ST 21:3;O5 (BioDeep_00000637523)

 

Secondary id: BioDeep_00000005249, BioDeep_00000005837, BioDeep_00000014577, BioDeep_00001868308, BioDeep_00001869042, BioDeep_00001869961


代谢物信息卡片


11beta,21-dihydroxy-3,20-dioxo-5beta-pregnan-18-al

化学式: C21H30O5 (362.209313)
中文名称: 5-Alpha-二氢可的松
谱图信息: 最多检出来源 Homo sapiens(blood) 0.08%

分子结构信息

SMILES: C1CC(=O)C=C2CC[C@@]3([H])[C@]4([H])CC[C@](O)([C@@H](CO)O)[C@@]4(C)CC(=O)[C@]3([H])[C@@]12C
InChI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12,14-15,18,22,26H,3-11H2,1-2H3/t12-,14+,15+,18-,19+,20+,21+/m1/s1

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

23 个代谢物同义名

11beta,21-dihydroxy-3,20-dioxo-5beta-pregnan-18-al; 5beta-pregnane-11beta,21-diol-3,20-one-18-al; 5beta-Dihydroaldosterone; ST 21:3;O5; 4-pregnene-17alpha,20beta,21-triol-3,11-dione; 20beta-Dihydrocortisone; 4-pregnene-17alpha,20alpha,21-triol-3,11-dione; 20alpha-Dihydrocortisone; Reichsteins substance U; 11beta,20R-dihydroxy-3-oxopregn-4-en-21-oic acid; 20alpha-DHOPA; 11beta,20-Dihydroxy-3-oxopregn-4-en-21-oic acid; 11b,21-Dihydroxy-3,20-oxo-5b-pregnan-18-al; 17,21-dihydroxy-5alpha-pregnane-3,11,20-trione; (5α)-17,21-Dihydroxypregnane-3,11,20-trione; 4,5alpha-Dihydrocortisone; 17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trione; 5beta-Pregnane-17alpha,21-diol-3,11,20-trione; 17,21-dihydroxy-5beta-pregnane-3,11,20-trione; 4,5beta-Dihydrocortisone; 5-dihydrocortisone; 11beta,18,21-trihydroxy-pregn-4-ene-3,20-dione; 18-Hydroxycorticosterone



