C17:0 (BioDeep_00000229650)

Main id: BioDeep_00000018500

 

human metabolite PANOMIX_OTCML-2023 BioNovoGene_Lab2019 Volatile Flavor Compounds natural product


代谢物信息卡片


HEPTADECANOIC ACID

化学式: C17H34O2 (270.2558664)
中文名称: 十七碳酸, 十七烷酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CCCCCCC)CCCCCCCCC(=O)O
InChI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)

描述信息

Heptadecanoic acid is an odd chain saturated fatty acid (OCS-FA). Heptadecanoic acid is associated with several diseases, including the incidence of coronary heart disease, prediabetes and type 2 diabetes as well as multiple sclerosis[1].
Heptadecanoic acid is an odd chain saturated fatty acid (OCS-FA). Heptadecanoic acid is associated with several diseases, including the incidence of coronary heart disease, prediabetes and type 2 diabetes as well as multiple sclerosis[1].

同义名列表

9 个代谢物同义名

HEPTADECANOIC ACID; Heptadecylic acid; Margarinic acid; Daturinic acid; Margaric acid; Daturic acid; FA 17:0; C17:0; Heptadecanoic acid



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

387 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Christopher A Bishop, Tina Machate, Janin Henkel, Matthias B Schulze, Susanne Klaus, Karolin Piepelow. Heptadecanoic Acid Is Not a Key Mediator in the Prevention of Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice. Nutrients. 2023 Apr; 15(9):. doi: 10.3390/nu15092052. [PMID: 37432205]
  • Youssef Khalil, Sara Carrino, Fujun Lin, Anna Ferlin, Heena V Lad, Francesca Mazzacuva, Sara Falcone, Natalie Rivers, Gareth Banks, Danilo Concas, Carlos Aguilar, Andrew R Haynes, Andy Blease, Thomas Nicol, Raya Al-Shawi, Wendy Heywood, Paul Potter, Kevin Mills, Daniel P Gale, Peter T Clayton. Tissue Proteome of 2-Hydroxyacyl-CoA Lyase Deficient Mice Reveals Peroxisome Proliferation and Activation of ω-Oxidation. International journal of molecular sciences. 2022 Jan; 23(2):. doi: 10.3390/ijms23020987. [PMID: 35055171]
  • Xiao Gai, Peng Qian, Benqiong Guo, Yixin Zheng, Zhihao Fu, Decai Yang, Chunmei Zhu, Yang Cao, Jingbin Niu, Jianghong Ling, Jin Zhao, Hailian Shi, Guoping Liu. Heptadecanoic acid and pentadecanoic acid crosstalk with fecal-derived gut microbiota are potential non-invasive biomarkers for chronic atrophic gastritis. Frontiers in cellular and infection microbiology. 2022; 12(?):1064737. doi: 10.3389/fcimb.2022.1064737. [PMID: 36699724]
  • Kathy Trieu, Saiuj Bhat, Zhaoli Dai, Karin Leander, Bruna Gigante, Frank Qian, Andres V Ardisson Korat, Qi Sun, Xiong-Fei Pan, Federica Laguzzi, Tommy Cederholm, Ulf de Faire, Mai-Lis Hellénius, Jason H Y Wu, Ulf Risérus, Matti Marklund. Biomarkers of dairy fat intake, incident cardiovascular disease, and all-cause mortality: A cohort study, systematic review, and meta-analysis. PLoS medicine. 2021 09; 18(9):e1003763. doi: 10.1371/journal.pmed.1003763. [PMID: 34547017]
  • Mary Catherine Sawh, Martina Wallace, Emma Shapiro, Nidhi P Goyal, Kimberly P Newton, Elizabeth L Yu, Craig Bross, Janis Durelle, Cynthia Knott, Jon A Gangoiti, Bruce A Barshop, Jivani M Gengatharan, Noah Meurs, Alexandra Schlein, Michael S Middleton, Claude B Sirlin, Christian M Metallo, Jeffrey B Schwimmer. Dairy Fat Intake, Plasma Pentadecanoic Acid, and Plasma Iso-heptadecanoic Acid Are Inversely Associated With Liver Fat in Children. Journal of pediatric gastroenterology and nutrition. 2021 04; 72(4):e90-e96. doi: 10.1097/mpg.0000000000003040. [PMID: 33399331]
