hydroxyprogesterone (BioDeep_00000406316)
Main id: BioDeep_00000002836
natural product PANOMIX_OTCML-2023
代谢物信息卡片
17Alpha-Hydroxyprogesterone
化学式: C21H30O3 (330.21948299999997)
中文名称: 17alpha-羟基黄体酮, 17α-羟孕酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)C1(CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C)O
InChI: InChI=1S/C21H30O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h12,16-18,24H,4-11H2,1-3H3
描述信息
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03D - Progestogens > G03DA - Pregnen (4) derivatives
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progesterone that serves as a chemical intermediate in the biosynthesis of other steroid hormones, including glucocorticoids, androgens, and estrogens.
同义名列表
数据库引用编号
28 个数据库交叉引用编号
- ChEBI: CHEBI:17252
- KEGG: C01176
- KEGGdrug: D08052
- PubChem: 6238
- DrugBank: DB14570
- ChEMBL: CHEMBL1062
- MeSH: 17-alpha-Hydroxyprogesterone
- CAS: 110850-01-6
- CAS: 604-09-1
- CAS: 68-96-2
- MoNA: Bruker_HCD_library001834
- MoNA: VF-NPL-LTQ006604
- MoNA: VF-NPL-LTQ006603
- MoNA: VF-NPL-LTQ006602
- MoNA: VF-NPL-LTQ006601
- MoNA: VF-NPL-QEHF000258
- MoNA: VF-NPL-QEHF000257
- MoNA: VF-NPL-QEHF000256
- MoNA: VF-NPL-QEHF000255
- MoNA: VF-NPL-QEHF000254
- MoNA: VF-NPL-QEHF000253
- PubChem: 4403
- LipidMAPS: LMST02030161
- PDB-CCD: 3QZ
- 3DMET: B01402
- NIKKAJI: J4.862C
- RefMet: Hydroxyprogesterone
- medchemexpress: HY-B0891
分类词条
相关代谢途径
Reactome(8)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
- 9606 Homo sapiens:
- 54477 Vitex agnus-castus: 10.1055/S-2006-961123
- 9606 Homo sapiens:
- 54477 Vitex agnus-castus: 10.1055/S-2006-961123
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- V A Filatova, R V Rozhivanov, I Z Bondarenko, V A Ioutsi, E N Andreeva, G A Mel'nichenko, N G Mokrysheva. [Features of steroidogenesis and arterial hypertension in men in different types of "physiological" male hyperandrogenism].
Problemy endokrinologii.
2023 May; 69(2):80-91. doi:
10.14341/probl13226. [PMID: 37448275] - Lei Ye, Zhiyun Zhao, Huixia Ren, Wencui Wang, Wenzhong Zhou, Sichang Zheng, Rulai Han, Jie Zhang, Haorong Li, Zhihan Wan, Chao Tang, Shouyue Sun, Weiqing Wang, Guang Ning. A Multiclassifier System to Identify and Subtype Congenital Adrenal Hyperplasia Based on Circulating Steroid Hormones.
The Journal of clinical endocrinology and metabolism.
2022 Jul; 107(8):e3304-e3312. doi:
10.1210/clinem/dgac271. [PMID: 35512387] - Özge Besci, İbrahim Mert Erbaş, Tuncay Küme, Kübra Yüksek Acinikli, Ayhan Abacı, Ece Böber, Korcan Demir. A 4-hour Profile of 17-hydroxyprogesterone in Salt-wasting Congenital Adrenal Hyperplasia: Is the Serial Monitoring Strategy Worth the Effort?.
Journal of clinical research in pediatric endocrinology.
2022 06; 14(2):145-152. doi:
10.4274/jcrpe.galenos.2021.2021-9-17. [PMID: 34866371] - Kellie A Fecteau, Luca Giori, Andrew Cushing, Joshua M Price, Xiaojuan Zhu. Comparison of steroid and thyroid hormone concentrations in blood serum and plasma of captive tigers.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.
2022 May; 34(3):547-551. doi:
10.1177/10406387221090538. [PMID: 35404190] - Taek Min Kim, Jung Hee Kim, Han Na Jang, Man Ho Choi, Jeong Yeon Cho, Sang Youn Kim. Adrenal Morphology as an Indicator of Long-Term Disease Control in Adults with Classic 21-Hydroxylase Deficiency.
Endocrinology and metabolism (Seoul, Korea).
2022 Feb; 37(1):124-137. doi:
10.3803/enm.2021.1278. [PMID: 35144332] - Marie Lind-Holst, Marie Bækvad-Hansen, Agnethe Berglund, Arieh S Cohen, Lars Melgaard, Kristin Skogstrand, Morten Duno, Katharina M Main, David Michael Hougaard, Claus Højbjerg Gravholt, Dorte Hansen. Neonatal Screening for Congenital Adrenal Hyperplasia in Denmark: 10 Years of Experience.
Hormone research in paediatrics.
2022; 95(1):35-42. doi:
10.1159/000522230. [PMID: 35114680] - Thiago Fernandes Negris Lima, Fabio Stefano Frech, Ruben Blachman-Braun, Evgeniya Rakitina, Premal Patel, Ranjith Ramasamy. Association of aging and obesity with decreased 17-hydroxyprogesterone, a serum biomarker of intratesticular testosterone.
International journal of impotence research.
