Trilostane (BioDeep_00000002608)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(1S,2R,6R,8S,11S,12S,15S,16S)-5,15-dihydroxy-2,16-dimethyl-7-oxapentacyclo[9.7.0.0²,⁸.0⁶,⁸.0¹²,¹⁶]octadec-4-ene-4-carbonitrile

化学式: C20H27NO3 (329.1991)
中文名称: 曲洛司坦
谱图信息: 最多检出来源 Mus musculus(blood) 5.57%

分子结构信息

SMILES: CC12CCC3C(C1CCC2O)CCC45C3(CC(=C(C4O5)O)C#N)C
InChI: InChI=1S/C20H27NO3/c1-18-7-6-14-12(13(18)3-4-15(18)22)5-8-20-17(24-20)16(23)11(10-21)9-19(14,20)2/h12-15,17,22-23H,3-9H2,1-2H3/t12-,13-,14-,15-,17+,18-,19+,20+/m0/s1

描述信息

Trilostane is only found in individuals that have used or taken this drug. It is an inhibitor of 3 beta-hydroxysteroid dehydrogenase used in the treatment of Cushings syndrome. It was withdrawn from the United States market in April 1994. [Wikipedia]Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.
H - Systemic hormonal preparations, excl. sex hormones and insulins > H02 - Corticosteroids for systemic use > H02C - Antiadrenal preparations > H02CA - Anticorticosteroids
C471 - Enzyme Inhibitor > C54678 - Hydroxysteroid Dehydrogenase Inhibitor > C2184 - 3-Hydroxysteroid Dehydrogenase Inhibitor
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C274 - Antineoplastic Agent > C129818 - Antineoplastic Hormonal/Endocrine Agent > C481 - Antiestrogen
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C1740 - Aromatase Inhibitor
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist > C2355 - Anti-Adrenal
D012102 - Reproductive Control Agents > D000019 - Abortifacient Agents
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
D000970 - Antineoplastic Agents
D004791 - Enzyme Inhibitors
Same as: D01180

同义名列表

8 个代谢物同义名

(1S,2R,6R,8S,11S,12S,15S,16S)-5,15-dihydroxy-2,16-dimethyl-7-oxapentacyclo[9.7.0.0²,⁸.0⁶,⁸.0¹²,¹⁶]octadec-4-ene-4-carbonitrile; 4alpha,5-Epoxy-17beta-hydroxy-3-oxoandrostane-2-carbonitrile; Trilostanum; Trilostane; Trilostano; Modrenal; Desopan; Trilostane



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AR, HSD3B1, NR3C1, NR3C2, PGR, POMC, PRL
Peripheral membrane protein 2 CYP11A1, CYP11B2
Endoplasmic reticulum membrane 5 CYP17A1, CYP19A1, HSD3B1, NR3C2, STAR
Mitochondrion membrane 2 CYP11A1, CYP11B2
Nucleus 6 AR, ESR2, NR3C1, NR3C2, PGR, PRL
cytosol 5 AR, GPT, NR3C1, NR3C2, PGR
centrosome 1 NR3C1
nucleoplasm 6 AR, ESR2, NR3C1, NR3C2, PGR, PRL
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 2 FSHR, STAR
Multi-pass membrane protein 2 CYP19A1, FSHR
Synapse 1 NR3C1
Golgi membrane 1 INS
mitochondrial inner membrane 3 CYP11A1, CYP11B2, HSD3B1
neuronal cell body 1 CYP17A1
plasma membrane 5 AR, FSHR, PGR, REN, STAR
Membrane 7 AR, CYP11A1, CYP11B2, CYP19A1, FSHR, NR3C1, REN
axon 1 CYP17A1
extracellular exosome 2 GPT, HP
endoplasmic reticulum 3 CYP17A1, CYP19A1, HSD3B1
extracellular space 7 CGA, GNRH1, HP, INS, POMC, PRL, REN
mitochondrion 5 CYP11A1, CYP11B2, ESR2, NR3C1, STAR
protein-containing complex 2 AR, NR3C1
intracellular membrane-bounded organelle 2 ESR2, HSD3B1
Microsome membrane 2 CYP17A1, CYP19A1
Single-pass type I membrane protein 1 STAR
Secreted 6 CGA, HP, INS, POMC, PRL, REN
extracellular region 7 CGA, GNRH1, HP, INS, POMC, PRL, REN
mitochondrial outer membrane 1 PGR
mitochondrial matrix 3 CYP11A1, NR3C1, STAR
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 NR3C1
nucleolus 1 HSD3B1
apical part of cell 1 REN
Mitochondrion inner membrane 2 CYP11A1, CYP11B2
Cytoplasm, cytoskeleton, spindle 1 NR3C1
spindle 1 NR3C1
mitochondrial intermembrane space 2 HSD3B1, STAR
secretory granule 1 POMC
nuclear speck 2 AR, NR3C1
receptor complex 2 FSHR, NR3C2
chromatin 6 AR, ESR2, NR3C1, NR3C2, PGR, PRL
Chromosome 1 NR3C1
blood microparticle 1 HP
intercellular bridge 1 HSD3B1
endosome lumen 2 INS, PRL
Nucleus, nucleoplasm 1 NR3C1
Smooth endoplasmic reticulum membrane 1 HSD3B1
secretory granule lumen 2 INS, POMC
Golgi lumen 2 CGA, INS
endoplasmic reticulum lumen 1 INS
specific granule lumen 1 HP
tertiary granule lumen 1 HP
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
[Isoform Alpha]: Cytoplasm 1 NR3C1
endocytic vesicle lumen 1 HP
haptoglobin-hemoglobin complex 1 HP
follicle-stimulating hormone complex 1 CGA
pituitary gonadotropin complex 1 CGA
[Isoform Beta]: Nucleus 1 NR3C1
[Isoform Alpha-B]: Nucleus 1 NR3C1
[Isoform 4]: Mitochondrion outer membrane 1 PGR


