Dobutamine (BioDeep_00000001951)

 

Secondary id: BioDeep_00000398425

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine

化学式: C18H23NO3 (301.1677848)
中文名称: 多巴酚丁胺
谱图信息: 最多检出来源 Homo sapiens(blood) 2.6%

分子结构信息

SMILES: CC(CCC1=CC=C(C=C1)O)NCCC2=CC(=C(C=C2)O)O
InChI: InChI=1S/C18H23NO3/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15/h4-9,12-13,19-22H,2-3,10-11H2,1H3

描述信息

Dobutamine is only found in individuals that have used or taken this drug. It is a beta-2 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. [PubChem]Dobutamine directly stimulates beta-1 receptors of the heart to increase myocardial contractility and stroke volume, resulting in increased cardiac output.
C - Cardiovascular system > C01 - Cardiac therapy > C01C - Cardiac stimulants excl. cardiac glycosides > C01CA - Adrenergic and dopaminergic agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
C78274 - Agent Affecting Cardiovascular System > C78322 - Cardiotonic Agent
D020011 - Protective Agents > D002316 - Cardiotonic Agents
D002317 - Cardiovascular Agents
KEIO_ID D185; [MS2] KO008933
KEIO_ID D185

同义名列表

52 个代谢物同义名

3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine; 4-{2-[3-(4-hydroxy-phenyl)-1-methyl-propylamino]-ethyl}-benzene-1,2-diol; (+-)-4-(2-((3-(p-Hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol; 3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenylethylamine; 3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-b-phenylethylamine; 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol; Boehringer ingelheim brand OF dobutamine hydrochloride; Dobutamine tartrate (1:1), (R-(r*,r*))-isomer; Dobutamine tartrate (1:1), (S-(r*,r*))-isomer; Ratiopharm brand OF dobutamine hydrochloride; Dobutamine, phosphate (1:1) salt (+)-isomer; Eli lilly brand OF dobutamine hydrochloride; Dobutamine phosphate (1:1) salt, (-)-isomer; Irisfarma brand OF dobutamine hydrochloride; Fresenius brand OF dobutamine hydrochloride; Kendrick brand OF dobutamine hydrochloride; Inibsa brand OF dobutamine hydrochloride; Solvay brand OF dobutamine hydrochloride; Hexal brand OF dobutamine hydrochloride; Lilly brand OF dobutamine hydrochloride; Juste brand OF dobutamine hydrochloride; Rovi brand OF dobutamine hydrochloride; Pisa brand OF dobutamine hydrochloride; Hydrochloride, dobutamine; Lactobionate, dobutamine; Hydrobromide, dobutamine; Dobutamine hydrochloride; Dobutamine lactobionate; Dobutamine hydrobromide; Dobutamine, (-)-isomer; Dobutamine (+)-isomer; Dobutamin-ratiopharm; Dobutamin ratiopharm; Tartrate, dobutamine; Dobutamin fresenius; Dobutamine tartrate; Racemic-dobutamine; Dobutamina inibsa; Dobutamin solvay; Dobutamin hexal; Dobutamina rovi; rac-Dobutamine; DL-Dobutamine; Dobutaminum; Lilly 81929; dobutamine; Dobutamina; Posiject; Dobuject; Dobutrex; Dobucor; Oxiken



