indian heart journal. 2021 May; 73(3):372-375. doi: 10.1016/j.ihj.2021.02.010. [PMID: 34154760]
  • Matthias Heringlake, Julian Alvarez, Dominique Bettex, Stefaan Bouchez, Sonja Fruhwald, Massimo Girardis, Elena Grossini, Fabio Guarracino, Antoine Herpain, Wolfgang Toller, Luigi Tritapepe, Piero Pollesello. An update on levosimendan in acute cardiac care: applications and recommendations for optimal efficacy and safety. Expert review of cardiovascular therapy. 2021 Apr; 19(4):325-335. doi: 10.1080/14779072.2021.1905520. [PMID: 33739204]
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  • Waqas Aftab, Ali Motabar, Ramdas G Pai, Padmini Varadarajan. Frequency of hypertensive response to dobutamine stress and diminished diagnostic value in patients with end-stage renal disease awaiting renal transplant. Echocardiography (Mount Kisco, N.Y.). 2021 02; 38(2):162-168. doi: 10.1111/echo.14932. [PMID: 33231883]
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  • Maarja Hallik, Mari-Liis Ilmoja, Joseph F Standing, Hiie Soeorg, Tiiu Jalas, Maila Raidmäe, Karin Uibo, Kristel Köbas, Margit Sõnajalg, Kalev Takkis, Rūta Veigure, Karin Kipper, Joel Starkopf, Tuuli Metsvaht. Population pharmacokinetics and pharmacodynamics of dobutamine in neonates on the first days of life. British journal of clinical pharmacology. 2020 02; 86(2):318-328. doi: 10.1111/bcp.14146. [PMID: 31657867]
  • Hossieny Ibrahim, Yassien Temerk. Synergistic electrocatalytic activity of In2O3@FMWCNTs nanocomposite for electrochemical quantification of dobutamine in clinical patient blood and in injection dosage form. Talanta. 2020 Feb; 208(?):120362. doi: 10.1016/j.talanta.2019.120362. [PMID: 31816808]
  • Mads Israelsen, Emilie Kristine Dahl, Bjørn Stæhr Madsen, Signe Wiese, Flemming Bendtsen, Søren Møller, Annette Dam Fialla, Boye L Jensen, Aleksander Krag. Dobutamine reverses the cardio-suppressive effects of terlipressin without improving renal function in cirrhosis and ascites: a randomized controlled trial. American journal of physiology. Gastrointestinal and liver physiology. 2020 02; 318(2):G313-G321. doi: 10.1152/ajpgi.00328.2019. [PMID: 31841026]
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  • Desiree Abdurrachim, Xing Qi Teo, Chern Chiuh Woo, Sing Yee Ong, Nurul Farhana Salleh, Janise Lalic, Ru-San Tan, Philip Teck Hock Lee. Cardiac metabolic modulation upon low-carbohydrate low-protein ketogenic diet in diabetic rats studied in vivo using hyperpolarized 13 C pyruvate, butyrate and acetoacetate probes. Diabetes, obesity & metabolism. 2019 04; 21(4):949-960. doi: 10.1111/dom.13608. [PMID: 30536560]
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