数据库引用编号

44 个数据库交叉引用编号

分类词条

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Fangjun Chen, Ziyun Cheng, Zhenxin Wang, Yingfei Peng, Beili Wang, Wei Guo, Baishen Pan. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) based assay for the simultaneous quantification of 18-hydroxycorticosterone, 18-hydroxycortisol and 18-oxocortisol in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Jan; 1188(?):123030. doi: 10.1016/j.jchromb.2021.123030. [PMID: 34871919]
  • Nina Makowski, Bjoern Bengt Burckhardt. Enabling insights into the maturation of the renin-angiotensin-aldosterone system in children-Development of a low-volume LC-MS assay for the simultaneous determination of aldosterone, its precursor, and main metabolite. Steroids. 2019 08; 148(?):73-81. doi: 10.1016/j.steroids.2019.04.009. [PMID: 31075338]
  • Kuniko Mitamura, Rika Satoh née Okihara, Mami Kamibayashi, Kanta Sato, Takashi Iida, Shigeo Ikegawa. Simultaneous determination of 18 tetrahydrocorticosteroid sulfates in human urine by liquid chromatography/electrospray ionization-tandem mass spectrometry. Steroids. 2014 Jul; 85(?):18-29. doi: 10.1016/j.steroids.2014.03.015. [PMID: 24721697]
  • Paolo Mulatero, Stefania Morra di Cella, Silvia Monticone, Domenica Schiavone, Maria Manzo, Giulio Mengozzi, Franco Rabbia, Massimo Terzolo, Elise P Gomez-Sanchez, Celso E Gomez-Sanchez, Franco Veglio. 18-hydroxycorticosterone, 18-hydroxycortisol, and 18-oxocortisol in the diagnosis of primary aldosteronism and its subtypes. The Journal of clinical endocrinology and metabolism. 2012 Mar; 97(3):881-9. doi: 10.1210/jc.2011-2384. [PMID: 22238407]
  • Vishal Gupta. Mineralocorticoid hypertension. Indian journal of endocrinology and metabolism. 2011 Oct; 15 Suppl 4(?):S298-312. doi: 10.4103/2230-8210.86972. [PMID: 22145132]
  • H Tveiten, M Frantzen, A M Scott, A P Scott. Synthesis of 17,20beta,21-trihydroxypregn-4-en-3-one by ovaries of reproductively mature Atlantic cod Gadus morhua. Journal of fish biology. 2010 Jul; 77(1):33-53. doi: 10.1111/j.1095-8649.2010.02655.x. [PMID: 20646137]
  • Takehiro Ko, Yutaka Kakizoe, Naoki Wakida, Manabu Hayata, Kohei Uchimura, Naoki Shiraishi, Taku Miyoshi, Masataka Adachi, Shizuka Aritomi, Tomoyuki Konda, Kimio Tomita, Kenichiro Kitamura. Regulation of adrenal aldosterone production by serine protease prostasin. Journal of biomedicine & biotechnology. 2010; 2010(?):793843. doi: 10.1155/2010/793843. [PMID: 20204133]
  • Lindsey A Loomba-Albrecht, Mato Nagel, Andrew A Bremer. Pseudohypoaldosteronism type 1 due to a novel mutation in the mineralocorticoid receptor gene. Hormone research in paediatrics. 2010; 73(6):482-6. doi: 10.1159/000281290. [PMID: 20453518]
  • Richard J Auchus, Donald W Chandler, Sarita Singeetham, Neema Chokshi, Fiemu E Nwariaku, Bart L Dolmatch, Shelby A Holt, Frank H Wians, Shellie C Josephs, Clayton K Trimmer, Jorge Lopera, Wanpen Vongpatanasin, Shawna D Nesbitt, David Leonard, Ronald G Victor. Measurement of 18-hydroxycorticosterone during adrenal vein sampling for primary aldosteronism. The Journal of clinical endocrinology and metabolism. 2007 Jul; 92(7):2648-51. doi: 10.1210/jc.2006-2631. [PMID: 17473070]
  • Mei-Chuan Chen, Shiu-Huey Chou, Cheng-Huang Lin. Determination of corticosterone and 17-hydroxycorticosterone in plasma and urine samples by sweeping techniques using micellar electrokinetic chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Mar; 801(2):347-53. doi: 10.1016/j.jchromb.2003.11.027. [PMID: 14751805]
  • Keiko Homma, Tomonobu Hasegawa, Masami Masumoto, Eiko Takeshita, Kiyoaki Watanabe, Hitoshi Chiba, Takao Kurosawa, Takao Takahashi, Nobutake Matsuo. Reference values for urinary steroids in Japanese newborn infants: gas chromatography/mass spectrometry in selected ion monitoring. Endocrine journal. 2003 Dec; 50(6):783-92. doi: 10.1507/endocrj.50.783. [PMID: 14709852]