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Andrew Burgess, Gareth Andrews, Katie M E Colby, Samuel J E Lucas, Kate Sprecher, Joseph Donnelly, Philip N Ainslie, Aparna S Basnet, Keith R Burgess. Loop gain response to increased cerebral blood flow at high altitude. Sleep & breathing = Schlaf & Atmung. 2023 Dec; ?(?):. doi: 10.1007/s11325-023-02956-4. [PMID: 38085496]
  • Yuliya Lytvyn, Kevin D Burns, Jeffrey M Testani, Andriy Lytvyn, Jaya Prakash N Ambinathan, Oluwatosin Osuntokun, Lucas C Godoy, David Z I Cherney, John D Parker. Renal Hemodynamics and Renin-Angiotensin-Aldosterone System Profiles in Patients With Heart Failure. Journal of cardiac failure. 2022 03; 28(3):385-393. doi: 10.1016/j.cardfail.2021.08.015. [PMID: 34487814]
  • Neymar de Oliveira, Joelma Gandolfi, Lígia Contrim, Roseli Pereira, Loraine Fernandes, João Silva, Brenno Gomes, Francisco Garcia Soriano, Suzana Lobo. The effects of vasopressors with and without dobutamine on haemodynamics, metabolism and gut injury during endotoxic shock in rabbits. A controlled study. Anaesthesiology intensive therapy. 2022; 54(2):141-149. doi: 10.5114/ait.2022.117264. [PMID: 35792110]
  • Anastasia Vamvakidou, Mohamed-Salah Annabi, Phillipe Pibarot, Edyta Plonska-Gosciniak, Ana G Almeida, Ezequiel Guzzetti, Abdellaziz Dahou, Ian G Burwash, Matthias Koschutnik, Philipp E Bartko, Jutta Bergler-Klein, Julia Mascherbauer, Stefan Orwat, Helmut Baumgartner, Joao Cavalcante, Fausto Pinto, Tomasz Kukulski, Jaroslaw D Kasprzak, Marie-Annick Clavel, Frank A Flachskampf, Roxy Senior. Clinical Value of Stress Transaortic Flow Rate During Dobutamine Echocardiography in Reduced Left Ventricular Ejection Fraction, Low-Gradient Aortic Stenosis: A Multicenter Study. Circulation. Cardiovascular imaging. 2021 11; 14(11):e012809. doi: 10.1161/circimaging.121.012809. [PMID: 34743529]
  • Xiangxu Tang, Yaqian Xu, Xiaomeng Dai, Yun Xing, Duomeng Yang, Qingyang Huang, Hongmei Li, Xiuxiu Lv, Yiyang Wang, Daxiang Lu, Huadong Wang. The Long-term Effect of Dobutamine on Intrinsic Myocardial Function and Myocardial Injury in Septic Rats with Myocardial Dysfunction. Shock (Augusta, Ga.). 2021 10; 56(4):582-592. doi: 10.1097/shk.0000000000001718. [PMID: 34524268]
  • Basil John, Mariya Babu, Sandramol Shaji, Suja Abraham, Jabir Abdullakutty. Clinical outcomes of levosimendan versus dobutamine in patients with acute decompensated heart failure with reduced ejection fraction and impaired renal function. Indian heart journal. 2021 May; 73(3):372-375. doi: 10.1016/j.ihj.2021.02.010. [PMID: 34154760]
  • Matthias Heringlake, Julian Alvarez, Dominique Bettex, Stefaan Bouchez, Sonja Fruhwald, Massimo Girardis, Elena Grossini, Fabio Guarracino, Antoine Herpain, Wolfgang Toller, Luigi Tritapepe, Piero Pollesello. An update on levosimendan in acute cardiac care: applications and recommendations for optimal efficacy and safety. Expert review of cardiovascular therapy. 2021 Apr; 19(4):325-335. doi: 10.1080/14779072.2021.1905520. [PMID: 33739204]
  • Adelina Pellicer, Ramón Fernández, Vincent Jullien, Clare Gleeson, María Carmen Bravo, Paloma López Ortego, Laura Sánchez, Marta Ybarra, Héctor Rojas-Anaya, Fernando Cabañas, Armin Koch, Andrea Smith, Heike Rabe. Pharmacokinetic study (phase I-II) of a new dobutamine formulation in preterm infants immediately after birth. Pediatric research. 2021 03; 89(4):981-986. doi: 10.1038/s41390-020-1009-0. [PMID: 32610341]
