Methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate (BioDeep_00000009558)

 

Secondary id: BioDeep_00001874698

human metabolite blood metabolite


代谢物信息卡片


3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, methyl ester

化学式: C16H15F3N2O4 (356.0983866)
中文名称: (+)-(S)-1,4-二氢-2,6-二甲基-5-硝基-4-[2-(三氟甲基)-苯基]吡啶-3-羧酸甲酯, (±)-BAYK8644
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC
InChI: InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Yi-Ke Lin, Yi-Jun Chen, Jie-Yi Li, Yu-Lin Chen, Dong He, Rui Zuo, Min-Jun Xiao, Dan-Ping Xu, Chao-Yang Zheng, Wei Wang, Rong-Rong He, Yang Chen. Salvianolic acid A from Danhong Injection induces vasorelaxation by Regulating L-type calcium channel in isolated mouse arteries. Journal of ethnopharmacology. 2022 Oct; 296(?):115431. doi: 10.1016/j.jep.2022.115431. [PMID: 35700852]
  • Kunal Khurana, Manish Kumar, Nitin Bansal. Lacidipine Attenuates Symptoms of Nicotine Withdrawal in Mice. Neurotoxicity research. 2021 Dec; 39(6):1920-1936. doi: 10.1007/s12640-021-00421-2. [PMID: 34613588]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Marek Kučka, Arturo E Gonzalez-Iglesias, Melanija Tomić, Rafael M Prévide, Kosara Smiljanic, Srdjan J Sokanovic, Patrick A Fletcher, Arthur Sherman, Tamas Balla, Stanko S Stojilkovic. Calcium-Prolactin Secretion Coupling in Rat Pituitary Lactotrophs Is Controlled by PI4-Kinase Alpha. Frontiers in endocrinology. 2021; 12(?):790441. doi: 10.3389/fendo.2021.790441. [PMID: 35058881]
  • Watcharee Waratchareeyakul, Fabio Fusi, Miriam Durante, Amer Ahmed, Walter Knirsch, Eduard Mas-Claret, Dulcie A Mulholland. Vasorelaxing Activity of Stilbenoid and Phenanthrene Derivatives from Brasiliorchis porphyrostele: Involvement of Smooth Muscle CaV1.2 Channels. Planta medica. 2020 Jun; 86(9):631-642. doi: 10.1055/a-1154-8832. [PMID: 32349139]
  • Mohammed F Alotaibi. Pimpinella anisum extract attenuates spontaneous and agonist-induced uterine contraction in term-pregnant rats. Journal of ethnopharmacology. 2020 May; 254(?):112730. doi: 10.1016/j.jep.2020.112730. [PMID: 32145331]
  • Zhengrong Guan, Joshua J Baty, Shali Zhang, Colton E Remedies, Edward W Inscho. Rho kinase inhibitors reduce voltage-dependent Ca2+ channel signaling in aortic and renal microvascular smooth muscle cells. American journal of physiology. Renal physiology. 2019 11; 317(5):F1132-F1141. doi: 10.1152/ajprenal.00212.2018. [PMID: 31432708]
  • Nele Seemann, Andrea Welling, Ingo Rustenbeck. The inhibitor of connexin Cx36 channels, mefloquine, inhibits voltage-dependent Ca2+ channels and insulin secretion. Molecular and cellular endocrinology. 2018 09; 472(?):97-106. doi: 10.1016/j.mce.2017.11.024. [PMID: 29208420]
  • Hiroki Teraoku, Sigurd Lenzen. Dynamics of Insulin Secretion from EndoC-βH1 β-Cell Pseudoislets in Response to Glucose and Other Nutrient and Nonnutrient Secretagogues. Journal of diabetes research. 2017; 2017(?):2309630. doi: 10.1155/2017/2309630. [PMID: 29201919]
  • Saumitra Pitake, Raymond S Ochs. Membrane depolarization increases ryanodine sensitivity to Ca2+ release to the cytosol in L6 skeletal muscle cells: Implications for excitation-contraction coupling. Experimental biology and medicine (Maywood, N.J.). 2016 04; 241(8):854-62. doi: 10.1177/1535370215619706. [PMID: 26643865]
  • Fan Di, Haifeng Zhai, Peng Li, Jianmei Huang. Effects of dehydroeffusol on spasmogen-induced contractile responses of rat intestinal smooth muscles. Planta medica. 2014 Aug; 80(12):978-83. doi: 10.1055/s-0034-1382901. [PMID: 25089735]
  • Kyungjin Lee, Jinho Jung, Gabsik Yang, Inhye Ham, Youngmin Bu, Hocheol Kim, Ho-Young Choi. Endothelium-independent vasorelaxation effects of Sigesbeckia glabrescens (Makino) Makino on isolated rat thoracic aorta. Phytotherapy research : PTR. 2013 Sep; 27(9):1308-12. doi: 10.1002/ptr.4874. [PMID: 23109264]