2022 Jan; 34(1):44-49. doi:
10.1038/s41443-020-00358-8. [PMID: 33009497] - Tiago Gabriel Correia, Vanessa Aparecida Rocha Oliveira Vieira, Amanda de Moraes Narcizo, Ricardo Andrade Zampieri, Lucile Maria Floeter-Winter, Renata Guimarães Moreira. Endocrine disruption caused by the aquatic exposure to aluminum and manganese in Astyanax altiparanae (Teleostei: Characidae) females during the final ovarian maturation.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2021 Nov; 249(?):109132. doi:
10.1016/j.cbpc.2021.109132. [PMID: 34246795] - Flávia A Costa-Barbosa, Valdemir M Carvalho, Kelly C Oliveira, José Gilberto H Vieira, Claudio E Kater. Reassessment of predictive values of ACTH-stimulated serum 21-deoxycortisol and 17-hydroxyprogesterone to identify CYP21A2 heterozygote carriers and nonclassic subjects.
Clinical endocrinology.
2021 10; 95(4):677-685. doi:
10.1111/cen.14550. [PMID: 34231242] - Rayanna Bahia de Almeida, Robson Augusto Cardoso Apóstolos, Luciana Mattos Barros Oliveira, Maria Betânia Pereira Toralles, Renata Maria R S Lago, José Antonio Diniz Faria, Renata Andion Arruti, Mônica Lima Barbosa Rodrigues, Tatiana Amorim, Helena Maria Guimarães Pimentel Dos Santos, Leonardo Azevedo de Sousa, Ubirajara Barroso. Is there an association between prostate-specific antigen and androgen levels in 46, XX patients with congenital adrenal hyperplasia?.
Journal of pediatric urology.
2021 08; 17(4):481.e1-481.e7. doi:
10.1016/j.jpurol.2021.05.003. [PMID: 34092513] - Janina Tokarz, Stefan M Schmitt, Gabriele Möller, André W Brändli, Jerzy Adamski. Functional characterization of two 20β-hydroxysteroid dehydrogenase type 2 homeologs from Xenopus laevis reveals multispecificity.
The Journal of steroid biochemistry and molecular biology.
2021 06; 210(?):105874. doi:
10.1016/j.jsbmb.2021.105874. [PMID: 33722706] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Patricia San Martín, María Laura Eugenio Russmann, Gabriela Mendeluk, María Fabiana Fierro, Roxana Marino, Ester Pardes. Classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21-OHD) in adult males: Clinical presentation, hormone function and the detection of adrenal and testicular adrenal rest tumors (TARTs).
Endocrinologia, diabetes y nutricion.
2021 Apr; 68(4):227-235. doi:
10.1016/j.endien.2020.07.003. [PMID: 34266634] - Uta Neumann, Katarina Braune, Martin J Whitaker, Susanna Wiegand, Heiko Krude, John Porter, Dena Digweed, Bernard Voet, Richard J M Ross, Oliver Blankenstein. A Prospective Study of Children Aged 0-8 Years with CAH and Adrenal Insufficiency Treated with Hydrocortisone Granules.
The Journal of clinical endocrinology and metabolism.
2021 03; 106(3):e1433-e1440. doi:
10.1210/clinem/dgaa626. [PMID: 32888021] - P Pan, L Y Zheng, L L Fang, X L Chen, J Huang, Q X Zhang, D Z Yang, M Q Xie, Y Li. [Clinical characteristics of 21 infertile women with non-classic 21-hydroxylase deficiency].
Zhonghua fu chan ke za zhi.
2021 Feb; 56(2):108-113. doi:
10.3760/cma.j.cn112141-20200526-00447. [PMID: 33631882] - Qichen Long, Tianjiao Zhang, Ying Yan, Haijian Zhao, Weiyan Zhou, Jie Zeng, Shuijun Li, Jiangtao Zhang, Qingzhang Zeng, Beibei Zhao, Chuanbao Zhang, Wenxiang Chen. Measurement of serum 17-hydroxyprogesterone using isotope dilution liquid chromatography-tandem mass spectrometry candidate reference method and evaluation of the performance for three routine methods.
Clinical chemistry and laboratory medicine.
2021 02; 59(3):523-532. doi:
10.1515/cclm-2020-0410. [PMID: 33554585] - Marie Lindhardt Ljubicic, Andre Madsen, Anders Juul, Kristian Almstrup, Trine Holm Johannsen. The Application of Principal Component Analysis on Clinical and Biochemical Parameters Exemplified in Children With Congenital Adrenal Hyperplasia.
Frontiers in endocrinology.
2021; 12(?):652888. doi:
10.3389/fendo.2021.652888. [PMID: 34531821] - Tomoyo Itonaga, Masako Izawa, Takashi Hamajima, Yukihiro Hasegawa. First Morning Pregnanetriol and 17-Hydroxyprogesterone Correlated Significantly in 21-Hydroxylase Deficiency.
Frontiers in endocrinology.
2021; 12(?):808254. doi:
10.3389/fendo.2021.808254. [PMID: 35140686] - Taylor L Langevin, Karen Maynard, Anil Dewan. Bilateral microscopic Leydig cell ovarian tumors in the postmenopausal woman.
BMJ case reports.
2020 Dec; 13(12):. doi:
10.1136/bcr-2020-236427. [PMID: 33370966] - Zheng Cao, Yifan Lu, Yuting Cong, Ying Liu, Youran Li, Husheng Wang, Qiaoli Zhang, Wenxi Huang, Jingrui Liu, Ying Dong, Guodong Tang, Yiqi R Luo, Chenghong Yin, Yanhong Zhai. Simultaneous quantitation of four androgens and 17-hydroxyprogesterone in polycystic ovarian syndrome patients by LC-MS/MS.
Journal of clinical laboratory analysis.
2020 Dec; 34(12):e23539. doi:
10.1002/jcla.23539. [PMID: 32820576] - Željko Debeljak, Ivana Marković, Jasna Pavela, Iva Lukić, Dario Mandić, Sanja Mandić, Vesna Horvat, Vatroslav Šerić. Analytical bias of automated immunoassays for six serum steroid hormones assessed by LC-MS/MS.
Biochemia medica.