  • F G Riepe, N Krone, M Peter, W G Sippell, C-J Partsch. Chromatographic system for the simultaneous measurement of plasma 18-hydroxy-11-deoxycorticosterone and 18-hydroxycorticosterone by radioimmunoassay: reference data for neonates and infants and its application in aldosterone-synthase deficiency. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Mar; 785(2):293-301. doi: 10.1016/s1570-0232(02)00921-2. [PMID: 12554142]
  • Chun-Hsueh Wu, Mei-Chuan Chen, An-Kai Su, Pin-Yan Shu, Shiu-Huey Chou, Cheng-Huang Lin. Determination of corticosterone in mouse plasma by a sweeping technique using micellar electrokinetic chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Mar; 785(2):317-25. doi: 10.1016/s1570-0232(02)00955-8. [PMID: 12554145]
  • Loai A Shakerdi, John M C Connell, Robert Fraser, A Michael Wallace. Analysis of biological samples by gas chromatography-mass spectrometry without a reference standard: measurement of urinary 18-hydroxytetrahydro-11-dehydrocorticosterone excretion rate in human subjects. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Feb; 784(2):367-73. doi: 10.1016/s1570-0232(02)00825-5. [PMID: 12505784]
  • Susan A Lloyd-MacGilp, Lucia Torielli, Stephanie Bechtel, Grazia Tripodi, Celso E Gomez-Sanchez, Laura Zagato, Rita Bernhardt, Christopher J Kenyon. Mutations in aldosterone synthase gene of Milan hypertensive rats: phenotypic consequences. American journal of physiology. Endocrinology and metabolism. 2002 Mar; 282(3):E608-17. doi: 10.1152/ajpendo.00043.2001. [PMID: 11832364]
  • F X Huber, U Hinz, D Haack, M Lucas, U Heuschen, C Herfarth, J Stern. ['High pouch output' syndrome. Role of mineralocorticoid diagnosis after restorative proctocolectomy]. Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen. 2001 Dec; 72(12):1446-52. doi: 10.1007/s001040170009. [PMID: 11824030]
  • J J Rivero-Marabé, J I Maynar-Mariño, M P García-de-Tiedra, A M Galán-Martín, M J Caballero-Loscos, M Maynar-Marinõ. Determination of natural corticosteroids in urine samples from sportsmen. Journal of chromatography. B, Biomedical sciences and applications. 2001 Sep; 761(1):77-84. doi: 10.1016/s0378-4347(01)00306-1. [PMID: 11585134]
  • K M Kayes-Wandover, R E Schindler, H C Taylor, P C White. Type 1 aldosterone synthase deficiency presenting in a middle-aged man. The Journal of clinical endocrinology and metabolism. 2001 Mar; 86(3):1008-12. doi: 10.1210/jcem.86.3.7326. [PMID: 11238478]
  • M Wasniewska, F De Luca, M Valenzise, F Lombardo, F De Luca. Aldosterone synthase deficiency type I with no documented homozygous mutations in the CYP11B2 gene. European journal of endocrinology. 2001 Jan; 144(1):59-62. doi: 10.1530/eje.0.1440059. [PMID: 11174838]
  • K Aoki, H Sekihara. [11-deoxycorticosterone (DOC) and 18-OH-DOC]. Nihon rinsho. Japanese journal of clinical medicine. 1999 Dec; 57 Suppl(?):142-5. doi: NULL. [PMID: 10778085]
  • M A Popot, E Lacabaratz, P Garcia, V Laroute, Y Bonnaire, P L Toutain, D A Cowan. New approaches to detect cortisol administration in the horse. Equine veterinary journal. 1999 Jul; 31(4):278-84. doi: 10.1111/j.2042-3306.1999.tb03817.x. [PMID: 10454084]
  • P Igarreta, C P Lantos, J C Calvo, A A Paladini, M C Damasco. Dose-dependence of the effects of corticosterone and the non-glucocorticoid, 18-hydroxycorticosterone, on the brush-border Na+/K+ exchanger. Endocrine research. 1998 Aug; 24(3-4):601-5. doi: 10.3109/07435809809032653. [PMID: 9888545]
  • M K Birmingham, A Barta, L Solyom, J G Lehoux, P Vecsei. Correlations between mood scores, LH, adrenocortical steroids, and urine volumes in a patient with a history of postpartum depression and monthly psychotic episodes. Endocrine research. 1998 Aug; 24(3-4):595-9. doi: 10.3109/07435809809032652. [PMID: 9888544]
  • M Peter, W Nikischin, P Heinz-Erian, W Fussenegger, K Kapelari, W G Sippell. Homozygous deletion of arginine-173 in the CYP11B2 gene in a girl with congenital hypoaldosteronism. Corticosterone methyloxidase deficiency type II. Hormone research. 1998; 50(4):222-5. doi: 10.1159/000023278. [PMID: 9838244]
