Bremazocine (BioDeep_00000008873)
代谢物信息卡片
Bremazocine
化学式: C20H29NO2 (315.2198)
中文名称: 布马佐辛
谱图信息:
最多检出来源 Mentha canadensis(plant) 81.58%
分子结构信息
SMILES: CCC12CCN(C(C1(C)C)CC3=C2C=C(C=C3)O)CC4(CC4)O
InChI: InChI=1S/C20H29NO2/c1-4-20-9-10-21(13-19(23)7-8-19)17(18(20,2)3)11-14-5-6-15(22)12-16(14)20/h5-6,12,17,22-23H,4,7-11,13H2,1-3H3
描述信息
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
3 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:3171
- KEGG: C11791
- PubChem: 443406
- PubChem: 1223
- Metlin: METLIN69221
- ChEMBL: CHEMBL350384
- CAS: 75684-07-0
- CAS: 83829-76-9
- CAS: 71990-00-6
- PMhub: MS000022577
- PubChem: 13955
- NIKKAJI: J18.646E
- RefMet: Bremazocine
- KNApSAcK: 3171
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhihua Xie, Rashmi G Bhushan, David J Daniels, Philip S Portoghese. Interaction of bivalent ligand KDN21 with heterodimeric delta-kappa opioid receptors in human embryonic kidney 293 cells.
Molecular pharmacology.
2005 Oct; 68(4):1079-86. doi:
10.1124/mol.105.012070. [PMID: 16006595] - Keith H Christoffers, Hong Li, Richard D Howells. Purification and mass spectrometric analysis of the delta opioid receptor.
Brain research. Molecular brain research.
2005 May; 136(1-2):54-64. doi:
10.1016/j.molbrainres.2005.01.016. [PMID: 15893587] - Elisabeth Greiner, John E Folk, Arthur E Jacobson, Kenner C Rice. A novel and facile preparation of bremazocine enantiomers through optically pure N-norbremazocines.
Bioorganic & medicinal chemistry.
2004 Jan; 12(1):233-8. doi:
10.1016/j.bmc.2003.10.029. [PMID: 14697788] - Keith H Christoffers, Hong Li, Susan M Keenan, Richard D Howells. Purification and mass spectrometric analysis of the mu opioid receptor.
Brain research. Molecular brain research.
2003 Oct; 118(1-2):119-31. doi:
10.1016/j.molbrainres.2003.08.008. [PMID: 14559361] - M C H Ko, K J Willmont, H Lee, G S Flory, J H Woods. Ultra-long antagonism of kappa opioid agonist-induced diuresis by intracisternal nor-binaltorphimine in monkeys.
Brain research.
2003 Aug; 982(1):38-44. doi:
10.1016/s0006-8993(03)02938-x. [PMID: 12915238] - Keith H Christoffers, Arshia Khokhar, Kirti Chaturvedi, Richard D Howells. Inhibition of mu and delta opioid receptor ligand binding by the peptide aldehyde protease inhibitor, leupeptin.
Regulatory peptides.
2002 Apr; 105(1):9-14. doi:
10.1016/s0167-0115(01)00382-2. [PMID: 11853866] - G Piñeyro, M Azzi, A De Léan, P Schiller, M Bouvier. Short-term inverse-agonist treatment induces reciprocal changes in delta-opioid agonist and inverse-agonist binding capacity.
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2001 Oct; 60(4):816-27. doi:
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2001 Aug; 426(1-2):25-34. doi:
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Behavioural pharmacology.
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10.1097/00008877-200107000-00002. [PMID: 11548109] - K Chaturvedi, X Jiang, K H Christoffers, N Chinen, P Bandari, L F Raveglia, S Ronzoni, G Dondio, R D Howells. Pharmacological profiles of selective non-peptidic delta opioid receptor ligands.
Brain research. Molecular brain research.
2000 Sep; 80(2):166-76. doi:
10.1016/s0169-328x(00)00134-0. [PMID: 11038249] - G Bonner, F Meng, H Akil. Selectivity of mu-opioid receptor determined by interfacial residues near third extracellular loop.
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1998 Dec; 61(4):395-403. doi:
10.1016/s0091-3057(98)00124-5. [PMID: 9802834] - C D Soulard, S Guerif, A Payne, S G Dahl. Differential effects of fedotozine compared to other kappa agonists on diuresis in rats.
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1996 Dec; 279(3):1379-85. doi:
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1995 Dec; 92(26):12436-40. doi:
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The Journal of pharmacology and experimental therapeutics.
1992 Jan; 260(1):327-33. doi:
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The Journal of pharmacy and pharmacology.
1991 Mar; 43(3):212-6. doi:
10.1111/j.2042-7158.1991.tb06670.x. [PMID: 1675283] - B R de Costa, K C Rice, W D Bowen, A Thurkauf, R B Rothman, L Band, A E Jacobson, L Radesca, P C Contreras, N M Gray. Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity sigma receptor ligands. Identification of a new class of highly potent and selective sigma receptor probes.
Journal of medicinal chemistry.
1990 Nov; 33(11):3100-10. doi:
10.1021/jm00173a030. [PMID: 2172538] - M A Scheideler, R S Zukin. Reconstitution of solubilized delta-opiate receptor binding sites in lipid vesicles.
