Latamoxef (BioDeep_00000006445)
Secondary id: BioDeep_00001868246
human metabolite blood metabolite
代谢物信息卡片
(6R,7R)-7-[2-carboxy-2-(4-hydroxyphenyl)acetamido]-7-methoxy-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
化学式: C20H20N6O9S (520.1012430000001)
中文名称: 拉氧头孢
谱图信息:
最多检出来源 Homo sapiens(blood) 5.71%
分子结构信息
SMILES: CN1C(=NN=N1)SCC2=C(N3C(C(C3=O)(NC(=O)C(C4=CC=C(C=C4)O)C(=O)O)OC)OC2)C(=O)O
InChI: InChI=1S/C20H20N6O9S/c1-25-19(22-23-24-25)36-8-10-7-35-18-20(34-2,17(33)26(18)13(10)16(31)32)21-14(28)12(15(29)30)9-3-5-11(27)6-4-9/h3-6,12,18,27H,7-8H2,1-2H3,(H,21,28)(H,29,30)(H,31,32)/t12?,18-,20+/m1/s1
描述信息
Broad- spectrum beta-lactam antibiotic similar in structure to the cephalosporins except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain cephalosporins. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections. [PubChem]
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DD - Third-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
18 个代谢物同义名
(6R,7R)-7-[2-carboxy-2-(4-hydroxyphenyl)acetamido]-7-methoxy-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; latamoxef (stereochemistry undefined); Moxalactam, disodium; Disodium, moxalactam; Latamoxef, disodium; Moxalactam disodium; Disodium moxalactam; 1 Oxacephalosporin; Disodium latamoxef; 1-Oxacephalosporin; Latamoxefum; Festamoxin; Moxalactam; Oxa-cephem; Lamoxactam; Shiomarin; Latamoxef; LMOX
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:599928
- KEGG: C07231
- KEGGdrug: D08109
- PubChem: 47499
- PubChem: 3889
- HMDB: HMDB0015574
- Metlin: METLIN1366
- DrugBank: DB04570
- ChEMBL: CHEMBL74632
- Wikipedia: Latamoxef
- MeSH: Moxalactam
- chemspider: 43215
- CAS: 79120-38-0
- CAS: 64952-97-2
- PMhub: MS000019487
- PubChem: 9440
- PDB-CCD: MXL
- NIKKAJI: J19.504I
- RefMet: Latamoxef
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 7461 Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 7461 Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 9606 Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hui Qi, Chen Kou, Yu-Jie Qi, Bo-Hao Tang, Yue-E Wu, Fei Jin, Xiao-Jing Luo, Yan-Hua Shen, Ya-Jie Guo, Xue Qi, Ya-Cui Wang, Qian Dong, Xing-Kai Chen, Hai-Yan Shi, Yi Zheng, Wei Zhao, A-Dong Shen. Population pharmacokinetics and dosing optimization of latamoxef in neonates and young infants.
International journal of antimicrobial agents.
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The Journal of antimicrobial chemotherapy.
1987 Aug; 20(2):273-82. doi:
10.1093/jac/20.2.273. [PMID: 3667483] - K Mizojiri, R Norikura, A Takashima, H Tanaka, T Yoshimori, K Inazawa, T Yukawa, H Okabe, K Sugeno. Disposition of moxalactam and N-methyltetrazolethiol in rats and monkeys.
Antimicrobial agents and chemotherapy.
1987 Aug; 31(8):1169-76. doi:
10.1128/aac.31.8.1169. [PMID: 3631941] - T Chimura, S Sato, T Suzuki, K Ito, Y Sumiyoshi, H Kanasugi, M Nakakuki, Y Abe, M Banzai. [Prophylactic effects of a combined use of a cephem antibiotic, latamoxef, and tobramycin on postoperative infection in obstetrics and gynecology].
The Japanese journal of antibiotics.
1987 Jul; 40(7):1253-8. doi:
. [PMID: 3682180] - H Nakahata, Y Hirai, Y Kumasaka, T Miyazawa, T Nakamura, K Imamura, I Makino, K Takebe, H Kudo. [Free methyltetrazolethiol concentrations in men subjected to intravenous administration of cephems with methyltetrazolethiol].
The Japanese journal of antibiotics.
1987 Jul; 40(7):1294-8. doi:
NULL. [PMID: 3479623] - K Shindo, N Oikawa, S Chida, T Tsuburaya, M Sato. [Pharmacokinetic and clinical studies on latamoxef in the field of obstetrics and gynecology].
The Japanese journal of antibiotics.
1987 Jul; 40(7):1243-52. doi:
NULL. [PMID: 3682179] - S Asari, M Horikawa, H Tsukamoto, K Kouda, C Hayashi, K Miyai. [Susceptibility of clinical isolates to aztreonam].
The Japanese journal of antibiotics.
