Globulol (BioDeep_00000000662)

human metabolite PANOMIX_OTCML-2023 Endogenous

代谢物信息卡片

(1aR,4R,4aS,7R,7aS,7bS)-1,1,4,7-tetramethyl-2,3,4a,5,6,7,7a,7b-octahydro-1aH-cyclopropa[e]azulen-4-ol

化学式: C15H26O (222.1983546)
中文名称: 蓝桉醇
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 94.12%

分子结构信息

SMILES: CC1CCC2C1C1C(CCC2(C)O)C1(C)C
InChI: InChI=1S/C15H26O/c1-9-5-6-10-12(9)13-11(14(13,2)3)7-8-15(10,4)16/h9-13,16H,5-8H2,1-4H3

描述信息

Ledol is a sesquiterpenoid.
Ledol is a natural product found in Waitzia acuminata, Aloysia gratissima, and other organisms with data available.
Ledol is found in allspice. Ledol is a constituent of Valeriana officinalis (valerian), Piper species and others.
Constituent of Eucalyptus globulus (Tasmanian blue gum). Globulol is found in allspice and pepper (spice).
Ledol ((+)-Ledol) is an antifungal agent that can be isolated from the essential oil fractions of Rhododendron tomentosum. Ledol is also the expectorant and antitussive agent, which is simultaneously responsible for adverse reactions such as dizziness, nausea and vomiting[1].
Ledol ((+)-Ledol) is an antifungal agent that can be isolated from the essential oil fractions of Rhododendron tomentosum. Ledol is also the expectorant and antitussive agent, which is simultaneously responsible for adverse reactions such as dizziness, nausea and vomiting[1].

同义名列表

10 个代谢物同义名

(1aR,4R,4aS,7R,7aS,7bS)-1,1,4,7-tetramethyl-2,3,4a,5,6,7,7a,7b-octahydro-1aH-cyclopropa[e]azulen-4-ol; 1,1,2,5-tetramethyl-decahydro-1H-cyclopropa[e]azulen-5-ol; 1,1,4,7-Tetramethyldecahydro-1H-cyclopropa(e)azulen-4-ol; ledum camphor; (-)-GLOBULOL; Porschcampho; Epiglobulol; Globulol; Ledol; (+)-Ledol

数据库引用编号

20 个数据库交叉引用编号

ChEBI: CHEBI:6401
KEGG: C09698
PubChem: 101716
PubChem: 92812
HMDB: HMDB0036645
Metlin: METLIN67892
ChEMBL: CHEMBL4525000
Wikipedia: Ledol
MeSH: ledol
KNApSAcK: C00003161
foodb: FDB015567
chemspider: 91904
CAS: 19078-39-8
CAS: 577-27-5
CAS: 489-41-8
medchemexpress: HY-121388
PMhub: MS000020948
PubChem: 11888
3DMET: B03206
NIKKAJI: J21.647J