2020 Oct; 30(3):030701. doi:
10.11613/bm.2020.030701. [PMID: 32774123] - C Oriolo, F Fanelli, S Castelli, M Mezzullo, P Altieri, F Corzani, C Pelusi, A Repaci, G Di Dalmazi, V Vicennati, L Baldazzi, S Menabò, A Dormi, E Nardi, G Brillanti, R Pasquali, U Pagotto, A Gambineri. Steroid biomarkers for identifying non-classic adrenal hyperplasia due to 21-hydroxylase deficiency in a population of PCOS with suspicious levels of 17OH-progesterone.
Journal of endocrinological investigation.
2020 Oct; 43(10):1499-1509. doi:
10.1007/s40618-020-01235-3. [PMID: 32236851] - Jae Hyun Kim, Young Ah Lee, Youn-Hee Lim, Kyunghoon Lee, Bung-Nyun Kim, Johanna Inhyang Kim, Yun-Chul Hong, Sei Won Yang, Junghan Song, Choong Ho Shin. Changes in Adrenal Androgens and Steroidogenic Enzyme Activities From Ages 2, 4, to 6 Years: A Prospective Cohort Study.
The Journal of clinical endocrinology and metabolism.
2020 10; 105(10):. doi:
10.1210/clinem/dgaa498. [PMID: 32750115] - Tze Ping Loh, Chung Shun Ho, Michaela F Hartmann, Rosita Zakaria, Clara Wai Shan Lo, Sjoerd van den Berg, Yolanda B de Rijke, Brian R Cooke, Kirsten Hoad, Peter Graham, Stephen R Davies, Lindsey G Mackay, Stefan A Wudy, Ronda F Greaves. Influence of isotopically labeled internal standards on quantification of serum/plasma 17α-hydroxyprogesterone (17OHP) by liquid chromatography mass spectrometry.
Clinical chemistry and laboratory medicine.
2020 09; 58(10):1731-1739. doi:
10.1515/cclm-2020-0318. [PMID: 32697750] - David J Marshall, Joanne E Adaway, James M Hawley, Brian G Keevil. Quantification of testosterone, androstenedione and 17-hydroxyprogesterone in whole blood collected using Mitra microsampling devices.
Annals of clinical biochemistry.
2020 09; 57(5):351-359. doi:
10.1177/0004563220937735. [PMID: 32524824] - Thiago Fernandes Negris Lima, Premal Patel, Ruben Blachman-Braun, Vinayak Madhusoodanan, Ranjith Ramasamy. Serum 17-Hydroxyprogesterone is a Potential Biomarker for Evaluating Intratesticular Testosterone.
The Journal of urology.
2020 Sep; 204(3):551-556. doi:
10.1097/ju.0000000000001016. [PMID: 32167868] - Miki Kamemura, Mai Yokota, Shoujiro Ogawa, Takahiro Sugiura, Tatsuya Higashi. Sample-multiplexing by derivatization using multiple analogous reagents for enhancing throughput in LC/ESI-MS/MS assay of steroids: Plasma 17α-hydroxyprogesterone as an example.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Jun; 1146(?):122117. doi:
10.1016/j.jchromb.2020.122117. [PMID: 32335501] - James M Hawley, Joanne E Adaway, Laura J Owen, Brian G Keevil. Development of a total serum testosterone, androstenedione, 17-hydroxyprogesterone, 11β-hydroxyandrostenedione and 11-ketotestosterone LC-MS/MS assay and its application to evaluate pre-analytical sample stability.
Clinical chemistry and laboratory medicine.
2020 04; 58(5):741-752. doi:
10.1515/cclm-2019-0959. [PMID: 31926069] - Sungwook Chun. Relationship between early follicular serum estrone level and other hormonal or ultrasonographic parameters in women with polycystic ovary syndrome.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2020 Feb; 36(2):143-147. doi:
10.1080/09513590.2019.1633296. [PMID: 31242783] - Simon Travers, Claire Bouvattier, Jérôme Fagart, Laetitia Martinerie, Say Viengchareun, Eric Pussard, Marc Lombès. Interaction between accumulated 21-deoxysteroids and mineralocorticoid signaling in 21-hydroxylase deficiency.
American journal of physiology. Endocrinology and metabolism.
2020 02; 318(2):E102-E110. doi:
10.1152/ajpendo.00368.2019. [PMID: 31821037] - Nathália Sigilló Cardoso, Victor Barbosa Ribeiro, Sabrina Graziani Veloso Dutra, Rui Alberto Ferriani, Ada Clarice Gastaldi, João Eduardo de Araújo, Hugo Celso Dutra de Souza. Polycystic ovary syndrome associated with increased adiposity interferes with serum levels of TNF-alpha and IL-6 differently from leptin and adiponectin.
Archives of endocrinology and metabolism.
2020 Feb; 64(1):4-10. doi:
10.20945/2359-3997000000197. [PMID: 32187268] - Nazaneen Eshragh, Luong Van Doan, Kara J Connelly, Sara Denniston, Sharon Willis, Stephen H LaFranchi. Outcome of Newborn Screening for Congenital Adrenal Hyperplasia at Two Time Points.
Hormone research in paediatrics.
2020; 93(2):128-136. doi:
10.1159/000508075. [PMID: 32659761] - Matthias K Auer, Aniko Krumbholz, Martin Bidlingmaier, Detlef Thieme, Nicole Reisch. Steroid 17-Hydroxyprogesterone in Hair Is a Potential Long-Term Biomarker of Androgen Control in Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency.
Neuroendocrinology.
