Z-Gly-Pro (BioDeep_00000003429)
Volatile Flavor Compounds
代谢物信息卡片
Carbobenzoxyglycyl-L-proline
化学式: C15H18N2O5 (306.1215658)
中文名称: Z-甘氨酰-L-脯氨酸
谱图信息:
最多检出来源 Mentha canadensis(plant) 43.66%
分子结构信息
SMILES: C1CC(N(C1)C(=O)CNC(=O)OCC2=CC=CC=C2)C(=O)O
InChI: InChI=1S/C15H18N2O5/c18-13(17-8-4-7-12(17)14(19)20)9-16-15(21)22-10-11-5-2-1-3-6-11/h1-3,5-6,12H,4,7-10H2,(H,16,21)(H,19,20)
描述信息
KEIO_ID Z003; [MS3] KO009084
KEIO_ID Z003; [MS2] KO009083
KEIO_ID Z003
同义名列表
数据库引用编号
26 个数据库交叉引用编号
- ChEBI: CHEBI:10096
- KEGG: C01632
- PubChem: 439540
- PubChem: 70877
- PubChem: 4782
- Metlin: METLIN65625
- CAS: 1160-54-9
- CAS: 68047-33-6
- MoNA: KO009086
- MoNA: KO004283
- MoNA: KO002023
- MoNA: KO002026
- MoNA: KO002025
- MoNA: KO004285
- MoNA: KO002027
- MoNA: KO004284
- MoNA: KO004282
- MoNA: KO004281
- MoNA: KO009085
- MoNA: KO002024
- MoNA: KO009083
- MoNA: KO009084
- PMhub: MS000009665
- PDB-CCD: P0H
- NIKKAJI: J203.419K
- KNApSAcK: 10096
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Melissa Moey, Xiaohong T Gan, Cathy Xiaoling Huang, Venkatesh Rajapurohitam, Eduardo Martínez-Abundis, Edmund M K Lui, Morris Karmazyn. Ginseng reverses established cardiomyocyte hypertrophy and postmyocardial infarction-induced hypertrophy and heart failure.
Circulation. Heart failure.
2012 Jul; 5(4):504-14. doi:
10.1161/circheartfailure.112.967489. [PMID: 22576957] - Richard Engbersen, Rosalinde Masereeuw, Miriam A van Gestel, Helene L M Siero, Miek M Moons, Paul Smits, Frans G M Russel. Differential effects of sulfonylurea derivatives on vascular ATP-sensitive potassium channels.
European journal of pharmacology.
2012 Apr; 681(1-3):75-9. doi:
10.1016/j.ejphar.2012.02.006. [PMID: 22366200] - Wen-Fei Chiou, Tian-Shung Wu. 9-hydroxycanthin-6-one induces penile erection and delays ejaculation.
The journal of sexual medicine.
2012 Apr; 9(4):1027-36. doi:
10.1111/j.1743-6109.2011.02296.x. [PMID: 21569213] - Ismaila A Raji, Pierre Mugabo, Kenechukwu Obikeze. Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats.
Journal of ethnopharmacology.
2012 Mar; 140(1):98-106. doi:
10.1016/j.jep.2011.12.034. [PMID: 22222281] - Jun Kyoung Lee, Dae Gill Kang, Ho-Sub Lee. Vascular relaxation induced by aqueous extract of Lespedeza cuneata via the NO-cGMP pathway.
Journal of natural medicines.
2012 Jan; 66(1):17-24. doi:
10.1007/s11418-011-0546-6. [PMID: 21607822] - Siddig Ibrahim Abdelwahab, Abdelwahab Hassan Mohamed, Osama Yousif Mohamed, Mahjoub Oall, Manal Mohamed Elhassan Taha, Syam Mohan, Mohamed Ibrahim Noordin, Mohd Rais Mustafa, Khalid M Alkharfy. Erectogenic Effects of Clerodendron capitatum: Involvement of Phosphodiesterase Type-5 Inhibition.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):137386. doi:
10.1155/2012/137386. [PMID: 21747892] - Galina Dvoriantchikova, Dmitry Ivanov, David Barakat, Alexander Grinberg, Rong Wen, Vladlen Z Slepak, Valery I Shestopalov. Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury.
PloS one.