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

173 个相关的物种来源信息

3483 Cannabis sativa: 10.1021/NP50008A001
4397 Hamamelis virginiana: 10.1055/S-2006-957420
2099548 Zanthoxylum zanthoxyloides: 10.1021/NP50046A035
39324 Hyssopus officinalis: 10.1021/JF00039A035
306398 Micromeria sinaica: 10.3109/13880209109082877
54477 Vitex agnus-castus:
1933764 Salvia vermifolia: 10.1076/PHBI.40.1.67.5852
72900 Baccharis dracunculifolia: 10.1002/(SICI)1099-1026(199601)11:1<15::AID-FFJ541>3.0.CO;2-H
72329 Artemisia herba-alba: 10.1016/J.ARABJC.2012.04.042
546409 Satureja cuneifolia: 10.1016/S0031-9422(00)90514-4
992795 Tetradenia riparia: 10.1055/S-2006-957672
2878271 Thymus camphoratus: 10.1016/S0031-9422(97)00117-9
2910975 Cantinoa americana: 10.1080/10412905.1993.9698206
1225816 Psiadia altissima: 10.1080/10412905.1994.9699347
179994 Entandrophragma cylindricum:
125673 Cassinia longifolia: 10.1016/S0031-9422(00)81508-3
211151 Cyanthillium cinereum: 10.1016/S0031-9422(00)81508-3
1405036 Lepechinia floribunda: 10.1080/10412905.1994.9698446
164942 Melaleuca quinquenervia:
105888 Aloysia gratissima: 10.1016/S0031-9422(00)81286-8
164936 Melaleuca leucadendra: 10.1021/NP9606052
1489152 Salvia iodantha: 10.1002/(SICI)1099-1573(1998)12:1+3.0.CO;2-2
3486 Humulus lupulus: 10.1021/JF00118A056
105903 Rhododendron mucronulatum: 10.1007/BF01386197
146995 Chrysanthemum indicum: 10.1002/CBDV.201000034
34316 Eucalyptus camaldulensis: 10.1080/10412905.1991.9697921
261796 Helichrysum petiolare: 10.1016/0031-9422(89)80195-5
401933 Artemisia sericea: 10.1080/10412905.1999.9701070
333952 Artemisia lagocephala: 10.1007/BF00630335
2602891 Psidium salutare: 10.1021/JF0116303
13808 Bazzania trilobata: 10.1016/S0031-9422(99)00123-5
637484 Artemisia rubripes: 10.1007/BF00629951
34317 Eucalyptus globulus: 10.1080/10412905.1992.9698059
627157 Eucalyptus paniculata: 10.1080/10412905.1992.9698059
1516054 Eucalyptus bosistoana: 10.1080/10412905.1992.9698059
1711162 Eucalyptus astringens: 10.1080/10412905.1992.9698059
183855 Eucalyptus tereticornis: 10.1080/10412905.1992.9698059
1711250 Eucalyptus dealbata: 10.1080/10412905.1992.9698129
1933698 Salvia absconditiflora: 10.1080/10412905.1999.9701113
41644 Santolina chamaecyparissus: 10.1002/FFJ.2730070109
512623 Cyperus rotundus: 10.1016/J.APJTM.2016.06.009
105891 Callicarpa japonica: 10.1016/S0031-9422(02)00207-8
1711432 Eucalyptus nova-anglica: 10.1080/10412905.1992.9698006
43073 Pittosporum tobira: 10.1016/0031-9422(89)80285-7
49984 Ajuga chamaepitys: 10.1080/10412905.1999.9701111
4113 Solanum tuberosum: 10.1021/JF0615653
588641 Bazzania tridens: 10.1002/JCCS.199900029
1654448 Baccharis sagittalis: 10.1135/CCCC19610811
1715998 Baccharis genistelloides: 10.1135/CCCC19610811
49605 Rhododendron groenlandicum:
155638 Guarea macrophylla: 10.1016/S0031-9422(00)00302-2
255962 Lepicolea ochroleuca: 10.1016/S0031-9422(99)00609-3
105498 Waitzia acuminata: 10.1016/S0031-9422(00)97891-9
1933761 Salvia tchihatcheffii:
1423403 Teucrium leucocladum: 10.1016/J.BSE.2003.12.009
158548 Aristolochia indica:
1548621 Pegolettia retrofracta: 10.1016/S0031-9422(00)97892-0
1234283 Aristolochia asclepiadifolia: 10.1002/FFJ.2730080104
