Deoxyloganin (BioDeep_00000006054)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


Deoxyloganin

化学式: C17H26O9 (374.1576746)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 0.53%

分子结构信息

SMILES: CC1CCC2C1C(OC=C2C(=O)OC)OC3C(C(C(C(O3)CO)O)O)O
InChI: InChI=1S/C17H26O9/c1-7-3-4-8-9(15(22)23-2)6-24-16(11(7)8)26-17-14(21)13(20)12(19)10(5-18)25-17/h6-8,10-14,16-21H,3-5H2,1-2H3/t7-,8+,10+,11+,12+,13-,14+,16-,17-/m0/s1

描述信息

同义名列表

2 个代谢物同义名

Deoxyloganin; Deoxyloganin



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

3 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(3)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

16 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yu Wang, Min Zhao, Jing Li, Yue Liu. Loganin exerts neuroprotective effect by inhibiting neuronal pyroptosis in rat with cerebral haemorrhage. Clinical and experimental pharmacology & physiology. 2024 Jun; 51(6):e13858. doi: 10.1111/1440-1681.13858. [PMID: 38636940]
  • Priya Rao, Mark A Yaroslavsky, Justin C Miller, Mary A Schuler. Catalytic Site Constraints in the P450s Mediating Loganic Acid (7DLH) and Secologanic Acid Synthesis (SLAS) in Camptotheca. Biochemistry. 2023 Sep; 62(18):2763-2774. doi: 10.1021/acs.biochem.3c00126. [PMID: 37656055]
  • Jingzi Chen, Jiaming Ge, Weisan Chen, Ying Zhao, Tianbao Song, Kun Fu, Xiankuan Li, Yanchao Zheng. UPLC-Q-TOF-MS based investigation into the bioactive compounds and molecular mechanisms of Lamiophlomis Herba against hepatic fibrosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Sep; 121(?):155085. doi: 10.1016/j.phymed.2023.155085. [PMID: 37757709]
  • Fan Zhang, Yu Yan, Kang Ding, Wen-Wen Lian, Li Li, Wen-Ping Wang, Cong-Yuan Xia, Hua Yang, Jun He, Wei-Ku Zhang, Jie-Kun Xu. Development and validation of a simple and rapid UPLC-MS/MS method for loganin and its application in pharmacokinetic and tissue distribution studies. Journal of ethnopharmacology. 2023 Sep; 319(Pt 1):117130. doi: 10.1016/j.jep.2023.117130. [PMID: 37678422]
  • Wenfan Li, Pei Fan, Xiaobo Wang, Haifeng Tang. Loganin alleviates myocardial ischemia-reperfusion injury through GLP-1R/NLRP3-mediated pyroptosis pathway. Environmental toxicology. 2023 Jul; ?(?):. doi: 10.1002/tox.23908. [PMID: 37497884]
  • Xudong Huang, Xiao Chen, Qi Li, Bai-He Ni, Weiguo Wang. Loganin reduces neuroinflammation and promotes functional recovery after spinal cord injury through inhibiting NF-κB/NLRP3 signalling. Toxicon : official journal of the International Society on Toxinology. 2023 Jun; ?(?):107202. doi: 10.1016/j.toxicon.2023.107202. [PMID: 37348819]
  • Yunfeng Zhou, Dongmei Luo, Junzhuo Shi, Xiaojia Yang, Wangjun Xu, Weiping Gao, Yukun Guo, Qian Zhao, Xinmei Xie, Yangyang He, Guanhua Du, Xiaobin Pang. Loganin alleviated cognitive impairment in 3×Tg-AD mice through promoting mitophagy mediated by optineurin. Journal of ethnopharmacology. 2023 Apr; ?(?):116455. doi: 10.1016/j.jep.2023.116455. [PMID: 37019163]