  • Linda E T Vissers, Sabita S Soedamah-Muthu, Yvonne T van der Schouw, Nicolaas P A Zuithoff, Johanna M Geleijnse, Ivonne Sluijs. Consumption of a diet high in dairy leads to higher 15:0 in cholesteryl esters of healthy people when compared to diets high in meat and grain. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2020 05; 30(5):804-809. doi: 10.1016/j.numecd.2020.01.006. [PMID: 32139254]
  • Chuanhui Xu, Chuanshang Cheng, Xiu Zhang, Jian Peng. Inclusion of Soluble Fiber in the Gestation Diet Changes the Gut Microbiota, Affects Plasma Propionate and Odd-Chain Fatty Acids Levels, and Improves Insulin Sensitivity in Sows. International journal of molecular sciences. 2020 Jan; 21(2):. doi: 10.3390/ijms21020635. [PMID: 31963640]
  • M Slim, C Ha, C A Vanstone, S N Morin, E Rahme, H A Weiler. Evaluation of plasma and erythrocyte fatty acids C15:0, t-C16:1n-7 and C17:0 as biomarkers of dairy fat consumption in adolescents. Prostaglandins, leukotrienes, and essential fatty acids. 2019 10; 149(?):24-29. doi: 10.1016/j.plefa.2019.07.007. [PMID: 31421524]
  • Luis O Romero, Andrew E Massey, Alejandro D Mata-Daboin, Francisco J Sierra-Valdez, Subhash C Chauhan, Julio F Cordero-Morales, Valeria Vásquez. Dietary fatty acids fine-tune Piezo1 mechanical response. Nature communications. 2019 03; 10(1):1200. doi: 10.1038/s41467-019-09055-7. [PMID: 30867417]
  • Fumiaki Imamura, Amanda Fretts, Matti Marklund, Andres V Ardisson Korat, Wei-Sin Yang, Maria Lankinen, Waqas Qureshi, Catherine Helmer, Tzu-An Chen, Kerry Wong, Julie K Bassett, Rachel Murphy, Nathan Tintle, Chaoyu Ian Yu, Ingeborg A Brouwer, Kuo-Liong Chien, Alexis C Frazier-Wood, Liana C Del Gobbo, Luc Djoussé, Johanna M Geleijnse, Graham G Giles, Janette de Goede, Vilmundur Gudnason, William S Harris, Allison Hodge, Frank Hu, Albert Koulman, Markku Laakso, Lars Lind, Hung-Ju Lin, Barbara McKnight, Kalina Rajaobelina, Ulf Risérus, Jennifer G Robinson, Cécilia Samieri, David S Siscovick, Sabita S Soedamah-Muthu, Nona Sotoodehnia, Qi Sun, Michael Y Tsai, Matti Uusitupa, Lynne E Wagenknecht, Nick J Wareham, Jason Hy Wu, Renata Micha, Nita G Forouhi, Rozenn N Lemaitre, Dariush Mozaffarian. Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies. PLoS medicine. 2018 10; 15(10):e1002670. doi: 10.1371/journal.pmed.1002670. [PMID: 30303968]
  • Marcia C de Oliveira Otto, Rozenn N Lemaitre, Xiaoling Song, Irena B King, David S Siscovick, Dariush Mozaffarian. Serial measures of circulating biomarkers of dairy fat and total and cause-specific mortality in older adults: the Cardiovascular Health Study. The American journal of clinical nutrition. 2018 09; 108(3):476-484. doi: 10.1093/ajcn/nqy117. [PMID: 30007304]
  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • Kayo Kurotani, Palitha Karunapema, Kapila Jayaratne, Masao Sato, Takuya Hayashi, Hiroshi Kajio, Shoji Fukuda, Hisao Hara, Osamu Okazaki, Achala Upendra Jayatilleke, Daisuke Nonaka, Mitsuhiko Noda, Tetsuya Mizoue. Circulating odd-chain saturated fatty acids were associated with arteriosclerosis among patients with diabetes, dyslipidemia, or hypertension in Sri Lanka but not Japan. Nutrition research (New York, N.Y.). 2018 02; 50(?):82-93. doi: 10.1016/j.nutres.2017.12.004. [PMID: 29540275]
