lidocaine (BioDeep_00000397485)

Main id: BioDeep_00000001487

 

natural product Volatile Flavor Compounds


代谢物信息卡片


LID_235.1805_10.1

化学式: C14H22N2O (234.1732042)
中文名称: 利多卡因
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCN(CC)C/C(=N\c1c(cccc1C)C)/O
InChI: InChI=1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)

描述信息

D - Dermatologicals > D04 - Antipruritics, incl. antihistamines, anesthetics, etc. > D04A - Antipruritics, incl. antihistamines, anesthetics, etc. > D04AB - Anesthetics for topical use
C - Cardiovascular system > C05 - Vasoprotectives > C05A - Agents for treatment of hemorrhoids and anal fissures for topical use > C05AD - Local anesthetics
C - Cardiovascular system > C01 - Cardiac therapy > C01B - Antiarrhythmics, class i and iii > C01BB - Antiarrhythmics, class ib
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers > D061567 - Voltage-Gated Sodium Channel Blockers
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
R - Respiratory system > R02 - Throat preparations > R02A - Throat preparations > R02AD - Anesthetics, local
S - Sensory organs > S02 - Otologicals > S02D - Other otologicals > S02DA - Analgesics and anesthetics
S - Sensory organs > S01 - Ophthalmologicals > S01H - Local anesthetics > S01HA - Local anesthetics
N - Nervous system > N01 - Anesthetics > N01B - Anesthetics, local > N01BB - Amides
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
CONFIDENCE standard compound; INTERNAL_ID 1212
CONFIDENCE Parent Substance with Reference Standard (Level 1); INTERNAL_ID 800
CONFIDENCE Reference Standard (Level 1)
Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia[2].

