Thienamycin (BioDeep_00000006272)

   

natural product


代谢物信息卡片


Epithienamycin

化学式: C11H16N2O4S (272.0831)
中文名称: 硫霉素
谱图信息: 最多检出来源 Homo sapiens(COVID-19)(blood) 20.9%

分子结构信息

SMILES: CC(C1C2CC(=C(N2C1=O)C(=O)O)SCCN)O
InChI: InChI=1S/C11H16N2O4S/c1-5(14)8-6-4-7(18-3-2-12)9(11(16)17)13(6)10(8)15/h5-6,8,14H,2-4,12H2,1H3,(H,16,17)

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D013845 - Thienamycins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams

同义名列表

3 个代谢物同义名

Thienamycin; Epithienamycin; Thienamycin



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 CTH, GLUL, ODC1, OPA1
Nucleus 2 ANKRD42, GLUL
cytosol 6 CTH, GLUL, GPT, LIPE, ODC1, OPA1
dendrite 1 OPA1
mitochondrial membrane 1 OPA1
phagocytic vesicle 1 STX8
trans-Golgi network 1 STX8
nucleoplasm 1 OPA1
Cell membrane 4 AGTR2, GLUL, LIPE, VNN1
Lipid-anchor 1 GLUL
Multi-pass membrane protein 1 AGTR2
mitochondrial inner membrane 2 ALDH18A1, OPA1
Cytoplasm, cytosol 2 GLUL, LIPE
endosome 1 STX8
plasma membrane 5 AGTR2, CTH, GLUL, STX8, VNN1
Membrane 5 CTH, LIPE, OPA1, STX8, VNN1
caveola 1 LIPE
extracellular exosome 4 CTH, GLUL, GPT, SPINK1
endoplasmic reticulum 2 GLUL, STX8
perinuclear region of cytoplasm 1 STX8
mitochondrion 3 ALDH18A1, GLUL, OPA1
Single-pass type I membrane protein 1 CTH
Secreted 1 SPINK1
extracellular region 1 VNN1
Single-pass membrane protein 2 OPA1, STX8
mitochondrial outer membrane 1 OPA1
axon cytoplasm 1 OPA1
Early endosome 1 STX8
recycling endosome 1 STX8
vesicle 1 STX8
Mitochondrion inner membrane 2 ALDH18A1, OPA1
microtubule 1 OPA1
Mitochondrion intermembrane space 1 OPA1
mitochondrial intermembrane space 1 OPA1
Late endosome 1 STX8
mitochondrial crista 1 OPA1
Lipid-anchor, GPI-anchor 1 VNN1
Endomembrane system 1 STX8
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
cell body 1 GLUL
side of membrane 1 VNN1
SNARE complex 1 STX8
Microsome 1 GLUL
azurophil granule membrane 1 VNN1
Single-pass type IV membrane protein 1 STX8
[Dynamin-like GTPase OPA1, long form]: Mitochondrion inner membrane 1 OPA1
[Dynamin-like GTPase OPA1, short form]: Mitochondrion intermembrane space 1 OPA1
glial cell projection 1 GLUL


文献列表

  • Micah J Bodner, Rongfeng Li, Ryan M Phelan, Michael F Freeman, Kristos A Moshos, Evan P Lloyd, Craig A Townsend. Definition of the common and divergent steps in carbapenem β-lactam antibiotic biosynthesis. Chembiochem : a European journal of chemical biology. 2011 Sep; 12(14):2159-65. doi: 10.1002/cbic.201100366. [PMID: 21913298]
  • J Birnbaum, F M Kahan, H Kropp, J S MacDonald. Carbapenems, a new class of beta-lactam antibiotics. Discovery and development of imipenem/cilastatin. The American journal of medicine. 1985 Jun; 78(6A):3-21. doi: 10.1016/0002-9343(85)90097-x. [PMID: 3859213]
  • A Von Graevenitz, C Bucher. Isolation of Pseudomonas maltophilia from human stools with thienamycin. Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious.... 1983 May; 254(3):403-4. doi: 10.1016/s0174-3031(83)80122-x. [PMID: 6675350]
  • H Kropp, J G Sundelof, R Hajdu, F M Kahan. Metabolism of thienamycin and related carbapenem antibiotics by the renal dipeptidase, dehydropeptidase. Antimicrobial agents and chemotherapy. 1982 Jul; 22(1):62-70. doi: 10.1128/aac.22.1.62. [PMID: 7125632]
  • E O Stapley, P J Cassidy, J Tunac, R L Monaghan, M Jackson, S Hernandez, S B Zimmerman, J M Mata, S A Currie, D Daoust, D Hendlin. Epithienamycins-novel beta-lactams related to thienamycin. I. Production and antibacterial activity. The Journal of antibiotics. 1981 Jun; 34(6):628-36. doi: 10.7164/antibiotics.34.628. [PMID: 7275847]