  • Benjamin Jenkins, Evelyn de Schryver, Paul P. Van Veldhoven, Albert Koulman. Peroxisomal 2-Hydroxyacyl-CoA Lyase Is Involved in Endogenous Biosynthesis of Heptadecanoic Acid. Molecules (Basel, Switzerland). 2017 10; 22(10):. doi: 10.3390/molecules22101718. [PMID: 29027957]
  • Karolin Weitkunat, Sara Schumann, Daniela Nickel, Silke Hornemann, Klaus J Petzke, Matthias B Schulze, Andreas Fh Pfeiffer, Susanne Klaus. Odd-chain fatty acids as a biomarker for dietary fiber intake: a novel pathway for endogenous production from propionate. The American journal of clinical nutrition. 2017 06; 105(6):1544-1551. doi: 10.3945/ajcn.117.152702. [PMID: 28424190]
  • Lei Yin, Kevin Shengyang Yu, Kun Lu, Xiaozhong Yu. Benzyl butyl phthalate promotes adipogenesis in 3T3-L1 preadipocytes: A High Content Cellomics and metabolomic analysis. Toxicology in vitro : an international journal published in association with BIBRA. 2016 Apr; 32(?):297-309. doi: 10.1016/j.tiv.2016.01.010. [PMID: 26820058]
  • Benjamin Jenkins, James A West, Albert Koulman. A review of odd-chain fatty acid metabolism and the role of pentadecanoic Acid (c15:0) and heptadecanoic Acid (c17:0) in health and disease. Molecules (Basel, Switzerland). 2015 Jan; 20(2):2425-44. doi: 10.3390/molecules20022425. [PMID: 25647578]
  • Stephanie K Venn-Watson, Celeste Parry, Mark Baird, Sacha Stevenson, Kevin Carlin, Risa Daniels, Cynthia R Smith, Richard Jones, Randall S Wells, Sam Ridgway, Eric D Jensen. Increased Dietary Intake of Saturated Fatty Acid Heptadecanoic Acid (C17:0) Associated with Decreasing Ferritin and Alleviated Metabolic Syndrome in Dolphins. PloS one. 2015; 10(7):e0132117. doi: 10.1371/journal.pone.0132117. [PMID: 26200116]
  • Mohammad Y Yakoob, Peilin Shi, Frank B Hu, Hannia Campos, Kathryn M Rexrode, E John Orav, Walter C Willett, Dariush Mozaffarian. Circulating biomarkers of dairy fat and risk of incident stroke in U.S. men and women in 2 large prospective cohorts. The American journal of clinical nutrition. 2014 Dec; 100(6):1437-47. doi: 10.3945/ajcn.114.083097. [PMID: 25411278]
  • H T Cho, L Salvia-Trujillo, J Kim, Y Park, H Xiao, D J McClements. Droplet size and composition of nutraceutical nanoemulsions influences bioavailability of long chain fatty acids and Coenzyme Q10. Food chemistry. 2014 Aug; 156(?):117-22. doi: 10.1016/j.foodchem.2014.01.084. [PMID: 24629946]
  • Mario Kratz, Santica Marcovina, James E Nelson, Matthew M Yeh, Kris V Kowdley, Holly S Callahan, Xiaoling Song, Chongzhi Di, Kristina M Utzschneider. Dairy fat intake is associated with glucose tolerance, hepatic and systemic insulin sensitivity, and liver fat but not β-cell function in humans. The American journal of clinical nutrition. 2014 Jun; 99(6):1385-96. doi: 10.3945/ajcn.113.075457. [PMID: 24740208]
  • Yekun Yang, Enming Miao, Yongqin Geng, Yuling Wei, Jicang Xu, Xuemei Li, Zhongtao Ding, Jun Zhou. [Pyrolysis of the Lysimachia foenum-graecum Hance extract by online pyrolysis-gas chromatography-mass spectrometry]. Se pu = Chinese journal of chromatography. 2014 May; 32(5):547-52. doi: 10.3724/sp.j.1123.2013.11049. [PMID: 25185319]