同义名列表

5 个代谢物同义名

lidocaine; LID_235.1805_10.1; Lignocaine; Lidocaine; Lidocaine



数据库引用编号

33 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Anna Detzlhofer, Christian Grechhamer, Lawrence Madikizela, Markus Himmelsbach, Franz Mlynek, Wolfgang Buchberger, Christian W Klampfl. Uptake, translocation, and metabolization of amitriptyline, lidocaine, orphenadrine, and tramadol by cress and pea. Environmental science and pollution research international. 2024 Mar; 31(13):19649-19657. doi: 10.1007/s11356-024-32379-x. [PMID: 38363510]
  • Yunli Xia, Ke Xu, Maoqi Luo, Zeya Li, Siwuxie He, Tao Gong, Zhirong Zhang, Li Deng. A Bilayer Microneedle for Modulated Sequential Release of Adrenaline and Lidocaine for Prolonged Local Anesthesia. ACS applied bio materials. 2024 Feb; 7(2):1229-1239. doi: 10.1021/acsabm.3c01128. [PMID: 38254256]
  • Tongtong Zhang, Xincheng Liao, Yuzhi Chen, Xinru Shu, Deshan Liu, Yusheng Yao. Dexmedetomidine Prolongs Lidocaine Intravenous Regional Anesthesia in Rats by Blocking the Hyperpolarization-Activated Cation Current. Drug design, development and therapy. 2024; 18(?):1103-1114. doi: 10.2147/dddt.s450971. [PMID: 38618283]
  • Ting Zhou, Feng Ju, Senbing Zhang, Yiyang Cui, Jianjun Xue. Efficacy of intravenous lidocaine for post-laparoscopic cholecystectomy analgesia: A systematic review and meta-analysis. Asian journal of surgery. 2023 Dec; 46(12):5500-5502. doi: 10.1016/j.asjsur.2023.07.132. [PMID: 37597985]
  • Tian-Hao Shi, Yu-Li Fu, Qi Zhang, Wen-Jie Huang, Bo-Dong Lü. [Clinical application of penile biological vibration threshold for precise use of 5\% lidocaine cream to treat hypersensitive premature ejaculation]. Zhonghua nan ke xue = National journal of andrology. 2023 Oct; 29(10):888-893. doi: ". [PMID: 38639657]
  • Vladimir Smrkolj, Domen Pregeljc, Hana Kavčič, Nejc Umek, Janez Mavri. Micro-pharmacokinetics of lidocaine and bupivacaine transfer across a myelinated nerve fiber. Computers in biology and medicine. 2023 10; 165(?):107375. doi: 10.1016/j.compbiomed.2023.107375. [PMID: 37611421]
  • Ji-Jie Feng, Jian-Jun Xu, Ke Wang, Jia Zhou, Tong-Yu Chen. [Retrospective cohort study on application of acupuncture-aided anesthesia technique to patients undergoing thoracoscopic lobectomy]. Zhen ci yan jiu = Acupuncture research. 2023 Sep; 48(9):946-50. doi: 10.13702/j.1000-0607.20220733. [PMID: 37730266]
  • Wenjie Xu, Yu Xiao, Minzhi Zhao, Jiahui Zhu, Yu Wang, Wenbin Wang, Peng Wang, Huan Meng. Effective Treatment of Knee Osteoarthritis Using a Nano-Enabled Drug Acupuncture Technology in Mice. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023 Aug; ?(?):e2302586. doi: 10.1002/advs.202302586. [PMID: 37555294]
  • Wei Shi, Yi-Feng Ren, Jian-Feng Chen, Xin Ye. Efficacy and Safety of Lidocaine Patch in the Management of Acute Postoperative Wound Pain: A Comprehensive Systematic Review and Meta-Analysis of Randomized Controlled Trials. Advances in wound care. 2023 08; 12(8):453-466. doi: 10.1089/wound.2022.0076. [PMID: 36047821]
  • Jiayu Tang, Yunchao Zhang, Chenxin Liu, Anqi Zeng, Linjiang Song. Therapeutic Strategies for Postherpetic Neuralgia: Mechanisms, Treatments, and Perspectives. Current pain and headache reports. 2023 Jul; ?(?):. doi: 10.1007/s11916-023-01146-x. [PMID: 37493871]
  • Yusuke Horizumi, Satoru Goto, Miwa Takatsuka, Hideshi Yokoyama. Effects of Local Anesthetics on Liposomal Membranes Determined by Their Inhibitory Activity of Lipid Peroxidation. Molecular pharmaceutics. 2023 Apr; ?(?):. doi: 10.1021/acs.molpharmaceut.2c01053. [PMID: 37104048]
  • Marisa Nunes Silva, Ana Ferro, Isabel Fragata. Lidocaine-induced central nervous system toxicity during implantable cardioverter defibrillator placement - A case report and literature review. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology. 2023 Mar; ?(?):. doi: 10.1016/j.repc.2020.07.025. [PMID: 36958570]
