Neurogard (BioDeep_00000009541)
Secondary id: BioDeep_00001028338
代谢物信息卡片
Dizocilpine
化学式: C16H15N (221.1204)
中文名称: 地佐环平
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12C3=CC=CC=C3CC(N1)C4=CC=CC=C24
InChI: InChI=1S/C16H15N/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16/h2-9,15,17H,10H2,1H3
描述信息
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
D020011 - Protective Agents
同义名列表
4 个代谢物同义名
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:34725
- KEGG: C13737
- PubChem: 1207
- Metlin: METLIN69670
- ChEMBL: CHEMBL442137
- MeSH: Dizocilpine Maleate
- CAS: 70449-94-4
- CAS: 77086-21-6
- PMhub: MS000023334
- PubChem: 586326
- PDB-CCD: BMK
- NIKKAJI: J246.194C
- KNApSAcK: 34725
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ping Yang, Sheng Huang, Zhihong Luo, Shaoming Zhou, Changjuan Zhang, Yong Zhu, Jingjing Yang, Liang Li. Radix Bupleuri aqueous extract attenuates MK801-induced schizophrenia-like symptoms in mice: Participation of intestinal flora.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 Mar; 172(?):116267. doi:
10.1016/j.biopha.2024.116267. [PMID: 38364739] - Yoichiro Kasuga, Ailing Hu, Zenji Kawakami, Masahiro Tabuchi, Takuji Yamaguchi, Hiroyuki Kobayashi, Shigaku Ikeda. Suppressive effect of Yokukansan on glutamate released from canine keratinocytes.
Open veterinary journal.
2024 Feb; 14(2):683-691. doi:
10.5455/ovj.2024.v14.i2.8. [PMID: 38549576] - Ayako Watanabe, Minori Shimada, Hayato Maeda, Tsuyoshi Narumi, Junji Ichita, Koh Itoku, Akira Nakajima. Apple Pomace Extract Improves MK-801-Induced Memory Impairment in Mice.
Nutrients.
2024 Jan; 16(2):. doi:
10.3390/nu16020194. [PMID: 38257087] - S B Caine, S Plant, K Furbish, M Yerton, E Smaragdi, B Niclou, J M Lorusso, J Y Chang, C Bitter, A Basu, S Miller, C-Y Huang, R Komson, D Liu, S Behar, M Thomsen. Sprague Dawley rats from different vendors vary in the modulation of prepulse inhibition of startle (PPI) by dopamine, acetylcholine, and glutamate drugs.
Psychopharmacology.
2023 Aug; ?(?):. doi:
10.1007/s00213-023-06444-1. [PMID: 37580441] - Huang Hongye, Wang Bingqian, Chen Shuijin, Fang Jiayu, Wang Xiaohua, Chen Lechun, Jiang Yu, Zhang Huanzhen, Chen Jincheng, Lin Zhigang. Chinese Tuina remodels the synaptic structure in neuropathic pain rats by downregulating the expression of N-methyl D-aspartate receptor subtype 2B and postsynaptic density protein-95 in the spinal cord dorsal horn.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2023 Aug; 43(4):715-724. doi:
10.19852/j.cnki.jtcm.20221214.002. [PMID: 37454256] - Kenan Yıldızhan, Mustafa Nazıroğlu. NMDA Receptor Activation Stimulates Hypoxia-Induced TRPM2 Channel Activation, Mitochondrial Oxidative Stress, and Apoptosis in Neuronal Cell Line: Modular Role of Memantine.
Brain research.
2023 Mar; 1803(?):148232. doi:
10.1016/j.brainres.2023.148232. [PMID: 36610553] - Mohamad Azmeer Effendy, Suleiman Yunusa, Noorul Hamizah Mat, Ahmad Tarmizi Che Has, Christian P Müller, Zurina Hassan. The role of AMPA and NMDA receptors in mitragynine effects on hippocampal synaptic plasticity.
Behavioural brain research.
2023 02; 438(?):114169. doi:
10.1016/j.bbr.2022.114169. [PMID: 36273648] - Xiao-Hong Li, Jie-Jun Fu, Xiao-Juan Shi, Yun-Na Zhang, Min Shao, Shao-Jie Yue, Chen Li, Zi-Qiang Luo. Sp1 mediated the inhibitory effect of glutamate on pulmonary surfactant synthesis.
PloS one.
2023; 18(8):e0289530. doi:
10.1371/journal.pone.0289530. [PMID: 37556489] - Bo Pan, Bing Han, Xiaoli Zhu, Yuting Wang, Hongyan Ji, Jianjun Weng, Yanqing Liu. Dysfunctional microRNA-144-3p/ZBTB20/ERK/CREB1 signalling pathway is associated with MK-801-induced schizophrenia-like abnormalities.
Brain research.
2023 01; 1798(?):148153. doi:
10.1016/j.brainres.2022.148153. [PMID: 36335997] - Sidrah Shahzad, Zehra Batool, Asia Afzal, Saida Haider. Reversal of oxidative stress, cytokine toxicity and DNA fragmentation by quercetin in dizocilpine-induced animal model of Schizophrenia.
Metabolic brain disease.
2022 12; 37(8):2793-2805. doi:
10.1007/s11011-022-01090-6. [PMID: 36152087] - Bo Pan, Lianlian Xu, Jianjun Weng, Yuting Wang, Hongyan Ji, Bing Han, Xiaoli Zhu, Yanqing Liu. Effects of icariin on alleviating schizophrenia-like symptoms by regulating the miR-144-3p/ATP1B2/mTOR signalling pathway.
Neuroscience letters.
