Globulol (BioDeep_00000000662)

human metabolite PANOMIX_OTCML-2023 Endogenous

代谢物信息卡片

(1aR,4R,4aS,7R,7aS,7bS)-1,1,4,7-tetramethyl-2,3,4a,5,6,7,7a,7b-octahydro-1aH-cyclopropa[e]azulen-4-ol

化学式: C15H26O (222.1983546)
中文名称: 蓝桉醇
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 94.12%

分子结构信息

SMILES: CC1CCC2C1C1C(CCC2(C)O)C1(C)C
InChI: InChI=1S/C15H26O/c1-9-5-6-10-12(9)13-11(14(13,2)3)7-8-15(10,4)16/h9-13,16H,5-8H2,1-4H3

描述信息

Ledol is a sesquiterpenoid.
Ledol is a natural product found in Waitzia acuminata, Aloysia gratissima, and other organisms with data available.
Ledol is found in allspice. Ledol is a constituent of Valeriana officinalis (valerian), Piper species and others.
Constituent of Eucalyptus globulus (Tasmanian blue gum). Globulol is found in allspice and pepper (spice).
Ledol ((+)-Ledol) is an antifungal agent that can be isolated from the essential oil fractions of Rhododendron tomentosum. Ledol is also the expectorant and antitussive agent, which is simultaneously responsible for adverse reactions such as dizziness, nausea and vomiting[1].
Ledol ((+)-Ledol) is an antifungal agent that can be isolated from the essential oil fractions of Rhododendron tomentosum. Ledol is also the expectorant and antitussive agent, which is simultaneously responsible for adverse reactions such as dizziness, nausea and vomiting[1].

同义名列表

10 个代谢物同义名

(1aR,4R,4aS,7R,7aS,7bS)-1,1,4,7-tetramethyl-2,3,4a,5,6,7,7a,7b-octahydro-1aH-cyclopropa[e]azulen-4-ol; 1,1,2,5-tetramethyl-decahydro-1H-cyclopropa[e]azulen-5-ol; 1,1,4,7-Tetramethyldecahydro-1H-cyclopropa(e)azulen-4-ol; ledum camphor; (-)-GLOBULOL; Porschcampho; Epiglobulol; Globulol; Ledol; (+)-Ledol

数据库引用编号

20 个数据库交叉引用编号

ChEBI: CHEBI:6401
KEGG: C09698
PubChem: 101716
PubChem: 92812
HMDB: HMDB0036645
Metlin: METLIN67892
ChEMBL: CHEMBL4525000
Wikipedia: Ledol
MeSH: ledol
KNApSAcK: C00003161
foodb: FDB015567
chemspider: 91904
CAS: 19078-39-8
CAS: 577-27-5
CAS: 489-41-8
medchemexpress: HY-121388
PMhub: MS000020948
PubChem: 11888
3DMET: B03206
NIKKAJI: J21.647J