2020; 110(11-12):938-949. doi:
10.1159/000504672. [PMID: 31711056] - Mehdi Basaki, Mehdi Saeb, Saeedeh Saeb. Androgen profile in young females with insulin resistance; the importance of 17-HydroxyprogesteroneAndrogens in young insulin resistant females.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2019 Dec; 35(12):1094-1098. doi:
10.1080/09513590.2019.1630377. [PMID: 31674860] - Bingyan Cao, Chunxiu Gong, Di Wu, Xuejun Liang, Wenjing Li, Min Liu, Chang Su, Miao Qin, Xi Meng, Liya Wei. A cross-sectional survey of adrenal steroid hormones among overweight/obese boys according to puberty stage.
BMC pediatrics.
2019 11; 19(1):414. doi:
10.1186/s12887-019-1755-5. [PMID: 31690265] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Qiaoxuan Zhang, Lu Zhang, Haibiao Lin, Zhiliang Cai, Jun Yan, Qiqin Wang, Liqiao Han, Jianbing Wang, Peifeng Ke, Junhua Zhuang, Xianzhang Huang. Evaluation of a bracketing calibration-based isotope dilution liquid chromatography-tandem mass spectrometry candidate reference measurement procedure for 17α-hydroxyprogesterone in human plasma.
Analytical and bioanalytical chemistry.
2019 Nov; 411(27):7095-7104. doi:
10.1007/s00216-019-02086-5. [PMID: 31673753] - Leah Kaye, Daniel Griffin, Jeffrey Thorne, Evelyn Neuber, John Nulsen, Claudio Benadiva, Lawrence Engmann. Independent serum markers of corpora lutea function after gonadotropin-releasing hormone agonist trigger and adjuvant low dose human chorionic gonadotropin in in vitro fertilization.
Fertility and sterility.
2019 09; 112(3):534-544. doi:
10.1016/j.fertnstert.2019.04.034. [PMID: 31227286] - Alexander Gaudl, Jürgen Kratzsch, Uta Ceglarek. Advancement in steroid hormone analysis by LC-MS/MS in clinical routine diagnostics - A three year recap from serum cortisol to dried blood 17α-hydroxyprogesterone.
The Journal of steroid biochemistry and molecular biology.
2019 09; 192(?):105389. doi:
10.1016/j.jsbmb.2019.105389. [PMID: 31158444] - C Peña-Bautista, R Escrig, I Lara, A García-Blanco, C Cháfer-Pericás, M Vento. Non-invasive monitoring of stress biomarkers in the newborn period.
Seminars in fetal & neonatal medicine.
2019 08; 24(4):101002. doi:
10.1016/j.siny.2019.04.002. [PMID: 30981693] - L T Zeng, B Han, B L Liu, X Chen, H Zhu, Y Chen, M Chen, J H Liu, Y Liu, J Qiao. [Clinical features and genetic characteristics of 33 patients with simple virilizing form of 21-hydroxylase deficiency].
Zhonghua nei ke za zhi.
2019 Jun; 58(6):428-434. doi:
10.3760/cma.j.issn.0578-1426.2019.06.006. [PMID: 31159521] - Anna van der Veen, Martijn van Faassen, Wilhelmina H A de Jong, André P van Beek, D A Janneke Dijck-Brouwer, Ido P Kema. Development and validation of a LC-MS/MS method for the establishment of reference intervals and biological variation for five plasma steroid hormones.
Clinical biochemistry.
2019 Jun; 68(?):15-23. doi:
10.1016/j.clinbiochem.2019.03.013. [PMID: 30922617] - Patrícia S Castro, Tatiana O Rassi, Raquel F Araujo, Isabela L Pezzuti, Andresa S Rodrigues, Tania A S S Bachega, Ivani N Silva. High frequency of non-classical congenital adrenal hyperplasia form among children with persistently elevated levels of 17-hydroxyprogesterone after newborn screening.
Journal of pediatric endocrinology & metabolism : JPEM.
2019 May; 32(5):499-504. doi:
10.1515/jpem-2018-0398. [PMID: 31028712] - Andreas Krebs, Karoline Dickhuth, Rebekka Mumm, Bernhard Stier, Jürgen Doerfer, Dirk Grueninger, Michael Wurm, Corinna Brichta, Karl Otfried Schwab. Evaluating the four most important salivary sex steroids during male puberty: testosterone best characterizes pubertal development.
Journal of pediatric endocrinology & metabolism : JPEM.
2019 Mar; 32(3):287-294. doi:
10.1515/jpem-2018-0451. [PMID: 30811345] - Wesley J Goedegebuure, Anita C S Hokken-Koelega. Aromatase Inhibitor as Treatment for Severely Advanced Bone Age in Congenital Adrenal Hyperplasia: A Case Report.
Hormone research in paediatrics.
2019; 92(3):209-213. doi:
10.1159/000501746. [PMID: 31390647] - Vitória Müller, Bruna R Curcio, Ramiro E Toribio, Lorena S Feijó, Luciana A Borba, Igor F Canisso, Carlos E W Nogueira. Cortisol, progesterone, 17αOHprogesterone, and pregnenolone in foals born from mare's hormone-treated for experimentally induced ascending placentitis.
Theriogenology.
2019 Jan; 123(?):139-144. doi:
10.1016/j.theriogenology.2018.06.024. [PMID: 30308389] - Elena Grodnitskaya, Mark Kurtser. The prevalence of non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency in Russian women with hyperandrogenism.
Human fertility (Cambridge, England).
2018 Dec; 21(4):281-287. doi:
10.1080/14647273.2017.1344360. [PMID: 28669219] - Anna Grandone, Pierluigi Marzuillo, Caterina Luongo, Roberto Toraldo, Michela Mariani, Emanuele Miraglia Del Giudice, Laura Perrone. Basal levels of 17-hydroxyprogesterone can distinguish children with isolated precocious pubarche.
Pediatric research.