  • Edson Santos Ferreira-Filho, Daniel Dias Rufino Arcanjo, Lucas Henrique Porfírio Moura, José Couras da Silva-Filho, Emanuel Tenório Paulino, Eurica Adélia Nogueira Ribeiro, Mariana Helena Chaves, Rita de Cássia Meneses Oliveira, Aldeídia Pereira de Oliveira. Antihypertensive and vasorelaxant effects of ethanol extract of stem barks from Zanthoxylum rhoifolium Lam. in rats. Indian journal of experimental biology. 2013 Aug; 51(8):661-9. doi: ". [PMID: 24228390]
  • Gustavo Benaim, Yael García-Marchán, Claudia Reyes, Graciela Uzcanga, Katherine Figarella. Identification of a sphingosine-sensitive Ca2+ channel in the plasma membrane of Leishmania mexicana. Biochemical and biophysical research communications. 2013 Jan; 430(3):1091-6. doi: 10.1016/j.bbrc.2012.12.033. [PMID: 23261440]
  • Milton Junio Cândido Bernardes, Flávio Silva de Carvalho, Ludmila Lima Silveira, José Realino de Paula, Maria Teresa Freitas Bara, Clévia Ferreira Garrote, Gustavo Rodrigues Pedrino, Matheus Lavorenti Rocha. Hypotensive effect of Aspidosperma subincanum Mart. in rats and its mechanism of vasorelaxation in isolated arteries. Journal of ethnopharmacology. 2013 Jan; 145(1):227-32. doi: 10.1016/j.jep.2012.10.057. [PMID: 23159385]
  • I N Iakovenko, V V Zhirnov, O P Kozachenko, O V Shablykin, V S Brovarets'. [Participation of proteinkinase CK2 in regulation of human erythrocytes plasma membrane redox system activity: relative contribution of ca(2+)-dependent and ca(2+)-independent mechanisms of its activation]. Ukrains'kyi biokhimichnyi zhurnal (1999 ). 2012 Sep; 84(5):55-61. doi: . [PMID: 23342635]
  • Raquel Moreira Britto, André Luiz Santos, Jader Santos Cruz, Antonio Nei Santana Gondim, Sandra Lauton-Santos, Aline Lara, Silvia Guatimosim, Carla Maria Lins Vasconcelos, Charles Dos Santos Estevam, Antonio Santos Dias, Evaleide Diniz Oliveira, Adriana Karla Lima, Rejane Cardoso Souza, Eduardo Antonio Conde-Garcia. Aqueous fraction from Costus spiralis (Jacq.) Roscoe leaf reduces contractility by impairing the calcium inward current in the mammalian myocardium. Journal of ethnopharmacology. 2011 Nov; 138(2):382-9. doi: 10.1016/j.jep.2011.09.013. [PMID: 21963557]
  • Athanasios Denelavas, Franziska Weibel, Michael Prummer, Alexander Imbach, Roger G Clerc, Christian M Apfel, Cornelia Hertel. Real-time cellular impedance measurements detect Ca(2+) channel-dependent oscillations of morphology in human H295R adrenoma cells. Biochimica et biophysica acta. 2011 May; 1813(5):754-62. doi: 10.1016/j.bbamcr.2011.01.016. [PMID: 21262275]
  • Roger A Bannister, Eric Estève, José M Eltit, Isaac N Pessah, Paul D Allen, José R López, Kurt G Beam. A malignant hyperthermia-inducing mutation in RYR1 (R163C): consequent alterations in the functional properties of DHPR channels. The Journal of general physiology. 2010 Jun; 135(6):629-40. doi: 10.1085/jgp.200910329. [PMID: 20479108]
  • Katsuo Kamata, Yuta Ozawa, Tsuneo Kobayashi, Takayuki Matsumoto. Effect of N-epsilon-(carboxymethyl)lysine on coronary vasoconstriction in isolated perfused hearts from control and streptozotocin-induced diabetic rats. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi. 2009 Jun; 45(2-3):125-37. doi: 10.1540/jsmr.45.125. [PMID: 19602856]
  • Shengzhou Wu, Krzysztof L Hyrc, Krista L Moulder, Ying Lin, Timothy Warmke, B Joy Snider. Cellular calcium deficiency plays a role in neuronal death caused by proteasome inhibitors. Journal of neurochemistry. 2009 Jun; 109(5):1225-36. doi: 10.1111/j.1471-4159.2009.06037.x. [PMID: 19476541]
  • Bharathi Balasubramanian, John P Imredy, David Kim, Jacob Penniman, Armando Lagrutta, Joseph J Salata. Optimization of Ca(v)1.2 screening with an automated planar patch clamp platform. Journal of pharmacological and toxicological methods. 2009 Mar; 59(2):62-72. doi: 10.1016/j.vascn.2009.02.002. [PMID: 19367686]