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

88 个相关的物种来源信息

1475093 - Aglaia foveolata: 10.1016/J.PHYTOCHEM.2008.08.025
306516 - Aglaia silvestris: 10.1016/S0031-9422(98)00305-7
49984 - Ajuga chamaepitys: 10.1080/10412905.1999.9701111
105888 - Aloysia gratissima: 10.1016/S0031-9422(00)81286-8
1234283 - Aristolochia asclepiadifolia: 10.1002/FFJ.2730080104
158548 - Aristolochia indica:
259893 - Artemisia argyi Lévl.et Vant.: -
72329 - Artemisia herba-alba: 10.1016/J.ARABJC.2012.04.042
333952 - Artemisia lagocephala: 10.1007/BF00630335
637484 - Artemisia rubripes: 10.1007/BF00629951
401933 - Artemisia sericea: 10.1080/10412905.1999.9701070
72900 - Baccharis dracunculifolia: 10.1002/(SICI)1099-1026(199601)11:1<15::AID-FFJ541>3.0.CO;2-H
1715998 - Baccharis genistelloides: 10.1135/CCCC19610811
1654448 - Baccharis sagittalis: 10.1135/CCCC19610811
588641 - Bazzania tridens: 10.1002/JCCS.199900029
13808 - Bazzania trilobata: 10.1016/J.PHYTOCHEM.2006.06.001
13808 - Bazzania trilobata: 10.1016/S0031-9422(99)00123-5
105891 - Callicarpa japonica: 10.1016/S0031-9422(02)00207-8
3483 - Cannabis sativa: 10.1021/NP50008A001
2910975 - Cantinoa americana: 10.1080/10412905.1993.9698206
125673 - Cassinia longifolia: 10.1016/S0031-9422(00)81508-3
146995 - Chrysanthemum indicum: 10.1002/CBDV.201000034
119260 - Cinnamomum aromaticum: 10.1007/S11418-006-0039-1
1155220 - Cinnamomum iners: 10.1007/S11418-006-0039-1
128608 - Cinnamomum verum: 10.1007/S11418-006-0039-1
136209 - Curcuma aromatica: 10.1002/PTR.2137
136216 - Curcuma kwangsiensis: 10.1002/PTR.2137
136218 - Curcuma phaeocaulis: 10.1002/PTR.2137
136221 - Curcuma wenyujin: 10.1002/PTR.2137
136224 - Curcuma zedoaria: 10.1002/PTR.2137
211151 - Cyanthillium cinereum: 10.1016/S0031-9422(00)81508-3
4610 - Cyperus: 10.3390/MOLECULES14082909
512623 - Cyperus rotundus: 10.1016/J.APJTM.2016.06.009
179994 - Entandrophragma cylindricum:
3932 - Eucalyptus: 10.1248/CPB.30.1952
1711162 - Eucalyptus astringens: 10.1080/10412905.1992.9698059
1516054 - Eucalyptus bosistoana: 10.1080/10412905.1992.9698059
34316 - Eucalyptus camaldulensis: 10.1080/10412905.1991.9697921
1711250 - Eucalyptus dealbata: 10.1080/10412905.1992.9698129
34317 - Eucalyptus globulus: 10.1080/10412905.1992.9698059
1711432 - Eucalyptus nova-anglica: 10.1080/10412905.1992.9698006
627157 - Eucalyptus paniculata: 10.1080/10412905.1992.9698059
183855 - Eucalyptus tereticornis: 10.1080/10412905.1992.9698059
155638 - Guarea macrophylla: 10.1016/S0031-9422(00)00302-2
4397 - Hamamelis virginiana: 10.1055/S-2006-957420
261796 - Helichrysum petiolare: 10.1016/0031-9422(89)80195-5
9606 - Homo sapiens: -
3486 - Humulus lupulus: 10.1021/JF00118A056
39324 - Hyssopus officinalis: 10.1021/JF00039A035
1405036 - Lepechinia floribunda: 10.1080/10412905.1994.9698446
255962 - Lepicolea ochroleuca: 10.1016/S0031-9422(99)00609-3
105884 - Lonicera japonica: 10.3390/MOLECULES14020893
164925 - Melaleuca: 10.1021/NP9606052
164936 - Melaleuca leucadendra: 10.1002/CBDV.200900162
164936 - Melaleuca leucadendra: 10.1021/NP9606052
164942 - Melaleuca quinquenervia:
104361 - Melanoleuca: 10.1021/NP9606052
306398 - Micromeria sinaica: 10.3109/13880209109082877
44586 - Panax notoginseng: 10.1021/JF301835V
44586 - Panax Notoginseng (Burk.) F. H. Chen Ex C. Chow: -
1548621 - Pegolettia retrofracta: 10.1016/S0031-9422(00)97892-0
511543 - Piper guineense: 10.1016/S0031-9422(00)84994-8
13216 - Piper nigrum: 10.1016/S0031-9422(97)00762-0
43073 - Pittosporum tobira: 10.1016/0031-9422(89)80285-7
33090 - Plants: -
1225816 - Psiadia altissima: 10.1080/10412905.1994.9699347
2602891 - Psidium salutare: 10.1021/JF0116303
49605 - Rhododendron groenlandicum:
105903 - Rhododendron mucronulatum: 10.1007/BF01386197
1933698 - Salvia absconditiflora: 10.1080/10412905.1999.9701113
1489152 - Salvia iodantha: 10.1002/(SICI)1099-1573(1998)12:1+3.0.CO;2-2
1933761 - Salvia tchihatcheffii:
1933764 - Salvia vermifolia: 10.1076/PHBI.40.1.67.5852
35974 - Santalum Album L\uff0e: -
41644 - Santolina chamaecyparissus: 10.1002/FFJ.2730070109
546409 - Satureja cuneifolia: 10.1016/S0031-9422(00)90514-4
4113 - Solanum tuberosum: 10.1021/JF0615653
992795 - Tetradenia riparia: 10.1055/S-2006-957672
1423403 - Teucrium leucocladum: 10.1016/J.BSE.2003.12.009
2878271 - Thymus camphoratus: 10.1016/S0031-9422(97)00117-9
1258758 - Toona calantas: 10.1590/S0103-50532000000600012
59170 - Valeriana jatamansi: 10.1016/S0031-9422(01)00018-8
19953 - Valeriana officinalis: 10.1016/S0031-9422(01)00018-8
54477 - Vitex agnus-castus:
105498 - Waitzia acuminata: 10.1016/S0031-9422(00)97891-9
199627 - Wurfbainia villosa: 10.1007/S11418-006-0039-1
2099548 - Zanthoxylum zanthoxyloides: 10.1021/NP50046A035
4577 - Zea mays: 10.1016/J.TET.2004.08.027

