Digitalin (BioDeep_00000007019)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


3beta-(4-O-beta-D-glucopyranosyl-3-O-methyl-6-deoxy-beta-D-galactopyranosyloxy)-14,16beta-dihydroxy-5beta-card-20(22)-enolide

化学式: C36H56O14 (712.367)
中文名称: 毛地黃苷
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 74.83%

分子结构信息

SMILES: C1[C@@]2(C)[C@]([H])(CC[C@]3([H])[C@]2([H])CC[C@@]2(C)[C@]3(O)C[C@H](O)[C@]2([H])C2=CC(=O)OC2)C[C@@H](O[C@H]2[C@H](O)[C@@H](OC)[C@@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)[C@@H](C)O2)C1
InChI: InChI=1S/C36H56O14/c1-16-30(50-32-28(42)27(41)26(40)23(14-37)49-32)31(45-4)29(43)33(47-16)48-19-7-9-34(2)18(12-19)5-6-21-20(34)8-10-35(3)25(17-11-24(39)46-15-17)22(38)13-36(21,35)44/h11,16,18-23,25-33,37-38,40-44H,5-10,12-15H2,1-4H3/t16-,18-,19+,20+,21-,22+,23-,25+,26-,27+,28-,29-,30+,31-,32+,33+,34+,35-,36+/m1/s1

描述信息

D020011 - Protective Agents > D002316 - Cardiotonic Agents > D004071 - Digitalis Glycosides
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002301 - Cardiac Glycosides
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent

同义名列表

5 个代谢物同义名

Digitalin; 3beta-(4-O-beta-D-glucopyranosyl-3-O-methyl-6-deoxy-beta-D-galactopyranosyloxy)-14,16beta-dihydroxy-5beta-card-20(22)-enolide; Gitoxigenin 3-O-glucosyldigitaloside; Glucostrospeside; Digitalin



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

20 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • K Yoshimatsu, M Satake, K Shimomura, J I Sawada, T Terao. Determination of cardenolides in hairy root cultures of Digitalis lanata by enzyme-linked immunosorbent assay. Journal of natural products. 1990 Nov; 53(6):1498-502. doi: 10.1021/np50072a015. [PMID: 2089119]
  • L SCEBAT. Digitalin drugs and digitalic glycosides. La Medecine en France. 1961 Sep; 9(?):20-8. doi: ". [PMID: 14497858]
  • C PROVVEDI BECATTI. [A digitalin (Digitalis lutea L.) suited for useful substitution for common Digitalis in pharmacological uses]. Atti della Accademia dei fisiocritici in Siena. Sezione medico-fisica. 1960; 7(?):xviii-xxv. doi: ". [PMID: 14038510]
  • E T SANTANA. [Current status of digitalins and digitoxins. (Pharmacology, clinical use and pharmaceutical industry)]. Hospital (Rio de Janeiro, Brazil). 1959 Nov; 56(?):813-20. doi: ". [PMID: 14441570]
  • R HAZARD, P MOUILLE. [Digitalin, veratrin and potassium]. Comptes rendus des seances de la Societe de biologie et de ses filiales. 1959; 153(?):1764-6. doi: . [PMID: 14400385]
  • R HAZARD, J HAZARD, J THOUVENOT. [Diminution of sensitivity to digitalin by rubidium chloride; analogies with potassium]. Comptes rendus des seances de la Societe de biologie et de ses filiales. 1957; 151(12):2049-50. doi: . [PMID: 13585700]
  • J LA BARRE. [Substances reenforcing and separating digitalin]. Journal de physiologie. 1957 Jan; 49(1):239-42. doi: ". [PMID: 13449800]
  • J LA BARRE, J DUMONT. [Digitalin poisoning and heptaminol hydrochloride in the guinea pig]. Comptes rendus des seances de la Societe de biologie et de ses filiales. 1955 May; 149(9-10):1073-5. doi: ". [PMID: 13270529]
  • P B CAMPONOVO, J R SALAS, I MALDONADO ALLENDE. [Effects of digitalin on various blood components]. Prensa medica argentina. 1955 Apr; 42(15):1022-5. doi: ". [PMID: 13245647]
  • J PAUTRAT. [Digitalin and digitalics]. La Presse medicale. 1954 Feb; 62(9):191-4. doi: ". [PMID: 13145571]
  • R SAN MARTIN CASAMADA. [Photocolorimetry of cardiotonic glucosides: application of Baljet reaction to digitalin for photocolorimetry]. Farmacognosia; anales del Instituto Jose Celestino Mutis. 1954 Jan; 14(31):15-26. doi: . [PMID: 13220638]
  • P LENEGRE, P MAURICE, B COBLENTZ, E LIMA. [Digitalin and mercurial diuretic therapy of chronic heart failure]. Therapie. 1953; 8(2):113-39. doi: ". [PMID: 13102381]
  • J LENEGRE, J HALLEZ. [Presentation of a case of primary auricular flutter with cardiac insufficiency cured by 20.8 mg. of digitalin in forty days]. Bulletins et memoires de la Societe medicale des hopitaux de Paris. 1952 Jul; 68(24-25):939-40. doi: . [PMID: 12988036]
  • R HAZARD, J HAZARD. [Variations of sensitivity to digitalin as a function of blood potassium]. Comptes rendus des seances de la Societe de biologie et de ses filiales. 1952 Jun; 146(11-12):832-4. doi: . [PMID: 12998267]
  • N MAVRODINOV. [Treatment of cardiac insufficiency with large doses of digitalin]. Casopis lekaru ceskych. 1951 Oct; 90(41):1197-9. doi: ". [PMID: 14879424]
  • C PIOT. [Administration of digitalin]. Gazette medicale de France. 1951 May; 58(10):657-68. doi: ". [PMID: 14849755]
  • J LAHAM. [Digitalin administered rectally]. France Medecine. 1951 Apr; 14(4):20-22. doi: ". [PMID: 14831709]
  • M G ALLMARK, W M BACHINSKI. A comparison of assay results by biological and chemical methods on Digitalis purpurea and digitalin (crystalline). Revue canadienne de biologie. 1946; 5(5):570-85. doi: ". [PMID: 20291014]