2018 10; 84(4):533-536. doi:
10.1038/s41390-018-0096-7. [PMID: 29976972] - Greilys Morejón García, Iria García de la Rosa, Ernesto C González Reyes, Anett Rubio Torres, Joel M Quintana Guerra, Milenén Hernández Marín, Pedro L Pérez Mora, Sadys Feal Carballo, Yesdiley Lafita Delfino, Maylín Pupo Infante, Elisa M Castells Martínez, Alik Rosabal Poloshkov, Liliana Hernández Pérez. Generation of monoclonal antibodies against 17α-hydroxyprogesterone for newborn screening of congenital adrenal hyperplasia.
Clinica chimica acta; international journal of clinical chemistry.
2018 Oct; 485(?):311-315. doi:
10.1016/j.cca.2018.07.019. [PMID: 30006291] - Ronda F Greaves, Chung Shun Ho, Tze Ping Loh, Jia Hui Chai, Lisa Jolly, Peter Graham, Michaela F Hartmann, Yolanda B de Rijke, Stefan A Wudy. Current state and recommendations for harmonization of serum/plasma 17-hydroxyprogesterone mass spectrometry methods.
Clinical chemistry and laboratory medicine.
2018 09; 56(10):1685-1697. doi:
10.1515/cclm-2017-1039. [PMID: 29397022] - Jessica K Hartman, Tyler Beames, Bethany Parks, Daniel Doheny, Gina Song, Alina Efremenko, Miyoung Yoon, Briana Foley, Chad Deisenroth, Patrick D McMullen, Rebecca A Clewell. An in vitro approach for prioritization and evaluation of chemical effects on glucocorticoid receptor mediated adipogenesis.
Toxicology and applied pharmacology.
2018 09; 355(?):112-126. doi:
10.1016/j.taap.2018.05.016. [PMID: 29782964] - Zihong He, Tuomo Rankinen, Arthur S Leon, James S Skinner, André Tchernof, Claude Bouchard. Plasma steroids, body composition, and fat distribution: effects of age, sex, and exercise training.
International journal of obesity (2005).
2018 07; 42(7):1366-1377. doi:
10.1038/s41366-018-0033-1. [PMID: 29507393] - Grethe Å Ueland, Paal Methlie, Marianne Øksnes, Hrafnkell B Thordarson, Jørn Sagen, Ralf Kellmann, Gunnar Mellgren, Maria Ræder, Per Dahlqvist, Sandra R Dahl, Per M Thorsby, Kristian Løvås, Eystein S Husebye. The Short Cosyntropin Test Revisited: New Normal Reference Range Using LC-MS/MS.
The Journal of clinical endocrinology and metabolism.
2018 04; 103(4):1696-1703. doi:
10.1210/jc.2017-02602. [PMID: 29452421] - Yoon-Myung Kim, Go Hun Seo, Gu-Hwan Kim, Jung Min Ko, Jin-Ho Choi, Han-Wook Yoo. A case of an infant suspected as IMAGE syndrome who were finally diagnosed with MIRAGE syndrome by targeted Mendelian exome sequencing.
BMC medical genetics.
2018 03; 19(1):35. doi:
10.1186/s12881-018-0546-4. [PMID: 29506479] - Valeria Tagliaferri, Daniela Romualdi, Elisa Scarinci, Simona De Cicco, Christian Di Florio, Valentina Immediata, Anna Tropea, Carla Mariaflavia Santarsiero, Antonio Lanzone, Rosanna Apa. Melatonin Treatment May Be Able to Restore Menstrual Cyclicity in Women With PCOS: A Pilot Study.
Reproductive sciences (Thousand Oaks, Calif.).
2018 Feb; 25(2):269-275. doi:
10.1177/1933719117711262. [PMID: 28558523] - Shih-Yao Liu, Cheng-Ting Lee, Yi-Ching Tung, Yin-Hsiu Chien, Wuh-Liang Hwu, Wen-Yu Tsai. Clinical characteristics of Taiwanese children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency detected by neonatal screening.
Journal of the Formosan Medical Association = Taiwan yi zhi.
2018 Feb; 117(2):126-131. doi:
10.1016/j.jfma.2017.03.008. [PMID: 28392195] - Leonardo Gatticchi, Bruno Cerra, Paolo Scarpelli, Lara Macchioni, Bartolomeo Sebastiani, Antimo Gioiello, Rita Roberti. Selected cholesterol biosynthesis inhibitors produce accumulation of the intermediate FF-MAS that targets nucleus and activates LXRα in HepG2 cells.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2017 Sep; 1862(9):842-852. doi:
10.1016/j.bbalip.2017.05.004. [PMID: 28499814] - Marco Mezzullo, Alessia Fazzini, Alessandra Gambineri, Guido Di Dalmazi, Roberta Mazza, Carla Pelusi, Valentina Vicennati, Renato Pasquali, Uberto Pagotto, Flaminia Fanelli. Parallel diurnal fluctuation of testosterone, androstenedione, dehydroepiandrosterone and 17OHprogesterone as assessed in serum and saliva: validation of a novel liquid chromatography-tandem mass spectrometry method for salivary steroid profiling.
Clinical chemistry and laboratory medicine.
2017 Aug; 55(9):1315-1323. doi:
10.1515/cclm-2016-0805. [PMID: 28076306] - M C Menet, M L Hebert-Schuster, N Lahlou, L Marcellin, M C Leguy, V Gayet, J Guibourdenche. rFSH in medically assisted procreation: Evidence for ovarian follicular hyperplasia and interest of mass spectrometry to measure 17-hydroxyprogesterone and Δ4-androstenedione in serum.
Molecular and cellular endocrinology.
2017 07; 450(?):105-112. doi:
10.1016/j.mce.2017.04.024. [PMID: 28461075] - Daniele Santi, Antonio Rm Granata, Elisa Pignatti, Tommaso Trenti, Laura Roli, Roberto Bozic, Stefano Zaza, Chiara Pacchioni, Vincenzo Rochira, Cesare Carani, Manuela Simoni. Effects of chronic administration of the phosphodiesterase inhibitor vardenafil on serum levels of adrenal and testicular steroids in men with type 2 diabetes mellitus.