2022 11; 791(?):136918. doi:
10.1016/j.neulet.2022.136918. [PMID: 36261079] - Xinyao Liu, Sitong Feng, Zhengtian Feng, Chao Ma, Yi He, Xue Li, Yanzhe Ning, Zuoli Sun, Hongxiao Jia. Protective Effects of Shi-Zhen-An-Shen Decoction on the Cognitive Impairment in MK801-Induced Schizophrenia Model.
Journal of integrative neuroscience.
2022 Sep; 21(6):164. doi:
10.31083/j.jin2106164. [PMID: 36424738] - Mengnan Zeng, Aozi Feng, Meng Li, Meng Liu, Pengli Guo, Yuhan Zhang, Qinqin Zhang, Beibei Zhang, Bing Cao, Jufang Jia, Ru Wang, Jun Lyu, Xiaoke Zheng. Corallodiscus flabellata B. L. Burtt extract and isonuomioside A ameliorate Aβ25-35-induced brain injury by inhibiting apoptosis, oxidative stress, and autophagy via the NMDAR2B/CamK Ⅱ/PKG pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jul; 101(?):154114. doi:
10.1016/j.phymed.2022.154114. [PMID: 35489325] - Saurabh Bhatia, Ahmed Al-Harrasi, Arun Kumar, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Md Khalid Anwer, Deepak Kaushik, Vineet Mittal, Sridevi Chigurupati, Pritam Babu Sharma, Lotfi Aleya, Celia Vargas-de-la-Cruz, Md Tanvir Kabir. Anti-migraine activity of freeze-dried latex obtained from Calotropis gigantea Linn.
Environmental science and pollution research international.
2022 Apr; 29(18):27460-27478. doi:
10.1007/s11356-021-17810-x. [PMID: 34981370] - Yongwoo Jeong, Ho Jung Bae, Keontae Park, Hyo Jeoung Bae, Xingquan Yang, Young-Jin Cho, Seo Yun Jung, Dae Sik Jang, Jong Hoon Ryu. 4-Methoxycinnamic acid attenuates schizophrenia-like behaviors induced by MK-801 in mice.
Journal of ethnopharmacology.
2022 Mar; 285(?):114864. doi:
10.1016/j.jep.2021.114864. [PMID: 34822958] - João F C Pedrazzi, Amanda J Sales, Francisco S Guimarães, Sâmia R L Joca, José A S Crippa, Elaine Del Bel. Cannabidiol prevents disruptions in sensorimotor gating induced by psychotomimetic drugs that last for 24-h with probable involvement of epigenetic changes in the ventral striatum.
Progress in neuro-psychopharmacology & biological psychiatry.
2021 12; 111(?):110352. doi:
10.1016/j.pnpbp.2021.110352. [PMID: 34015384] - Takaaki Ozawa, Tatsumi Itokazu, Yukio Ichitani, Kazuo Yamada. Pharmacologically induced N-methyl-D-aspartate receptor hypofunction impairs goal-directed food seeking in rats.
Neuropsychopharmacology reports.
2021 12; 41(4):526-531. doi:
10.1002/npr2.12209. [PMID: 34542935] - Radharani Benvenutti, Matheus Gallas-Lopes, Adrieli Sachett, Matheus Marcon, Nathan Ryzewski Strogulski, Carlos Guilherme Reis, Rafael Chitolina, Angelo Piato, Ana Paula Herrmann. How do zebrafish (Danio rerio) respond to MK-801 and amphetamine? Relevance for assessing schizophrenia-related endophenotypes in alternative model organisms.
Journal of neuroscience research.
2021 11; 99(11):2844-2859. doi:
10.1002/jnr.24948. [PMID: 34496062] - Paulina Cieślik, Adrianna Radulska, Grzegorz Burnat, Leszek Kalinowski, Joanna M Wierońska. Serotonergic-Muscarinic Interaction within the Prefrontal Cortex as a Novel Target to Reverse Schizophrenia-Related Cognitive Symptoms.
International journal of molecular sciences.
2021 Aug; 22(16):. doi:
10.3390/ijms22168612. [PMID: 34445318] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Cristiane Busnardo, Aline Fassini, Bruno Rodrigues, José Antunes-Rodrigues, Carlos C Crestani, Fernando M A Corrêa. N-Methyl-D-aspartate Glutamate Receptor Modulates Cardiovascular and Neuroendocrine Responses Evoked by Hemorrhagic Shock in Rats.
BioMed research international.
2021; 2021(?):1156031. doi:
10.1155/2021/1156031. [PMID: 34423030] - Marco Zattoni, Chiara Garrovo, Elena Xerxa, Giada Spigolon, Gilberto Fisone, Krister Kristensson, Giuseppe Legname. NMDA Receptor and L-Type Calcium Channel Modulate Prion Formation.
Cellular and molecular neurobiology.
2021 Jan; 41(1):191-198. doi:
10.1007/s10571-020-00834-1. [PMID: 32239389] - Jingyi Zhou, Shuaihui Liu, Luying Guo, Rending Wang, Jianghua Chen, Jia Shen. NMDA receptor-mediated CaMKII/ERK activation contributes to renal fibrosis.
BMC nephrology.
2020 09; 21(1):392. doi:
10.1186/s12882-020-02050-x. [PMID: 32907546] - Hideaki Ono, Takahiro Shimizu, Suo Zou, Masaki Yamamoto, Yohei Shimizu, Takaaki Aratake, Tomoya Hamada, Yoshiki Nagao, Shogo Shimizu, Youichirou Higashi, Motoaki Saito. Brain nitric oxide induces facilitation of the micturition reflex through brain glutamatergic receptors in rats.
Neurourology and urodynamics.
2020 08; 39(6):1687-1699. doi:
10.1002/nau.24440. [PMID: 32558992] - Chao Luo, Xu Wang, Xiaoyuan Mao, Hanxue Huang, Yong Liu, Jingping Zhao, Honghao Zhou, Zhaoqian Liu, Xiangping Li. Metformin attenuates antipsychotic-induced metabolic dysfunctions in MK801-induced schizophrenia-like rats.