  • Hyoju Jeon, Chang-Gun Lee, Hyesoo Jeong, Seong-Hoon Yun, Jeonghyun Kim, Laxmi Prasad Uprety, Kang-Il Oh, Shivani Singh, Jisu Yoo, Eunkuk Park, Seon-Yong Jeong. Inhibitory Effects of Loganin on Adipogenesis In Vitro and In Vivo. International journal of molecular sciences. 2023 Mar; 24(5):. doi: 10.3390/ijms24054752. [PMID: 36902181]
  • Yu-Xuan Guo, Cong-Yuan Xia, Yu Yan, Yan Han, Rui Shi, Jun He, Yu-Ming Wang, Ze-Xing Wang, Wei-Ku Zhang, Jie-Kun Xu. Loganin improves chronic unpredictable mild stress-induced depressive-like behaviors and neurochemical dysfunction. Journal of ethnopharmacology. 2023 Feb; ?(?):116288. doi: 10.1016/j.jep.2023.116288. [PMID: 36809822]
  • Jiaqi Zhang, Yaoyao Wang, Xiaoran Liu, Hao Liu, Xingli Zhao, Shufang Lv, Huawei Xu, Hongxiao Zhang, Xiaogai Hou, Dianyun Hou. Expression Analysis of CoHMGS in Cornus officinalis and Subcellular Localization of the Enzyme It Encodes. DNA and cell biology. 2023 Feb; 42(2):91-96. doi: 10.1089/dna.2022.0527. [PMID: 36730809]
  • Xiaolong Hao, Can Wang, Wei Zhou, Qingyan Ruan, Chenhong Xie, Yinkai Yang, Chengyu Xiao, Yan Cai, Jingyi Wang, Yao Wang, Xuebin Zhang, Itay Maoz, Guoyin Kai. OpNAC1 transcription factor regulates the biosynthesis of the anticancer drug camptothecin by targeting loganic acid O-methyltransferase in Ophiorrhiza pumila. Journal of integrative plant biology. 2023 Jan; 65(1):133-149. doi: 10.1111/jipb.13377. [PMID: 36194508]
  • Fan Zhang, Yu Yan, Jia Zhang, Li Li, Yu-Wei Wang, Cong-Yuan Xia, Wen-Wen Lian, Ying Peng, Jiang Zheng, Jun He, Jie-Kun Xu, Wei-Ku Zhang. Phytochemistry, synthesis, analytical methods, pharmacological activity, and pharmacokinetics of loganin: A comprehensive review. Phytotherapy research : PTR. 2022 Jun; 36(6):2272-2299. doi: 10.1002/ptr.7347. [PMID: 35583806]
  • Fei Huang, Xiang Wang, Guifang Xiao, Juan Xiao. Loganin exerts a protective effect on ischemia-reperfusion-induced acute kidney injury by regulating JAK2/STAT3 and Nrf2/HO-1 signaling pathways. Drug development research. 2022 02; 83(1):150-157. doi: 10.1002/ddr.21853. [PMID: 34189758]
  • Yu-Chi Cheng, Yu-Min Chiu, Zen-Kong Dai, Bin-Nan Wu. Loganin Ameliorates Painful Diabetic Neuropathy by Modulating Oxidative Stress, Inflammation and Insulin Sensitivity in Streptozotocin-Nicotinamide-Induced Diabetic Rats. Cells. 2021 10; 10(10):. doi: 10.3390/cells10102688. [PMID: 34685668]
  • Qiu Du, Ying-Xue Fu, An-Mei Shu, Xing Lv, Yu-Ping Chen, Yu-Yan Gao, Jing Chen, Wei Wang, Gao-Hong Lv, Jin-Fu Lu, Hui-Qin Xu. Loganin alleviates macrophage infiltration and activation by inhibiting the MCP-1/CCR2 axis in diabetic nephropathy. Life sciences. 2021 May; 272(?):118808. doi: 10.1016/j.lfs.2020.118808. [PMID: 33245967]
  • Dong-Uk Kim, Dong-Gu Kim, Ji-Won Choi, Joon Yeon Shin, Bitna Kweon, Ziqi Zhou, Ho-Sub Lee, Ho-Joon Song, Gi-Sang Bae, Sung-Joo Park. Loganin Attenuates the Severity of Acute Kidney Injury Induced by Cisplatin through the Inhibition of ERK Activation in Mice. International journal of molecular sciences. 2021 Jan; 22(3):. doi: 10.3390/ijms22031421. [PMID: 33572597]