13216 Piper nigrum: 10.1016/S0031-9422(97)00762-0
4610 Cyperus: 10.3390/MOLECULES14082909
44586 Panax notoginseng: 10.1021/JF301835V
104361 Melanoleuca: 10.1021/NP9606052
164925 Melaleuca: 10.1021/NP9606052
1258758 Toona calantas: 10.1590/S0103-50532000000600012
19953 Valeriana officinalis: 10.1016/S0031-9422(01)00018-8
59170 Valeriana jatamansi: 10.1016/S0031-9422(01)00018-8
136218 Curcuma phaeocaulis: 10.1002/PTR.2137
136209 Curcuma aromatica: 10.1002/PTR.2137
136221 Curcuma wenyujin: 10.1002/PTR.2137
136216 Curcuma kwangsiensis: 10.1002/PTR.2137
136224 Curcuma zedoaria: 10.1002/PTR.2137
164936 Melaleuca leucadendra: 10.1002/CBDV.200900162
128608 Cinnamomum verum: 10.1007/S11418-006-0039-1
1155220 Cinnamomum iners: 10.1007/S11418-006-0039-1
199627 Wurfbainia villosa: 10.1007/S11418-006-0039-1
119260 Cinnamomum aromaticum: 10.1007/S11418-006-0039-1
105884 Lonicera japonica: 10.3390/MOLECULES14020893
4577 Zea mays: 10.1016/J.TET.2004.08.027
3932 Eucalyptus: 10.1248/CPB.30.1952
306516 Aglaia silvestris: 10.1016/S0031-9422(98)00305-7
1475093 Aglaia foveolata: 10.1016/J.PHYTOCHEM.2008.08.025
511543 Piper guineense: 10.1016/S0031-9422(00)84994-8
13808 Bazzania trilobata: 10.1016/J.PHYTOCHEM.2006.06.001
4113 Solanum tuberosum: 10.1021/JF0615653
3483 Cannabis sativa: 10.1021/NP50008A001
4397 Hamamelis virginiana: 10.1055/S-2006-957420
2099548 Zanthoxylum zanthoxyloides: 10.1021/NP50046A035
39324 Hyssopus officinalis: 10.1021/JF00039A035
306398 Micromeria sinaica: 10.3109/13880209109082877
54477 Vitex agnus-castus:
1933764 Salvia vermifolia: 10.1076/PHBI.40.1.67.5852
72900 Baccharis dracunculifolia: 10.1002/(SICI)1099-1026(199601)11:1<15::AID-FFJ541>3.0.CO;2-H
72329 Artemisia herba-alba: 10.1016/J.ARABJC.2012.04.042
546409 Satureja cuneifolia: 10.1016/S0031-9422(00)90514-4
992795 Tetradenia riparia: 10.1055/S-2006-957672
2878271 Thymus camphoratus: 10.1016/S0031-9422(97)00117-9
2910975 Cantinoa americana: 10.1080/10412905.1993.9698206
1225816 Psiadia altissima: 10.1080/10412905.1994.9699347
179994 Entandrophragma cylindricum:
125673 Cassinia longifolia: 10.1016/S0031-9422(00)81508-3
211151 Cyanthillium cinereum: 10.1016/S0031-9422(00)81508-3
1405036 Lepechinia floribunda: 10.1080/10412905.1994.9698446
164942 Melaleuca quinquenervia:
105888 Aloysia gratissima: 10.1016/S0031-9422(00)81286-8
164936 Melaleuca leucadendra: 10.1021/NP9606052
1489152 Salvia iodantha: 10.1002/(SICI)1099-1573(1998)12:1+3.0.CO;2-2
3486 Humulus lupulus: 10.1021/JF00118A056
105903 Rhododendron mucronulatum: 10.1007/BF01386197
146995 Chrysanthemum indicum: 10.1002/CBDV.201000034
34316 Eucalyptus camaldulensis: 10.1080/10412905.1991.9697921
261796 Helichrysum petiolare: 10.1016/0031-9422(89)80195-5
401933 Artemisia sericea: 10.1080/10412905.1999.9701070
333952 Artemisia lagocephala: 10.1007/BF00630335
2602891 Psidium salutare: 10.1021/JF0116303
13808 Bazzania trilobata: 10.1016/S0031-9422(99)00123-5
637484 Artemisia rubripes: 10.1007/BF00629951
34317 Eucalyptus globulus: 10.1080/10412905.1992.9698059
627157 Eucalyptus paniculata: 10.1080/10412905.1992.9698059
1516054 Eucalyptus bosistoana: 10.1080/10412905.1992.9698059
