Plicatic acid (BioDeep_00000008377)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


Plicatic acid

化学式: C20H22O10 (422.1213)
中文名称:
谱图信息: 最多检出来源 Escherichia coli(otcml) 45.16%

分子结构信息

SMILES: c12c(cc(c(c1)O)OC)C[C@@]([C@@]([C@H]2c1cc(c(c(c1)O)O)OC)(C(=O)O)O)(O)CO
InChI: InChI=1S/C20H22O10/c1-29-14-5-10-7-19(27,8-21)20(28,18(25)26)16(11(10)6-12(14)22)9-3-13(23)17(24)15(4-9)30-2/h3-6,16,21-24,27-28H,7-8H2,1-2H3,(H,25,26)/t16-,19+,20+/m0/s1

描述信息

同义名列表

2 个代谢物同义名

Plicatic acid; Plicatic acid



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 ALB, MARK2, TNK1
Peripheral membrane protein 1 TNK1
Nucleus 2 ALB, DR1
cytosol 1 ALB
dendrite 1 MARK2
centrosome 1 ALB
nucleoplasm 2 DR1, MARK2
RNA polymerase II transcription regulator complex 1 DR1
cell surface 1 C3
Golgi apparatus 2 ALB, SERPINA1
plasma membrane 4 C3, IGHE, MARK2, TNK1
Membrane 2 MARK2, TNK1
extracellular exosome 4 ALB, C3, SERPINA1, SERPING1
endoplasmic reticulum 2 ALB, SERPINA1
extracellular space 8 ALB, C1S, C3, IGHE, IL4, IL5, SERPINA1, SERPING1
mitochondrion 1 MARK2
protein-containing complex 2 ALB, C3
intracellular membrane-bounded organelle 1 SERPINA1
Single-pass type I membrane protein 1 IGHE
Secreted 4 ALB, C3, IL4, IL5
extracellular region 8 ALB, C1S, C3, IGHE, IL4, IL5, SERPINA1, SERPING1
anchoring junction 1 ALB
COPII-coated ER to Golgi transport vesicle 1 SERPINA1
collagen-containing extracellular matrix 2 SERPINA1, SERPING1
lateral plasma membrane 1 MARK2
ciliary basal body 1 ALB
IgE immunoglobulin complex 1 IGHE
mitotic spindle 1 DR1
centriole 1 ALB
spindle pole 1 ALB
actin filament 1 MARK2
blood microparticle 4 ALB, C1S, C3, SERPING1
[Isoform 2]: Cell membrane 1 IGHE
Cell projection, dendrite 1 MARK2
ficolin-1-rich granule lumen 1 SERPINA1
secretory granule lumen 1 C3
endoplasmic reticulum lumen 4 ALB, C3, SERPINA1, SERPING1
platelet alpha granule lumen 3 ALB, SERPINA1, SERPING1
azurophil granule lumen 1 C3
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 SERPINA1
ATAC complex 1 DR1
[Isoform 3]: Cell membrane 1 IGHE
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
ciliary transition fiber 1 ALB
negative cofactor 2 complex 1 DR1
microtubule bundle 1 MARK2