Psychopharmacology.
2020 Aug; 237(8):2257-2277. doi:
10.1007/s00213-020-05524-w. [PMID: 32588080] - Carey Wilson, Shanshan Li, Anthony J Hannan, Thibault Renoir. Antidepressant-like effects of ketamine in a mouse model of serotonergic dysfunction.
Neuropharmacology.
2020 05; 168(?):107998. doi:
10.1016/j.neuropharm.2020.107998. [PMID: 32061666] - Ann-Katrin Kraeuter, Tadiwa Mashavave, Aditya Suvarna, Maarten van den Buuse, Zoltán Sarnyai. Effects of beta-hydroxybutyrate administration on MK-801-induced schizophrenia-like behaviour in mice.
Psychopharmacology.
2020 May; 237(5):1397-1405. doi:
10.1007/s00213-020-05467-2. [PMID: 31993694] - Peijun Ju, Wenhua Ding, Jianhua Chen, Ying Cheng, Beibei Yang, Lanting Huang, Qiong Zhou, Cuizhen Zhu, Xiaobo Li, Mengyue Wang, Jinghong Chen. The protective effects of Mogroside V and its metabolite 11-oxo-mogrol of intestinal microbiota against MK801-induced neuronal damages.
Psychopharmacology.
2020 Apr; 237(4):1011-1026. doi:
10.1007/s00213-019-05431-9. [PMID: 31900523] - Bokyung Koo, Ho Jung Bae, Nayeon Goo, Jaehoon Kim, Jihyun Kim, Mudan Cai, In Ho Jung, Kyungnam Cho, Seo Yun Jung, Suk Woo Chang, Dae Sik Jang, Jong Hoon Ryu. A botanical drug composed of three herbal materials attenuates the sensorimotor gating deficit and cognitive impairment induced by MK-801 in mice.
The Journal of pharmacy and pharmacology.
2020 Jan; 72(1):149-160. doi:
10.1111/jphp.13199. [PMID: 31713882] - Baiba Svalbe, Gundega Stelfa, Edijs Vavers, Baiba Zvejniece, Solveiga Grinberga, Eduards Sevostjanovs, Osvalds Pugovics, Maija Dambrova, Liga Zvejniece. Effects of the N-methyl-d-aspartate receptor antagonist, MK-801, on spatial memory and influence of the route of administration.
Behavioural brain research.
2019 10; 372(?):112067. doi:
10.1016/j.bbr.2019.112067. [PMID: 31276703] - Misae Takakuwa, Yumi Watanabe, Kiichi Tanaka, Taketoshi Ishii, Kenta Kagaya, Hiroyuki Taniguchi, Jun Kotera, Kenji Hashimoto. Antipsychotic-like effects of a novel phosphodiesterase 10A inhibitor T-251 in rodents.
Pharmacology, biochemistry, and behavior.
2019 10; 185(?):172757. doi:
10.1016/j.pbb.2019.172757. [PMID: 31404565] - Ju-Chun Pei, Wei-Li Hung, Bei-Xuan Lin, Min-Han Shih, Liang-Yin Lu, Da-Zhong Luo, Hwan-Ching Tai, Vincent Studer, Ming-Yuan Min, Wen-Sung Lai. Therapeutic potential and underlying mechanism of sarcosine (N-methylglycine) in N-methyl-D-aspartate (NMDA) receptor hypofunction models of schizophrenia.
Journal of psychopharmacology (Oxford, England).
2019 10; 33(10):1288-1302. doi:
10.1177/0269881119856558. [PMID: 31294644] - Guillermo Aquino-Miranda, Nayeli Rivera-Ramírez, Ricardo Márquez-Gómez, Juan Escamilla-Sánchez, Raúl González-Pantoja, Laura-Elisa Ramos-Languren, Iván Perez-Neri, Antonio Bueno-Nava, Camilo Ríos, José-Antonio Arias-Montaño. Histamine H3 receptor activation reduces the impairment in prepulse inhibition (PPI) of the acoustic startle response and Akt phosphorylation induced by MK-801 (dizocilpine), antagonist at N-Methyl-d-Aspartate (NMDA) receptors.
Progress in neuro-psychopharmacology & biological psychiatry.
2019 08; 94(?):109653. doi:
10.1016/j.pnpbp.2019.109653. [PMID: 31108178] - X Du, C R McCarthny, M Notaras, M van den Buuse, R A Hill. Effect of adolescent androgen manipulation on psychosis-like behaviour in adulthood in BDNF heterozygous and control mice.
Hormones and behavior.
2019 06; 112(?):32-41. doi:
10.1016/j.yhbeh.2019.03.005. [PMID: 30928609] - Andreas Coors, Marcel Brosch, Evelyn Kahl, Radwa Khalil, Birgit Michels, Annegret Laub, Katrin Franke, Bertram Gerber, Markus Fendt. Rhodiola rosea root extract has antipsychotic-like effects in rodent models of sensorimotor gating.
Journal of ethnopharmacology.
2019 May; 235(?):320-328. doi:
10.1016/j.jep.2019.02.031. [PMID: 30776471] - Gabriela Starowicz, Magdalena Jarosz, Ewelina Frąckiewicz, Natalia Grzechnik, Beata Ostachowicz, Gabriel Nowak, Katarzyna Mlyniec. Long-lasting antidepressant-like activity of the GPR39 zinc receptor agonist TC-G 1008.
Journal of affective disorders.