Endocrine.
2017 May; 56(2):426-437. doi:
10.1007/s12020-016-1055-x. [PMID: 27515804] - Elaine Hui, Alan C H Lee, Brian H H Lang, Angel O K Chan, Karen S L Lam, Kathryn C B Tan. Congenital adrenal hyperplasia presenting as a large adrenal incidentaloma in an elderly man.
ANZ journal of surgery.
2017 Apr; 87(4):310-312. doi:
10.1111/ans.12909. [PMID: 25388095] - Giselle Y Hayashi, Daniel F Carvalho, Mirela C de Miranda, Cláudia Faure, Carla Vallejos, Vinícius N Brito, Andresa De Santi Rodrigues, Guiomar Madureira, Berenice B Mendonca, Tânia A S S Bachega. Neonatal 17-hydroxyprogesterone levels adjusted according to age at sample collection and birthweight improve the efficacy of congenital adrenal hyperplasia newborn screening.
Clinical endocrinology.
2017 Apr; 86(4):480-487. doi:
10.1111/cen.13292. [PMID: 27978607] - Carolina F Macruz, Sônia M R R Lima, João E N Salles, Gustavo M D da Silva, Nilza M Scalissi. Assessment of the body composition of patients with polycystic ovary syndrome using dual-energy X-ray absorptiometry.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.
2017 Mar; 136(3):285-289. doi:
10.1002/ijgo.12066. [PMID: 28099715] - Rachel Bello, Yael Lebenthal, Liora Lazar, Shlomit Shalitin, Ariel Tenenbaum, Moshe Phillip, Liat de Vries. Basal 17-hydroxyprogesterone cannot accurately predict nonclassical congenital adrenal hyperplasia in children and adolescents.
Acta paediatrica (Oslo, Norway : 1992).
2017 Jan; 106(1):155-160. doi:
10.1111/apa.13630. [PMID: 27743484] - Jasmin L Shearer, Nabeel Salmons, Damian J Murphy, Rousseau Gama. Postmenopausal hyperandrogenism: the under-recognized value of inhibins.
Annals of clinical biochemistry.
2017 Jan; 54(1):174-177. doi:
10.1177/0004563216656873. [PMID: 27278937] - Eleni-Magdalini Kyritsi, Georgia Koltsida, Ioanna Farakla, Aikaterini Papanikolaou, Elena Critselis, Emilia Mantzou, Emmanouil Zoumakis, Gerasimos Kolaitis, George P Chrousos, Evangelia Charmandari. Psychological vulnerability to stress in carriers of congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
Hormones (Athens, Greece).
2017 Jan; 16(1):42-53. doi:
10.14310/horm.2002.1718. [PMID: 28500827] - Niels H Birkebaek, David M Hougaard, Arieh S Cohen. Monitoring steroid replacement therapy in children with congenital adrenal hyperplasia.
Journal of pediatric endocrinology & metabolism : JPEM.
2017 Jan; 30(1):85-88. doi:
10.1515/jpem-2016-0203. [PMID: 27977405] - T M Fung, W C Wong, K W Chan, K S Fung. Virilisation in a menopausal woman with a previous kidney transplant.
Hong Kong medical journal = Xianggang yi xue za zhi.
2016 Dec; 22(6):623.e3-4. doi:
10.12809/hkmj164901. [PMID: 27920403] - Gerard Noppe, Yolanda B de Rijke, Jan W Koper, Elisabeth F C van Rossum, Erica L T van den Akker. Scalp hair 17-hydroxyprogesterone and androstenedione as a long-term therapy monitoring tool in congenital adrenal hyperplasia.
Clinical endocrinology.
2016 Oct; 85(4):522-7. doi:
10.1111/cen.13078. [PMID: 27061431] - Jurate Aleknaviciute, Joke H M Tulen, Mirjam Timmermans, Yolanda B de Rijke, Elisabeth F C van Rossum, Frank H de Jong, Steven A Kushner. Adrenocorticotropic hormone elicits gonadotropin secretion in premenopausal women.
Human reproduction (Oxford, England).
2016 10; 31(10):2360-8. doi:
10.1093/humrep/dew190. [PMID: 27591239] - Jacopo Gervasoni, Arcangelo Schiattarella, Aniello Primiano, Ilaria D'Addurno, Andrea Cocci, Cecilia Zuppi, Silvia Persichilli. Simultaneous quantification of 17-hydroxyprogesterone, androstenedione, testosterone and cortisol in human serum by LC-MS/MS using TurboFlow online sample extraction.
Clinical biochemistry.
2016 Sep; 49(13-14):998-1003. doi:
10.1016/j.clinbiochem.2016.05.012. [PMID: 27208555] - Sophie Hepburn, Michael J P Wright, Conchita Boyder, Renee C Sahertian, Ben Lu, Rui Zhang, Chris P White, Andrea R Horvath. Sex steroid hormone stability in serum tubes with and without separator gels.
Clinical chemistry and laboratory medicine.
2016 Sep; 54(9):1451-9. doi:
10.1515/cclm-2015-1133. [PMID: 26872314] - D Y Zhou, W J Qiu, M S Xu, J H Luo, J Ye, L S Han, H W Zhang, Y G Yu, L L Liang, X F Gu. [Clinical and genetic analysis of an infant with isolated 17, 20-lyase deficiency].
Zhonghua er ke za zhi = Chinese journal of pediatrics.