  • M Peter, L Fawaz, S L Drop, H K Visser, W G Sippell. Hereditary defect in biosynthesis of aldosterone: aldosterone synthase deficiency 1964-1997. The Journal of clinical endocrinology and metabolism. 1997 Nov; 82(11):3525-8. doi: 10.1210/jcem.82.11.4399. [PMID: 9360501]
  • P Igarreta, J C Calvo, A Paladini, M C Damasco. Acute effects of two natural corticosteroids on the kinetics of the Na+/H+ exchanger in rat renal brush-border membranes. Canadian journal of physiology and pharmacology. 1997 Oct; 75(10-11):1226-31. doi: NULL. [PMID: 9431447]
  • T Un-no, S Kageyama, T Ushiyama, K Suzuki, K Fujita. Adrenocortical adenoma producing 18-hydroxycorticosterone. International journal of urology : official journal of the Japanese Urological Association. 1996 Nov; 3(6):491-3. doi: 10.1111/j.1442-2042.1996.tb00582.x. [PMID: 9170579]
  • Y Takeda, I Miyamori, T Yoneda, K Furukawa, H Hatakeyama, S Inaba, Y Ito, R Takeda, H Mabuchi. Effect of adrenocorticotropin stimulation on the synthesis of 19-noraldosterone in man. The Journal of clinical endocrinology and metabolism. 1996 May; 81(5):1852-5. doi: 10.1210/jcem.81.5.8626846. [PMID: 8626846]
  • A L Sanna, T Ciampani, G Mancini, D Giannini, V Bonifacio. [Adrenal adenoma or hyperplasia? Problems of differential diagnosis in an unusual case of primary hyperaldosteronism]. Minerva medica. 1996 Mar; 87(3):93-7. doi: NULL. [PMID: 8668294]
  • Y Takeda, I Miyamori, T Yoneda, K Iki, R Takeda. Effect of aging on urinary excretion of 19-noraldosterone and 18,19-dihydroxycorticosterone. The Journal of steroid biochemistry and molecular biology. 1995 Apr; 52(4):383-6. doi: 10.1016/0960-0760(94)00186-p. [PMID: 7734407]
  • A B Yong, J Montalto, J Pitt, S Oakes, T Preston, C Buchanan. Corticosterone methyl oxidase type II (CMO II) deficiency: biochemical approach to diagnosis. Clinical biochemistry. 1994 Dec; 27(6):491-4. doi: 10.1016/0009-9120(94)00048-z. [PMID: 7697895]
  • R Fraser, A K Ancil, W B Brown, M C Ingram, C D Holloway, I W Henderson, C J Kenyon. Evidence of abnormalities in corticosteroid secretion leading to volume-dependent hypertension in Milan rats. Hypertension (Dallas, Tex. : 1979). 1994 Oct; 24(4):512-5. doi: 10.1161/01.hyp.24.4.512. [PMID: 8088920]
  • M Zenatti, N Blanchouin-Emeric, S Koplewicz, G Defaye, B Aupetit-Faisant. Suramin: an inhibitor of the final steps of the mineralocorticoid pathway?. The Journal of steroid biochemistry and molecular biology. 1994 Feb; 48(2-3):265-70. doi: 10.1016/0960-0760(94)90154-6. [PMID: 8142303]
  • N Yamakita, C E Gomez-Sanchez, T Mune, H Yoshida, S Miyazaki, K Yasuda, T Nakai. Regulation of 18-oxocortisol and 18-hydroxycortisol by the renin-angiotensin system and ACTH in man. The Journal of steroid biochemistry and molecular biology. 1993 Sep; 46(3):395-9. doi: 10.1016/0960-0760(93)90230-t. [PMID: 9831489]
  • T Kigoshi, M Kaneko, S Nakano, S Azukizawa, K Uchida, S Morimoto. [Aldosterone response to various stimuli in hyperthyroidism: in vivo and in vitro studies]. Nihon Naibunpi Gakkai zasshi. 1993 Jun; 69(6):609-20. doi: 10.1507/endocrine1927.69.6_609. [PMID: 8396050]
  • B Aupetit-Faisant, C Battaglia, M Zenatti, N Emeric-Blanchouin, J C Legrand. Hypoaldosteronism accompanied by normal or elevated mineralocorticosteroid pathway steroid: a marker of adrenal carcinoma. The Journal of clinical endocrinology and metabolism. 1993 Jan; 76(1):38-43. doi: 10.1210/jcem.76.1.8421100. [PMID: 8421100]
  • G P Vinson, S M Laird, J P Hinson, R Teja. Origin of aldosterone in trypsin-stimulated rat adrenal zona glomerulosa incubations. The Journal of endocrinology. 1992 Oct; 135(1):125-33. doi: 10.1677/joe.0.1350125. [PMID: 1331285]
  • M Sander, M Bader, B Djavidani, C Maser-Gluth, P Vecsei, J Mullins, D Ganten, J Peters. The role of the adrenal gland in hypertensive transgenic rat TGR(mREN2)27. Endocrinology. 1992 Aug; 131(2):807-14. doi: 10.1210/endo.131.2.1322284. [PMID: 1322284]