2019 02; 245(?):325-334. doi:
10.1016/j.jad.2018.11.003. [PMID: 30419533] - Kentaro Suina, Kenji Tsuchihashi, Juntaro Yamasaki, Shohei Kamenori, Subaru Shintani, Yuki Hirata, Shogo Okazaki, Oltea Sampetrean, Eishi Baba, Koichi Akashi, Yoichiro Mitsuishi, Fumiyuki Takahashi, Kazuhisa Takahashi, Hideyuki Saya, Osamu Nagano. Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B-containing N-methyl-d-aspartate-sensitive glutamate receptor signaling.
Cancer science.
2018 Dec; 109(12):3874-3882. doi:
10.1111/cas.13826. [PMID: 30298963] - Ying Wang, Jian-Liang Tang, Xingxing Xu, Xin-Ping Zhou, Jing Du, Xin Wang, Yi Zhou, Qiaojuan Zhu, Ling-Ling Yao, Yong-Gang Wang, Shuangxing Hou, Zhihui Huang. NMDA receptors inhibit axonal outgrowth by inactivating Akt and activating GSK-3β via calcineurin in cultured immature hippocampal neurons.
Experimental cell research.
2018 10; 371(2):389-398. doi:
10.1016/j.yexcr.2018.08.033. [PMID: 30176218] - Disha Shukla, Rajesh A Maheshwari, Kirti Patel, R Balaraman, Ashim Kumar Sen. Effect of Vaccinium macrocarpon on MK-801-induced psychosis in mice.
Indian journal of pharmacology.
2018 Sep; 50(5):227-235. doi:
10.4103/ijp.ijp_74_17. [PMID: 30636825] - Jiandong Lu, Lijun Fu, Guozhong Qin, Pengliang Shi, Wenjun Fu. The regulatory effect of Xiaoyao San on glucocorticoid receptors under the condition of chronic stress.
Cellular and molecular biology (Noisy-le-Grand, France).
2018 May; 64(6):103-109. doi:
. [PMID: 29808808] - Kai Lei, Guo-Fang He, Cheng-Liang Zhang, Ya-Nan Liu, Juan Li, Guang-Zhao He, Xi-Ping Li, Xiu-Hua Ren, Dong Liu. Investigation of the synergistic effects of haloperidol combined with Calculus Bovis Sativus in treating MK-801-induced schizophrenia in rats.
Experimental animals.
2018 May; 67(2):163-173. doi:
10.1538/expanim.17-0091. [PMID: 29225304] - Yanan Xu, Xiaoyin Zhu, Hongbo Wang, Shanyue Sun, Xin Yue, Jingwei Tian. In Vitro and In Vivo Characterization of PCC0104005, a Novel Modulator of Serotonin-Dopamine Activity, as an Atypical Antipsychotic Drug.
Scientific reports.
2018 05; 8(1):6892. doi:
10.1038/s41598-018-25036-0. [PMID: 29720711] - X-S Wang, H Huang. Study of molecular mechanisms of learning and memory impairment in neonatal rats post intrauterine distress via the pathway of Tau protein hyperphosphorylation.
European review for medical and pharmacological sciences.
2018 05; 22(9):2787-2800. doi:
10.26355/eurrev_201805_14978. [PMID: 29771431] - K Gawel, M Jenda-Wojtanowska, E Gibula-Bruzda, E Kedzierska, J Filarowska, M Marszalek-Grabska, K K Wojtanowski, L Komsta, S Talarek, J H Kotlinska. The influence of AMN082, metabotropic glutamate receptor 7 (mGlu7) allosteric agonist on the acute and chronic antinociceptive effects of morphine in the tail-immersion test in mice: Comparison with mGlu5 and mGlu2/3 ligands.
Physiology & behavior.
2018 03; 185(?):112-120. doi:
10.1016/j.physbeh.2017.12.035. [PMID: 29294304] - Robert W Gould, Michael D Grannan, Barak W Gunter, Jacob Ball, Michael Bubser, Thomas M Bridges, Jurgen Wess, Michael W Wood, Nicholas J Brandon, Mark E Duggan, Colleen M Niswender, Craig W Lindsley, P Jeffrey Conn, Carrie K Jones. Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M4 PAM VU0467154.
Neuropharmacology.
2018 Jan; 128(?):492-502. doi:
10.1016/j.neuropharm.2017.07.013. [PMID: 28729220] - Se Jin Jeon, Eunji Kim, Jin Su Lee, Hee Kyong Oh, Jiabao Zhang, Yubeen Kwon, Dae Sik Jang, Jong Hoon Ryu. Maslinic acid ameliorates NMDA receptor blockade-induced schizophrenia-like behaviors in mice.
Neuropharmacology.
2017 Nov; 126(?):168-178. doi:
10.1016/j.neuropharm.2017.09.014. [PMID: 28899728] - Sidrah Shahzad, Saara Ahmad, Syeda Madiha, Saima Khaliq, Laraib Liaquat, Sadia Sadir, Sahar Rafiq, Saiqa Tabassum, Zehra Batool, Saida Haider. Dizocilpine induced psychosis-like behavior in rats: A possible animal model with full spectrum of schizophrenia.
Pakistan journal of pharmaceutical sciences.
2017 Nov; 30(6(Supplementary)):2423-2427. doi:
". [PMID: 29188780] - Ichiro Kawahata, Tatsuya Suzuki, Evelyn Gutiérrez Rico, Shuichi Kusano, Hiroshi Tamura, Yoshihiro Mimaki, Tohru Yamakuni. Fermented Citrus reticulata (ponkan) fruit squeezed draff that contains a large amount of 4'-demethylnobiletin prevents MK801-induced memory impairment.
Journal of natural medicines.
2017 Oct; 71(4):617-631. doi:
10.1007/s11418-017-1091-8. [PMID: 28488113] - Chun-Sung Sung, Zhi-Hong Wen, Chien-Wei Feng, Chun-Hong Chen, Shi-Ying Huang, Nan-Fu Chen, Wu-Fu Chen, Chih-Shung Wong. Potentiation of spinal glutamatergic response in the neuron-glia interactions underlies the intrathecal IL-1β-induced thermal hyperalgesia in rats.