2016 Aug; 54(8):619-22. doi:
10.3760/cma.j.issn.0578-1310.2016.08.014. [PMID: 27510877] - A Zulfa Juniarto, Yvonne G van der Zwan, Ardy Santosa, Mahayu Dewi Ariani, Stefanie Eggers, Remko Hersmus, Axel P N Themmen, Hennie T Bruggenwirth, Katja P Wolffenbuttel, Andrew Sinclair, Stefan J White, Leendert H J Looijenga, Frank H de Jong, Sultana M H Faradz, Stenvert L S Drop. Hormonal evaluation in relation to phenotype and genotype in 286 patients with a disorder of sex development from Indonesia.
Clinical endocrinology.
2016 08; 85(2):247-57. doi:
10.1111/cen.13051. [PMID: 26935236] - Jingwen Hou, Heidi Cook-Andersen, H Irene Su, Rana Shayya, Kevin H Maas, Christine M Burt-Solorzano, Ajay Kumar, R Jeffrey Chang. 17-Hydroxyprogesterone responses to human chorionic gonadotropin are not associated with serum anti-Mullerian hormone levels among adolescent girls with polycystic ovary syndrome.
Journal of pediatric endocrinology & metabolism : JPEM.
2016 Jul; 29(7):835-40. doi:
10.1515/jpem-2015-0461. [PMID: 27166718] - Varun Sondhi, Bryn M Owen, Jiayan Liu, Robert Chomic, Steven A Kliewer, Beverly A Hughes, Wiebke Arlt, David J Mangelsdorf, Richard J Auchus. Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b5 in Leydig Cells.
Molecular endocrinology (Baltimore, Md.).
2016 Apr; 30(4):469-78. doi:
10.1210/me.2015-1282. [PMID: 26974035] - Rachael A Cohen, Jerome H Check, Michael P Dougherty. Evidence that exposure to progesterone alone is a sufficient stimulus to cause a precipitous rise in the immunomodulatory protein the progesterone induced blocking factor (PIBF).
Journal of assisted reproduction and genetics.
2016 Feb; 33(2):221-9. doi:
10.1007/s10815-015-0619-7. [PMID: 26634256] - M Chihaoui, F Kanoun, F Chaker, M Yazidi, K Bouchrit, H Mizouni, M Feki, M Kharrat, H Slimane. Testicular adrenal rest tumours in young adult males with congenital adrenal hyperplasia: prevalence and impact on testicular function.
Andrologia.
2016 Feb; 48(1):45-50. doi:
10.1111/and.12416. [PMID: 25880899] - Carla Bizzarri, Arianna Massimi, Luca Federici, Antonio Cualbu, Sandro Loche, Lorenza Bellincampi, Sergio Bernardini, Marco Cappa, Ottavia Porzio. A New Homozygous Frameshift Mutation in the HSD3B2 Gene in an Apparently Nonconsanguineous Italian Family.
Hormone research in paediatrics.
2016; 86(1):53-61. doi:
10.1159/000444712. [PMID: 27082427] - Robert Krysiak, Agnieszka Drosdzol-Cop, Violetta Skrzypulec-Plinta, Bogusław Okopien. Sexual Function and Depressive Symptoms in Young Women With Nonclassic Congenital Adrenal Hyperplasia.
The journal of sexual medicine.
2016 Jan; 13(1):34-9. doi:
10.1016/j.jsxm.2015.11.002. [PMID: 26755084] - Urszula Ambroziak, Anna Kępczyńska-Nyk, Alina Kuryłowicz, Ewa Maria Małunowicz, Anna Wójcicka, Piotr Miśkiewicz, Magdalena Macech. The diagnosis of nonclassic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, based on serum basal or post-ACTH stimulation 17-hydroxyprogesterone, can lead to false-positive diagnosis.
Clinical endocrinology.
2016 Jan; 84(1):23-9. doi:
10.1111/cen.12935. [PMID: 26331608] - Antonín Pařízek, Martin Hill, Michaela Dušková, Libor Vítek, Marta Velíková, Radmila Kancheva, Patrik Šimják, Michal Koucký, Zuzana Kokrdová, Karolína Adamcová, Andrej Černý, Zdeněk Hájek, Luboslav Stárka. A Comprehensive Evaluation of Steroid Metabolism in Women with Intrahepatic Cholestasis of Pregnancy.
PloS one.
2016; 11(8):e0159203. doi:
10.1371/journal.pone.0159203. [PMID: 27494119] - Mesut Parlak, Hamit Yaşar Ellidağ, Doğa Türkkahraman. High-Dose Hook Effect in 17-Hydroxyprogesterone Assay in a Patient with 21-Hydroxylase Deficiency.
Journal of clinical research in pediatric endocrinology.
2015 Dec; 7(4):329-32. doi:
10.4274/jcrpe.2180. [PMID: 26777045] - Miguel Debono, Ashwini Mallappa, Verena Gounden, Aikaterini A Nella, Robert F Harrison, Christopher A Crutchfield, Peter S Backlund, Steven J Soldin, Richard J Ross, Deborah P Merke. Hormonal circadian rhythms in patients with congenital adrenal hyperplasia: identifying optimal monitoring times and novel disease biomarkers.
European journal of endocrinology.
2015 Dec; 173(6):727-37. doi:
10.1530/eje-15-0064. [PMID: 26340969] - O S Kuprienko, L V Dubovskaya, P S Shabunya, S A Fatykhava, O V Sviridov. [Functionalized Metal Chelates Based on Diethylenetriaminetetraacetic Acids for Chemical Modification of Proteins and Small Biomolecules].
Bioorganicheskaia khimiia.
2015 Nov; 41(6):675-85. doi:
10.1134/s1068162015060072. [PMID: 27125021] - Teresa Modesto, Ana M M S Freitas, Adelino V M Canario. Steroidogenesis by testis and accessory glands of the Lusitanian toadfish, Halobatrachus didactylus, during reproductive season.