1711162 Eucalyptus astringens: 10.1080/10412905.1992.9698059
183855 Eucalyptus tereticornis: 10.1080/10412905.1992.9698059
1711250 Eucalyptus dealbata: 10.1080/10412905.1992.9698129
1933698 Salvia absconditiflora: 10.1080/10412905.1999.9701113
41644 Santolina chamaecyparissus: 10.1002/FFJ.2730070109
512623 Cyperus rotundus: 10.1016/J.APJTM.2016.06.009
105891 Callicarpa japonica: 10.1016/S0031-9422(02)00207-8
1711432 Eucalyptus nova-anglica: 10.1080/10412905.1992.9698006
43073 Pittosporum tobira: 10.1016/0031-9422(89)80285-7
49984 Ajuga chamaepitys: 10.1080/10412905.1999.9701111
4113 Solanum tuberosum: 10.1021/JF0615653
588641 Bazzania tridens: 10.1002/JCCS.199900029
1654448 Baccharis sagittalis: 10.1135/CCCC19610811
1715998 Baccharis genistelloides: 10.1135/CCCC19610811
49605 Rhododendron groenlandicum:
155638 Guarea macrophylla: 10.1016/S0031-9422(00)00302-2
255962 Lepicolea ochroleuca: 10.1016/S0031-9422(99)00609-3
105498 Waitzia acuminata: 10.1016/S0031-9422(00)97891-9
1933761 Salvia tchihatcheffii:
1423403 Teucrium leucocladum: 10.1016/J.BSE.2003.12.009
158548 Aristolochia indica:
1548621 Pegolettia retrofracta: 10.1016/S0031-9422(00)97892-0
1234283 Aristolochia asclepiadifolia: 10.1002/FFJ.2730080104
13216 Piper nigrum: 10.1016/S0031-9422(97)00762-0
4610 Cyperus: 10.3390/MOLECULES14082909
44586 Panax notoginseng: 10.1021/JF301835V
104361 Melanoleuca: 10.1021/NP9606052
164925 Melaleuca: 10.1021/NP9606052
1258758 Toona calantas: 10.1590/S0103-50532000000600012
19953 Valeriana officinalis: 10.1016/S0031-9422(01)00018-8
59170 Valeriana jatamansi: 10.1016/S0031-9422(01)00018-8
136218 Curcuma phaeocaulis: 10.1002/PTR.2137
136209 Curcuma aromatica: 10.1002/PTR.2137
136221 Curcuma wenyujin: 10.1002/PTR.2137
136216 Curcuma kwangsiensis: 10.1002/PTR.2137
136224 Curcuma zedoaria: 10.1002/PTR.2137
164936 Melaleuca leucadendra: 10.1002/CBDV.200900162
128608 Cinnamomum verum: 10.1007/S11418-006-0039-1
1155220 Cinnamomum iners: 10.1007/S11418-006-0039-1
199627 Wurfbainia villosa: 10.1007/S11418-006-0039-1
119260 Cinnamomum aromaticum: 10.1007/S11418-006-0039-1
105884 Lonicera japonica: 10.3390/MOLECULES14020893
4577 Zea mays: 10.1016/J.TET.2004.08.027
3932 Eucalyptus: 10.1248/CPB.30.1952
306516 Aglaia silvestris: 10.1016/S0031-9422(98)00305-7
1475093 Aglaia foveolata: 10.1016/J.PHYTOCHEM.2008.08.025
511543 Piper guineense: 10.1016/S0031-9422(00)84994-8
13808 Bazzania trilobata: 10.1016/J.PHYTOCHEM.2006.06.001
4113 Solanum tuberosum: 10.1021/JF0615653
9606 Homo sapiens: -
44586 Panax Notoginseng (Burk.) F. H. Chen Ex C. Chow: -
35974 Santalum Album L\uff0e: -
259893 Artemisia argyi Lévl.et Vant.: -
33090 Plants: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Said I Behiry, Mervat El-Hefny, Mohamed Z M Salem. Toxicity effects of Eriocephalus africanus L. leaf essential oil against some molecularly identified phytopathogenic bacterial strains. Natural product research. 2020 Dec; 34(23):3394-3398. doi: 10.1080/14786419.2019.1566824. [PMID: 30689407]
Jun-Li Yang, Trong Tuan Dao, Tran Thi Hien, Ya-Min Zhao, Yan-Ping Shi. Further sesquiterpenoids from the rhizomes of Homalomena occulta and their anti-inflammatory activity. Bioorganic & medicinal chemistry letters. 2019 05; 29(10):1162-1167. doi: 10.1016/j.bmcl.2019.03.031. [PMID: 30928195]