CNS neuroscience & therapeutics.
2017 Jul; 23(7):580-589. doi:
10.1111/cns.12705. [PMID: 28544775] - Reza Samavati, Ferenc Zádor, Edina Szűcs, Bernadett Tuka, Diána Martos, Gábor Veres, Róbert Gáspár, István M Mándity, Ferenc Fülöp, László Vécsei, Sándor Benyhe, Anna Borsodi. Kynurenic acid and its analogue can alter the opioid receptor G-protein signaling after acute treatment via NMDA receptor in rat cortex and striatum.
Journal of the neurological sciences.
2017 May; 376(?):63-70. doi:
10.1016/j.jns.2017.02.053. [PMID: 28431630] - Satoshi Okuyama, Kohei Miyazaki, Rie Yamada, Yoshiaki Amakura, Morio Yoshimura, Atsushi Sawamoto, Mitsunari Nakajima, Yoshiko Furukawa. Permeation of Polymethoxyflavones into the Mouse Brain and Their Effect on MK-801-Induced Locomotive Hyperactivity.
International journal of molecular sciences.
2017 Feb; 18(3):. doi:
10.3390/ijms18030489. [PMID: 28245567] - Hee Kyong Oh, Se Jin Jeon, Sunhee Lee, Hyung Eun Lee, Eunji Kim, Se Jin Park, Ha Neul Kim, Won Yong Jung, Jae Hoon Cheong, Dae Sik Jang, Jong Hoon Ryu. Swertisin ameliorates pre-pulse inhibition deficits and cognitive impairment induced by MK-801 in mice.
Journal of psychopharmacology (Oxford, England).
2017 02; 31(2):250-259. doi:
10.1177/0269881116672098. [PMID: 27729563] - Jinlong Zhao, Lexi Wang, Chunyu Fan, Kongtong Yu, Ximing Liu, Xiaolei Zhao, Dan Wang, Wenhua Liu, Zhengxing Su, Fengying Sun, Youxin Li. Development of near zero-order release PLGA-based microspheres of a novel antipsychotic.
International journal of pharmaceutics.
2017 Jan; 516(1-2):32-38. doi:
10.1016/j.ijpharm.2016.11.007. [PMID: 27825865] - Emilia M Lefevre, Gregory A Medley, Timothy Reeks, Suzy Alexander, Thomas H J Burne, Darryl W Eyles. Effect of the glucocorticoid receptor antagonist RU486 on MK-801 induced behavioural sensitisation.
PloS one.
2017; 12(4):e0176156. doi:
10.1371/journal.pone.0176156. [PMID: 28430805] - Mariola Herbet, Aleksandra Szopa, Sylwia Wosko, Anna Serefko, Magdalena Izdebska, Monika Gawronska-Grzywacz, Iwona Piatkowska-Chmiel, Martyna Janas, Renata Gieroba, Agnieszka Korga, Ewa Poleszak, Jaroslaw Dudka. The Positive Synergism of CPT and MK-801 in Behavioral Tests and in Reduction of Environmental Stress and Redox Signaling Changes in Mice Cerebral Cortex.
CNS & neurological disorders drug targets.
2017; 16(7):837-845. doi:
10.2174/1871527315666161010152414. [PMID: 27748185] - H Zhu, R Zhu, Z D Deng, Y C Feng, H L Shen. [Analgesic effects of ionotropic glutamate receptor antagonists MK-801 and NBQX on collagen-induced arthritis rats].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences.
2016 12; 48(6):977-981. doi:
. [PMID: 27987500] - Jing Ni, Nan Wang, Lili Gao, Lili Li, Siwen Zheng, Yuejian Liu, Molu Ozukum, Anna Nikiforova, Guangming Zhao, Zhiqi Song. The effect of the NMDA receptor-dependent signaling pathway on cell morphology and melanosome transfer in melanocytes.
Journal of dermatological science.
2016 Dec; 84(3):296-304. doi:
10.1016/j.jdermsci.2016.08.534. [PMID: 27596138] - Yan Zhang, Xiao-Jing Yu, Wen-Sheng Chen, Hong-Li Gao, Kai-Li Liu, Xiao-Lian Shi, Xiao-Yan Fan, Lin-Lin Jia, Wei Cui, Guo-Qing Zhu, Jin-Jun Liu, Yu-Ming Kang. Exercise training attenuates renovascular hypertension partly via RAS- ROS- glutamate pathway in the hypothalamic paraventricular nucleus.
Scientific reports.
2016 11; 6(?):37467. doi:
10.1038/srep37467. [PMID: 27881877] - Hila Roshanravan, Eun Young Kim, Stuart E Dryer. NMDA Receptors as Potential Therapeutic Targets in Diabetic Nephropathy: Increased Renal NMDA Receptor Subunit Expression in Akita Mice and Reduced Nephropathy Following Sustained Treatment With Memantine or MK-801.
Diabetes.
2016 10; 65(10):3139-50. doi:
10.2337/db16-0209. [PMID: 27388219] - Andréia S Cunha, Filipe C Matheus, Morgana Moretti, Tuane B Sampaio, Anicleto Poli, Danúbia B Santos, Dirleise Colle, Mauricio P Cunha, Carlos H Blum-Silva, Louis P Sandjo, Flávio H Reginatto, Ana Lúcia S Rodrigues, Marcelo Farina, Rui D Prediger. Agmatine attenuates reserpine-induced oral dyskinesia in mice: Role of oxidative stress, nitric oxide and glutamate NMDA receptors.
Behavioural brain research.
2016 10; 312(?):64-76. doi:
10.1016/j.bbr.2016.06.014. [PMID: 27306571] - Yumi Takemoto. Central cardiovascular actions of L-homocysteine microinjected into ventrolateral medullary autonomic areas of the rat.