  • Edwin E Daniel, Tahereh Eteraf, Bettina Sommer, Woo Jung Cho, Ahmed Elyazbi. The role of caveolae and caveolin 1 in calcium handling in pacing and contraction of mouse intestine. Journal of cellular and molecular medicine. 2009 Feb; 13(2):352-64. doi: 10.1111/j.1582-4934.2008.00667.x. [PMID: 19166483]
  • Shih-Min Hsia, Yueh-Hsiung Kuo, Wenchang Chiang, Paulus S Wang. Effects of adlay hull extracts on uterine contraction and Ca2+ mobilization in the rat. American journal of physiology. Endocrinology and metabolism. 2008 Sep; 295(3):E719-26. doi: 10.1152/ajpendo.90367.2008. [PMID: 18577689]
  • M Chahine, Y Qu, S Mancarella, M Boutjdir. Protein kinase C activation inhibits alpha1D L-type Ca channel: a single-channel analysis. Pflugers Archiv : European journal of physiology. 2008 Feb; 455(5):913-9. doi: 10.1007/s00424-007-0342-z. [PMID: 17909852]
  • Hiroto Tsujikawa, Yumei Song, Makino Watanabe, Haruko Masumiya, Sachin A Gupte, Rikuo Ochi, Takao Okada. Cholesterol depletion modulates basal L-type Ca2+ current and abolishes its -adrenergic enhancement in ventricular myocytes. American journal of physiology. Heart and circulatory physiology. 2008 Jan; 294(1):H285-92. doi: 10.1152/ajpheart.00824.2007. [PMID: 17982015]
  • Masayoshi Yamaguchi, Susumu Tomono, Taeko Nakagawa. Overexpression of RGPR-p117 suppresses apoptotic cell death and its related gene expression in cloned normal rat kidney proximal tubular epithelial NRK52E cells. International journal of molecular medicine. 2007 Oct; 20(4):565-71. doi: . [PMID: 17786289]
  • Young-Woo Kee, Dong-Yoon Lim. Influence of polyphenolic compounds isolated from Rubus coreanum on catecholamine release in the rat adrenal medulla. Archives of pharmacal research. 2007 Oct; 30(10):1240-51. doi: 10.1007/bf02980265. [PMID: 18038903]
  • Tiffany L Thai, Susan K Fellner, William J Arendshorst. ADP-ribosyl cyclase and ryanodine receptor activity contribute to basal renal vasomotor tone and agonist-induced renal vasoconstriction in vivo. American journal of physiology. Renal physiology. 2007 Oct; 293(4):F1107-14. doi: 10.1152/ajprenal.00483.2006. [PMID: 17652368]
  • Maxwell P A Jones, Jin Cao, Rob O'Brien, Susan J Murch, Praveen K Saxena. The mode of action of thidiazuron: auxins, indoleamines, and ion channels in the regeneration of Echinacea purpurea L. Plant cell reports. 2007 Sep; 26(9):1481-90. doi: 10.1007/s00299-007-0357-0. [PMID: 17483954]
  • Natsumi Sawada, Masayoshi Yamaguchi. Overexpression of RGPR-p117 enhances regucalcin gene promoter activity in cloned normal rat kidney proximal tubular epithelial cells: involvement of TTGGC motif. Journal of cellular biochemistry. 2006 Oct; 99(2):589-97. doi: 10.1002/jcb.20907. [PMID: 16676356]
  • Natsumi Sawada, Masayoshi Yamaguchi. Involvement of nuclear factor I-A1 in the regulation of regucalcin gene promoter activity in cloned normal rat kidney proximal tubular epithelial cells. International journal of molecular medicine. 2006 Oct; 18(4):665-71. doi: . [PMID: 16964421]
  • Jorge Marrero-Alonso, Benito García Marrero, Tomás Gómez, Mario Díaz. Functional inhibition of intestinal and uterine muscles by non-permeant triphenylethylene derivatives. European journal of pharmacology. 2006 Feb; 532(1-2):115-27. doi: 10.1016/j.ejphar.2005.11.031. [PMID: 16466652]
  • Kwokyin Hui, Peter Gardzinski, Hong-Shuo Sun, Peter H Backx, Zhong-Ping Feng. Permeable ions differentially affect gating kinetics and unitary conductance of L-type calcium channels. Biochemical and biophysical research communications. 2005 Dec; 338(2):783-92. doi: 10.1016/j.bbrc.2005.10.014. [PMID: 16243294]