  • Waqas Aftab, Ali Motabar, Ramdas G Pai, Padmini Varadarajan. Frequency of hypertensive response to dobutamine stress and diminished diagnostic value in patients with end-stage renal disease awaiting renal transplant. Echocardiography (Mount Kisco, N.Y.). 2021 02; 38(2):162-168. doi: 10.1111/echo.14932. [PMID: 33231883]
  • Takahiro Motonaga, Takashi Furuta, Seigo Okada, Yuji Ohnishi, Yasuo Suzuki, Hiroki Yasudo, Shunji Hasegawa. Responses to Treatment According to the Cytokine Profiles of Pericardial Effusion in Two Children with Idiopathic Pericarditis. International heart journal. 2020 Nov; 61(6):1307-1310. doi: 10.1536/ihj.20-282. [PMID: 33191347]
  • Günther Krumpl, Ivan Ulč, Michaela Trebs, Pavla Kadlecová, Juri Hodisch. Pharmacodynamic and pharmacokinetic behavior of landiolol during dobutamine challenge in healthy adults. BMC pharmacology & toxicology. 2020 11; 21(1):82. doi: 10.1186/s40360-020-00462-x. [PMID: 33239108]
  • Antonio Piperata, Tomaso Bottio, Gino Gerosa. COVID-19 infection in left ventricular assist device patients. Journal of cardiac surgery. 2020 Nov; 35(11):3231-3234. doi: 10.1111/jocs.14969. [PMID: 32827186]
  • Julie Kelly, Judy Cheng, Rhynn Malloy, Kenneth Lupi. Comparison of Positive Inotropic Agents in the Management of Acute Decompensated Heart Failure. Journal of cardiovascular pharmacology. 2020 05; 75(5):455-459. doi: 10.1097/fjc.0000000000000811. [PMID: 32091426]
  • Maarja Hallik, Mari-Liis Ilmoja, Joseph F Standing, Hiie Soeorg, Tiiu Jalas, Maila Raidmäe, Karin Uibo, Kristel Köbas, Margit Sõnajalg, Kalev Takkis, Rūta Veigure, Karin Kipper, Joel Starkopf, Tuuli Metsvaht. Population pharmacokinetics and pharmacodynamics of dobutamine in neonates on the first days of life. British journal of clinical pharmacology. 2020 02; 86(2):318-328. doi: 10.1111/bcp.14146. [PMID: 31657867]
  • Hossieny Ibrahim, Yassien Temerk. Synergistic electrocatalytic activity of In2O3@FMWCNTs nanocomposite for electrochemical quantification of dobutamine in clinical patient blood and in injection dosage form. Talanta. 2020 Feb; 208(?):120362. doi: 10.1016/j.talanta.2019.120362. [PMID: 31816808]
  • Mads Israelsen, Emilie Kristine Dahl, Bjørn Stæhr Madsen, Signe Wiese, Flemming Bendtsen, Søren Møller, Annette Dam Fialla, Boye L Jensen, Aleksander Krag. Dobutamine reverses the cardio-suppressive effects of terlipressin without improving renal function in cirrhosis and ascites: a randomized controlled trial. American journal of physiology. Gastrointestinal and liver physiology. 2020 02; 318(2):G313-G321. doi: 10.1152/ajpgi.00328.2019. [PMID: 31841026]
  • Premanand Krishnan, Fong-Kai Lee, Veronica Alicia Yap, Yun-Yee Low, Toh-Seok Kam, Kien-Thai Yong, Kang-Nee Ting, Kuan-Hon Lim. Schwarzinicines A-G, 1,4-Diarylbutanoid-Phenethylamine Conjugates from the Leaves of Ficus schwarzii. Journal of natural products. 2020 01; 83(1):152-158. doi: 10.1021/acs.jnatprod.9b01160. [PMID: 31935094]