Amino acids.
2016 09; 48(9):2215-25. doi:
10.1007/s00726-016-2259-3. [PMID: 27178024] - Herbert M Himmel, Michael Hoffmann. The 'induced hyperactivity' test for the de-risking of potential off-target activity of antihypertensive drugs.
Journal of pharmacological and toxicological methods.
2016 Sep; 81(?):313-22. doi:
10.1016/j.vascn.2016.05.004. [PMID: 27179911] - Yisong Qian, Xuzhen Tang, Teng Guan, Yunman Li, Hongbin Sun. Neuroprotection by Combined Administration with Maslinic Acid, a Natural Product from Olea europaea, and MK-801 in the Cerebral Ischemia Model.
Molecules (Basel, Switzerland).
2016 Aug; 21(8):. doi:
10.3390/molecules21081093. [PMID: 27548129] - L Hondebrink, A H A Verboven, W S Drega, S Schmeink, M W G D M de Groot, R G D M van Kleef, F M J Wijnolts, A de Groot, J Meulenbelt, R H S Westerink. Neurotoxicity screening of (illicit) drugs using novel methods for analysis of microelectrode array (MEA) recordings.
Neurotoxicology.
2016 07; 55(?):1-9. doi:
10.1016/j.neuro.2016.04.020. [PMID: 27149913] - Fabiana K Ludka, Lori de Fátima Tandler, Gislaine Kuminek, Gislaine Olescowicz, Jonatha Jacobsen, Simone Molz. Ilex paraguariensis hydroalcoholic extract exerts antidepressant-like and neuroprotective effects: involvement of the NMDA receptor and the L-arginine-NO pathway.
Behavioural pharmacology.
2016 06; 27(4):384-92. doi:
10.1097/fbp.0000000000000211. [PMID: 26703367] - Alexandre V Ivachtchenko, Yan Lavrovsky, Ilya Okun. AVN-101: A Multi-Target Drug Candidate for the Treatment of CNS Disorders.
Journal of Alzheimer's disease : JAD.
2016 05; 53(2):583-620. doi:
10.3233/jad-151146. [PMID: 27232215] - Pradip K Kamat, Philip Kyles, Anuradha Kalani, Neetu Tyagi. Hydrogen Sulfide Ameliorates Homocysteine-Induced Alzheimer's Disease-Like Pathology, Blood-Brain Barrier Disruption, and Synaptic Disorder.
Molecular neurobiology.
2016 May; 53(4):2451-2467. doi:
10.1007/s12035-015-9212-4. [PMID: 26019015] - Fumiya Tatsuki, Genshiro A Sunagawa, Shoi Shi, Etsuo A Susaki, Hiroko Yukinaga, Dimitri Perrin, Kenta Sumiyama, Maki Ukai-Tadenuma, Hiroshi Fujishima, Rei-ichiro Ohno, Daisuke Tone, Koji L Ode, Katsuhiko Matsumoto, Hiroki R Ueda. Involvement of Ca(2+)-Dependent Hyperpolarization in Sleep Duration in Mammals.
Neuron.
2016 Apr; 90(1):70-85. doi:
10.1016/j.neuron.2016.02.032. [PMID: 26996081] - Stella Mahieu, Maximiliano Klug, Néstor Millen, Ana Fabro, Adriana Benmelej, Maria Del Carmen Contini. Monosodium glutamate intake affect the function of the kidney through NMDA receptor.
Life sciences.
2016 Mar; 149(?):114-9. doi:
10.1016/j.lfs.2016.02.023. [PMID: 26905191] - Valentino Rački, Daniela Petrić, Natalia Kučić, Nika Gržeta, Kristina Jurdana, Ika Rončević-Gržeta. Cortical gray matter loss in schizophrenia: Could microglia be the culprit?.
Medical hypotheses.
2016 Mar; 88(?):18-21. doi:
10.1016/j.mehy.2015.12.021. [PMID: 26880628] - Lauren Kosten, Jeroen Verhaeghe, Robert Verkerk, David Thomae, Livia De Picker, Leonie Wyffels, Annemie Van Eetveldt, Stefanie Dedeurwaerdere, Sigrid Stroobants, Steven Staelens. Multiprobe molecular imaging of an NMDA receptor hypofunction rat model for glutamatergic dysfunction.
Psychiatry research. Neuroimaging.
2016 Feb; 248(?):1-11. doi:
10.1016/j.pscychresns.2016.01.013. [PMID: 26803479] - Jui-Tai Chen, Tyng-Guey Chen, Yung-Chia Chang, Cheng-Yu Chen, Ruei-Ming Chen. Roles of NMDARs in maintenance of the mouse cerebrovascular endothelial cell-constructed tight junction barrier.
Toxicology.
2016 Jan; 339(?):40-50. doi:
10.1016/j.tox.2015.11.006. [PMID: 26655082] - T S Gan'shina, E V Kurza, I N Kurdyumov, D V Maslennikov, R S Mirzoyan. [PECULIARITIES OF THE CEREBROVASCULAR EFFECTS OF GLUTAMIC ACID].
Eksperimental'naia i klinicheskaia farmakologiia.
2016; 79(3):9-12. doi:
". [PMID: 27455572] - Marjaana A Peltola, Juha Kuja-Panula, Johanna Liuhanen, Vootele Võikar, Petteri Piepponen, Tero Hiekkalinna, Tomi Taira, Sari E Lauri, Jaana Suvisaari, Natalia Kulesskaya, Tiina Paunio, Heikki Rauvala. AMIGO-Kv2.1 Potassium Channel Complex Is Associated With Schizophrenia-Related Phenotypes.
Schizophrenia bulletin.