  • Yogesh Pandey, Srujan Kumar Dondapati, Stefan Kubick. Enriched cell-free and cell-based native membrane derived vesicles (nMV) enabling rapid in-vitro electrophysiological analysis of the voltage-gated sodium channel 1.5. Biochimica et biophysica acta. Biomembranes. 2023 Mar; 1865(5):184144. doi: 10.1016/j.bbamem.2023.184144. [PMID: 36889502]
  • Fei Liu, Liu-Lin Xiong, Ting-Ting Li, Yan-Jun Chen, Wei Ma, Qi-Jun Li, Qian Li, Ting-Hua Wang. Analgesic Effects and Adverse Reactions of Lidocaine for Patient-Controlled Intravenous Analgesia on Patients Undergoing Open Hepatectomy: A Retrospective Analysis. Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses. 2023 Feb; 38(1):39-44. doi: 10.1016/j.jopan.2022.05.069. [PMID: 35989234]
  • Jianshi Yin, Yongzhao Zhang, Xiangmei Zhao, Han Yan, Jun Liu, Xiaohui Chang, Junsheng Wang. Intraoperative analgesic effect of intravertebral lidocaine injection during percutaneous kyphoplasty in the treatment of thoracolumbar compression fractures in elderly patients. Journal of back and musculoskeletal rehabilitation. 2023; 36(5):1095-1100. doi: 10.3233/bmr-220174. [PMID: 37458006]
  • Xincheng Liao, Jie Lin, Xinru Shu, Shisen Hong, Yusheng Yao, Hao Li. Regional versus systemic dexmedetomidine as an adjuvant to lidocaine for intravenous regional anaesthesia in healthy volunteers: a randomized crossover study. Annals of medicine. 2023; 55(2):2300663. doi: 10.1080/07853890.2023.2300663. [PMID: 38175807]
  • Yuan Lai, Qi Chen, Chunfang Xiang, Guanzhu Li, Ke Wei. Comparison of the Effects of Dexmedetomidine and Lidocaine on Stress Response and Postoperative Delirium of Older Patients Undergoing Thoracoscopic Surgery: A Randomized Controlled Trial. Clinical interventions in aging. 2023; 18(?):1275-1283. doi: 10.2147/cia.s419835. [PMID: 37554513]
  • Fei Wang, Yanxia He, Miyi Zhou, Qingyong Luo, Zuojia Zeng, Li Liu, Si Zeng, Qian Lei. Efficacy of perioperative intravenous lidocaine infusion on postoperative pulmonary complications in patients undergoing video-assisted thoracoscopic lung resection surgery: protocol for a randomised controlled trial. BMJ open. 2022 12; 12(12):e066828. doi: 10.1136/bmjopen-2022-066828. [PMID: 36523235]
  • San-Biao Li. [A case of shock caused by lidocaine hydrochloride poisoning during manual reduction of distal radius fracture under local anesthesia]. Zhongguo gu shang = China journal of orthopaedics and traumatology. 2022 10; 35(10):977-8. doi: 10.12200/j.issn.1003-0034.2022.10.013. [PMID: 36280416]
  • Marcella Pavan, Priscila Yamamoto, Rodrigo Moreira da Silva, Wilson Salgado Junior, José Dos Santos, Rafael Kemp, Ajith Sankarankutty, Natália de Moraes, Cristiane de Gaitani. Chemometric optimization of salting-out assisted liquid-liquid extraction (SALLE) combined with LC-MS/MS for the analysis of carvedilol enantiomers in human plasma: Application to clinical pharmacokinetics. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Aug; 1205(?):123338. doi: 10.1016/j.jchromb.2022.123338. [PMID: 35724550]
  • Fei Peng, Jing Liu, Yujun Zhang, Jing Fan, Deying Gong, Liu He, Wensheng Zhang, Feng Qiu. Designer self-assembling peptide nanofibers induce biomineralization of lidocaine for slow-release and prolonged analgesia. Acta biomaterialia. 2022 Jul; 146(?):66-79. doi: 10.1016/j.actbio.2022.05.002. [PMID: 35545185]
  • Eric S Schwenk, Aaron Walter, Marc C Torjman, Sarah Mukhtar, Harsh T Patel, Bryan Nardone, George Sun, Bhavana Thota, Clinton G Lauritsen, Stephen D Silberstein. Lidocaine infusions for refractory chronic migraine: a retrospective analysis. Regional anesthesia and pain medicine. 2022 07; 47(7):408-413. doi: 10.1136/rapm-2021-103180. [PMID: 35609890]
  • Marc Alan Buren, Alekos Theologis, Ariadne Zuraek, Matthias Behrends, Aaron J Clark, Jacqueline M Leung. Lidocaine Infusion for the Management of Postoperative Pain and Delirium (LIMPP): protocol for a randomised control trial. BMJ open. 2022 06; 12(6):e059416. doi: 10.1136/bmjopen-2021-059416. [PMID: 35667730]
  • Yue-Xia Lu, Qin-Feng Cai. [Application value and safety of prostate peripheral nerve block combined with dezocine in transrectal prostate biopsy]. Zhonghua nan ke xue = National journal of andrology. 2022 Jun; 28(6):506-510. doi: . [PMID: 37477467]