General and comparative endocrinology.
2015 Nov; 223(?):120-8. doi:
10.1016/j.ygcen.2015.09.026. [PMID: 26435361] - Pablo U Díaz, Matías L Stangaferro, Natalia C Gareis, William J Silvia, Valentina Matiller, Natalia R Salvetti, Florencia Rey, Fabián Barberis, Luciano Cattaneo, Hugo H Ortega. Characterization of persistent follicles induced by prolonged treatment with progesterone in dairy cows: an experimental model for the study of ovarian follicular cysts.
Theriogenology.
2015 Oct; 84(7):1149-60. doi:
10.1016/j.theriogenology.2015.06.015. [PMID: 26187329] - A E Kulle, F G Riepe, J Hedderich, W G Sippell, J Schmitz, L Niermeyer, P M Holterhus. LC-MS/MS based determination of basal- and ACTH-stimulated plasma concentrations of 11 steroid hormones: implications for detecting heterozygote CYP21A2 mutation carriers.
European journal of endocrinology.
2015 Oct; 173(4):517-24. doi:
10.1530/eje-14-1084. [PMID: 26315375] - Azra Rizwan, Marium Hayat. Unusual presentation with polymenorrhagia and markedly high 17-hydroxy progesterone levels in a lady with Non-Classic Congenital Adrenal Hyperplasia.
JPMA. The Journal of the Pakistan Medical Association.
2015 Aug; 65(8):889-91. doi:
. [PMID: 26228339] - Isabelle Wieacker, Michael Peter, Katrin Borucki, Susann Empting, Friedrich-Wilhelm Roehl, Klaus Mohnike. Therapy monitoring in congenital adrenal hyperplasia by dried blood samples.
Journal of pediatric endocrinology & metabolism : JPEM.
2015 Jul; 28(7-8):867-71. doi:
10.1515/jpem-2014-0303. [PMID: 25781526] - Liliana Noemi Muñoz, Mariana Ochetti, Gonzalo Perez, Gabriela Maria Sobrero, Liliana Karina Silvano, Silvia Edith Martin, Graciela María Testa, Mirta Beatriz Miras. Measurement of Serum 17α-Hydroxyprogesterone in Infants by Radioimmunoassay.
Pediatric endocrinology reviews : PER.
2015 Jun; 12(4):366-72. doi:
NULL. [PMID: 26182481] - N Cinar, F Cetinozman, D Y Aksoy, G Elcin, B O Yildiz. Comparison of adrenocortical steroidogenesis in women with post-adolescent severe acne and polycystic ovary syndrome.
Journal of the European Academy of Dermatology and Venereology : JEADV.
2015 May; 29(5):875-80. doi:
10.1111/jdv.12696. [PMID: 25176476] - Urszula Ambroziak, Anna Kępczyńska-Nyk, Alina Kuryłowicz, Aleksandra Wysłouch-Cieszyńska, Ewa Maria Małunowicz, Zbigniew Bartoszewicz, Agnieszka Kondracka, Radosław Jaźwiec, Emilia Pawłowska, Magdalena Szcześniak, Michał Dadlez, Tomasz Bednarczuk. LC-MS/MS improves screening towards 21-hydroxylase deficiency.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2015 Apr; 31(4):296-300. doi:
10.3109/09513590.2014.994599. [PMID: 25539143] - Marina Boscolo, Hélène Bry-Gauillard, Véronique Tardy, Jacques Young. Secondary amenorrhoea associated with high serum 17-hydroxyprogesterone levels revealing a heterozygous CYP21A2 mutation in a woman with Addison disease.
Clinical endocrinology.
2015 Apr; 82(4):620-2. doi:
10.1111/cen.12646. [PMID: 25353971] - Irum Atta, Taj Muhammad Laghari, Yasir Naqi Khan, Saira Waqar Lone, Mohsina Ibrahim, Jamal Raza. Precocious puberty in children.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2015 Feb; 25(2):124-8. doi:
02.2015/jcpsp.124128. [PMID: 25703757] - Julie A Ray, Mark M Kushnir, Richard A Yost, Alan L Rockwood, A Wayne Meikle. Performance enhancement in the measurement of 5 endogenous steroids by LC-MS/MS combined with differential ion mobility spectrometry.
Clinica chimica acta; international journal of clinical chemistry.
2015 Jan; 438(?):330-6. doi:
10.1016/j.cca.2014.07.036. [PMID: 25110813] - Heidi Cook-Andersen, Sandy S Chuan, Kevin Maas, Marcus A Rosencrantz, H Irene Su, Mark Lawson, Helen D Mason, R Jeffrey Chang. Lack of Serum anti-Mullerian hormone responses after recombinant human chorionic gonadotropin stimulation in women with polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism.
2015 Jan; 100(1):251-7. doi:
10.1210/jc.2014-2948. [PMID: 25303490] - Diane Dufour-Rainfray, Valérie Moal, Lucie Cloix, Elisabeth Mathieu, Anne-Sophie Gauchez, Julie Brossaud, Jean-Benoît Corcuff, François Fraissinet, Christine Collet, Florence Boux de Casson, Denis Guilloteau, Patrick Emond, Pascal Reynier. [Mass spectrometry for steroid assays].
Annales de biologie clinique.
2015 Jan; 73(1):70-8. doi:
10.1684/abc.2014.0988. [PMID: 25582724] - Yuki Kawashima, Takeshi Usui, Masanobu Fujimoto, Naoki Miyahara, Rei Nishimura, Keiichi Hanaki, Susumu Kanzaki. A rare CYP 21 mutation (p.E431K) induced deactivation of CYP 21A2 and resulted in congenital adrenal hyperplasia.
Endocrine journal.
2015; 62(1):101-6. doi:
10.1507/endocrj.ej14-0437. [PMID: 25319875]