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Said I Behiry, Mervat El-Hefny, Mohamed Z M Salem. Toxicity effects of Eriocephalus africanus L. leaf essential oil against some molecularly identified phytopathogenic bacterial strains. Natural product research. 2020 Dec; 34(23):3394-3398. doi: 10.1080/14786419.2019.1566824. [PMID: 30689407]
Jun-Li Yang, Trong Tuan Dao, Tran Thi Hien, Ya-Min Zhao, Yan-Ping Shi. Further sesquiterpenoids from the rhizomes of Homalomena occulta and their anti-inflammatory activity. Bioorganic & medicinal chemistry letters. 2019 05; 29(10):1162-1167. doi: 10.1016/j.bmcl.2019.03.031. [PMID: 30928195]
Anaí L Dos Santos, Allan Dos S Polidoro, Cláudia A L Cardoso, Margareth Batistote, Maria do Carmo Vieira, Rosângela A Jacques, Elina B Caramão. GC×GC/qMS analyses of Campomanesia guazumifolia (Cambess.) O. Berg essential oils and their antioxidant and antimicrobial activity. Natural product research. 2019 Feb; 33(4):593-597. doi: 10.1080/14786419.2017.1399383. [PMID: 29105503]
Anna Jesionek, Loretta Poblocka-Olech, Bozena Zabiegala, Adam Bucinski, Miroslawa Krauze-Baranowska, Maria Luczkiewicz. Validated HPTLC method for determination of ledol and alloaromadendrene in the essential oil fractions of Rhododendron tomentosum plants and in vitro cultures and bioautography for their activity screening. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Jun; 1086(?):63-72. doi: 10.1016/j.jchromb.2018.04.006. [PMID: 29656085]
Jessyka A da Cunha, Fernando J Sutili, Anita M Oliveira, Leticia T Gressler, Cecília de A Scheeren, Lenise de L Silva, Rodrigo de A Vaucher, Bernardo Baldisserotto, Berta M Heinzmann. The Essential Oil of Hyptis mutabilis in Ichthyophthirius multifiliis Infection and its Effect on Hematological, Biochemical, and Immunological Parameters in Silver Catfish, Rhamdia quelen. The Journal of parasitology. 2017 12; 103(6):778-785. doi: 10.1645/16-174. [PMID: 28731834]
Santosh Kumar, Chase Kempinski, Xun Zhuang, Ayla Norris, Sibongile Mafu, Jiachen Zi, Stephen A Bell, Stephen Eric Nybo, Scott E Kinison, Zuodong Jiang, Sheba Goklany, Kristin B Linscott, Xinlu Chen, Qidong Jia, Shoshana D Brown, John L Bowman, Patricia C Babbitt, Reuben J Peters, Feng Chen, Joe Chappell. Molecular Diversity of Terpene Synthases in the Liverwort Marchantia polymorpha. The Plant cell. 2016 10; 28(10):2632-2650. doi: 10.1105/tpc.16.00062. [PMID: 27650333]
Luana Riccobono, Antonella Maggio, Sergio Rosselli, Vincenzo Ilardi, Felice Senatore, Maurizio Bruno. Chemical composition of volatile and fixed oils from of Salvia argentea L. (Lamiaceae) growing wild in Sicily. Natural product research. 2016; 30(1):25-34. doi: 10.1080/14786419.2015.1030742. [PMID: 25880372]
Michele D'Ambrosio, Alexandru Ciocarlan, Elisa Colombo, Antonio Guerriero, Cosimo Pizza, Enrico Sangiovanni, Mario Dell'Agli. Structure and cytotoxic activity of sesquiterpene glycoside esters from Calendula officinalis L.: Studies on the conformation of viridiflorol. Phytochemistry. 2015 Sep; 117(?):1-9. doi: 10.1016/j.phytochem.2015.05.005. [PMID: 26057223]
Anna Dampc, Maria Luczkiewicz. Labrador tea--the aromatic beverage and spice: a review of origin, processing and safety. Journal of the science of food and agriculture. 2015 Jun; 95(8):1577-83. doi: 10.1002/jsfa.6889. [PMID: 25156477]
Sameh Baananou, Edita Bagdonaite, Bruno Marongiu, Alessandra Piras, Silvia Porcedda, Danilo Falconieri, Naceur A Boughattas. Supercritical CO₂ extract and essential oil of aerial part of Ledum palustre L.--Chemical composition and anti-inflammatory activity. Natural product research. 2015; 29(11):999-1005. doi: 10.1080/14786419.2014.965167. [PMID: 25427723]
Ain Raal, Anne Orav, Tatjana Gretchushnikova. Composition of the essential oil of the Rhododendron tomentosum Harmaja from Estonia. Natural product research. 2014; 28(14):1091-8. doi: 10.1080/14786419.2014.907287. [PMID: 24716612]