文献列表

  • Stefania Golinelli, Viviani de Marco, Rodolfo Oliveira Leal, Andrea Barbarossa, Camilla Aniballi, Elisa Maietti, Antonio Maria Tardo, Sara Galac, Federico Fracassi. Comparison of methods to monitor dogs with hypercortisolism treated with trilostane. Journal of veterinary internal medicine. 2021 Nov; 35(6):2616-2627. doi: 10.1111/jvim.16269. [PMID: 34672018]
  • A Wehner, S Glöckner, B Weiss, D Ballhausen, C Stockhaus, Y Zablotski, K Hartmann. Association between ACTH stimulation test results and clinical signs in dogs with hyperadrenocorticism treated with trilostane. Veterinary journal (London, England : 1997). 2021 Oct; 276(?):105740. doi: 10.1016/j.tvjl.2021.105740. [PMID: 34416401]
  • Akiko Yuno, Yoshiyuki Kenmotsu, Yuka Takahashi, Hiroshi Nomoto, Hiraku Kameda, Kyu Yong Cho, Akinobu Nakamura, Yu Yamashita, Junichi Nakamura, Sho Nakakubo, Keisuke Kamada, Masaru Suzuki, Hirokazu Sugino, Naoko Inoshita, Satoshi Konno, Hideaki Miyoshi, Tatsuya Atsumi, Yutaka Sawamura, Akira Shimatsu. Successful management of a patient with active Cushing's disease complicated with coronavirus disease 2019 (COVID-19) pneumonia. Endocrine journal. 2021 Apr; 68(4):477-484. doi: 10.1507/endocrj.ej20-0613. [PMID: 33361650]
  • Carolina Arenas Bermejo, Dolores Pérez Alenza, Paula García San José, Lidia Llauet, Laura Pérez-López, Carlos Melián, Edward C Feldman. Laboratory assessment of trilostane treatment in dogs with pituitary-dependent hyperadrenocorticism. Journal of veterinary internal medicine. 2020 Jul; 34(4):1413-1422. doi: 10.1111/jvim.15830. [PMID: 32533623]
  • Sungin Lee, Aeri Lee, Suh-Hyun Chai, Seulji Lee, Oh-Kyeong Kweon, Wan Hee Kim. Ectopic Cushing's syndrome associated with a pheochromocytoma in a dog: a case report. BMC veterinary research. 2020 Feb; 16(1):35. doi: 10.1186/s12917-020-2244-7. [PMID: 32014021]
  • Ga-Won Lee, Cho-Rong Yoo, Dan Lee, Hee-Myung Park. Favorable outcome of pheochromocytoma in a dog with atypical Cushing's syndrome and diabetes mellitus following medical treatment: a case report. BMC veterinary research. 2020 Jan; 16(1):3. doi: 10.1186/s12917-019-2225-x. [PMID: 31900158]
  • Nadja Sieber-Ruckstuhl, Elena Salesov, Saskia Quante, Barbara Riond, Katharina Rentsch, Regina Hofmann-Lehmann, Claudia Reusch, Felicitas Boretti. Effects of Trilostane on urinary Catecholamines and their metabolites in dogs with Hypercortisolism. BMC veterinary research. 2017 Sep; 13(1):279. doi: 10.1186/s12917-017-1187-0. [PMID: 28870207]
  • K-H Kim, S-M Han, K-O Jeon, H-T Kim, Q Li, M-O Ryu, W-J Song, S-C Park, H-Y Youn. Clinical Relationship between Cholestatic Disease and Pituitary-Dependent Hyperadrenocorticism in Dogs: A Retrospective Case Series. Journal of veterinary internal medicine. 2017 Mar; 31(2):335-342. doi: 10.1111/jvim.14608. [PMID: 28064467]
  • Sungjun Noh, Hye-Sun Kim, Jinhwa Chang, Ji-Houn Kang, Dongwoo Chang, Mhan-Pyo Yang. Serum cholecystokinin concentrations in dogs with naturally acquired pituitary-dependent hyperadrenocorticism. American journal of veterinary research. 2016 Oct; 77(10):1101-7. doi: 10.2460/ajvr.77.10.1101. [PMID: 27668581]
  • Takahiro Teshima, Hirotaka Matsumoto, Tomoko Okusa, Rion Uchiyama, Hidekazu Koyama. Carbenoxolone Disodium Treatment for Canine Pituitary-Dependent Hyperadrenocorticism. PloS one. 2016; 11(11):e0166267. doi: 10.1371/journal.pone.0166267. [PMID: 27824928]
