18-Hydroxycorticosterone (BioDeep_00000004582)

   

human metabolite Endogenous blood metabolite Toxin


代谢物信息卡片


(1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-15-(hydroxymethyl)-2-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one

化学式: C21H30O5 (362.2093)
中文名称: 18-羟基皮质酮
谱图信息: 最多检出来源 Homo sapiens(plant) 6.72%

Reviewed

Last reviewed on 2024-09-06.

Cite this Page

18-Hydroxycorticosterone. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/18-hydroxycorticosterone (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000004582). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC12CCC(=O)C=C1CCC1C2C(O)CC2(CO)C(C(=O)CO)CCC12
InChI: InChI=1S/C21H30O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,14-17,19,22-23,25H,2-7,9-11H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1

描述信息

18-Hydroxycorticosterone is a corticosteroid and a derivative of corticosterone. If it is present in sufficiently high concentrations, it can lead to serious electrolyte imbalances (an electrolyte toxin). 18-Hydroxycorticosterone serves as an intermediate in the synthesis of aldosterone by the enzyme aldosterone synthase in the zona glomerulosa. Chronically high levels of 18-hydroxycorticosterone are associated with at least three inborn errors of metabolism including adrenal hyperplasia type V, corticosterone methyl oxidase I deficiency, and corticosterone methyl oxidase II deficiency. Each of these conditions is characterized by excessive amounts of sodium being released in the urine (salt wasting), along with insufficient release of potassium in the urine, usually beginning in the first few weeks of life. This imbalance leads to low levels of sodium and high levels of potassium in the blood (hyponatremia and hyperkalemia, respectively). Individuals with corticosterone methyloxidase deficiency can also have high levels of acid in the blood (metabolic acidosis). Acidosis typically occurs when arterial pH falls below 7.35. In infants with acidosis the initial symptoms include poor feeding, vomiting, loss of appetite, weak muscle tone (hypotonia), and lack of energy (lethargy). The hyponatremia, hyperkalemia, and metabolic acidosis associated with corticosterone methyloxidase deficiency can cause nausea, vomiting, dehydration, low blood pressure, extreme tiredness (fatigue), and muscle weakness.
11 beta,18,21-Trihydroxypregn-4-ene-3,20-dione. 18-Hydroxycorticosterone is a derivative of corticosterone. It serves as an intermediate in the synthesis of aldosterone by the enzyme aldosterone synthase in the zona glomerulosa. [HMDB]
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

11 个代谢物同义名

(1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-15-(hydroxymethyl)-2-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one; (11beta)-11,18,21-Trihydroxypregn-4-ene-3,20-dione; (11β)-11,18,21-Trihydroxypregn-4-ene-3,20-dione; 11beta,18,21-trihydroxy-pregn-4-ene-3,20-dione; 11b,18,21-Trihydroxy-pregn-4-ene-3,20-dione; Hydroxycorticosterone, 18; 18 Hydroxycorticosterone; 18-Hydroxycorticosterone; 18-Hydrocorticosterone; 18 Hydrocorticosterone; 18-Hydroxycorticosterone



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(13)

BioCyc(0)

PlantCyc(0)

代谢反应

101 个相关的代谢反应过程信息。

Reactome(63)

BioCyc(0)

WikiPathways(3)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(35)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ACE, NR3C2, PLA2G12A, POMC, PRL
Peripheral membrane protein 3 CYP11A1, CYP11B2, FDXR
Endoplasmic reticulum membrane 3 CYP17A1, CYP19A1, NR3C2
Mitochondrion membrane 2 CYP11A1, CYP11B2
Nucleus 3 NR3C2, PLCZ1, PRL
cytosol 4 NR3C2, PLCZ1, PRKCQ, SHB
nucleoplasm 4 NR3C2, PLCZ1, PRL, SHB
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 1 ACE
Multi-pass membrane protein 2 CACNA1I, CYP19A1
Synapse 1 CRH
Golgi membrane 1 INS
mitochondrial inner membrane 3 CYP11A1, CYP11B2, FDXR
neuronal cell body 1 CYP17A1
Lysosome 1 ACE
endosome 1 ACE
plasma membrane 5 ACE, CACNA1I, PRKCQ, REN, SHB
Membrane 6 ACE, CACNA1I, CYP11A1, CYP11B2, CYP19A1, REN
axon 1 CYP17A1
extracellular exosome 2 ACE, SERPINA6
endoplasmic reticulum 2 CYP17A1, CYP19A1
extracellular space 7 ACE, CRH, INS, POMC, PRL, REN, SERPINA6
perinuclear region of cytoplasm 1 PLCZ1
mitochondrion 5 BCO2, CYP11A1, CYP11B2, FDX1, FDXR
Microsome membrane 2 CYP17A1, CYP19A1
pronucleus 1 PLCZ1
Single-pass type I membrane protein 1 ACE
Secreted 7 ACE, CRH, INS, PLA2G12A, POMC, PRL, REN
extracellular region 8 ACE, CRH, INS, PLA2G12A, POMC, PRL, REN, SERPINA6
Mitochondrion matrix 1 FDX1
mitochondrial matrix 4 BCO2, CYP11A1, FDX1, FDXR
centriolar satellite 1 PRKCQ
external side of plasma membrane 1 ACE
varicosity 1 CRH
neuronal dense core vesicle lumen 1 CRH
perikaryon 1 CRH
nucleolus 1 PLCZ1
apical part of cell 1 REN
Cytoplasm, perinuclear region 1 PLCZ1
Mitochondrion inner membrane 3 CYP11A1, CYP11B2, FDXR
secretory granule 1 POMC
receptor complex 1 NR3C2
chromatin 2 NR3C2, PRL
cytoplasmic ribonucleoprotein granule 1 SHB
brush border membrane 1 ACE
sperm midpiece 1 ACE
endosome lumen 2 INS, PRL
basal plasma membrane 1 ACE
secretory granule lumen 2 INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
sperm head 1 PLCZ1
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE


文献列表

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  • Paolo Mulatero, Stefania Morra di Cella, Silvia Monticone, Domenica Schiavone, Maria Manzo, Giulio Mengozzi, Franco Rabbia, Massimo Terzolo, Elise P Gomez-Sanchez, Celso E Gomez-Sanchez, Franco Veglio. 18-hydroxycorticosterone, 18-hydroxycortisol, and 18-oxocortisol in the diagnosis of primary aldosteronism and its subtypes. The Journal of clinical endocrinology and metabolism. 2012 Mar; 97(3):881-9. doi: 10.1210/jc.2011-2384. [PMID: 22238407]
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  • Richard J Auchus, Donald W Chandler, Sarita Singeetham, Neema Chokshi, Fiemu E Nwariaku, Bart L Dolmatch, Shelby A Holt, Frank H Wians, Shellie C Josephs, Clayton K Trimmer, Jorge Lopera, Wanpen Vongpatanasin, Shawna D Nesbitt, David Leonard, Ronald G Victor. Measurement of 18-hydroxycorticosterone during adrenal vein sampling for primary aldosteronism. The Journal of clinical endocrinology and metabolism. 2007 Jul; 92(7):2648-51. doi: 10.1210/jc.2006-2631. [PMID: 17473070]
  • Mei-Chuan Chen, Shiu-Huey Chou, Cheng-Huang Lin. Determination of corticosterone and 17-hydroxycorticosterone in plasma and urine samples by sweeping techniques using micellar electrokinetic chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Mar; 801(2):347-53. doi: 10.1016/j.jchromb.2003.11.027. [PMID: 14751805]
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