2,6-Diamino-4-hydroxy-5-N-methylformamidopyrimidine (BioDeep_00000005642)

 

Secondary id: BioDeep_00001870473

human metabolite Endogenous


代谢物信息卡片


N-(2,4-diamino-1,6-dihydro-6-oxo-5-Pyrimidinyl)-N-methyl-formamide

化学式: C6H9N5O2 (183.0756)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(not specific) 1.75%

分子结构信息

SMILES: CN(C=O)C1=C(N)N=C(N)N=C1O
InChI: InChI=1S/C6H9N5O2/c1-11(2-12)3-4(7)9-6(8)10-5(3)13/h2H,1H3,(H5,7,8,9,10,13)

描述信息

2,6-Diamino-4-hydroxy-5-N-methylformamidopyrimidine is a methylated derivative of 2,6-Diamino-4-hydroxy-5-N-formamidopyrimidine or FapyGua. It is produced by DNA-formamidopyrimidine glycosylase (EC 3.2.2.23). This enzyme catalyzes the hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine. More specifically, this enzyme catalyzes the removal of oxidized purine bases by cleaving the N-C1 glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3 of the apurinic (AP) site. The presence of this compound in urine is indicative of oxidative damage to DNA (oxidized purine base lesions) [HMDB]
2,6-Diamino-4-hydroxy-5-N-methylformamidopyrimidine is a methylated derivative of 2,6-Diamino-4-hydroxy-5-N-formamidopyrimidine or FapyGua. It is produced by DNA-formamidopyrimidine glycosylase (EC 3.2.2.23). This enzyme catalyzes the hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine. More specifically, this enzyme catalyzes the removal of oxidized purine bases by cleaving the N-C1 glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3 of the apurinic (AP) site. The presence of this compound in urine is indicative of oxidative damage to DNA (oxidized purine base lesions).

同义名列表

9 个代谢物同义名

N-(2,4-diamino-1,6-dihydro-6-oxo-5-Pyrimidinyl)-N-methyl-formamide; N(5)-Methyl-N(5)-formyl-2,5,6-triamino-4-hydroxypyrimidine; N-(2,4-diamino-6-hydroxypyrimidin-5-yl)-N-methylformamide; N5-Methyl-N5-formyl-2,5,6-triamino-4-hydroxypyrimidine; 2,6-Diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine; 2,6-Diamino-4-hydroxy-5-N-methylformamidopyrimidine; 2,6-diamino-4-Hydroxy- 5- formamidopyrimidine; Me-fapygua; MFTAHP



数据库引用编号

13 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

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