  • J N Midence, K J Drobatz, R S Hess. Cortisol Concentrations in Well-Regulated Dogs with Hyperadrenocorticism Treated with Trilostane. Journal of veterinary internal medicine. 2015 Nov; 29(6):1529-33. doi: 10.1111/jvim.13615. [PMID: 26374943]
  • Anna Janeczko, Jana Oklestkova, Ondrej Novak, Katarzyna Śniegowska-Świerk, Zuzanna Snaczke, Ewa Pociecha. Disturbances in production of progesterone and their implications in plant studies. Steroids. 2015 Apr; 96(?):153-63. doi: 10.1016/j.steroids.2015.01.025. [PMID: 25676788]
  • F Fracassi, S Corradini, D Floriano, A Boari, G Aste, M Pietra, P F Bergamini, F Dondi. Prognostic factors for survival in dogs with pituitary-dependent hypercortisolism treated with trilostane. The Veterinary record. 2015 Jan; 176(2):49. doi: 10.1136/vr.102546. [PMID: 25170036]
  • C M Bonadio, E C Feldman, T A Cohen, P H Kass. Comparison of adrenocorticotropic hormone stimulation test results started 2 versus 4 hours after trilostane administration in dogs with naturally occurring hyperadrenocorticism. Journal of veterinary internal medicine. 2014 Jul; 28(4):1239-43. doi: 10.1111/jvim.12357. [PMID: 24863172]
  • K-D Cho, J Paek, J-H Kang, D Chang, K-J Na, M-P Yang. Serum adipokine concentrations in dogs with naturally occurring pituitary-dependent hyperadrenocorticism. Journal of veterinary internal medicine. 2014 Mar; 28(2):429-36. doi: 10.1111/jvim.12270. [PMID: 24372863]
  • L E Reid, E N Behrend, L G Martin, R J Kemppainen, C R Ward, J C Lurye, T C Donovan, H P Lee. Effect of trilostane and mitotane on aldosterone secretory reserve in dogs with pituitary-dependent hyperadrenocorticism. Journal of veterinary internal medicine. 2014 Mar; 28(2):443-50. doi: 10.1111/jvim.12276. [PMID: 24400747]
  • C Griebsch, C Lehnert, G J Williams, K Failing, R Neiger. Effect of trilostane on hormone and serum electrolyte concentrations in dogs with pituitary-dependent hyperadrenocorticism. Journal of veterinary internal medicine. 2014 Jan; 28(1):160-5. doi: 10.1111/jvim.12268. [PMID: 24341822]
  • A M Mellett Keith, D Bruyette, S Stanley. Trilostane therapy for treatment of spontaneous hyperadrenocorticism in cats: 15 cases (2004-2012). Journal of veterinary internal medicine. 2013 Nov; 27(6):1471-7. doi: 10.1111/jvim.12178. [PMID: 24011349]
  • C Arenas, C Melián, M D Pérez-Alenza. Evaluation of 2 trilostane protocols for the treatment of canine pituitary-dependent hyperadrenocorticism: twice daily versus once daily. Journal of veterinary internal medicine. 2013 Nov; 27(6):1478-85. doi: 10.1111/jvim.12207. [PMID: 24118316]
  • K-D Cho, J-H Kang, D Chang, K-J Na, M-P Yang. Efficacy of low- and high-dose trilostane treatment in dogs (< 5 kg) with pituitary-dependent hyperadrenocorticism. Journal of veterinary internal medicine. 2013 Jan; 27(1):91-8. doi: 10.1111/jvim.12007. [PMID: 23167780]
  • Nicole B Schreiber, Leon J Spicer. Effects of fibroblast growth factor 9 (FGF9) on steroidogenesis and gene expression and control of FGF9 mRNA in bovine granulosa cells. Endocrinology. 2012 Sep; 153(9):4491-501. doi: 10.1210/en.2012-1003. [PMID: 22798350]