2016 Jan; 42(1):191-201. doi:
10.1093/schbul/sbv105. [PMID: 26240432] - V Kumar, M A Ahmad, A K Najmi, M Akhtar. Effect of Sarcosine (a Glycine Transport 1 Inhibitor) and Risperidone (an Atypical antipsychotic Drug) on MK-801 Induced Learning and Memory Deficits in Rats.
Drug research.
2016 Jan; 66(1):11-7. doi:
10.1055/s-0035-1545299. [PMID: 25710578] - Laura Osorio-Rico, Juana Villeda-Hernández, Abel Santamaría, Mina Königsberg, Sonia Galván-Arzate. The N-Methyl-d-Aspartate Receptor Antagonist MK-801 Prevents Thallium-Induced Behavioral and Biochemical Alterations in the Rat Brain.
International journal of toxicology.
2015 Nov; 34(6):505-13. doi:
10.1177/1091581815603936. [PMID: 26350230] - Xiao-Long Hu, Li-Ping Guo, Qi Song, Qiao Zhang, Ying Chen, Jian Wang, Wei-Hong Meng, Qing-Chun Zhao. Kukoamine B, an amide alkaloid, protects against NMDA-induced neurotoxicity and potential mechanisms in vitro.
Neurochemistry international.
2015 Aug; 87(?):66-76. doi:
10.1016/j.neuint.2015.06.001. [PMID: 26065936] - Christian Roux, Caroline Aligny, Céline Lesueur, Virginie Girault, Valery Brunel, Yasmina Ramdani, Damien Genty, Azeddine Driouich, Annie Laquerrière, Stéphane Marret, Carole Brasse-Lagnel, Bruno J Gonzalez, Soumeya Bekri. NMDA receptor blockade in the developing cortex induces autophagy-mediated death of immature cortical GABAergic interneurons: An ex vivo and in vivo study in Gad67-GFP mice.
Experimental neurology.
2015 May; 267(?):177-93. doi:
10.1016/j.expneurol.2015.02.037. [PMID: 25795167] - Yoki Nakamura, Norimitsu Morioka, Fang Fang Zhang, Kazue Hisaoka-Nakashima, Yoshihiro Nakata. Downregulation of connexin36 in mouse spinal dorsal horn neurons leads to mechanical allodynia.
Journal of neuroscience research.
2015 Apr; 93(4):584-91. doi:
10.1002/jnr.23515. [PMID: 25400139] - Ramune Morkuniene, Paulius Cizas, Silvija Jankeviciute, Robertas Petrolis, Odeta Arandarcikaite, Algimantas Krisciukaitis, Vilmante Borutaite. Small Aβ1-42 oligomer-induced membrane depolarization of neuronal and microglial cells: role of N-methyl-D-aspartate receptors.
Journal of neuroscience research.
2015 Mar; 93(3):475-86. doi:
10.1002/jnr.23510. [PMID: 25400096] - Ivan Srejovic, Vladimir Jakovljevic, Vladimir Zivkovic, Nevena Barudzic, Ana Radovanovic, Olivera Stanojlovic, Dragan M Djuric. The effects of the modulation of NMDA receptors by homocysteine thiolactone and dizocilpine on cardiodynamics and oxidative stress in isolated rat heart.
Molecular and cellular biochemistry.
2015 Mar; 401(1-2):97-105. doi:
10.1007/s11010-014-2296-8. [PMID: 25467376] - Kazuaki Kawaura, Hiroyuki Koike, Kohnosuke Kinoshita, Daiji Kambe, Ayaka Kaku, Jun-ichi Karasawa, Shigeyuki Chaki, Hirohiko Hikichi. Effects of a glycine transporter-1 inhibitor and D-serine on MK-801-induced immobility in the forced swimming test in rats.
Behavioural brain research.
2015 Feb; 278(?):186-92. doi:
10.1016/j.bbr.2014.09.046. [PMID: 25300471] - Jun Ho Jang, Taick Sang Nam, Jaebeom Jun, Se Jung Jung, Dong-Wook Kim, Joong Woo Leem. Peripheral NMDA Receptors Mediate Antidromic Nerve Stimulation-Induced Tactile Hypersensitivity in the Rat.
Mediators of inflammation.
2015; 2015(?):793624. doi:
10.1155/2015/793624. [PMID: 26770021] - Pavel Montes de Oca Balderas, Penélope Aguilera. A Metabotropic-Like Flux-Independent NMDA Receptor Regulates Ca2+ Exit from Endoplasmic Reticulum and Mitochondrial Membrane Potential in Cultured Astrocytes.
PloS one.
2015; 10(5):e0126314. doi:
10.1371/journal.pone.0126314. [PMID: 25954808] - Chian-Shiung Lin, Shun-Fa Hung, Ho-Shiang Huang, Ming-Chieh Ma. Blockade of the N-Methyl-D-Aspartate Glutamate Receptor Ameliorates Lipopolysaccharide-Induced Renal Insufficiency.
PloS one.
2015; 10(7):e0132204. doi:
10.1371/journal.pone.0132204. [PMID: 26133372] - Xiuyun Liu, Ning Guo, Jia Lin, Yinglan Zhang, Xiao Qian Chen, Sheng Li, Lin He, Qiang Li. Strain-dependent differential behavioral responses of zebrafish larvae to acute MK-801 treatment.
Pharmacology, biochemistry, and behavior.
2014 Dec; 127(?):82-9. doi:
10.1016/j.pbb.2014.11.007. [PMID: 25449354] - Christopher L Shaffer, Sarah M Osgood, Deborah L Smith, JianHua Liu, Patrick E Trapa. Enhancing ketamine translational pharmacology via receptor occupancy normalization.
Neuropharmacology.