2012; 7(2):e31991. doi:
10.1371/journal.pone.0031991. [PMID: 22384122] - Gulnur Sevin, Yasemin Delen Akcay, Gonen Ozsarlak-Sozer, Mukadder Yasa. Low-dose fluvastatin prevents the functional alterations of endothelium induced by short-term cholesterol feeding in rabbit carotid artery.
TheScientificWorldJournal.
2012; 2012(?):671728. doi:
10.1100/2012/671728. [PMID: 22547992] - Johnny Tam, Pavan Tiruveedhula, Austin Roorda. Characterization of single-file flow through human retinal parafoveal capillaries using an adaptive optics scanning laser ophthalmoscope.
Biomedical optics express.
2011 Mar; 2(4):781-93. doi:
10.1364/boe.2.000781. [PMID: 21483603] - Hideki Shuto, Koji Tominaga, Atsushi Yamauchi, Munehiko Ikeda, Kenji Kusaba, Daisuke Mitsunaga, Yasutoshi Hirabara, Takashi Egawa, Yukio Takano, Yasufumi Kataoka. The statins fluvastatin and pravastatin exert anti-flushing effects by improving vasomotor dysfunction through nitric oxide-mediated mechanisms in ovariectomized animals.
European journal of pharmacology.
2011 Jan; 651(1-3):234-9. doi:
10.1016/j.ejphar.2010.10.084. [PMID: 21114974] - Yong-Liang Xue, Hai-Xia Shi, Ferid Murad, Ka Bian. Vasodilatory effects of cinnamaldehyde and its mechanism of action in the rat aorta.
Vascular health and risk management.
2011; 7(?):273-80. doi:
10.2147/vhrm.s15429. [PMID: 21603596] - Sabrine Hassane, Nanna Claij, Martine Jodar, Alexandra Dedman, Inger Lauritzen, Fabrice Duprat, Jorine S Koenderman, Annemieke van der Wal, Martijn H Breuning, Emile de Heer, Eric Honore, Marco C DeRuiter, Dorien J M Peters. Pkd1-inactivation in vascular smooth muscle cells and adaptation to hypertension.
Laboratory investigation; a journal of technical methods and pathology.
2011 Jan; 91(1):24-32. doi:
10.1038/labinvest.2010.159. [PMID: 20856231] - Nicolás Belforte, Pablo H Sande, Nuria de Zavalía, Diego C Fernandez, Dafne M Silberman, Mónica S Chianelli, Ruth E Rosenstein. Ischemic tolerance protects the rat retina from glaucomatous damage.
PloS one.
2011; 6(8):e23763. doi:
10.1371/journal.pone.0023763. [PMID: 21887313] - Kamsiah Jaarin, Mohd Rais Mustafa, Xin-Fang Leong. The effects of heated vegetable oils on blood pressure in rats.
Clinics (Sao Paulo, Brazil).
2011; 66(12):2125-32. doi:
10.1590/s1807-59322011001200020. [PMID: 22189740] - Xin-Fang Leong, Mohd Rais Mustafa, Srijit Das, Kamsiah Jaarin. Association of elevated blood pressure and impaired vasorelaxation in experimental Sprague-Dawley rats fed with heated vegetable oil.
Lipids in health and disease.
2010 Jun; 9(?):66. doi:
10.1186/1476-511x-9-66. [PMID: 20573259] - Anwarul Hassan Gilani, Saf-ur-Rehman Mandukhail, Javeid Iqbal, Masoom Yasinzai, Nauman Aziz, Aslam Khan, Najeeb-ur-Rehman. Antispasmodic and vasodilator activities of Morinda citrifolia root extract are mediated through blockade of voltage dependent calcium channels.
BMC complementary and alternative medicine.
2010 Jan; 10(?):2. doi:
10.1186/1472-6882-10-2. [PMID: 20070879] - Gail K Adler, Istvan Bonyhay, Hannah Failing, Elizabeth Waring, Sarah Dotson, Roy Freeman. Antecedent hypoglycemia impairs autonomic cardiovascular function: implications for rigorous glycemic control.
Diabetes.