  • P M Y Smets, H P Lefebvre, B P Meij, S Croubels, E Meyer, I Van de Maele, S Daminet. Long-term follow-up of renal function in dogs after treatment for ACTH-dependent hyperadrenocorticism. Journal of veterinary internal medicine. 2012 May; 26(3):565-74. doi: 10.1111/j.1939-1676.2012.00915.x. [PMID: 22463105]
  • Julie Espallergues, Takayoshi Mamiya, Monique Vallée, Takenao Koseki, Toshitaka Nabeshima, Jamal Temsamani, Claude Laruelle, Tangui Maurice. The antidepressant-like effects of the 3β-hydroxysteroid dehydrogenase inhibitor trilostane in mice is related to changes in neuroactive steroid and monoamine levels. Neuropharmacology. 2012 Jan; 62(1):492-502. doi: 10.1016/j.neuropharm.2011.09.005. [PMID: 21945799]
  • Gerald T Ankley, Jenna E Cavallin, Elizabeth J Durhan, Kathleen M Jensen, Michael D Kahl, Elizabeth A Makynen, Dalma Martinovic-Weigelt, Leah C Wehmas, Daniel L Villeneuve. Temporal evaluation of effects of a model 3β-hydroxysteroid dehydrogenase inhibitor on endocrine function in the fathead minnow. Environmental toxicology and chemistry. 2011 Sep; 30(9):2094-102. doi: 10.1002/etc.593. [PMID: 21671258]
  • J de Gier, C H J Wolthers, S Galac, A C Okkens, H S Kooistra. Effects of the 3β-hydroxysteroid dehydrogenase inhibitor trilostane on luteal progesterone production in the dog. Theriogenology. 2011 Apr; 75(7):1271-9. doi: 10.1016/j.theriogenology.2010.11.041. [PMID: 21295836]
  • Daisuke Mori, Naotaka Ogino, Tomohiro Yonezawa, Mitsumori Kawaminami, Shiro Kurusu. Anti-ovulatory effects of RU486 and trilostane involve impaired cyclooxygenase-2 expression and mitotic activity of follicular granulosa cells in rats. Prostaglandins & other lipid mediators. 2011 Apr; 94(3-4):118-23. doi: 10.1016/j.prostaglandins.2011.02.002. [PMID: 21376132]
  • G McLauchlan, C Knottenbelt, M Augusto, J Helm, Y McGrotty, I Ramsey. Retrospective evaluation of the effect of trilostane on insulin requirement and fructosamine concentration in eight diabetic dogs with hyperadrenocorticism. The Journal of small animal practice. 2010 Dec; 51(12):642-8. doi: 10.1111/j.1748-5827.2010.01005.x. [PMID: 21121919]
  • A Arteaga, N K Dhand, T McCann, C M Knottenbelt, A J Tebb, H Evans, P David Eckersall, I K Ramsey. Monitoring the response of canine hyperadrenocorticism to trilostane treatment by assessment of acute phase protein concentrations. The Journal of small animal practice. 2010 Apr; 51(4):204-9. doi: 10.1111/j.1748-5827.2009.00863.x. [PMID: 20406368]
  • Ian K Ramsey. Trilostane in dogs. The Veterinary clinics of North America. Small animal practice. 2010 Mar; 40(2):269-83. doi: 10.1016/j.cvsm.2009.10.008. [PMID: 20219488]
  • Sara Galac, Jenny J C W M Buijtels, Jan A Mol, Hans S Kooistra. Effects of trilostane on the pituitary-adrenocortical and renin-aldosterone axis in dogs with pituitary-dependent hypercortisolism. Veterinary journal (London, England : 1997). 2010 Jan; 183(1):75-80. doi: 10.1016/j.tvjl.2008.10.007. [PMID: 19042143]
  • S Galac, J J C W M Buijtels, H S Kooistra. Urinary corticoid: creatinine ratios in dogs with pituitary-dependent hypercortisolism during trilostane treatment. Journal of veterinary internal medicine. 2009 Nov; 23(6):1214-9. doi: 10.1111/j.1939-1676.2009.0374.x. [PMID: 19709356]
