Butabarbital (BioDeep_00000002338)

 

Secondary id: BioDeep_00000406122

human metabolite blood metabolite


代谢物信息卡片


2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-(1-methylpropyl)-, monosodium salt

化学式: C10H16N2O3 (212.1161)
中文名称: 仲丁巴比妥, 巴比妥
谱图信息: 最多检出来源 Homo sapiens(plant) 14.74%

分子结构信息

SMILES: CCC(C)C1(C(=O)NC(=O)NC1=O)CC
InChI: InChI=1S/C10H16N2O3/c1-4-6(3)10(5-2)7(13)11-9(15)12-8(10)14/h6H,4-5H2,1-3H3,(H2,11,12,13,14,15)

描述信息

Butabarbital (trade name Butisol) is a prescription barbiturate sleep aid. Butabarbital has a particularly fast onset of effects and short duration of action compared to other barbiturates, which makes it useful for certain applications such as treating severe insomnia and relieving anxiety before surgical procedures; however it is also relatively dangerous particularly when combined with alcohol, and so is now rarely used, although it is still prescribed in some Eastern European and South American countries. Its short duration of action gives butabarbital a high abuse potential, comparable to secobarbital. [Wikipedia]
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C67084 - Barbiturate

同义名列表

29 个代谢物同义名

2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-(1-methylpropyl)-, monosodium salt; 5-Ethyl-5-(1-methylpropyl)-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-Sec-butyl-5-ethylpyrimidine-2,4,6(1H,3H,5H)-trione; 5-Sec-butyl-5-ethyl-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-(butan-2-yl)-5-ethyl-1,3-diazinane-2,4,6-trione; 5-Ethyl-5-(1-methylpropyl)barbituric acid; Halsey drug brand OF butabarbital sodium; 5-Ethyl-5-(1-methylpropyl)barbitic acid; Wallace brand OF butabarbital sodium; 5-Ethyl-5-(1-methylpropyl)barbitate; 5-Sec-butyl-5-ethylbarbituric acid; 5-Sec-butyl-5-ethylbarbitic acid; 5-Sec-butyl-5-ethylbarbitate; Secbutabarbital sodium; Sodium butabarbital; Butabarbital sodium; Secbutobarbitone; Secbutobarbital; Secbutabarbital; Butisol sodium; Butabarbitone; Secbubarbital; butabarbital; Secumalum; Sarisol; Butrate; Butisol; Butabarbital; Butabarbital



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 AXIN2, CASP3, GAPDH, GGPS1, POMC, XDH
Nucleus 3 AXIN2, CASP3, GAPDH
cytosol 8 AVP, AXIN2, CASP3, GAPDH, GGPS1, LEP, SST, XDH
dendrite 1 AVP
trans-Golgi network 1 GRN
centrosome 1 AXIN2
nucleoplasm 3 ATP2B1, CASP3, GGPS1
Cell membrane 2 ATP2B1, GPRC5A
Multi-pass membrane protein 2 ATP2B1, GPRC5A
Synapse 1 ATP2B1
glutamatergic synapse 3 ATP2B1, CASP3, GHRL
Golgi apparatus 1 GRN
Golgi membrane 1 INS
lysosomal membrane 1 GRN
neuronal cell body 2 CASP3, SST
postsynapse 1 GHRL
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 1 GAPDH
Lysosome 1 GRN
endosome 1 GRN
plasma membrane 7 ATP2B1, AXIN2, GAPDH, GCG, GPRC5A, GRN, REN
synaptic vesicle membrane 1 ATP2B1
Membrane 4 ATP2B1, GAPDH, GRN, REN
axon 1 GHRL
basolateral plasma membrane 1 ATP2B1
extracellular exosome 5 ATP2B1, GAPDH, GPRC5A, GRN, LYZ
endoplasmic reticulum 1 GRN
extracellular space 12 AVP, GCG, GHRL, GNRH1, GRN, INS, LEP, LYZ, POMC, REN, SST, XDH
perinuclear region of cytoplasm 2 GAPDH, GGPS1
Schaffer collateral - CA1 synapse 1 GHRL
intracellular membrane-bounded organelle 3 ATP2B1, GAPDH, GPRC5A
postsynaptic density 1 CASP3
Secreted 9 AVP, GCG, GHRL, GRN, INS, LEP, POMC, REN, SST
extracellular region 11 AVP, GCG, GHRL, GNRH1, GRN, INS, LEP, LYZ, POMC, REN, SST
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
nuclear membrane 1 GAPDH
neuronal dense core vesicle lumen 1 GHRL
Z disc 1 GGPS1
beta-catenin destruction complex 1 AXIN2
microtubule cytoskeleton 1 GAPDH
nucleolus 1 GPRC5A
apical part of cell 1 REN
vesicle 2 GAPDH, GPRC5A
Cytoplasm, perinuclear region 2 GAPDH, GGPS1
Cytoplasm, cytoskeleton 1 GAPDH
GABA-ergic synapse 1 SST
Peroxisome 1 XDH
sarcoplasmic reticulum 1 XDH
secretory granule 2 AVP, POMC
lateral plasma membrane 1 ATP2B1
Late endosome 1 GRN
receptor complex 1 GPRC5A
cell projection 1 ATP2B1
cytoskeleton 1 GAPDH
Basolateral cell membrane 1 ATP2B1
endosome lumen 1 INS
Lipid droplet 1 GAPDH
Cytoplasmic vesicle membrane 1 GPRC5A
Presynaptic cell membrane 1 ATP2B1
Cytoplasm, myofibril, sarcomere, Z line 1 GGPS1
secretory granule lumen 4 GCG, GHRL, INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 GCG, GHRL, INS
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
transport vesicle 1 INS
azurophil granule lumen 2 GRN, LYZ
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ATP2B1
neuronal dense core vesicle 2 AVP, SST
clathrin-coated endocytic vesicle membrane 1 AVP
ribonucleoprotein complex 1 GAPDH
death-inducing signaling complex 1 CASP3
GAIT complex 1 GAPDH
[Glucagon-like peptide 1]: Secreted 1 GCG
photoreceptor ribbon synapse 1 ATP2B1


文献列表

  • Y Martín-Biosca, S Sagrado, R M Villaneuva-Camañas, M J Medina-Hernández. Determination of barbiturates in urine by micellar liquid chromatography and direct injection of sample. Journal of pharmaceutical and biomedical analysis. 1999 Nov; 21(2):331-8. doi: 10.1016/s0731-7085(99)00147-8. [PMID: 10703988]