  • Taeko Nakagawa, Masayoshi Yamaguchi. Overexpression of regucalcin suppresses apoptotic cell death in cloned normal rat kidney proximal tubular epithelial NRK52E cells: change in apoptosis-related gene expression. Journal of cellular biochemistry. 2005 Dec; 96(6):1274-85. doi: 10.1002/jcb.20617. [PMID: 16167335]
  • Taeko Nakagawa, Natumi Sawada, Masayoshi Yamaguchi. Overexpression of regucalcin suppresses cell proliferation of cloned normal rat kidney proximal tubular epithelial NRK52E cells. International journal of molecular medicine. 2005 Oct; 16(4):637-43. doi: . [PMID: 16142398]
  • Yuko Fukaya, Masayoshi Yamaguchi. Overexpression of regucalcin suppresses cell death and apoptosis in cloned rat hepatoma H4-II-E cells induced by insulin or insulin-like growth factor-I. Journal of cellular biochemistry. 2005 Sep; 96(1):145-54. doi: 10.1002/jcb.20485. [PMID: 15880694]
  • Dong-Yoon Lim. Comparison of green tea extract and epigallocatechin gallate on secretion of catecholamines from the rabbit adrenal medulla. Archives of pharmacal research. 2005 Aug; 28(8):914-22. doi: 10.1007/bf02973877. [PMID: 16178417]
  • Mahendra K Patel, Gerard F Clunn, Joanne S Lymn, Oneka Austin, Alun D Hughes. Effect of serum withdrawal on the contribution of L-type calcium channels (CaV1.2) to intracellular Ca2+ responses and chemotaxis in cultured human vascular smooth muscle cells. British journal of pharmacology. 2005 Jul; 145(6):811-7. doi: 10.1038/sj.bjp.0706237. [PMID: 15880143]
  • Matsui Toshiro, Takao Ueno, Mitsuru Tanaka, Hiromi Oka, Takahisa Miyamotq, Katsuhiro Osajima, Kiyoshi Matsumoto. Antiproliferative action of an angiotensin I-converting enzyme inhibitory peptide, Val-Tyr, via an L-type Ca2+ channel inhibition in cultured vascular smooth muscle cells. Hypertension research : official journal of the Japanese Society of Hypertension. 2005 Jun; 28(6):545-52. doi: 10.1291/hypres.28.545. [PMID: 16231761]
  • Stefan I McDonough, Yasuo Mori, Bruce P Bean. FPL 64176 modification of Ca(V)1.2 L-type calcium channels: dissociation of effects on ionic current and gating current. Biophysical journal. 2005 Jan; 88(1):211-23. doi: 10.1529/biophysj.104.051714. [PMID: 15501945]
  • Takako Izumi, Masayoshi Yamaguchi. Overexpression of regucalcin suppresses cell death and apoptosis in cloned rat hepatoma H4-II-E cells induced by lipopolysaccharide, PD 98059, dibucaine, or Bay K 8644. Journal of cellular biochemistry. 2004 Oct; 93(3):598-608. doi: 10.1002/jcb.20214. [PMID: 15378600]
  • J Rex Lee, Xin-Jian Zhang, Bor-Kang Lin, Charles E Reigel, Thomas E Tenner. Altered inotropic reactivity in diabetic rabbit right ventricular myocardium. Canadian journal of physiology and pharmacology. 2004 Oct; 82(10):903-10. doi: 10.1139/y04-101. [PMID: 15573151]
  • Emeline Perrier, Romain Perrier, Sylvain Richard, Jean-Pierre Bénitah. Ca2+ controls functional expression of the cardiac K+ transient outward current via the calcineurin pathway. The Journal of biological chemistry. 2004 Sep; 279(39):40634-9. doi: 10.1074/jbc.m407470200. [PMID: 15280354]
  • B R Wamhoff, D K Bowles, O G McDonald, S Sinha, A P Somlyo, A V Somlyo, G K Owens. L-type voltage-gated Ca2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase/myocardin/SRF-dependent mechanism. Circulation research. 2004 Aug; 95(4):406-14. doi: 10.1161/01.res.0000138582.36921.9e. [PMID: 15256479]
  • C L Chik, B Li, E Karpinski, A K Ho. Ceramide inhibits L-type calcium channel currents in GH3 cells. Molecular and cellular endocrinology. 2004 Apr; 218(1-2):175-83. doi: 10.1016/j.mce.2003.10.048. [PMID: 15130522]
  • Gregory N Hyde, Andre P Seale, E Gordon Grau, Russell J Borski. Cortisol rapidly suppresses intracellular calcium and voltage-gated calcium channel activity in prolactin cells of the tilapia (Oreochromis mossambicus). American journal of physiology. Endocrinology and metabolism. 2004 Apr; 286(4):E626-33. doi: 10.1152/ajpendo.00088.2003. [PMID: 14656715]