  • Julie Espallergues, Laurent Givalois, Jamal Temsamani, Claude Laruelle, Tangui Maurice. The 3beta-hydroxysteroid dehydrogenase inhibitor trilostane shows antidepressant properties in mice. Psychoneuroendocrinology. 2009 Jun; 34(5):644-59. doi: 10.1016/j.psyneuen.2008.11.003. [PMID: 19117688]
  • Takahiro Teshima, Yasushi Hara, Susumu Takekoshi, Yoshinori Nezu, Yasuji Harada, Takuya Yogo, Akira Teramoto, Robert Y Osamura, Masahiro Tagawa. Trilostane-induced inhibition of cortisol secretion results in reduced negative feedback at the hypothalamic-pituitary axis. Domestic animal endocrinology. 2009 Jan; 36(1):32-44. doi: 10.1016/j.domaniend.2008.10.002. [PMID: 19041802]
  • N S Sieber-Ruckstuhl, F S Boretti, M Wenger, C Maser-Gluth, C E Reusch. Serum concentrations of cortisol and cortisone in healthy dogs and dogs with pituitary-dependent hyperadrenocorticism treated with trilostane. The Veterinary record. 2008 Oct; 163(16):477-81. doi: 10.1136/vr.163.16.477. [PMID: 18931355]
  • Daniel L Villeneuve, Lindsey S Blake, Jeffrey D Brodin, Jenna E Cavallin, Elizabeth J Durhan, Kathleen M Jensen, Michael D Kahl, Elizabeth A Makynen, Dalma Martinovic, Nathaniel D Mueller, Gerald T Ankley. Effects of a 3beta-hydroxysteroid dehydrogenase inhibitor, trilostane, on the fathead minnow reproductive axis. Toxicological sciences : an official journal of the Society of Toxicology. 2008 Jul; 104(1):113-23. doi: 10.1093/toxsci/kfn073. [PMID: 18397916]
  • B Peijie, D Zicai, W Tian. Changes of cytosol glucocorticoid receptor and renal Na(+)-K(+)-ATPase activity after swimming training in rat. The Journal of sports medicine and physical fitness. 2007 Jun; 47(2):246-9. doi: . [PMID: 17557067]
  • Qinglei Li, Fermin Jimenez-Krassel, Anilkumar Bettegowda, James J Ireland, George W Smith. Evidence that the preovulatory rise in intrafollicular progesterone may not be required for ovulation in cattle. The Journal of endocrinology. 2007 Mar; 192(3):473-83. doi: 10.1677/joe-06-0020. [PMID: 17332517]
  • Ling-Ling Chang, Alfred Wan-Song Wun, Chien-Te Hung, Shih-Min Hsia, Wenchang Chiang, Paulus S Wang. Effects of crude adlay hull acetone extract on corticosterone release from rat zona fasciculata-reticularis cells. Naunyn-Schmiedeberg's archives of pharmacology. 2006 Nov; 374(2):141-52. doi: 10.1007/s00210-006-0094-x. [PMID: 17019563]
  • N S Sieber-Ruckstuhl, F S Boretti, M Wenger, C Maser-Gluth, C E Reusch. Cortisol, aldosterone, cortisol precursor, androgen and endogenous ACTH concentrations in dogs with pituitary-dependant hyperadrenocorticism treated with trilostane. Domestic animal endocrinology. 2006 Jul; 31(1):63-75. doi: 10.1016/j.domaniend.2005.09.004. [PMID: 16233969]
  • Mary Iruthayanathan, Yi-Hong Zhou, Gwen V Childs. Dehydroepiandrosterone restoration of growth hormone gene expression in aging female rats, in vivo and in vitro: evidence for actions via estrogen receptors. Endocrinology. 2005 Dec; 146(12):5176-87. doi: 10.1210/en.2005-0811. [PMID: 16150906]
  • A J Tebb, A Arteaga, H Evans, I K Ramsey. Canine hyperadrenocorticism: effects of trilostane on parathyroid hormone, calcium and phosphate concentrations. The Journal of small animal practice. 2005 Nov; 46(11):537-42. doi: 10.1111/j.1748-5827.2005.tb00283.x. [PMID: 16300115]