  • Jin Zhang, Changsong Wang, Kai Kang, Haitao Liu, Xiaowei Liu, Xiaonan Jia, Kaijiang Yu. Loganin Attenuates Septic Acute Renal Injury with the Participation of AKT and Nrf2/HO-1 Signaling Pathways. Drug design, development and therapy. 2021; 15(?):501-513. doi: 10.2147/dddt.s294266. [PMID: 33603340]
  • Shi Liu, Hui Shen, Jiyan Li, Ying Gong, Haidong Bao, Jingyuan Zhang, Lanqing Hu, Zhengpeng Wang, Jian Gong. Loganin inhibits macrophage M1 polarization and modulates sirt1/NF-κB signaling pathway to attenuate ulcerative colitis. Bioengineered. 2020 12; 11(1):628-639. doi: 10.1080/21655979.2020.1774992. [PMID: 33034242]
  • Su-Jin Ahn, Hyung Joo Kim, Ayoung Lee, Seung-Sik Min, Sangwhan In, Eunmi Kim. Determination of 12 herbal compounds for estimating the presence of Angelica Gigas Root, Cornus Fruit, Licorice Root, Pueraria Root, and Schisandra Fruit in foods by LC-MS/MS. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2020 Sep; 37(9):1437-1448. doi: 10.1080/19440049.2020.1778187. [PMID: 32530783]
  • Yuping Chen, Ni Jiao, Ming Jiang, Liping Liu, Yihui Zhu, Hongyan Wu, Jing Chen, Yingxue Fu, Qiu Du, Huiqin Xu, Jihu Sun. Loganin alleviates testicular damage and germ cell apoptosis induced by AGEs upon diabetes mellitus by suppressing the RAGE/p38MAPK/NF-κB pathway. Journal of cellular and molecular medicine. 2020 06; 24(11):6083-6095. doi: 10.1111/jcmm.15198. [PMID: 32307890]
  • Jiahui Yuan, Weipeng Cheng, Gongye Zhang, Qiujuan Ma, Xiaomei Li, Bing Zhang, Tianhui Hu, Gang Song. Protective effects of iridoid glycosides on acute colitis via inhibition of the inflammatory response mediated by the STAT3/NF-кB pathway. International immunopharmacology. 2020 Apr; 81(?):106240. doi: 10.1016/j.intimp.2020.106240. [PMID: 32044657]
  • Jia-Wen Wang, Yi-Bin Pan, Yong-Qing Cao, Chen Wang, Wei-Dong Jiang, Wei-Feng Zhai, Jin-Gen Lu. Loganin alleviates LPS-activated intestinal epithelial inflammation by regulating TLR4/NF-κB and JAK/STAT3 signaling pathways. The Kaohsiung journal of medical sciences. 2020 Apr; 36(4):257-264. doi: 10.1002/kjm2.12160. [PMID: 31859422]
  • Jiaming Hu, Jinyi Zhou, Jinting Wu, Quan Chen, Weibin Du, Fangda Fu, Huan Yu, Sai Yao, Hongting Jin, Peijian Tong, Di Chen, Chengliang Wu, Hongfeng Ruan. Loganin ameliorates cartilage degeneration and osteoarthritis development in an osteoarthritis mouse model through inhibition of NF-κB activity and pyroptosis in chondrocytes. Journal of ethnopharmacology. 2020 Jan; 247(?):112261. doi: 10.1016/j.jep.2019.112261. [PMID: 31577939]
  • Eulogio J Llorent-Martínez, María Luisa Fernández-de Córdova, Gokhan Zengin, Mir Babak Bahadori, Muhammad Zakariyyah Aumeeruddy, Kannan Rr Rengasamy, Mohamad Fawzi Mahomoodally. Parentucellia latifolia subsp. latifolia: A potential source for loganin iridoids by HPLC-ESI-MSn technique. Journal of pharmaceutical and biomedical analysis. 2019 Feb; 165(?):374-380. doi: 10.1016/j.jpba.2018.12.025. [PMID: 30590334]
  • Jinwei Gao, Jinbo Yu, Panpan Xu, Jinmei Chen, Guanghui Gao, Binglong Li, Lixin Sun. Established UPLC-MS/MS procedure for multicomponent quantitative analysis in rat plasma: A contrastive pharmacokinetics study of Qiangshen tablet in normal and kidney yang deficiency syndrome models. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Feb; 1106-1107(?):35-42. doi: 10.1016/j.jchromb.2018.12.031. [PMID: 30639948]