L L Silva, Q I Garlet, S C Benovit, G Dolci, C A Mallmann, M E Bürger, B Baldisserotto, S J Longhi, B M Heinzmann. Sedative and anesthetic activities of the essential oils of Hyptis mutabilis (Rich.) Briq. and their isolated components in silver catfish (Rhamdia quelen). Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2013 Sep; 46(9):771-9. doi: 10.1590/1414-431x20133013. [PMID: 24068193]
Yanqing Liu, Hongwu Wang, Shoulian Wei, Xuan Cai. Characterisation of the essential oil from different aerial parts of Lindera chunii Merr. (Lauraceae). Natural product research. 2013; 27(19):1804-7. doi: 10.1080/14786419.2012.761619. [PMID: 23327534]
Asta Judzentiene, Rita Butkiene, Jurga Budiene, Félix Tomi, Joseph Casanova. Composition of seed essential oils of Rhododendron tomentosum. Natural product communications. 2012 Feb; 7(2):227-30. doi: . [PMID: 22474965]
Maryam Yousefi, Somayyeh Gandomkar, Zohreh Habibi. Essential oil from aerial parts of of Betonica grandiflora Willd. from Iran. Natural product research. 2012; 26(2):146-51. doi: 10.1080/14786419.2010.534992. [PMID: 21809955]
Masoumeh Firozy, Zahra Talebpour, Ali Sonboli. Essential oil composition and antioxidant activities of the various extracts of Tanacetum sonbolii Mozaff. (Asteraceae) from Iran. Natural product research. 2012; 26(23):2204-7. doi: 10.1080/14786419.2011.636746. [PMID: 22115413]
Birgit Waltenberger, Daniela Schuster, Sompol Paramapojn, Wandee Gritsanapan, Gerhard Wolber, Judith M Rollinger, Hermann Stuppner. Predicting cyclooxygenase inhibition by three-dimensional pharmacophoric profiling. Part II: Identification of enzyme inhibitors from Prasaplai, a Thai traditional medicine. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2011 Jan; 18(2-3):119-33. doi: 10.1016/j.phymed.2010.08.002. [PMID: 20851587]
E Nibret, M Wink. Trypanocidal and antileukaemic effects of the essential oils of Hagenia abyssinica, Leonotis ocymifolia, Moringa stenopetala, and their main individual constituents. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2010 Oct; 17(12):911-20. doi: 10.1016/j.phymed.2010.02.009. [PMID: 20359874]
Zilda Cristiani Gazim, Ana Carolina L Amorim, Ana Maria C Hovell, Claudia Moraes Rezende, Izalina Ansilieiro Nascimento, Gilberto Alves Ferreira, Diógenes Aparício Garcia Cortez. Seasonal variation, chemical composition, and analgesic and antimicrobial activities of the essential oil from leaves of Tetradenia riparia (Hochst.) Codd in southern Brazil. Molecules (Basel, Switzerland). 2010 Aug; 15(8):5509-24. doi: 10.3390/molecules15085509. [PMID: 20714310]
Chen-Lung Ho, Pei-Chun Liao, Kuang-Ping Hsu, Eugene I-Chen Wang, Wei-Chih Dong, Yu-Chang Su. Composition and antimicrobial and anti-wood-decay fungal activities of the leaf essential oils of Machilus pseudolongifolia from Taiwan. Natural product communications. 2010 Jul; 5(7):1143-6. doi: ". [PMID: 20734960]
Sari J Himanen, James D Blande, Tero Klemola, Juha Pulkkinen, Juha Heijari, Jarmo K Holopainen. Birch (Betula spp.) leaves adsorb and re-release volatiles specific to neighbouring plants--a mechanism for associational herbivore resistance?. The New phytologist. 2010 May; 186(3):722-32. doi: 10.1111/j.1469-8137.2010.03220.x. [PMID: 20298484]
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Beata Szafranek, Karolina Chrapkowska, Danuta Waligóra, Richard Palavinskas, Arkadiusz Banach, Janusz Szafranek. Leaf surface sesquiterpene alcohols of the potato (Solanum tuberosum) and their influence on colorado beetle (Leptinotarsa decemlineata Say) feeding. Journal of agricultural and food chemistry. 2006 Oct; 54(20):7729-34. doi: 10.1021/jf0615653. [PMID: 17002446]
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Jiayuan Zhao, Peng Nan, Yang Zhong, Jiayuan Zhao, Peng Nan, Yang Zhong. Chemical composition of the essential oils of Clausena lansium from Hainan Island, China. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2004 Mar; 59(3-4):153-6. doi: 10.1515/znc-2004-3-401. [PMID: 15241914]