  • Iratxe Zarragoikoetxea, Rosario Vicente, Azucena Pajares, Paula Carmona, Marta Lopez, Ignacio Moreno, Pilar Argente, Fernando Hornero, Francisco Valera, Jaume Aguero. Quantitative Transthoracic Echocardiography of the Response to Dobutamine in Cardiac Surgery Patients With Low Cardiac Output Syndrome. Journal of cardiothoracic and vascular anesthesia. 2020 Jan; 34(1):87-96. doi: 10.1053/j.jvca.2019.08.019. [PMID: 31515188]
  • Xianyong Liao, Lin Qian, Song Zhang, Xiang Chen, Jing Lei. Network Meta-Analysis of the Safety of Drug Therapy for Cardiogenic Shock. Journal of healthcare engineering. 2020; 2020(?):8862256. doi: 10.1155/2020/8862256. [PMID: 32802302]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Jesse C Seegmiller, Kathy A Larson, Amy K Saenger. An investigation of enzymatic creatinine interference in a patient receiving dopamine and dobutamine. Clinical biochemistry. 2019 Nov; 73(?):115-117. doi: 10.1016/j.clinbiochem.2019.08.001. [PMID: 31398309]
  • Desiree Abdurrachim, Xing Qi Teo, Chern Chiuh Woo, Sing Yee Ong, Nurul Farhana Salleh, Janise Lalic, Ru-San Tan, Philip Teck Hock Lee. Cardiac metabolic modulation upon low-carbohydrate low-protein ketogenic diet in diabetic rats studied in vivo using hyperpolarized 13 C pyruvate, butyrate and acetoacetate probes. Diabetes, obesity & metabolism. 2019 04; 21(4):949-960. doi: 10.1111/dom.13608. [PMID: 30536560]
  • M Abass, S Picek, J F G Garzón, C Kühnle, A Zaghlou, R Bettschart-Wolfensberger. Local mepivacaine before castration of horses under medetomidine isoflurane balanced anaesthesia is effective to reduce perioperative nociception and cytokine release. Equine veterinary journal. 2018 Nov; 50(6):733-738. doi: 10.1111/evj.12947. [PMID: 29660154]
  • Toru Hashimoto, Grace E Kim, Richard S Tunin, Tolulope Adesiyun, Steven Hsu, Ryo Nakagawa, Guangshuo Zhu, Jennifer J O'Brien, Joseph P Hendrick, Robert E Davis, Wei Yao, David Beard, Helen R Hoxie, Lawrence P Wennogle, Dong I Lee, David A Kass. Acute Enhancement of Cardiac Function by Phosphodiesterase Type 1 Inhibition. Circulation. 2018 10; 138(18):1974-1987. doi: 10.1161/circulationaha.117.030490. [PMID: 30030415]
  • Paola Cassis, Domenico Cerullo, Cristina Zanchi, Daniela Corna, Vincenzo Lionetti, Fabrizio Giordano, Rubina Novelli, Sara Conti, Valentina Casieri, Marco Matteucci, Monica Locatelli, Giulia Taraboletti, Sebastian Villa, Sara Gastoldi, Giuseppe Remuzzi, Ariela Benigni, Carlamaria Zoja. ADAMTS13 Deficiency Shortens the Life Span of Mice With Experimental Diabetes. Diabetes. 2018 10; 67(10):2069-2083. doi: 10.2337/db17-1508. [PMID: 29976618]
  • Lukas Lannemyr, Sven-Erik Ricksten, Bengt Rundqvist, Bert Andersson, Sven-Erik Bartfay, Charlotta Ljungman, Pia Dahlberg, Niklas Bergh, Clara Hjalmarsson, Thomas Gilljam, Entela Bollano, Kristjan Karason. Differential Effects of Levosimendan and Dobutamine on Glomerular Filtration Rate in Patients With Heart Failure and Renal Impairment:A Randomized Double-Blind Controlled Trial. Journal of the American Heart Association. 2018 08; 7(16):e008455. doi: 10.1161/jaha.117.008455. [PMID: 30369310]
  • James B Diskin, Christopher Brandon Walker, Michael D Oberle, Charles J Diskin. Use of the Fractional Excretion of Urea in an Azotemic Nonoliguric State: Type 1 Cardiorenal Syndrome. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. 2018 Aug; 22(4):319-324. doi: 10.1111/1744-9987.12661. [PMID: 29377609]