1987 Jul; 40(7):1317-31. doi:
. [PMID: 3479624] - S Murakami, S Shiraishi, S Miyauchi, Y Miki. False-positive Thormählen test induced by latamoxef sodium.
The Journal of dermatology.
1987 Jun; 14(3):237-40. doi:
10.1111/j.1346-8138.1987.tb03567.x. [PMID: 3312342] - R R Salem, A McIndoe, J A Matkin, A C Lidou, A Clarke, C B Wood. The hematologic effects of latamoxef sodium when used as a prophylaxis during surgical treatment.
Surgery, gynecology & obstetrics.
1987 Jun; 164(6):525-9. doi:
. [PMID: 3296254] - J Godard, M E Reverdy, P Mahul, D Perrot, G Fond, J Motin. [Erythromycin and latamoxef in the initial treatment of diffuse peritonitis with visceral failure].
Pathologie-biologie.
1987 Jun; 35(5 Pt 2):861-4. doi:
. [PMID: 3309830] - E G Rhodes, R I Harris, R S Welch, D J Perry, R M Brown, B J Boughton. Empirical treatment of febrile, neutropenic patients with tobramycin and latamoxef.
The Journal of hospital infection.
1987 May; 9(3):278-84. doi:
10.1016/0195-6701(87)90125-3. [PMID: 2886533] - U Ganzinger, F Schatz, H Haberl, A Haslberger, H Schiel, G Hitzenberger. Comparative pharmacokinetic analysis of latamoxef and CPW 86-363, a novel carboxy-pyrazol-cephalosporin and formation of N-methyl-thiotetrazole.
International journal of clinical pharmacology, therapy, and toxicology.
1987 Mar; 25(3):152-6. doi:
NULL. [PMID: 3557743] - Y Nakata, M Mizunaga, M Morikawa, H Osanai, M Fujisawa, F Inada, S Yachiku. [Study of levels of latamoxef in prostatic tissue and bladder mucosal tissue].
Hinyokika kiyo. Acta urologica Japonica.
1987 Feb; 33(2):289-93. doi:
NULL. [PMID: 2438917] - P Van der Auwera, Y Van Laethem, N Defresne, M Husson, J Klastersky. Comparative serum bactericidal activity against test anaerobes in volunteers receiving imipenem, clindamycin, latamoxef and metronidazole.
The Journal of antimicrobial chemotherapy.
1987 Feb; 19(2):205-10. doi:
10.1093/jac/19.2.205. [PMID: 3471750] - J Prokopowicz, M Dabrowska, J Wysocka, N Wołosowicz, A Gabryelewicz. Does ceftazidime or latamoxef affect the phagocytic capabilities of human granulocytes?.
Folia haematologica (Leipzig, Germany : 1928).
1987; 114(3):390-7. doi:
. [PMID: 2444513] - A Gabryelewicz, J Prokopowicz, N Wołosowicz, A Czajkowski, M Dabrowska. Changes in some hemostatic parameters in patients with infections treated with ceftazidime and latamoxef.
Folia haematologica (Leipzig, Germany : 1928).
1987; 114(3):398-407. doi:
. [PMID: 2444514] - K Uchida, M Nakamura, M Konishi, T Ishigami, T Komeno. Effect of latamoxef on platelet function and prothrombin time in partially nephrectomized rats.
Japanese journal of pharmacology.
1987 Jan; 43(1):9-16. doi:
10.1254/jjp.43.9. [PMID: 3573419] - R Kojima, M Ito, Y Suzuki. Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects (4). Effects of tobramycin alone and in combination with latamoxef on the stability of rat kidney lysosomal membranes.
Japanese journal of pharmacology.
1987 Jan; 43(1):73-80. doi:
10.1254/jjp.43.73. [PMID: 3573418] - N Takeuchi, T Kinukawa, O Matsuura, R Hattori, S Hasegawa, S Ohshima, Y Ono. [A study of prostatic tissue levels of latamoxef, cefoperazone and cefotaxime].
Hinyokika kiyo. Acta urologica Japonica.
1986 Dec; 32(12):1831-41. doi:
. [PMID: 2435132] - R P Rapp, J E Connors, W D Hager, E S Donaldson, J R van Nagell. Comparison of single-dose moxalactam and a three-dose regimen of cefoxitin for prophylaxis in vaginal hysterectomy.
Clinical pharmacy.
1986 Dec; 5(12):988-93. doi:
. [PMID: 3542346] - R Kojima, M Ito, Y Suzuki. Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects (3). Protective effect of latamoxef against tobramycin nephrotoxicity and its protective mechanism.
Japanese journal of pharmacology.
1986 Nov; 42(3):397-404. doi:
10.1254/jjp.42.397. [PMID: 3820859] - F Carpentier, P Granier, J Croize, F Serre-Debeauvais, D Barnoud, M Guignier. [Latamoxef in resuscitation in acute renal failure. Measurement of plasma levels].
Therapie.