2009 Feb; 58(2):360-6. doi:
10.2337/db08-1153. [PMID: 19056608] - Grzegorz Godlewski, László Offertáler, Douglas Osei-Hyiaman, Fong Ming Mo, Judith Harvey-White, Jie Liu, Margaret I Davis, Li Zhang, Raj K Razdan, Garry Milman, Pal Pacher, Partha Mukhopadhyay, David M Lovinger, George Kunos. The endogenous brain constituent N-arachidonoyl L-serine is an activator of large conductance Ca2+-activated K+ channels.
The Journal of pharmacology and experimental therapeutics.
2009 Jan; 328(1):351-61. doi:
10.1124/jpet.108.144717. [PMID: 18923087] - Walter Di Nardo, Dario Pitocco, Mauro A S Di Leo, Pasqualina M Picciotti, Enrico Di Stasio, Chiara Collina, Stefano Santini, Emanuele Scarano, Giovanni Ghirlanda. Modifications in nasal function and nitric oxide serum level in type 1 diabetes.
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale.
2008 Oct; 37(5):611-5. doi:
NULL. [PMID: 19128664] - Hui-ping Wang, Fu-yu Qiu, Cheng Chen, Meng-hui Zhao, Yuan Lu, Qiang Xia. [Endothelium-independent vasorelaxation of plant-derived estrogen biochanin A and its mechanism in rat aortic rings].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2006 Aug; 22(3):274-7. doi:
". [PMID: 21158067] - Alexis Zamble, Marie Carpentier, Abdelmejid Kandoussi, Sevser Sahpaz, Olivier Petrault, Tawarak Ouk, Nathalie Hennuyer, Jean-Charles Fruchart, Bart Staels, Régis Bordet, Patrick Duriez, François Bailleul, Françoise Martin-Nizard. Paullinia pinnata extracts rich in polyphenols promote vascular relaxation via endothelium-dependent mechanisms.
Journal of cardiovascular pharmacology.
2006 Apr; 47(4):599-608. doi:
10.1097/01.fjc.0000211734.53798.1d. [PMID: 16680075] - Adèle Thomas, Lesley A Stevenson, Kerrie N Wease, Martin R Price, Gemma Baillie, Ruth A Ross, Roger G Pertwee. Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist.
British journal of pharmacology.
2005 Dec; 146(7):917-26. doi:
10.1038/sj.bjp.0706414. [PMID: 16205722] - Jun Taniguchi, Hideo Honda, Yoichi Shibusawa, Takeshi Iwata, Yoko Notoya. Alteration in endothelial function and modulation by treatment with pioglitazone in rabbit renal artery from short-term hypercholesterolemia.
Vascular pharmacology.
2005 Jun; 43(1):47-55. doi:
10.1016/j.vph.2005.03.005. [PMID: 15953770] - Markus Tölle, Bodo Levkau, Petra Keul, Volker Brinkmann, Günter Giebing, Gilbert Schönfelder, Michael Schäfers, Karin von Wnuck Lipinski, Joachim Jankowski, Vera Jankowski, Jerold Chun, Walter Zidek, Markus Van der Giet. Immunomodulator FTY720 Induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3.
Circulation research.
2005 Apr; 96(8):913-20. doi:
10.1161/01.res.0000164321.91452.00. [PMID: 15802614] - Phuong A Vo, Bhavini Lad, James A P Tomlinson, Stephanie Francis, Amrita Ahluwalia. autoregulatory role of endothelium-derived nitric oxide (NO) on Lipopolysaccharide-induced vascular inducible NO synthase expression and function.
The Journal of biological chemistry.
2005 Feb; 280(8):7236-43. doi:
10.1074/jbc.m411317200. [PMID: 15583003] - Ho Kyun Cho, Kyung Koo Kang, Gook Jun Ahn, Hyun Joo Shim, Won Bae Kim. Effect of DA-8159, a selective phosphodiesterase type 5 inhibitor, on electroretinogram and retinal histology in rabbits.
Journal of Korean medical science.
2004 Aug; 19(4):586-90. doi:
10.3346/jkms.2004.19.4.586. [PMID: 15308852] - Kevin D Monahan, Iratxe Eskurza, Douglas R Seals. Ascorbic acid increases cardiovagal baroreflex sensitivity in healthy older men.
American journal of physiology. Heart and circulatory physiology.