  • Yong Cui, Yanjie Wang, Danyu Zhao, Xiaofan Feng, Lin Zhang, Chun Liu. Loganin prevents BV-2 microglia cells from Aβ1-42 -induced inflammation via regulating TLR4/TRAF6/NF-κB axis. Cell biology international. 2018 Dec; 42(12):1632-1642. doi: 10.1002/cbin.11060. [PMID: 30288860]
  • Nattawut Suchaichit, Somdej Kanokmedhakul, Kwanjai Kanokmedhakul, Panawan Moosophon, Chantana Boonyarat, Kusawadee Plekratoke, Ruchanok Tearavarich, Natcha P Suchaichit. Phytochemical investigation and acetylcholinesterase inhibitory activity of bark of Hymenodictyon orixense. Natural product research. 2018 Dec; 32(24):2936-2939. doi: 10.1080/14786419.2017.1389930. [PMID: 29047314]
  • Jin-Hua Tao, Min Zhao, Shu Jiang, Wei Zhang, Bo-Hui Xu, Jin-Ao Duan. UPLC-Q-TOF/MS-based metabolic profiling comparison of four major bioactive components in normal and CKD rat plasma, urine and feces following oral administration of Cornus officinalis Sieb and Rehmannia glutinosa Libosch herb couple extract. Journal of pharmaceutical and biomedical analysis. 2018 Nov; 161(?):254-261. doi: 10.1016/j.jpba.2018.08.051. [PMID: 30172880]
  • M Rajabi, G Mohaddes, F Farajdokht, S Nayebi Rad, M Mesgari, S Babri. Impact of loganin on pro-inflammatory cytokines and depression- and anxiety-like behaviors in male diabetic rats. Physiology international. 2018 09; 105(3):199-209. doi: 10.1556/2060.105.2018.1.8. [PMID: 29855187]
  • M Rajabi, G Mohaddes, F Farajdokht, S Nayebi Rad, M Mesgari, S Babri. Impact of loganin on pro-inflammatory cytokines and depression- and anxiety-like behaviors in male diabetic rats. Physiology international. 2018 Jun; 105(2):116-126. doi: 10.1556/2060.105.2018.2.8. [PMID: 29975123]
  • Jin-Hua Tao, Min Zhao, Shu Jiang, Xue-Lian Pu, Xiao-Yan Wei. Comparative metabolism of two major compounds in Fructus Corni extracts by gut microflora from normal and chronic nephropathy rats in vitro by UPLC-Q-TOF/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Jan; 1073(?):170-176. doi: 10.1016/j.jchromb.2017.12.025. [PMID: 29276981]
  • Min Zhao, Jinhua Tao, Leyue Du, Shu Jiang, Dawei Qian, Jinao Duan. UPLC-Q-TOF/MS-Based Metabolic Profiling Comparison of Two Major Bioactive Components and Their Metabolites in Normal and CKD Rat Plasma, Urine and Feces Following Oral Administration of Fructus Corni Extract. Journal of chromatographic science. 2017 Sep; 55(8):857-865. doi: 10.1093/chromsci/bmx046. [PMID: 28541451]
  • Bo Larsen, Victoria L Fuller, Jacob Pollier, Alex Van Moerkercke, Fabian Schweizer, Richard Payne, Maite Colinas, Sarah E O'Connor, Alain Goossens, Barbara A Halkier. Identification of Iridoid Glucoside Transporters in Catharanthus roseus. Plant & cell physiology. 2017 Sep; 58(9):1507-1518. doi: 10.1093/pcp/pcx097. [PMID: 28922750]
