N-Hydroxymethyl-N-methylformamide (BioDeep_00000008682)

 

Secondary id: BioDeep_00001878131

human metabolite blood metabolite


代谢物信息卡片


N-(hydroxymethyl)-N-methylformamide

化学式: C3H7NO2 (89.0476762)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 25%

分子结构信息

SMILES: CN(C=O)CO
InChI: InChI=1S/C3H7NO2/c1-4(2-5)3-6/h2,6H,3H2,1H3

描述信息

同义名列表

4 个代谢物同义名

N-(hydroxymethyl)-N-methylformamide; N-Hydroxymethyl-N-methylformamide; DMF-OH; HMMF



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sonja Kilo, Thomas Göen, Hans Drexler. Cross-sectional study on N,N-dimethylformamide (DMF); effects on liver and alcohol intolerance. International archives of occupational and environmental health. 2016 Nov; 89(8):1309-1320. doi: 10.1007/s00420-016-1164-0. [PMID: 27587219]
  • Vagner Fernandes Knupp, Edna Maria Alvarez Leite, Zenilda de Lourdes Cardeal. Development of a solid phase microextraction-gas chromatography method to determine N-hydroxymethyl-N-methylformamide and N-methylformamide in urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 Dec; 828(1-2):103-7. doi: 10.1016/j.jchromb.2005.09.030. [PMID: 16221575]
  • Jae Ho Sohn, Min Jeong Han, Mi Young Lee, Seong-Kyu Kang, Jeong Sun Yang. Simultaneous determination of N-hydroxymethyl-N-methylformamide, N-methylformamide and N-acetyl-S-(N-methylcarbamoyl)cystein in urine samples from workers exposed to N,N-dimethylformamide by liquid chromatography-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2005 Feb; 37(1):165-70. doi: 10.1016/j.jpba.2004.10.001. [PMID: 15664757]
  • H U Käfferlein, J Mráz, C Ferstl, J Angerer. Analysis of metabolites of N,N-dimethylformamide in urine samples. International archives of occupational and environmental health. 2004 Aug; 77(6):427-32. doi: 10.1007/s00420-004-0538-x. [PMID: 15309551]
  • H U Käfferlein, J Angerer. Simultaneous determination of two human urinary metabolites of N,N-dimethylformamide using gas chromatography-thermionic sensitive detection with mass spectrometric confirmation. Journal of chromatography. B, Biomedical sciences and applications. 1999 Nov; 734(2):285-98. doi: 10.1016/s0378-4347(99)00372-2. [PMID: 10595726]
  • A M Saillenfait, J P Payan, D Beydon, J P Fabry, I Langonne, J P Sabate, F Gallissot. Assessment of the developmental toxicity, metabolism, and placental transfer of N,N-dimethylformamide administered to pregnant rats. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1997 Sep; 39(1):33-43. doi: 10.1006/faat.1997.2343. [PMID: 9325025]
  • R D Farrant, B C Cupid, J K Nicholson, J C Lindon. Investigation of the feasibility of directly-coupled HPLC-NMR with 2H detection with application to the metabolism of N-dimethylformamide-d7. Journal of pharmaceutical and biomedical analysis. 1997 Sep; 16(1):1-5. doi: 10.1016/s0731-7085(96)01958-9. [PMID: 9447545]
  • M Van den Bulcke, M T Rosseel, P Wijnants, W Buylaert, F M Belpaire. Metabolism and hepatotoxicity of N,N-dimethylformamide, N-hydroxymethyl-N-methylformamide, and N-methylformamide in the rat. Archives of toxicology. 1994; 68(5):291-5. doi: 10.1007/s002040050071. [PMID: 8085939]
  • M T Rosseel, F M Belpaire, N Samijn, P Wijnant. Simultaneous determination of N,N-dimethylformamide, N-monomethylformamide and N-hydroxymethyl-N-methylformamide in rat plasma by capillary gas chromatography. Journal of chromatography. 1993 May; 615(1):154-8. doi: 10.1016/0378-4347(93)80302-k. [PMID: 8340454]
  • G Santoni, P Bavazzano, A Perico, A Colzi, S Benassi, A Medica, R La Morgia, G Giuliano. High-performance liquid chromatographic determination of N-methylformamide and N-methyl-N-(hydroxymethyl)-formamide in human urine. Journal of chromatography. 1992 Oct; 581(2):287-92. doi: 10.1016/0378-4347(92)80284-w. [PMID: 1452621]
  • J Mráz, H Nohová. Percutaneous absorption of N,N-dimethylformamide in humans. International archives of occupational and environmental health. 1992; 64(2):79-83. doi: 10.1007/bf00381473. [PMID: 1399027]
  • J Mráz, H Nohová. Absorption, metabolism and elimination of N,N-dimethylformamide in humans. International archives of occupational and environmental health. 1992; 64(2):85-92. doi: 10.1007/bf00381474. [PMID: 1399028]
  • P Kestell, M H Gill, M D Threadgill, A Gescher, O W Howarth, E H Curzon. Identification by proton NMR of N-(hydroxymethyl)-N-methylformamide as the major urinary metabolite of N,N-dimethylformamide in mice. Life sciences. 1986 Feb; 38(8):719-24. doi: 10.1016/0024-3205(86)90586-2. [PMID: 3951328]
  • V Scailteur, R Lauwerys. In vivo metabolism of dimethylformamide and relationship to toxicity in the male rat. Archives of toxicology. 1984 Dec; 56(2):87-91. doi: 10.1007/bf00349077. [PMID: 6532382]