  • Y L McGrotty, A Arteaga, C M Knottenbelt, I K Ramsey, P D Eckersall. Haptoglobin concentrations in dogs undergoing trilostane treatment for hyperadrenocorticism. Veterinary clinical pathology. 2005 Sep; 34(3):255-8. doi: 10.1111/j.1939-165x.2005.tb00050.x. [PMID: 16134074]
  • N S Jain, K Hirani, C T Chopde. Reversal of caffeine-induced anxiety by neurosteroid 3-alpha-hydroxy-5-alpha-pregnane-20-one in rats. Neuropharmacology. 2005 Apr; 48(5):627-38. doi: 10.1016/j.neuropharm.2004.11.016. [PMID: 15814098]
  • Elise P Gomez-Sanchez, Jacqueline Samuel, Gaston Vergara, Naveed Ahmad. Effect of 3beta-hydroxysteroid dehydrogenase inhibition by trilostane on blood pressure in the Dahl salt-sensitive rat. American journal of physiology. Regulatory, integrative and comparative physiology. 2005 Feb; 288(2):R389-93. doi: 10.1152/ajpregu.00441.2004. [PMID: 15458970]
  • Monique Wenger, Nadja S Sieber-Ruckstuhl, Claudia Müller, Claudia E Reusch. Effect of trilostane on serum concentrations of aldosterone, cortisol, and potassium in dogs with pituitary-dependent hyperadrenocorticism. American journal of veterinary research. 2004 Sep; 65(9):1245-50. doi: 10.2460/ajvr.2004.65.1245. [PMID: 15478772]
  • A K Boag, R Neiger, D B Church. Trilostane treatment of bilateral adrenal enlargement and excessive sex steroid hormone production in a cat. The Journal of small animal practice. 2004 May; 45(5):263-6. doi: 10.1111/j.1748-5827.2004.tb00234.x. [PMID: 15163055]
  • C M McGowan, R Frost, D U Pfeiffer, R Neiger. Serum insulin concentrations in horses with equine Cushing's syndrome: response to a cortisol inhibitor and prognostic value. Equine veterinary journal. 2004 Apr; 36(3):295-8. doi: 10.2746/0425164044877288. [PMID: 15147141]
  • Ling-Ling Chang, Wan-Song Alfred Wun, L Low-Tone Ho, Paulus S Wang. Effects of dehydroepiandrosterone on corticosterone release in rat zona fasciculata-reticularis cells. Naunyn-Schmiedeberg's archives of pharmacology. 2003 Dec; 368(6):487-95. doi: 10.1007/s00210-003-0846-9. [PMID: 14615881]
  • Paul Micevych, Kevin Sinchak, Richard H Mills, Leslie Tao, Philip LaPolt, John K H Lu. The luteinizing hormone surge is preceded by an estrogen-induced increase of hypothalamic progesterone in ovariectomized and adrenalectomized rats. Neuroendocrinology. 2003 Jul; 78(1):29-35. doi: 10.1159/000071703. [PMID: 12869797]
  • J M Eastwood, C M Elwood, K J Hurley. Trilostane treatment of a dog with functional adrenocortical neoplasia. The Journal of small animal practice. 2003 Mar; 44(3):126-31. doi: 10.1111/j.1748-5827.2003.tb00133.x. [PMID: 12653328]
  • Utpal Sen, Dola Mukherjee, S P Bhattacharyya, Dilip Mukherjee. Seasonal changes in plasma steroid levels in Indian major carp Labeo rohita: influence of homologous pituitary extract on steroid production and development of oocyte maturational competence. General and comparative endocrinology. 2002 Sep; 128(2):123-34. doi: 10.1016/s0016-6480(02)00060-6. [PMID: 12392685]
  • P A le Roux, S K Tregoning, P M Zinn, Z M van der Spuy. Inhibition of progesterone secretion with trilostane for mid-trimester termination of pregnancy: randomized controlled trials. Human reproduction (Oxford, England). 2002 Jun; 17(6):1483-9. doi: 10.1093/humrep/17.6.1483. [PMID: 12042266]
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