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  • Yi Tao, Yuchao Ren, Weidong Li, Baochang Cai, Liuqing Di, Liyun Shi, Lihong Hu. Comparative pharmacokinetic analysis of extracts of crude and wine-processed Dipsacus asper in rats by a sensitive ultra performance liquid chromatography-tandem mass spectrometry approach. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Nov; 1036-1037(?):33-41. doi: 10.1016/j.jchromb.2016.09.024. [PMID: 27710888]
  • Wen-Hsin Tsai, Chung-Hsin Wu, Chen-Hung Cheng, Chiang-Ting Chien. Ba-Wei-Di-Huang-Wan through its active ingredient loganin counteracts substance P-enhanced NF-κB/ICAM-1 signaling in rats with bladder hyperactivity. Neurourology and urodynamics. 2016 09; 35(7):771-9. doi: 10.1002/nau.22816. [PMID: 26287995]
  • Yang Li, Zheng Li, Lei Shi, Chenxu Zhao, Bingyu Shen, Ye Tian, Haihua Feng. Loganin inhibits the inflammatory response in mouse 3T3L1 adipocytes and mouse model. International immunopharmacology. 2016 Jul; 36(?):173-179. doi: 10.1016/j.intimp.2016.04.026. [PMID: 27155393]
  • Jin-qian Yu, Zhao-ping Wang, Heng Zhu, Gang Li, Xiao Wang. [Chemical constituents of Lonicera japonica roots and their anti-inflammatory effects]. Yao xue xue bao = Acta pharmaceutica Sinica. 2016 07; 51(7):1110-6. doi: . [PMID: 29897205]
  • Kai He, Shanghua Song, Zongyao Zou, Min Feng, Dezhen Wang, Yanzhi Wang, Xuegang Li, Xiaoli Ye. The Hypoglycemic and Synergistic Effect of Loganin, Morroniside, and Ursolic Acid Isolated from the Fruits of Cornus officinalis. Phytotherapy research : PTR. 2016 Feb; 30(2):283-91. doi: 10.1002/ptr.5529. [PMID: 26619955]
  • Min Zhao, Jinhua Tao, Dawei Qian, Pei Liu, Er-xin Shang, Shu Jiang, Jianming Guo, Shu-lan Su, Jin-ao Duan, Leyue Du. Simultaneous determination of loganin, morroniside, catalpol and acteoside in normal and chronic kidney disease rat plasma by UPLC-MS for investigating the pharmacokinetics of Rehmannia glutinosa and Cornus officinalis Sieb drug pair extract. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Jan; 1009-1010(?):122-9. doi: 10.1016/j.jchromb.2015.12.020. [PMID: 26720701]
  • Min Zhao, Dawei Qian, Er-xin Shang, Shu Jiang, Jianming Guo, Pei Liu, Shu-lan Su, Jin-ao Duan, Leyue Du, Jinhua Tao. Comparative pharmacokinetics of the main compounds of Shanzhuyu extract after oral administration in normal and chronic kidney disease rats. Journal of ethnopharmacology. 2015 Sep; 173(?):280-6. doi: 10.1016/j.jep.2015.07.037. [PMID: 26231452]
  • Xiang-dan Liu, Pan Huang, Yue-hua Lu, Ming Ma, Ri-bao Zhou, Lin-xiang Yuan, Xin-jun Peng. [Pharmacokinetics of loganin, ferulic acid and stilbene glucoside in Bushen Tongluo formula in vivo]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2015 Jun; 40(12):2428-34. doi: . [PMID: 26591537]
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  • Kai Liu, Huiqin Xu, Gaohong Lv, Bin Liu, Maxwell Kim Kit Lee, Chunhong Lu, Xing Lv, Yunhao Wu. Loganin attenuates diabetic nephropathy in C57BL/6J mice with diabetes induced by streptozotocin and fed with diets containing high level of advanced glycation end products. Life sciences. 2015 Feb; 123(?):78-85. doi: 10.1016/j.lfs.2014.12.028. [PMID: 25623853]
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