  • Anna Cavigelli-Brunner, Maja I Hug, Hitendu Dave, Oskar Baenziger, Christoph Buerki, Dominique Bettex, Vincenzo Cannizzaro, Christian Balmer. Prevention of Low Cardiac Output Syndrome After Pediatric Cardiac Surgery: A Double-Blind Randomized Clinical Pilot Study Comparing Dobutamine and Milrinone. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2018 07; 19(7):619-625. doi: 10.1097/pcc.0000000000001533. [PMID: 29538053]
  • Dotan Yogev, Maamoun Basheer, Amichai Perlman, Simcha Blotnick, Yoseph Caraco, Mordechai Muszkat. The hemodynamic response to constant dobutamine infusion: the effect of ADRB1 389 polymorphism and sex. Pharmacogenetics and genomics. 2018 06; 28(6):139-146. doi: 10.1097/fpc.0000000000000338. [PMID: 29768300]
  • O E Albóniga, M L Alonso, M E Blanco, O González, A Grisaleña, M A Campanero, R M Alonso. Quantitative determination of dobutamine in newborn pig plasma samples by HPLC-MS/MS. Journal of pharmaceutical and biomedical analysis. 2017 Oct; 145(?):178-185. doi: 10.1016/j.jpba.2017.06.050. [PMID: 28666164]
  • Marta Madeira, Francisca Caetano, Inês Almeida, Andreia Fernandes, Liliana Reis, Marco Costa, Lino Gonçalves. Inotropes and cardiorenal syndrome in acute heart failure - A retrospective comparative analysis. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology. 2017 Sep; 36(9):619-625. doi: 10.1016/j.repc.2017.03.006. [PMID: 28826934]
  • Felix Jansen, Lisa Schäfer, Han Wang, Theresa Schmitz, Anna Flender, Robert Schueler, Christoph Hammerstingl, Georg Nickenig, Jan-Malte Sinning, Nikos Werner. Kinetics of Circulating MicroRNAs in Response to Cardiac Stress in Patients With Coronary Artery Disease. Journal of the American Heart Association. 2017 Jul; 6(8):. doi: 10.1161/jaha.116.005270. [PMID: 28751542]
  • Roshanak Irannejad, Veronica Pessino, Delphine Mika, Bo Huang, Philip B Wedegaertner, Marco Conti, Mark von Zastrow. Functional selectivity of GPCR-directed drug action through location bias. Nature chemical biology. 2017 Jul; 13(7):799-806. doi: 10.1038/nchembio.2389. [PMID: 28553949]
  • Mari Sakai, Tokiko Suzuki, Kengo Tomita, Shigeyuki Yamashita, Sailesh Palikhe, Kohshi Hattori, Naoki Yoshimura, Naoyuki Matsuda, Yuichi Hattori. Diminished responsiveness to dobutamine as an inotrope in mice with cecal ligation and puncture-induced sepsis: attribution to phosphodiesterase 4 upregulation. American journal of physiology. Heart and circulatory physiology. 2017 Jun; 312(6):H1224-H1237. doi: 10.1152/ajpheart.00828.2016. [PMID: 28455289]
  • Genevieve Abigail Wilson, Luke C Wilson, Regis R Lamberts, Kamran Majeed, Sudish Lal, Gerard T Wilkins, James Chris Baldi. β-Adrenergic Responsiveness in the Type 2 Diabetic Heart: Effects on Cardiac Reserve. Medicine and science in sports and exercise. 2017 05; 49(5):907-914. doi: 10.1249/mss.0000000000001184. [PMID: 27984428]
  • Frederic Chagnon, David Coquerel, Dany Salvail, Eric Marsault, Robert Dumaine, Mannix Auger-Messier, Philippe Sarret, Olivier Lesur. Apelin Compared With Dobutamine Exerts Cardioprotection and Extends Survival in a Rat Model of Endotoxin-Induced Myocardial Dysfunction. Critical care medicine. 2017 Apr; 45(4):e391-e398. doi: 10.1097/ccm.0000000000002097. [PMID: 27571457]
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