2004 Jun; 286(6):H2113-7. doi:
10.1152/ajpheart.01054.2003. [PMID: 14962830] - Carlos R Tirapelli, Sergio R Ambrosio, Fernando B da Costa, Silvia T Coutinho, Dionéia C R de Oliveira, Ana M de Oliveira. Analysis of the mechanisms underlying the vasorelaxant action of kaurenoic acid in the isolated rat aorta.
European journal of pharmacology.
2004 May; 492(2-3):233-41. doi:
10.1016/j.ejphar.2004.04.003. [PMID: 15178370] - Bruno A Rezende, Steyner F Cortes, Virgínia S Lemos. Mechanisms involved in the vasodilator effect of the flavanol floranol in rat small mesenteric arteries.
Planta medica.
2004 May; 70(5):465-7. doi:
10.1055/s-2004-818977. [PMID: 15124094] - Richard J Davis, Colin E Murdoch, Mozam Ali, Stuart Purbrick, Rivka Ravid, Gordon S Baxter, Nick Tilford, Robert L G Sheldrick, Kenneth L Clark, Robert A Coleman. EP4 prostanoid receptor-mediated vasodilatation of human middle cerebral arteries.
British journal of pharmacology.
2004 Feb; 141(4):580-5. doi:
10.1038/sj.bjp.0705645. [PMID: 14744815] - Phouangmala Scruggs, Siok L Dun, Nae J Dun. Cocaine- and amphetamine-regulated transcript peptide attenuates phenylephrine-induced bradycardia in anesthetized rats.
American journal of physiology. Regulatory, integrative and comparative physiology.
2003 Dec; 285(6):R1496-503. doi:
10.1152/ajpregu.00183.2003. [PMID: 12933358] - Mohan F Pamarthi, M Audrey Rudd, Richard D Bukoski. Normal perivascular sensory dilator nerve function in arteries of Zucker diabetic fatty rats.
American journal of hypertension.
2002 Apr; 15(4 Pt 1):310-5. doi:
10.1016/s0895-7061(01)02334-2. [PMID: 11991215] - David G Witte, Michael E Brune, Sweta P Katwala, Ivan Milicic, Deanne Stolarik, Yu-Hua Hui, Kennan C Marsh, James F Kerwin, Michael D Meyer, Arthur A Hancock. Modeling of relationships between pharmacokinetics and blockade of agonist-induced elevation of intraurethral pressure and mean arterial pressure in conscious dogs treated with alpha(1)-adrenoceptor antagonists.
The Journal of pharmacology and experimental therapeutics.
2002 Feb; 300(2):495-504. doi:
10.1124/jpet.300.2.495. [PMID: 11805209] - T M Saleh, M C Saleh, B J Connell. Estrogen blocks the cardiovascular and autonomic changes following vagal stimulation in ovariectomized rats.
Autonomic neuroscience : basic & clinical.
2001 Apr; 88(1-2):25-35. doi:
10.1016/s1566-0702(01)00220-x. [PMID: 11474543] - W F Chiou, Y L Huang, C F Chen, C C Chen. Vasorelaxing effect of coumarins from Cnidium monnieri on rabbit corpus cavernosum.
Planta medica.
2001 Apr; 67(3):282-4. doi:
10.1055/s-2001-12013. [PMID: 11345705] - Y Bergqvist, J al Kabbani, C Pettersson, N H Huynh. Enantioselective high-performance liquid chromatographic determination of (SR)- and (RS)-mefloquine in plasma using N-benzyloxycarbonyl-glycyl-L-proline as chiral counter ion.
Journal of chromatography.
1993 Oct; 620(2):217-24. doi:
10.1016/0378-4347(93)80007-q. [PMID: 8300789] - A Karlsson, C Pettersson, S Björkman. Determination of (R)- and (S)-propranolol in plasma by high-performance liquid chromatography using N-benzoxycarbonylglycyl-L-proline as chiral selector in the mobile phase.
Journal of chromatography.
1989 Sep; 494(?):157-71. doi:
10.1016/s0378-4347(00)82665-1. [PMID: 2584313] - J H Holmes, I Kanfer, H Zwarenstein. Effect of benzodiazepine derivatives on human blood cholinesterase in vitro.
Research communications in chemical pathology and pharmacology.
1978 Aug; 21(2):367-70. doi:
. [PMID: 29327]