dCDP (BioDeep_00000002934)

 

Secondary id: BioDeep_00000400218, BioDeep_00001868784

natural product human metabolite PANOMIX_OTCML-2023 Endogenous BioNovoGene_Lab2019


代谢物信息卡片


[({[(2R,3S,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid

化学式: C9H15N3O10P2 (387.0233)
中文名称: 2'-脱氧胞苷-5'-二磷酸, 2'-脱氧胞苷5'-二磷酸
谱图信息: 最多检出来源 Homo sapiens(natural_products) 12.62%

分子结构信息

SMILES: C1C(C(OC1N2C=CC(=NC2=O)N)COP(=O)(O)OP(=O)(O)O)O
InChI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,

描述信息

dCDP is a substrate for Uridine-cytidine kinase 1, Nucleoside diphosphate kinase (mitochondrial), Nucleoside diphosphate kinase homolog 5, Ribonucleoside-diphosphate reductase large subunit, Nucleoside diphosphate kinase A, Nucleoside diphosphate kinase 7, Ribonucleoside-diphosphate reductase M2 chain, Nucleoside diphosphate kinase B, Nucleoside diphosphate kinase 3, Nucleoside diphosphate kinase 6 and UMP-CMP kinase. [HMDB]. dCDP is found in many foods, some of which are oil palm, sweet bay, garden onion (variety), and italian sweet red pepper.
dCDP is a substrate for Uridine-cytidine kinase 1, Nucleoside diphosphate kinase (mitochondrial), Nucleoside diphosphate kinase homolog 5, Ribonucleoside-diphosphate reductase large subunit, Nucleoside diphosphate kinase A, Nucleoside diphosphate kinase 7, Ribonucleoside-diphosphate reductase M2 chain, Nucleoside diphosphate kinase B, Nucleoside diphosphate kinase 3, Nucleoside diphosphate kinase 6 and UMP-CMP kinase.
Acquisition and generation of the data is financially supported in part by CREST/JST.

同义名列表

27 个代谢物同义名

[({[(2R,3S,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid; 4-Amino-1-[2-deoxy-5-O-[hydroxy(phosphonooxy)phosphinyl]-beta-delta-erythro-pentofuranosyl]-2(1H)-pyrimidinone; 4-Amino-1-[2-deoxy-5-O-[hydroxy(phosphonooxy)phosphinyl]-beta-D-erythro-pentofuranosyl]-2(1H)-pyrimidinone; D-1beta-Ribofuranosylcytosine diphosphoric acid; delta-1beta-Ribofuranosylcytosine diphosphate; D-1Β-ribofuranosylcytosine diphosphoric acid; D-1b-Ribofuranosylcytosine diphosphoric acid; 2-Deoxycytidine-5-diphosphate sodium salt; D-1beta-Ribofuranosylcytosine diphosphate; D-1b-Ribofuranosylcytosine diphosphate; D-1Β-ribofuranosylcytosine diphosphate; 2-Deoxycytidine 5-diphosphoric acid; 2-Deoxycytidine diphosphate (dCDP); 2-Deoxycytidine diphosphoric acid; 2-Deoxy-cytidine 5-pyrophosphate; Deoxycytidine diphosphoric acid; 2-Deoxy-cytidine pyrophosphate; 2-Deoxycytidine-5-diphosphate; 2-Deoxycytidine 5-diphosphate; 2-Deoxycytidine diphosphate; Deoxycytidine 5-diphosphate; Deoxycytidine diphosphate; Deoxy-CDP; dCDP; Deoxycytidine-diphosphate; dCDP; 2'-Deoxycytidine 5'-diphosphate



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

29 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(1)

Plant Reactome(0)

INOH(3)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(22)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ALB, BGLAP, CMPK2, DCK, NME1, PNP, PNPT1, RBFOX3, TXN, TYMS
Peripheral membrane protein 1 PNPT1
Endoplasmic reticulum membrane 2 DOLK, PNPT1
Nucleus 9 ALB, DCK, GLRX, NME1, NUDT5, OMP, RBFOX3, TXN, TYMS
cytosol 13 ALB, CDA, DCK, GLRX, GSR, GUK1, NME1, NUDT5, OMP, PNP, PNPT1, TXN, TYMS
dendrite 1 BGLAP
centrosome 1 ALB
nucleoplasm 3 CMPK2, DCK, TXN
ruffle membrane 1 NME1
Multi-pass membrane protein 1 DOLK
Synapse 1 OMP
Golgi apparatus 1 ALB
mitochondrial inner membrane 1 TYMS
neuronal cell body 1 OMP
Cytoplasm, cytosol 1 GUK1
Membrane 2 DOLK, NME1
axon 1 OMP
extracellular exosome 8 ALB, BMP3, GLRX, GSR, NME1, NUDT5, PNP, TXN
endoplasmic reticulum 2 ALB, DOLK
extracellular space 4 ALB, BGLAP, BMP3, PNP
mitochondrion 6 CMPK2, DCK, GSR, GUK1, PNPT1, TYMS
protein-containing complex 1 ALB
Secreted 5 ALB, BGLAP, BMP3, PNP, TXN
extracellular region 6 ALB, BGLAP, BMP3, CDA, PNP, TXN
Mitochondrion matrix 2 PNPT1, TYMS
mitochondrial matrix 3 GSR, PNPT1, TYMS
anchoring junction 1 ALB
photoreceptor inner segment 1 GUK1
external side of plasma membrane 1 GSR
perikaryon 2 BGLAP, RBFOX3
Early endosome 1 NME1
vesicle 1 BGLAP
Mitochondrion inner membrane 1 TYMS
Mitochondrion intermembrane space 1 PNPT1
mitochondrial intermembrane space 1 PNPT1
ciliary basal body 1 ALB
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
ficolin-1-rich granule lumen 2 CDA, PNP
secretory granule lumen 2 CDA, PNP
Golgi lumen 1 BGLAP
endoplasmic reticulum lumen 2 ALB, BGLAP
platelet alpha granule lumen 1 ALB
tertiary granule lumen 1 CDA
ribosome 1 PNPT1
catalytic complex 1 PNPT1
ciliary transition fiber 1 ALB
mitochondrial degradosome 1 PNPT1


文献列表

  • J Taljanidisz, M Sasvari-Szekely, T Spasokutotskaja, F Antoni, M Staub. Reversible permeabilization of lymphocytes destroys the incorporation of deoxythymidine but not of deoxycytidine. Biochimica et biophysica acta. 1986 Mar; 885(3):266-71. doi: 10.1016/0167-4889(86)90241-7. [PMID: 3947681]
  • D R Narine, S Bacchetti, W W Chan. An assay for ribonucleotide reductase based on ion-exchange chromatography of the reaction product. Analytical biochemistry. 1985 Mar; 145(2):331-8. doi: 10.1016/0003-2697(85)90370-7. [PMID: 2990252]
  • W C SCHNEIDER. INTRACELLULAR DISTRIBUTION OF ENZYMES. XIII. ENZYMATIC SYNTHESIS OF DEOXYCYTIDINE DIPHOSPHATE CHOLINE AND LECITHIN IN RAT LIVER. The Journal of biological chemistry. 1963 Nov; 238(?):3572-8. doi: ". [PMID: 14109188]