  • Xincheng Liao, Bingbing Fu, Jia Yun, Huifen Lin, Bin Qian, Yusheng Yao. Efficacy of systemic lidocaine in postoperative delirium in elderly patients undergoing laparoscopic colorectal surgery: study protocol for a multicentre, prospective, double-blind, randomised, parallel-group, superiority, placebo-controlled trial. BMJ open. 2022 05; 12(5):e056959. doi: 10.1136/bmjopen-2021-056959. [PMID: 35577476]
  • Ning Cong, Tian Tian, Bin Hu, Fu-Shan Xue. Is addition of lidocaine to ketamine beneficial for rapid sequence endotracheal intubation in patients with septic shock?. Anaesthesia, critical care & pain medicine. 2022 04; 41(2):101023. doi: 10.1016/j.accpm.2022.101023. [PMID: 35121187]
  • Jace J Franko, Michael M Vu, Michael E Parsons, Jeffrey R Conner, Daniel T Lammers, Nicholas Ieronimakis, Gregory D Reynolds, Matthew J Eckert, Jason R Bingham. Adenosine, lidocaine, and magnesium for attenuating ischemia reperfusion injury from resuscitative endovascular balloon occlusion of the aorta in a porcine model. The journal of trauma and acute care surgery. 2022 04; 92(4):631-639. doi: 10.1097/ta.0000000000003482. [PMID: 34840271]
  • Kathleen McMahon, Jared Paster, Keith A Baker. Local anesthetic systemic toxicity in the pediatric patient. The American journal of emergency medicine. 2022 Apr; 54(?):325.e3-325.e6. doi: 10.1016/j.ajem.2021.10.021. [PMID: 34742600]
  • Jason Charles Ray, Zhibin Chen, Georgia Ramsay, Jack Germaine, Elspeth J Hutton. Status migrainosus inpatient treatment with eptinezumab (SMITE): study protocol for a randomised controlled trial. BMJ open. 2022 03; 12(3):e059647. doi: 10.1136/bmjopen-2021-059647. [PMID: 35260463]
  • Ross Barman, Kathryn Clark, Oludare Olatoye. Short-Term Lidocaine Infusion as a Nonsedative Option to Maintain Ventilator Synchrony During Opioid Tapering in a COVID-19 Patient. Pain medicine (Malden, Mass.). 2022 03; 23(3):592-595. doi: 10.1093/pm/pnab311. [PMID: 34672352]
  • Djo Hasan, Atsuko Shono, Coenraad K van Kalken, Peter J van der Spek, Eric P Krenning, Toru Kotani. A novel definition and treatment of hyperinflammation in COVID-19 based on purinergic signalling. Purinergic signalling. 2022 03; 18(1):13-59. doi: 10.1007/s11302-021-09814-6. [PMID: 34757513]
  • Yi Deng, Rachel W Li, Yong Liang Yang, Steven Weiss, Paul N Smith. Pharmacological prevention of renal ischemia-reperfusion injury in a rat model. ANZ journal of surgery. 2022 03; 92(3):518-525. doi: 10.1111/ans.17381. [PMID: 34820987]
  • Catherine Doherty, Natalie Quinn, Sara Mistry, Jacques Diacono, Robert Walker, Anna Harrison, Neil Bateman, Iain Bruce. LID study: Plasma lidocaine levels following airway topicalisation for paediatric microlaryngobronchoscopy (MLB). Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery. 2022 03; 47(2):279-286. doi: 10.1111/coa.13833. [PMID: 34213821]
  • Sun Jae Won, Da-Ye Kim, Jae Min Kim. Effect of platelet-rich plasma injections for chronic nonspecific low back pain: A randomized controlled study. Medicine. 2022 Feb; 101(8):e28935. doi: 10.1097/md.0000000000028935. [PMID: 35212300]
  • LongYuan Zhou, RuiLan Wu, Chang Cai, Yong Qi, XingHua Bi, Qi Hang. The effects of target-controlled infusion of lidocaine undergoing vocal cord polypectomy: A randomized controlled trial (CONSORT compliant). Medicine. 2022 Feb; 101(6):e27642. doi: 10.1097/md.0000000000027642. [PMID: 35147085]
  • Yafeng Li, Xiaoxiang Liao, Bin Zheng. Studies on local anesthetic lidocaine hydrochloride delivery via photo-triggered implantable polymeric microneedles as a patient-controlled transdermal analgesia system. Journal of biomaterials science. Polymer edition. 2022 02; 33(2):155-173. doi: 10.1080/09205063.2021.1981535. [PMID: 34635015]