1986 Nov; 41(6):487-92. doi:
NULL. [PMID: 3810544] - J R Sharman, A Howarth. Modified method for the determination of moxalactam in plasma by high-performance liquid chromatography.
Journal of chromatography.
1986 Sep; 381(2):447-52. doi:
10.1016/s0378-4347(00)83613-0. [PMID: 3760101] - J L Axelrod, R M Klein, R L Bergen, M Z Sheikh. Human vitreous levels of cefamandole and moxalactam.
American journal of ophthalmology.
1986 Jun; 101(6):684-7. doi:
10.1016/0002-9394(86)90769-5. [PMID: 3717251] - M G Bergeron, P Simard. Influence of three modes of administration on the penetration of latamoxef into interstitial fluid and fibrin clots and its in-vivo activity against Haemophilus influenzae.
The Journal of antimicrobial chemotherapy.
1986 Jun; 17(6):775-84. doi:
10.1093/jac/17.6.775. [PMID: 3488309] - C A De Jongh, J H Joshi, B W Thompson, K A Newman, R S Finley, M R Moody, P C Salvatore, J H Tenney, G L Drusano, S C Schimpff. A double beta-lactam combination versus an aminoglycoside-containing regimen as empiric antibiotic therapy for febrile granulocytopenic cancer patients.
The American journal of medicine.
1986 May; 80(5C):101-11. doi:
NULL. [PMID: 3521269] - D Charles, B Larsen. Pharmacokinetics of cefotaxime, moxalactam, and cefoperazone in the early puerperium.
Antimicrobial agents and chemotherapy.
1986 May; 29(5):873-6. doi:
10.1128/aac.29.5.873. [PMID: 3729345] - Y Matsuura, M Tamura, H Yamashina, M Higo, T Fujii, M Yamamoto, H Shimamoto, H Yamada, T Oguma, K Shimamura. [The prophylactic effects of latamoxef against the postoperative infections to open heart surgery. Studies on the penetration of latamoxef into the pericardial fluid and the auricle of heart].
The Japanese journal of antibiotics.
1986 May; 39(5):1241-9. doi:
NULL. [PMID: 3761554] - D E Fry, L Trachtenberg, H C Polk. Serum kinetics of intraperitoneal moxalactam.
Archives of surgery (Chicago, Ill. : 1960).
1986 Mar; 121(3):282-4. doi:
10.1001/archsurg.1986.01400030036005. [PMID: 3947227] - H C Standiford, G L Drusano, C I Bustamante, G Rivera, A Forrest, B Tatem, J Leslie, M Moody. Imipenem coadministered with cilastatin compared with moxalactam: integration of serum pharmacokinetics and microbiologic activity following single-dose administration to normal volunteers.
Antimicrobial agents and chemotherapy.
1986 Mar; 29(3):412-7. doi:
10.1128/aac.29.3.412. [PMID: 3459390] - S H Zinner, J Blaser. In-vitro studies of antibiotic combinations with special emphasis on the evaluation of newly developed methods.
The Journal of antimicrobial chemotherapy.
1986 Mar; 17 Suppl A(?):1-5. doi:
10.1093/jac/17.suppl_a.1. [PMID: 3086275] - I Cho, J M Bertoni, L Hopkins. Moxalactam myoclonus, seizures, and encephalopathy.
Drug intelligence & clinical pharmacy.
1986 Mar; 20(3):223-4. doi:
10.1177/106002808602000310. [PMID: 3956381] - G Fradet, S Brister, G K Richards, J Prentis, R A Brown, R C Chiu, D S Mulder. Antibiotic prophylaxis in vascular surgery: pharmacokinetic study of four commonly used cephalosporins.
Journal of vascular surgery.
1986 Mar; 3(3):535-9. doi:
10.1067/mva.1986.avs0030535. [PMID: 3512862] - G Drusano, H Standiford, P Ryan, W McNamee, B Tatem, S Schimpff. Correlation of predicted serum bactericidal activities and values measured in volunteers.
European journal of clinical microbiology.
1986 Feb; 5(1):88-92. doi:
10.1007/bf02013475. [PMID: 3084247] - A Contrepois, J M Vallois, J J Garaud, B Pangon, J Mohler, A Meulemans, C Carbon. Kinetics and bactericidal effect of gentamicin and latamoxef (moxalactam) in experimental Escherichia coli endocarditis.
The Journal of antimicrobial chemotherapy.
1986 Feb; 17(2):227-37. doi:
10.1093/jac/17.2.227. [PMID: 3516963] - T Inoue, K Sakaguchi, K Yoshida, T Imai, Y Kajimoto, D Shirai. [Effect of latamoxef on platelet aggregation in hemodialysis and continuous ambulatory peritoneal dialysis (CAPD) patients].
Nihon Jinzo Gakkai shi.
1986 Feb; 28(2):177-83. doi:
NULL. [PMID: 3735768]