  • John E McRory, Jawed Hamid, Clinton J Doering, Esperanza Garcia, Robin Parker, Kevin Hamming, Lina Chen, Michael Hildebrand, Aaron M Beedle, Laura Feldcamp, Gerald W Zamponi, Terrance P Snutch. The CACNA1F gene encodes an L-type calcium channel with unique biophysical properties and tissue distribution. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Feb; 24(7):1707-18. doi: 10.1523/jneurosci.4846-03.2004. [PMID: 14973233]
  • Ludwig Baumann, Andrea Gerstner, Xiangang Zong, Martin Biel, Christian Wahl-Schott. Functional characterization of the L-type Ca2+ channel Cav1.4alpha1 from mouse retina. Investigative ophthalmology & visual science. 2004 Feb; 45(2):708-13. doi: 10.1167/iovs.03-0937. [PMID: 14744918]
  • Ming-Jae Lo, Paulus S Wang. Relative and combined effects of estradiol and prolactin on corticosterone secretion in ovariectomized rats. The Chinese journal of physiology. 2003 Sep; 46(3):103-9. doi: NULL. [PMID: 14672278]
  • Alexandra Koschak, Daniel Reimer, Doris Walter, Jean-Charles Hoda, Thomas Heinzle, Manfred Grabner, Jörg Striessnig. Cav1.4alpha1 subunits can form slowly inactivating dihydropyridine-sensitive L-type Ca2+ channels lacking Ca2+-dependent inactivation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003 Jul; 23(14):6041-9. doi: 10.1523/jneurosci.23-14-06041.2003. [PMID: 12853422]
  • Tsuneo Takenaka, Yoichi Ohno, Koichi Hayashi, Takao Saruta, Hiromichi Suzuki. Governance of arteriolar oscillation by ryanodine receptors. American journal of physiology. Regulatory, integrative and comparative physiology. 2003 Jul; 285(1):R125-31. doi: 10.1152/ajpregu.00711.2002. [PMID: 12793994]
  • Daniel J Haisenleder, Heather A Ferris, Margaret A Shupnik. The calcium component of gonadotropin-releasing hormone-stimulated luteinizing hormone subunit gene transcription is mediated by calcium/calmodulin-dependent protein kinase type II. Endocrinology. 2003 Jun; 144(6):2409-16. doi: 10.1210/en.2002-0013. [PMID: 12746302]
  • Shuangqing Peng, Ravindra K Hajela, William D Atchison. Effects of methylmercury on human neuronal L-type calcium channels transiently expressed in human embryonic kidney cells (HEK-293). The Journal of pharmacology and experimental therapeutics. 2002 Aug; 302(2):424-32. doi: 10.1124/jpet.102.032748. [PMID: 12130699]
  • Wendy B Bollag, EunMi Jung, Roberto A Calle. Mechanism of angiotensin II-induced phospholipase D activation in bovine adrenal glomerulosa cells. Molecular and cellular endocrinology. 2002 Jun; 192(1-2):7-16. doi: 10.1016/s0303-7207(02)00134-x. [PMID: 12088862]
  • Kinga K Borowicz, Zdzislaw Kleinrok, Stanislaw J Czuczwar. Niguldipine impairs the protective activity of carbamazepine and phenobarbital in amygdala-kindled seizures in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2002 Jun; 12(3):225-33. doi: 10.1016/s0924-977x(02)00027-5. [PMID: 12007674]
  • Tao Ma, Zhen-Zhong Fan, Rui-Rong He. Electrophysiological effects of phytoestrogen genistein on pacemaker cells in sinoatrial nodes of rabbits. Acta pharmacologica Sinica. 2002 Apr; 23(4):367-70. doi: ". [PMID: 11931696]
  • Y S Prakash, Inanc Seckin, Larry W Hunter, Gary C Sieck. Mechanisms underlying greater sensitivity of neonatal cardiac muscle to volatile anesthetics. Anesthesiology. 2002 Apr; 96(4):893-906. doi: 10.1097/00000542-200204000-00017. [PMID: 11964597]
  • May Simaan, Chanterelle Cadorette, Matthieu Poterek, Jean St-Louis, Michèle Brochu. Calcium channels contribute to the decrease in blood pressure of pregnant rats. American journal of physiology. Heart and circulatory physiology. 2002 Feb; 282(2):H665-71. doi: 10.1152/ajpheart.01183.2000. [PMID: 11788416]