The Journal of biological chemistry.
1990 Sep; 265(25):15176-82. doi:
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Journal of the autonomic nervous system.
1990 Jul; 30 Suppl(?):S191-3. doi:
10.1016/0165-1838(90)90129-7. [PMID: 2170490] - B R de Costa, R B Rothman, V Bykov, L Band, A Pert, A E Jacobson, K C Rice. Probes for narcotic receptor mediated phenomena. 17. Synthesis and evaluation of a series of trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacet amide (U50,488) related isothiocyanate derivatives as opioid receptor affinity ligands.
Journal of medicinal chemistry.
1990 Apr; 33(4):1171-6. doi:
10.1021/jm00166a014. [PMID: 2157008] - B E Sumner, J E Coombes, K M Pumford, J A Russell. Opioid receptor subtypes in the supraoptic nucleus and posterior pituitary gland of morphine-tolerant rats.
Neuroscience.
1990; 37(3):635-45. doi:
10.1016/0306-4522(90)90095-l. [PMID: 2174133] - S P Salas, J Roblero, H Ureta, J P Huidobro-Toro. Diuretic effect of bremazocine, a kappa-opioid with central and peripheral sites of action.
The Journal of pharmacology and experimental therapeutics.
1989 Sep; 250(3):992-9. doi:
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European journal of pharmacology.
1989 Jul; 166(1):41-8. doi:
10.1016/0014-2999(89)90681-x. [PMID: 2553430] - B R de Costa, R B Rothman, V Bykov, A E Jacobson, K C Rice. Selective and enantiospecific acylation of kappa opioid receptors by (1S,2S)-trans-2-isothiocyanato-N-methyl-N-[2-(1-pyrrolidinyl) cyclohexy l] benzeneacetamide. Demonstration of kappa receptor heterogeneity.
Journal of medicinal chemistry.
1989 Feb; 32(2):281-3. doi:
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Neuropharmacology.
1987 Oct; 26(10):1503-7. doi:
10.1016/0028-3908(87)90170-5. [PMID: 2825059] - L A Dykstra, D E Gmerek, G Winger, J H Woods. Kappa opioids in rhesus monkeys. II. Analysis of the antagonistic actions of quadazocine and beta-funaltrexamine.
The Journal of pharmacology and experimental therapeutics.
1987 Aug; 242(2):421-7. doi:
. [PMID: 3302207] - J D Leander, J C Hart, R L Zerbe. Kappa agonist-induced diuresis: evidence for stereoselectivity, strain differences, independence of hydration variables and a result of decreased plasma vasopressin levels.
The Journal of pharmacology and experimental therapeutics.
1987 Jul; 242(1):33-9. doi:
. [PMID: 3039112] - J D Leander. Bremazocine-induced urination in rats of different sizes.
Research communications in chemical pathology and pharmacology.
1987 Jul; 57(1):141-4. doi:
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Research communications in chemical pathology and pharmacology.
1986 Oct; 54(1):23-34. doi:
NULL. [PMID: 2879325] - H Ensinger, L Hedler, B Szabo, K Starke. Bremazocine causes sympatho-inhibition and hypotension in rabbits by activating peripheral kappa-receptors.
Journal of cardiovascular pharmacology.
1986 May; 8(3):470-5. doi:
10.1097/00005344-198605000-00005. [PMID: 2425160] - J C Reubi. Central nervous system-mediated growth inhibition of a rat prostate carcinoma by an opioid.
The Journal of endocrinology.
1985 Nov; 107(2):247-50. doi:
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1985 Oct; 116(1-2):75-9. doi:
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Journal of neurochemistry.
1985 Sep; 45(3):688-99. doi:
10.1111/j.1471-4159.1985.tb04047.x. [PMID: 2993510] - J D Leander, R L Zerbe, J C Hart. Diuresis and suppression of vasopressin by kappa opioids: comparison with mu and delta opioids and clonidine.
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1985 Aug; 234(2):463-9. doi:
NULL. [PMID: 2991502] - M L Richards, W Sadée. In vivo binding of benzomorphans to mu, delta and kappa opioid receptors: comparison with urine output in the rat.
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1985 May; 233(2):425-32. doi:
NULL. [PMID: 2987482] - J P Huidobro-Toro, S Parada. Kappa-opiates and urination: pharmacological evidence for an endogenous role of the kappa-opiate receptor in fluid and electrolyte balance.
European journal of pharmacology.
1984 Dec; 107(1):1-10. doi:
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Neuropeptides.
1984 Dec; 5(1-3):283-6. doi:
10.1016/0143-4179(84)90083-0. [PMID: 6099514] - R W Fuller, J D Leander. Elevation of serum corticosterone in rats by bremazocine, a kappa-opioid agonist.
The Journal of pharmacy and pharmacology.
1984 May; 36(5):345-6. doi:
10.1111/j.2042-7158.1984.tb04392.x. [PMID: 6145778] - M Markó, D Römer. Inhibitory effect of a new opioid agonist on reproductive endocrine activity in rats of both sexes.
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1983 Jul; 33(3):233-40. doi:
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