  • Bang-Zhi Li, Wen-Hai Tang, Yang Li, Lei Zhou, Ming-Guo Liu, Sheng-Xue Bao. Clinical Efficacy of Epidural Injections of Local Anesthetic Alone or Combined with Steroid for Neck Pain: A Systematic Review and Meta-Analysis. BioMed research international. 2022; 2022(?):8952220. doi: 10.1155/2022/8952220. [PMID: 35663039]
  • Kai Zhao, Yushan Dong, Gaowei Su, Yaolin Wang, Tao Ji, Nanling Wu, Xiaojie Cui, Wenzhan Li, Yanming Yang, Xiuxia Chen. Effect of Systemic Lidocaine on Postoperative Early Recovery Quality in Patients Undergoing Supratentorial Tumor Resection. Drug design, development and therapy. 2022; 16(?):1171-1181. doi: 10.2147/dddt.s359755. [PMID: 35496368]
  • Baichun Xing, Linlin Yang, Yanan Cui. Lidocaine inhibited migration of NSCLCA549 cells via the CXCR4 regulation. Cancer biomarkers : section A of Disease markers. 2022; 33(3):317-330. doi: 10.3233/cbm-210249. [PMID: 34334384]
  • Wanyun Zhang, Chunjing He. Clinical Efficacy of Pulsed Radiofrequency Combined with Intravenous Lidocaine Infusion in the Treatment of Subacute Herpes Zoster Neuralgia. Pain research & management. 2022; 2022(?):5299753. doi: 10.1155/2022/5299753. [PMID: 35450055]
  • LiLi Zhao, Ning Ma, Gaihong Liu, Ni Mao, Fei Chen, Jiao Li. Lidocaine Inhibits Hepatocellular Carcinoma Development by Modulating circ_ITCH/miR-421/CPEB3 Axis. Digestive diseases and sciences. 2021 12; 66(12):4384-4397. doi: 10.1007/s10620-020-06787-1. [PMID: 33433806]
  • Tao Jiang, Shuangshuang Ma, Yangyang Shen, Yuwen Li, Ruirui Pan, Huaixin Xing. Topical anesthetic and pain relief using penetration enhancer and transcriptional transactivator peptide multi-decorated nanostructured lipid carriers. Drug delivery. 2021 Dec; 28(1):478-486. doi: 10.1080/10717544.2021.1889717. [PMID: 33641554]
  • Wenshui Yao, Longxin Zhang, Guolin Lu, Jing Wang, Li Zhang, Yuping Wang, Peihan Xiao, Xiaofen Chen, Chanjuan Chen, Min Zhou. Use of intravenous lidocaine for dose reduction of propofol in paediatric colonoscopy patients: a randomised placebo-controlled study. BMC anesthesiology. 2021 12; 21(1):299. doi: 10.1186/s12871-021-01525-0. [PMID: 34852767]
  • Ryan C Dregalla, Yvette Uribe, Marko Bodor. Effect of local anesthetics on platelet physiology and function. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2021 Dec; 39(12):2744-2754. doi: 10.1002/jor.25019. [PMID: 33694196]
  • Eric S Schwenk, Rajnish K Gupta. Comparison of continuous intravenous lidocaine versus TAP block for kidney transplant: an infographic. Regional anesthesia and pain medicine. 2021 11; 46(11):954. doi: 10.1136/rapm-2021-103095. [PMID: 34452982]
  • Neil A Hanson, Joseph Strunk, Genna Saunders, Nick G Cowan, Jared Brandenberger, Christian S Kuhr, Christine Oryhan, Daniel T Warren, April E Slee, Wyndam Strodtbeck. Comparison of continuous intravenous lidocaine versus transversus abdominis plane block for kidney transplant surgery: a randomized, non-inferiority trial. Regional anesthesia and pain medicine. 2021 11; 46(11):955-959. doi: 10.1136/rapm-2021-102973. [PMID: 34417343]
  • Rattaphol Seangrung, Koravee Pasutharnchat, Subundit Injampa, Sirima Kumdang, Rojnarin Komonhirun. Comparison of the hemodynamic response of dexmedetomidine versus additional intravenous lidocaine with propofol during tracheal intubation: a randomized controlled study. BMC anesthesiology. 2021 10; 21(1):265. doi: 10.1186/s12871-021-01484-6. [PMID: 34717532]
  • Himawan Fernando, Thy Duong, Kevin Huynh, Jonathan Noonan, James Shaw, Stephen J Duffy, Ziad Nehme, Karen Smith, Paul S Myles, Peter J Meikle, Karlheinz Peter, Dion Stub. Effects of lignocaine vs. opioids on antiplatelet activity of ticagrelor: the LOCAL trial. European heart journal. 2021 10; 42(39):4025-4036. doi: 10.1093/eurheartj/ehab557. [PMID: 34423354]
  • A J Toner, M A Bailey, S A Schug, T B Corcoran. A pilot multicentre randomised controlled trial of lidocaine infusion in women undergoing breast cancer surgery. Anaesthesia. 2021 Oct; 76(10):1326-1341. doi: 10.1111/anae.15440. [PMID: 33651896]