Anaí L Dos Santos, Allan Dos S Polidoro, Cláudia A L Cardoso, Margareth Batistote, Maria do Carmo Vieira, Rosângela A Jacques, Elina B Caramão. GC×GC/qMS analyses of Campomanesia guazumifolia (Cambess.) O. Berg essential oils and their antioxidant and antimicrobial activity. Natural product research. 2019 Feb; 33(4):593-597. doi: 10.1080/14786419.2017.1399383. [PMID: 29105503]
Anna Jesionek, Loretta Poblocka-Olech, Bozena Zabiegala, Adam Bucinski, Miroslawa Krauze-Baranowska, Maria Luczkiewicz. Validated HPTLC method for determination of ledol and alloaromadendrene in the essential oil fractions of Rhododendron tomentosum plants and in vitro cultures and bioautography for their activity screening. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Jun; 1086(?):63-72. doi: 10.1016/j.jchromb.2018.04.006. [PMID: 29656085]
Jessyka A da Cunha, Fernando J Sutili, Anita M Oliveira, Leticia T Gressler, Cecília de A Scheeren, Lenise de L Silva, Rodrigo de A Vaucher, Bernardo Baldisserotto, Berta M Heinzmann. The Essential Oil of Hyptis mutabilis in Ichthyophthirius multifiliis Infection and its Effect on Hematological, Biochemical, and Immunological Parameters in Silver Catfish, Rhamdia quelen. The Journal of parasitology. 2017 12; 103(6):778-785. doi: 10.1645/16-174. [PMID: 28731834]
Santosh Kumar, Chase Kempinski, Xun Zhuang, Ayla Norris, Sibongile Mafu, Jiachen Zi, Stephen A Bell, Stephen Eric Nybo, Scott E Kinison, Zuodong Jiang, Sheba Goklany, Kristin B Linscott, Xinlu Chen, Qidong Jia, Shoshana D Brown, John L Bowman, Patricia C Babbitt, Reuben J Peters, Feng Chen, Joe Chappell. Molecular Diversity of Terpene Synthases in the Liverwort Marchantia polymorpha. The Plant cell. 2016 10; 28(10):2632-2650. doi: 10.1105/tpc.16.00062. [PMID: 27650333]
Luana Riccobono, Antonella Maggio, Sergio Rosselli, Vincenzo Ilardi, Felice Senatore, Maurizio Bruno. Chemical composition of volatile and fixed oils from of Salvia argentea L. (Lamiaceae) growing wild in Sicily. Natural product research. 2016; 30(1):25-34. doi: 10.1080/14786419.2015.1030742. [PMID: 25880372]
Michele D'Ambrosio, Alexandru Ciocarlan, Elisa Colombo, Antonio Guerriero, Cosimo Pizza, Enrico Sangiovanni, Mario Dell'Agli. Structure and cytotoxic activity of sesquiterpene glycoside esters from Calendula officinalis L.: Studies on the conformation of viridiflorol. Phytochemistry. 2015 Sep; 117(?):1-9. doi: 10.1016/j.phytochem.2015.05.005. [PMID: 26057223]
Anna Dampc, Maria Luczkiewicz. Labrador tea--the aromatic beverage and spice: a review of origin, processing and safety. Journal of the science of food and agriculture. 2015 Jun; 95(8):1577-83. doi: 10.1002/jsfa.6889. [PMID: 25156477]
Sameh Baananou, Edita Bagdonaite, Bruno Marongiu, Alessandra Piras, Silvia Porcedda, Danilo Falconieri, Naceur A Boughattas. Supercritical CO₂ extract and essential oil of aerial part of Ledum palustre L.--Chemical composition and anti-inflammatory activity. Natural product research. 2015; 29(11):999-1005. doi: 10.1080/14786419.2014.965167. [PMID: 25427723]