2014 Nov; 86(?):174-80. doi:
10.1016/j.neuropharm.2014.07.008. [PMID: 25063581] - Se Jin Park, Younghwa Lee, Hee Kyong Oh, Hyung Eun Lee, Younghwan Lee, Sang Yoon Ko, Boseong Kim, Jae Hoon Cheong, Chan Young Shin, Jong Hoon Ryu. Oleanolic acid attenuates MK-801-induced schizophrenia-like behaviors in mice.
Neuropharmacology.
2014 Nov; 86(?):49-56. doi:
10.1016/j.neuropharm.2014.06.025. [PMID: 24997455] - Katerina Zavitsanou, Chai K Lim, Tertia Purves-Tyson, Tim Karl, Michael Kassiou, Samuel D Banister, Gilles J Guillemin, Cynthia Shannon Weickert. Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: amelioration by COX-2 inhibition.
Brain, behavior, and immunity.
2014 Oct; 41(?):173-81. doi:
10.1016/j.bbi.2014.05.011. [PMID: 24878170] - Andrew J Linsenbardt, Amanda Taylor, Christine M Emnett, James J Doherty, Kathiresan Krishnan, Douglas F Covey, Steven M Paul, Charles F Zorumski, Steven Mennerick. Different oxysterols have opposing actions at N-methyl-D-aspartate receptors.
Neuropharmacology.
2014 Oct; 85(?):232-42. doi:
10.1016/j.neuropharm.2014.05.027. [PMID: 24878244] - Yan He, Sheng-Ya Zeng, Shi-Wen Zhou, Gui-Sheng Qian, Kang Peng, Zhi-Xian Mo, Ji-Yin Zhou. Effects of rhynchophylline on GluN1 and GluN2B expressions in primary cultured hippocampal neurons.
Fitoterapia.
2014 Oct; 98(?):166-73. doi:
10.1016/j.fitote.2014.08.002. [PMID: 25110195] - M S da Rosa, B Seminotti, A U Amaral, B Parmeggiani, F H de Oliveira, G Leipnitz, M Wajner. Disruption of redox homeostasis and histopathological alterations caused by in vivo intrastriatal administration of D-2-hydroxyglutaric acid to young rats.
Neuroscience.
2014 Sep; 277(?):281-93. doi:
10.1016/j.neuroscience.2014.07.011. [PMID: 25043325] - Omar Cauli, Alba González-Usano, Andrea Cabrera-Pastor, Carla Gimenez-Garzó, Pilar López-Larrubia, Amparo Ruiz-Sauri, Vicente Hernández-Rabaza, Malgorzata Duszczyk, Michal Malek, Jerzy W Lazarewicz, Arturo Carratalá, Amparo Urios, Alfonso Miguel, Isidro Torregrosa, Carmen Carda, Carmina Montoliu, Vicente Felipo. Blocking NMDA receptors delays death in rats with acute liver failure by dual protective mechanisms in kidney and brain.
Neuromolecular medicine.
2014 Jun; 16(2):360-75. doi:
10.1007/s12017-013-8283-5. [PMID: 24338618] - Elżbieta Ziemińska, Aleksandra Stafiej, Lidia Strużyńska. The role of the glutamatergic NMDA receptor in nanosilver-evoked neurotoxicity in primary cultures of cerebellar granule cells.
Toxicology.
2014 Jan; 315(?):38-48. doi:
10.1016/j.tox.2013.11.008. [PMID: 24291493] - Xianlin Sun, Jingquan Zhong, Deguo Wang, Jian Xu, Hao Su, Chunsheng An, Hongjun Zhu, Ji Yan. Increasing glutamate promotes ischemia-reperfusion-induced ventricular arrhythmias in rats in vivo.
Pharmacology.
2014; 93(1-2):4-9. doi:
10.1159/000356311. [PMID: 24401762] - Se Jin Park, Se Jin Jeon, Ike C Dela Peña, Hyung Eun Lee, Dong Hyun Kim, Jong Min Kim, Young Woo Lee, Jun Man Jung, Bum Young Shin, Seungheon Lee, Jae Hoon Cheong, Chan Young Shin, Dae Sik Jang, Jong Hoon Ryu. Prunella vulgaris attenuates prepulse inhibition deficit and attention disruption induced by MK-801 in mice.
Phytotherapy research : PTR.
2013 Dec; 27(12):1763-9. doi:
10.1002/ptr.4929. [PMID: 23348874] - Takashi Sugane, Takahiko Tobe, Wataru Hamaguchi, Itsuro Shimada, Kyoichi Maeno, Junji Miyata, Takeshi Suzuki, Tetsuya Kimizuka, Shuichi Sakamoto, Shin-ichi Tsukamoto. Atropisomeric 4-phenyl-4H-1,2,4-triazoles as selective glycine transporter 1 inhibitors.
Journal of medicinal chemistry.
2013 Jul; 56(14):5744-56. doi:
10.1021/jm400383w. [PMID: 23837744] - Sourav Kundu, Sathnur B Pushpakumar, Aaron Tyagi, Denise Coley, Utpal Sen. Hydrogen sulfide deficiency and diabetic renal remodeling: role of matrix metalloproteinase-9.
American journal of physiology. Endocrinology and metabolism.
2013 Jun; 304(12):E1365-78. doi:
10.1152/ajpendo.00604.2012. [PMID: 23632630] - Carolina Gonçalves Fernandes, Mateus Struecker da Rosa, Bianca Seminotti, Paula Pierozan, Rafael Wolter Martell, Valeska Lizzi Lagranha, Estela Natacha Brandt Busanello, Guilhian Leipnitz, Moacir Wajner. In vivo experimental evidence that the major metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency induce oxidative stress in striatum of developing rats: a potential pathophysiological mechanism of striatal damage in this disorder.
Molecular genetics and metabolism.
2013 Jun; 109(2):144-53. doi:
10.1016/j.ymgme.2013.03.017. [PMID: 23611578]