文献列表

  • Bradly J Biagioni, Mandy M Pui, Elkie Fung, SzeWing Wong, Ali Hosseini, Anne Dybuncio, Neil E Alexis, Chris Carlsten. Sputum adiponectin as a marker for western red cedar asthma. The Journal of allergy and clinical immunology. 2014 Dec; 134(6):1446-1448.e5. doi: 10.1016/j.jaci.2014.06.037. [PMID: 25129682]
  • Ann M Patten, Laurence B Davin, Norman G Lewis. Relationship of dirigent protein and 18s RNA transcript localization to heartwood formation in western red cedar. Phytochemistry. 2008 Dec; 69(18):3032-7. doi: 10.1016/j.phytochem.2008.06.020. [PMID: 18789459]
  • A Frew, J H Chang, H Chan, S Quirce, K Noertjojo, P Keown, M Chan-Yeung. T-lymphocyte responses to plicatic acid-human serum albumin conjugate in occupational asthma caused by western red cedar. The Journal of allergy and clinical immunology. 1998 Jun; 101(6 Pt 1):841-7. doi: 10.1016/s0091-6749(98)70313-6. [PMID: 9648713]
  • P O Malmberg, A Rask-Andersen, K A Larsson , N Stjernberg, B M Sundblad, K Eriksson. Increased bronchial responsiveness in workers sawing Scots pine. American journal of respiratory and critical care medicine. 1996 Mar; 153(3):948-52. doi: 10.1164/ajrccm.153.3.8630578. [PMID: 8630578]
  • H Salari, S Howard, H Chan, P Dryden, M Chan-Yeung. Involvement of immunologic mechanisms in a guinea pig model of western red cedar asthma. The Journal of allergy and clinical immunology. 1994 May; 93(5):877-84. doi: 10.1016/0091-6749(94)90381-6. [PMID: 8182231]
  • A J Frew, H Chan, M Chan-Yeung. Lack of role for mononuclear cell-derived histamine releasing factors in occupational asthma due to western red cedar. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 1993 Oct; 23(10):861-7. doi: 10.1111/j.1365-2222.1993.tb00265.x. [PMID: 10780894]
  • A Frew, H Chan, P Dryden, H Salari, S Lam, M Chan-Yeung. Immunologic studies of the mechanisms of occupational asthma caused by western red cedar. The Journal of allergy and clinical immunology. 1993 Sep; 92(3):466-78. doi: 10.1016/0091-6749(93)90126-z. [PMID: 8360398]
  • S Vedal, D A Enarson, H Chan, J Ochnio, K S Tse, M Chan-Yeung. A longitudinal study of the occurrence of bronchial hyperresponsiveness in western red cedar workers. The American review of respiratory disease. 1988 Mar; 137(3):651-5. doi: 10.1164/ajrccm/137.3.651. [PMID: 3278663]
  • P L Paggiaro, M Chan Yeung. Pattern of specific airway response in asthma due to western red cedar (Thuja plicata): relationship with length of exposure and lung function measurements. Clinical allergy. 1987 Jul; 17(4):333-9. doi: 10.1111/j.1365-2222.1987.tb02023.x. [PMID: 3304709]
  • M Kinsella, H Salari, H Chan, K S Tse, M Chan-Yeung. Plasma histamine after methacholine, allergen, and aspirin challenges. The Journal of asthma : official journal of the Association for the Care of Asthma. 1987; 24(6):327-34. doi: 10.3109/02770908709070964. [PMID: 3327856]
  • S Vedal, M Chan-Yeung, D A Enarson, H Chan, E Dorken, K S Tse. Plicatic acid-specific IgE and nonspecific bronchial hyperresponsiveness in western red-cedar workers. The Journal of allergy and clinical immunology. 1986 Dec; 78(6):1103-9. doi: 10.1016/0091-6749(86)90257-5. [PMID: 3782674]
  • A Cartier, H Chan, J L Malo, L Pineau, K S Tse, M Chan-Yeung. Occupational asthma caused by eastern white cedar (Thuja occidentalis) with demonstration that plicatic acid is present in this wood dust and is the causal agent. The Journal of allergy and clinical immunology. 1986 Apr; 77(4):639-45. doi: 10.1016/0091-6749(86)90359-3. [PMID: 3958393]
  • K M Schegg, W Welch. The effect of nordihydroguaiaretic acid and related lignans on formyltetrahydrofolate synthetase and carboxylesterase. Biochimica et biophysica acta. 1984 Jul; 788(2):167-80. doi: 10.1016/0167-4838(84)90259-0. [PMID: 6331513]
  • P C Giclas. Effect of plicatic acid on human serum complement includes interference with C1 inhibitor function. Journal of immunology (Baltimore, Md. : 1950). 1982 Jul; 129(1):168-72. doi: . [PMID: 6979566]
  • K S Tse, H Chan, M Chan-Yeung. Specific IgE antibodies in workers with occupational asthma due to western red cedar. Clinical allergy. 1982 May; 12(3):249-58. doi: 10.1111/j.1365-2222.1982.tb02525.x. [PMID: 6179654]
  • M Chan-Yeung, P C Giclas, P M Henson. Activation of complement by plicatic acid, the chemical compound responsible for asthma due to western red cedar (Thuja plicata). The Journal of allergy and clinical immunology. 1980 May; 65(5):333-7. doi: 10.1016/0091-6749(80)90209-2. [PMID: 6768786]
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