  • Arlin B Blood, Yu Zhao, Wen Long, Lubo Zhang, Lawrence D Longo. L-type Ca2+ channels in fetal and adult ovine cerebral arteries. American journal of physiology. Regulatory, integrative and comparative physiology. 2002 Jan; 282(1):R131-8. doi: 10.1152/ajpregu.00318.2001. [PMID: 11742831]
  • D J Haisenleder, L J Workman, L L Burger, K W Aylor, A C Dalkin, J C Marshall. Gonadotropin subunit transcriptional responses to calcium signals in the rat: evidence for regulation by pulse frequency. Biology of reproduction. 2001 Dec; 65(6):1789-93. doi: 10.1095/biolreprod65.6.1789. [PMID: 11717142]
  • F Van Goor, D Zivadinovic, A J Martinez-Fuentes, S S Stojilkovic. Dependence of pituitary hormone secretion on the pattern of spontaneous voltage-gated calcium influx. Cell type-specific action potential secretion coupling. The Journal of biological chemistry. 2001 Sep; 276(36):33840-6. doi: 10.1074/jbc.m105386200. [PMID: 11457854]
  • G E Callera, W A Varanda, L M Bendhack. Ca(2+) influx is increased in 2-kidney, 1-clip hypertensive rat aorta. Hypertension (Dallas, Tex. : 1979). 2001 Sep; 38(3 Pt 2):592-6. doi: 10.1161/hy09t1.096248. [PMID: 11566937]
  • W Xu, D Lipscombe. Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001 Aug; 21(16):5944-51. doi: 10.1523/jneurosci.21-16-05944.2001. [PMID: 11487617]
  • L Valencia, M Bidet, S Martial, E Sanchez, E Melendez, M Tauc, C Poujeol, D Martin, M D Namorado, J L Reyes, P Poujeol. Nifedipine-activated Ca(2+) permeability in newborn rat cortical collecting duct cells in primary culture. American journal of physiology. Cell physiology. 2001 May; 280(5):C1193-203. doi: 10.1152/ajpcell.2001.280.5.c1193. [PMID: 11287333]
  • R M Touyz, C Mercure, T L Reudelhuber. Angiotensin II type I receptor modulates intracellular free Mg2+ in renally derived cells via Na+-dependent Ca2+-independent mechanisms. The Journal of biological chemistry. 2001 Apr; 276(17):13657-63. doi: 10.1074/jbc.m008101200. [PMID: 11278387]
  • D C Bell, A J Butcher, N S Berrow, K M Page, P F Brust, A Nesterova, K A Stauderman, G R Seabrook, B Nürnberg, A C Dolphin. Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents. Journal of neurophysiology. 2001 Feb; 85(2):816-27. doi: 10.1152/jn.2001.85.2.816. [PMID: 11160515]
  • S Inagaki, M Yamaguchi. Regulatory role of endogenous regucalcin in the enhancement of nuclear deoxyribonuleic acid synthesis with proliferation of cloned rat hepatoma cells (H4-II-E). Journal of cellular biochemistry. 2001; 82(4):704-11. doi: 10.1002/jcb.1193. [PMID: 11500948]
  • M Słomka, K Celiński, J Wargocki, Z Kleinrok, K Czerny, H Cichoz-Lach. The influence of nifedipine (calcium channel blocker) and Bay-K-8644 (calcium channel agonist) on the development of experimental acute pancreatitis. Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina. 2001; 56(?):29-34. doi: NULL. [PMID: 11977328]
  • J Wang, P S Krysiak, L G Laurier, S M Sims, H G Preiksaitis. Human esophageal smooth muscle cells express muscarinic receptor subtypes M(1) through M(5). American journal of physiology. Gastrointestinal and liver physiology. 2000 Nov; 279(5):G1059-69. doi: 10.1152/ajpgi.2000.279.5.g1059. [PMID: 11053004]
  • S Inagaki, H Misawa, M Yamaguchi. Role of endogenous regucalcin in protein tyrosine phosphatase regulation in the cloned rat hepatoma cells (H4-II-E). Molecular and cellular biochemistry. 2000 Oct; 213(1-2):43-50. doi: 10.1023/a:1007100631753. [PMID: 11129957]
  • S Inagaki, M Yamaguchi. Enhancement of protein tyrosine phosphatase activity in the proliferation of cloned rat hepatoma H4-II-E cells: suppressive role of endogenous regucalcin. International journal of molecular medicine. 2000 Sep; 6(3):323-8. doi: 10.3892/ijmm.6.3.323. [PMID: 10934298]