Ain Raal, Anne Orav, Tatjana Gretchushnikova. Composition of the essential oil of the Rhododendron tomentosum Harmaja from Estonia. Natural product research. 2014; 28(14):1091-8. doi: 10.1080/14786419.2014.907287. [PMID: 24716612]
L L Silva, Q I Garlet, S C Benovit, G Dolci, C A Mallmann, M E Bürger, B Baldisserotto, S J Longhi, B M Heinzmann. Sedative and anesthetic activities of the essential oils of Hyptis mutabilis (Rich.) Briq. and their isolated components in silver catfish (Rhamdia quelen). Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2013 Sep; 46(9):771-9. doi: 10.1590/1414-431x20133013. [PMID: 24068193]
Yanqing Liu, Hongwu Wang, Shoulian Wei, Xuan Cai. Characterisation of the essential oil from different aerial parts of Lindera chunii Merr. (Lauraceae). Natural product research. 2013; 27(19):1804-7. doi: 10.1080/14786419.2012.761619. [PMID: 23327534]
Asta Judzentiene, Rita Butkiene, Jurga Budiene, Félix Tomi, Joseph Casanova. Composition of seed essential oils of Rhododendron tomentosum. Natural product communications. 2012 Feb; 7(2):227-30. doi: . [PMID: 22474965]
Maryam Yousefi, Somayyeh Gandomkar, Zohreh Habibi. Essential oil from aerial parts of of Betonica grandiflora Willd. from Iran. Natural product research. 2012; 26(2):146-51. doi: 10.1080/14786419.2010.534992. [PMID: 21809955]
Masoumeh Firozy, Zahra Talebpour, Ali Sonboli. Essential oil composition and antioxidant activities of the various extracts of Tanacetum sonbolii Mozaff. (Asteraceae) from Iran. Natural product research. 2012; 26(23):2204-7. doi: 10.1080/14786419.2011.636746. [PMID: 22115413]
Birgit Waltenberger, Daniela Schuster, Sompol Paramapojn, Wandee Gritsanapan, Gerhard Wolber, Judith M Rollinger, Hermann Stuppner. Predicting cyclooxygenase inhibition by three-dimensional pharmacophoric profiling. Part II: Identification of enzyme inhibitors from Prasaplai, a Thai traditional medicine. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2011 Jan; 18(2-3):119-33. doi: 10.1016/j.phymed.2010.08.002. [PMID: 20851587]
E Nibret, M Wink. Trypanocidal and antileukaemic effects of the essential oils of Hagenia abyssinica, Leonotis ocymifolia, Moringa stenopetala, and their main individual constituents. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2010 Oct; 17(12):911-20. doi: 10.1016/j.phymed.2010.02.009. [PMID: 20359874]
Zilda Cristiani Gazim, Ana Carolina L Amorim, Ana Maria C Hovell, Claudia Moraes Rezende, Izalina Ansilieiro Nascimento, Gilberto Alves Ferreira, Diógenes Aparício Garcia Cortez. Seasonal variation, chemical composition, and analgesic and antimicrobial activities of the essential oil from leaves of Tetradenia riparia (Hochst.) Codd in southern Brazil. Molecules (Basel, Switzerland). 2010 Aug; 15(8):5509-24. doi: 10.3390/molecules15085509. [PMID: 20714310]
Chen-Lung Ho, Pei-Chun Liao, Kuang-Ping Hsu, Eugene I-Chen Wang, Wei-Chih Dong, Yu-Chang Su. Composition and antimicrobial and anti-wood-decay fungal activities of the leaf essential oils of Machilus pseudolongifolia from Taiwan. Natural product communications. 2010 Jul; 5(7):1143-6. doi: ". [PMID: 20734960]
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