  • Tian Li, Xin Y Feng, Xiao M Feng, Jian W Lv, Ting T Lv, Si Y Wang. The short-term efficacy of electrical pudendal nerve stimulation versus intravesical instillation for the urethral pain syndrome: a randomized clinical trial. World journal of urology. 2021 Oct; 39(10):3993-3998. doi: 10.1007/s00345-021-03698-2. [PMID: 33934208]
  • Makiko Shibuya, Rie Iwamoto, Yukifumi Kimura, Nobuhito Kamekura, Toshiaki Fujisawa. Anesthetic Management of a Patient With Citrullinemia Type I During Dental Treatment. Anesthesia progress. 2021 10; 68(3):158-162. doi: 10.2344/anpr-68-02-04. [PMID: 34606567]
  • Peter Matzneller, Zoe Oesterreicher, Beatrix Wulkersdorfer, Valentin Al Jalali, Daniel Mascher, Hermann Mascher, Markus Zeitlinger. Microdialysis as a potential tool for comparative assessment of tissue pharmacokinetics of two different patches containing lidocaine: A crossover pilot study. International journal of clinical pharmacology and therapeutics. 2021 Sep; 59(9):603-609. doi: 10.5414/cp203922. [PMID: 34236302]
  • Yue Xin, Xiang Wen, Xian Jiang. Analgesic effect of topical lidocaine is enhanced by cold atmospheric plasma pretreatment in facial CO2 laser treatments. Journal of cosmetic dermatology. 2021 Sep; 20(9):2794-2799. doi: 10.1111/jocd.13983. [PMID: 33550716]
  • Marijana Matas, Vlatka Sotošek, Ana Kozmar, Robert Likić, Goran Mrak, Bálint Nagy, Ante Sekulić. Effect of adjunctive lidocaine-based scalp block and laryngotracheal local anesthesia vs general anesthesia only on plasma and cerebrospinal fluid pro-inflammatory cytokine concentrations in patients with cerebral aneurysm: a randomized controlled trial. Croatian medical journal. 2021 Aug; 62(4):338-346. doi: NULL. [PMID: 34472736]
  • Emileigh Greuber, Kip Vought, Kalpana Patel, Hiroaki Suzuki, Kazuhiro Usuda, Akira Shiramizu, Luana Pesco Koplowitz, Barry Koplowitz, Howard I Maibach, Dmitri Lissin. Biorelevant In Vitro Skin Permeation Testing and In Vivo Pharmacokinetic Characterization of Lidocaine from a Nonaqueous Drug-in-Matrix Topical System. AAPS PharmSciTech. 2021 Aug; 22(6):215. doi: 10.1208/s12249-021-02101-y. [PMID: 34386908]
  • Mengmeng Zheng, Chunpu Li, Mi Zhou, Ru Jia, Gang Cai, Fengyu She, Lulu Wei, Shaohui Wang, Jie Yu, Dingyan Wang, Laurent Calcul, Xingmin Sun, Xiaomin Luo, Feng Cheng, Qi Li, Yan Wang, Jianfeng Cai. Discovery of Cyclic Peptidomimetic Ligands Targeting the Extracellular Domain of EGFR. Journal of medicinal chemistry. 2021 08; 64(15):11219-11228. doi: 10.1021/acs.jmedchem.1c00607. [PMID: 34297567]
  • Laura J England, Charles A Syms, Christopher York. Pharmacokinetics of Single Dose Lidocaine and Epinephrine Following Iontophoresis of the Tympanic Membrane in a Double-Blinded Randomized Trial. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 2021 08; 42(7):1095-1103. doi: 10.1097/mao.0000000000003128. [PMID: 33859140]
  • Kathleen E Singer, Taylor E Wallen, Mackenzie C Morris, Emily McGlone, Sabre Stevens-Topie, Ryan Earnest, Michael D Goodman. Postinjury treatments to make early tactical aeromedical evacuation practical for the brain after TBI. The journal of trauma and acute care surgery. 2021 08; 91(2S Suppl 2):S89-S98. doi: 10.1097/ta.0000000000003259. [PMID: 33938511]
  • Rui Sasaki, Katsuhisa Sunada. Effect of epinephrine on the absorption of lidocaine following application to the oral mucosa in rats. BMC oral health. 2021 07; 21(1):327. doi: 10.1186/s12903-021-01691-0. [PMID: 34210305]
  • Priscila Cordeiro Lima Fernandes, Ludmilla David de Moura, Fernando Freitas de Lima, Gustavo Henrique Rodrigues da Silva, Roosevelt Isaias Carvalho Souza, Eneida de Paula. Lipid nanocapsules loaded with prilocaine and lidocaine and incorporated in gel for topical application. International journal of pharmaceutics. 2021 Jun; 602(?):120675. doi: 10.1016/j.ijpharm.2021.120675. [PMID: 33961954]
  • Hyun-Chul Kim, Wonhye Lee, Mark Böhlke, Kyungho Yoon, Seung-Schik Yoo. Focused ultrasound enhances the anesthetic effects of topical lidocaine in rats. BMC anesthesiology. 2021 05; 21(1):158. doi: 10.1186/s12871-021-01381-y. [PMID: 34020595]
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