  • E Monjaraz, A Navarrete, L F Lopez-Santiago, A V Vega, J A Arias-Montaño, G Cota. L-type calcium channel activity regulates sodium channel levels in rat pituitary GH3 cells. The Journal of physiology. 2000 Feb; 523 Pt 1(?):45-55. doi: 10.1111/j.1469-7793.2000.00045.x. [PMID: 10673544]
  • M Tomić, T Koshimizu, D Yuan, S A Andric, D Zivadinovic, S S Stojilkovic. Characterization of a plasma membrane calcium oscillator in rat pituitary somatotrophs. The Journal of biological chemistry. 1999 Dec; 274(50):35693-702. doi: 10.1074/jbc.274.50.35693. [PMID: 10585449]
  • J Ren, L Jefferson, J R Sowers, R A Brown. Influence of age on contractile response to insulin-like growth factor 1 in ventricular myocytes from spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). 1999 Dec; 34(6):1215-22. doi: 10.1161/01.hyp.34.6.1215. [PMID: 10601121]
  • X Si, R C Webb, J M Richey. Bezafibrate, an anti-hypertriglyceridemic drug, attenuates vascular hyperresponsiveness and elevated blood pressure in fructose-induced hypertensive rats. Canadian journal of physiology and pharmacology. 1999 Oct; 77(10):755-62. doi: 10.1139/y99-061. [PMID: 10588479]
  • Z Ungvari, P Pacher, V Kecskemeti, G Papp, L Szollár, A Koller. Increased myogenic tone in skeletal muscle arterioles of diabetic rats. Possible role of increased activity of smooth muscle Ca2+ channels and protein kinase C. Cardiovascular research. 1999 Sep; 43(4):1018-28. doi: 10.1016/s0008-6363(99)00106-6. [PMID: 10615429]
  • M Nakajima, T Murata, M Yamaguchi. Expression of calcium-binding protein regucalcin mRNA in the cloned rat hepatoma cells (H4-II-E) is stimulated through Ca2+ signaling factors: involvement of protein kinase C. Molecular and cellular biochemistry. 1999 Aug; 198(1-2):101-7. doi: 10.1023/a:1006996506238. [PMID: 10497883]
  • M Yamaguchi, M Nakajima. Involvement of intracellular signaling factors in the serum-enhanced Ca2+-binding protein regucalcin mRNA expression in the cloned rat hepatoma cells (H4-II-E). Journal of cellular biochemistry. 1999 Jul; 74(1):81-9. doi: 10.1002/(sici)1097-4644(19990701)74:1<81::aid-jcb9>3.0.co;2-3. [PMID: 10381264]
  • R G Tsushima, A D Wickenden, R A Bouchard, G Y Oudit, P P Liu, P H Backx. Modulation of iron uptake in heart by L-type Ca2+ channel modifiers: possible implications in iron overload. Circulation research. 1999 Jun; 84(11):1302-9. doi: 10.1161/01.res.84.11.1302. [PMID: 10364568]
  • R Vinet, F F Vargas. L- and T-type voltage-gated Ca2+ currents in adrenal medulla endothelial cells. The American journal of physiology. 1999 04; 276(4):H1313-22. doi: 10.1152/ajpheart.1999.276.4.h1313. [PMID: 10199857]
  • M E Williams, M S Washburn, M Hans, A Urrutia, P F Brust, P Prodanovich, M M Harpold, K A Stauderman. Structure and functional characterization of a novel human low-voltage activated calcium channel. Journal of neurochemistry. 1999 Feb; 72(2):791-9. doi: 10.1046/j.1471-4159.1999.0720791.x. [PMID: 9930755]
  • A L Le Roy, I Messer-Létienne, N Bernard, D Benzoni. Effects of L-type calcium channel activation on renal vascular resistances in the Lyon hypertensive rat. Journal of cardiovascular pharmacology. 1999 Jan; 33(1):65-9. doi: 10.1097/00005344-199901000-00010. [PMID: 9890398]
  • H Satoh, H Katoh, P Velez, M Fill, D M Bers. Bay K 8644 increases resting Ca2+ spark frequency in ferret ventricular myocytes independent of Ca influx: contrast with caffeine and ryanodine effects. Circulation research. 1998 Dec; 83(12):1192-204. doi: 10.1161/01.res.83.12.1192. [PMID: 9851936]
  • N Kanaya, S Kawana, H Tsuchida, A Miyamoto, H Ohshika, A Namiki. Comparative myocardial depression of sevoflurane, isoflurane, and halothane in cultured neonatal rat ventricular myocytes. Anesthesia and analgesia. 1998 Nov; 87(5):1041-7. doi: 10.1097/00000539-199811000-00013. [PMID: 9806680]