  • Y Takeda, I Miyamori, K Iki, R Takeda, P Vecsei. Urinary excretion of 19-noraldosterone, 18, 19-dihydroxycorticosterone and 18-hydroxy-19-norcorticosterone in patients with aldosterone-producing adenoma or idiopathic hyperaldosteronism. Acta endocrinologica. 1992 Jun; 126(6):484-8. doi: 10.1530/acta.0.1260484. [PMID: 1642080]
  • S Ulick, J Z Wang, D H Morton. The biochemical phenotypes of two inborn errors in the biosynthesis of aldosterone. The Journal of clinical endocrinology and metabolism. 1992 Jun; 74(6):1415-20. doi: 10.1210/jcem.74.6.1592889. [PMID: 1592889]
  • M Ansaldo, M C Damasco, M S de Lavallaz, C P Lantos, G Malnic. Role of corticosteroids in distal acidification of amiloride-treated rats. Canadian journal of physiology and pharmacology. 1992 May; 70(5):695-700. doi: 10.1139/y92-089. [PMID: 1423011]
  • Y Takeda, I Miyamori, R Takeda, S Lewicka, P Vecsei. Effect of sodium restriction on urinary excretion of 19-noraldosterone and 18,19-dihydroxycorticosterone, newly identified mineralocorticoids in man. The Journal of clinical endocrinology and metabolism. 1992 May; 74(5):1195-7. doi: 10.1210/jcem.74.5.1569167. [PMID: 1569167]
  • E Mayatepek, H W Seyberth, W Nützenadel. Effects of indomethacin in congenital chloride diarrhea. Journal of pediatric gastroenterology and nutrition. 1992 Apr; 14(3):319-22. doi: 10.1097/00005176-199204000-00014. [PMID: 1619538]
  • J Wacker, N E-Mistry, H Bauer, P Vecsei, W Stolz, G Bastert. Mineralocorticoids and mineralocorticoid receptors in mononuclear leukocytes in patients with pregnancy-induced hypertension. The Journal of clinical endocrinology and metabolism. 1992 Apr; 74(4):910-3. doi: 10.1210/jcem.74.4.1312541. [PMID: 1312541]
  • D R Radin, C Manoogian, J L Nadler. Diagnosis of primary hyperaldosteronism: importance of correlating CT findings with endocrinologic studies. AJR. American journal of roentgenology. 1992 Mar; 158(3):553-7. doi: 10.2214/ajr.158.3.1738993. [PMID: 1738993]
  • P Picco, L Garibaldi, M Cotellessa, M DiRocco, C Borrone. Corticosterone methyl oxidase type II deficiency: a cause of failure to thrive and recurrent dehydration in early infancy. European journal of pediatrics. 1992 Mar; 151(3):170-3. doi: 10.1007/bf01954376. [PMID: 1601005]
  • I Miyamori, Y Takeda, H Takasaki, Y Itoh, K Iki, R Takeda. Determination of urinary 18-hydroxycortisol in the diagnosis of primary aldosteronism. Journal of endocrinological investigation. 1992 Jan; 15(1):19-24. doi: 10.1007/bf03348648. [PMID: 1560187]
  • Y Takeda, K Bige, T Iwuanyanwu, S Lewicka, P Vecsei, S Abdelhamid, M Harnik. Urinary 18,19-dihydroxycorticosterone and 18-hydroxy-19-norcorticosterone excretion in patients with primary and secondary aldosteronism. Steroids. 1991 Nov; 56(11):566-70. doi: 10.1016/0039-128x(91)90015-n. [PMID: 1814024]
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  • B Aupetit, R Fraser, P Vecsei, M Zenatti, S Lewicka, P Corvol, N Zaugg, J C Legrand. [18-Hydroxycorticosterone, 18-hydroxydesoxycorticosterone. Why, when, how to determine plasma levels in some adrenal pathologies]. Annales d'endocrinologie. 1990; 51(1):1-15. doi: NULL. [PMID: 2221818]
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  • K J Osterziel, M Zeier, F Raue, H Buhr, K Andrassy, R Ziegler, P Vecsei. [Primary hyperaldosteronism without arterial hypertension]. Deutsche medizinische Wochenschrift (1946). 1989 Dec; 114(51-52):2001-5. doi: 10.1055/s-2008-1066861. [PMID: 2689127]
  • M M Lee, L Rajagopalan, G J Berg, T Moshang. Serum adrenal steroid concentrations in premature infants. The Journal of clinical endocrinology and metabolism. 1989 Dec; 69(6):1133-6. doi: 10.1210/jcem-69-6-1133. [PMID: 2531155]
  • M Minato, M Honda, M Hatano. [Clinical significance of serum and urinary 18-hydroxycorticosterone analysis in endocrine tests of the adrenal cortex]. Nihon rinsho. Japanese journal of clinical medicine. 1989 Dec; 48 Suppl(?):1227-30. doi: NULL. [PMID: 2560070]
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