  • E Cigola, B T Volpe, J W Lee, L Franzen, H Baker. Tyrosine hydroxylase expression in primary cultures of olfactory bulb: role of L-type calcium channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1998 Oct; 18(19):7638-49. doi: 10.1523/jneurosci.18-19-07638.1998. [PMID: 9742135]
  • D M Bers, L Li, H Satoh, E McCall. Factors that control sarcoplasmic reticulum calcium release in intact ventricular myocytes. Annals of the New York Academy of Sciences. 1998 Sep; 853(?):157-77. doi: 10.1111/j.1749-6632.1998.tb08264.x. [PMID: 10603944]
  • D Larsson, T Lundgren, K Sundell. Ca2+ uptake through voltage-gated L-type Ca2+ channels by polarized enterocytes from Atlantic cod Gadus morhua. The Journal of membrane biology. 1998 Aug; 164(3):229-37. doi: 10.1007/s002329900408. [PMID: 9691116]
  • I V Nizhenkovskaia, Iu I Gubskiĭ, I S Checkman, A G Goriushko, N A Gorchakova, L G Sachenko. [Antiradical activity and membranotropic action of cardio- and vasotropic compounds of varying chemical nature]. Ukrainskii biokhimicheskii zhurnal (1978). 1998 Jul; 70(4):51-8. doi: ". [PMID: 9848201]
  • J M Simard, X Li, K Tewari. Increase in functional Ca2+ channels in cerebral smooth muscle with renal hypertension. Circulation research. 1998 Jun; 82(12):1330-7. doi: 10.1161/01.res.82.12.1330. [PMID: 9648730]
  • N Kanaya, M Matsumoto, S Kawana, H Tsuchida, H Kimura, A Miyamoto, H Ohshika, A Namiki. Ca2+ channel modulation alters halothane-induced depression of ventricular myocytes. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 1998 Jun; 45(6):584-91. doi: 10.1007/bf03012714. [PMID: 9669017]
  • E Patterson, L Ma, B Szabo, C P Robinson, U Thadani. Ovariectomy and estrogen-induced alterations in myocardial contractility in female rabbits: role of the L-type calcium channel. The Journal of pharmacology and experimental therapeutics. 1998 Feb; 284(2):586-91. doi: . [PMID: 9454801]
  • M Wakamori, M Strobeck, T Niidome, T Teramoto, K Imoto, Y Mori. Functional characterization of ion permeation pathway in the N-type Ca2+ channel. Journal of neurophysiology. 1998 Feb; 79(2):622-34. doi: 10.1152/jn.1998.79.2.622. [PMID: 9463426]
  • T Murata, M Yamaguchi. Ca2+ administration stimulates the binding of AP-1 factor to the 5'-flanking region of the rat gene for the Ca2+-binding protein regucalcin. The Biochemical journal. 1998 Jan; 329 ( Pt 1)(?):157-63. doi: 10.1042/bj3290157. [PMID: 9405289]
  • M Jordinson, I L Beales, J Calam. Soybean agglutinin stimulated cholecystokinin release from cultured rabbit jejunal cells requires calcium influx via L-type calcium channels. Peptides. 1998; 19(9):1541-7. doi: 10.1016/s0196-9781(98)00088-6. [PMID: 9864061]
  • A De Roos, P H Willems, E J van Zoelen, A P Theuvenet. Synchronized Ca2+ signaling by intercellular propagation of Ca2+ action potentials in NRK fibroblasts. The American journal of physiology. 1997 12; 273(6):C1900-7. doi: 10.1152/ajpcell.1997.273.6.c1900. [PMID: 9435495]
  • D J Haisenleder, M Yasin, J C Marshall. Gonadotropin subunit and gonadotropin-releasing hormone receptor gene expression are regulated by alterations in the frequency of calcium pulsatile signals. Endocrinology. 1997 Dec; 138(12):5227-30. doi: 10.1210/endo.138.12.5611. [PMID: 9389505]
  • Y Nakae, N Kanaya, A Namiki. The direct effects of diazepam and midazolam on myocardial depression in cultured rat ventricular myocytes. Anesthesia and analgesia. 1997 Oct; 85(4):729-33. doi: 10.1097/00000539-199710000-00004. [PMID: 9322447]
  • H Ito, N Klugbauer, F Hofmann. Transfer of the high affinity dihydropyridine sensitivity from L-type To non-L-type calcium channel. Molecular pharmacology. 1997 Oct; 52(4):735-40. doi: 10.1124/mol.52.4.735. [PMID: 9380037]