  • Virginia A Stallings, John T Mondick, Joan I Schall, Jeffrey S Barrett, Martha Wilson, Maria R Mascarenhas. Diagnosing malabsorption with systemic lipid profiling: pharmacokinetics of pentadecanoic acid and triheptadecanoic acid following oral administration in healthy subjects and subjects with cystic fibrosis. International journal of clinical pharmacology and therapeutics. 2013 Apr; 51(4):263-73. doi: 10.5414/cp201793. [PMID: 23357842]
  • Rokayya Sami, Jiang Lianzhou, Li Yang, Ying Ma, Jing Jing. Evaluation of fatty acid and amino acid compositions in okra (Abelmoschus esculentus) grown in different geographical locations. BioMed research international. 2013; 2013(?):574283. doi: 10.1155/2013/574283. [PMID: 24171167]
  • Hua Liang Liu, Zhi Jie Yin, Li Xiao, Yi Nong Xu, Le Qing Qu. Identification and evaluation of ω-3 fatty acid desaturase genes for hyperfortifying α-linolenic acid in transgenic rice seed. Journal of experimental botany. 2012 May; 63(8):3279-87. doi: 10.1093/jxb/ers051. [PMID: 22378946]
  • Edgar Weigand, Christine Boesch-Saadatmandi. Interaction between marginal zinc and high fat supply on lipid metabolism and growth of weanling rats. Lipids. 2012 Mar; 47(3):291-302. doi: 10.1007/s11745-011-3629-y. [PMID: 22127571]
  • James R Petrie, Thomas Vanhercke, Pushkar Shrestha, Anna El Tahchy, Adam White, Xue-Rong Zhou, Qing Liu, Maged P Mansour, Peter D Nichols, Surinder P Singh. Recruiting a new substrate for triacylglycerol synthesis in plants: the monoacylglycerol acyltransferase pathway. PloS one. 2012; 7(4):e35214. doi: 10.1371/journal.pone.0035214. [PMID: 22523576]
  • David C Nieman, Nicholas D Gillitt, Dru A Henson, Wei Sha, R Andrew Shanely, Amy M Knab, Lynn Cialdella-Kam, Fuxia Jin. Bananas as an energy source during exercise: a metabolomics approach. PloS one. 2012; 7(5):e37479. doi: 10.1371/journal.pone.0037479. [PMID: 22616015]
  • Simon J Evans, Alan R Prossin, Gloria J Harrington, Masoud Kamali, Vicki L Ellingrod, Charles F Burant, Melvin G McInnis. Fats and factors: lipid profiles associate with personality factors and suicidal history in bipolar subjects. PloS one. 2012; 7(1):e29297. doi: 10.1371/journal.pone.0029297. [PMID: 22253709]
  • Katharina Effenberger-Neidnicht, Sandra Breyer, Katharina Mahal, Florenz Sasse, Rainer Schobert. Modification of uptake and subcellular distribution of doxorubicin by N-acylhydrazone residues as visualised by intrinsic fluorescence. Cancer chemotherapy and pharmacology. 2012 Jan; 69(1):85-90. doi: 10.1007/s00280-011-1675-z. [PMID: 21607555]
  • Piyachat Chansela, Naoko Goto-Inoue, Nobuhiro Zaima, Takahiro Hayasaka, Morakot Sroyraya, Napamanee Kornthong, Attakorn Engsusophon, Montakan Tamtin, Chatchawalee Chaisri, Prasert Sobhon, Mitsutoshi Setou. Composition and localization of lipids in Penaeus merguiensis ovaries during the ovarian maturation cycle as revealed by imaging mass spectrometry. PloS one. 2012; 7(3):e33154. doi: 10.1371/journal.pone.0033154. [PMID: 22432001]
  • F Agostini, R A Bertussi, G Agostini, A C Atti Dos Santos, M Rossato, R Vanderlinde. Supercritical extraction from vinification residues: fatty acids, α-tocopherol, and phenolic compounds in the oil seeds from different varieties of grape. TheScientificWorldJournal. 2012; 2012(?):790486. doi: 10.1100/2012/790486. [PMID: 22593706]
  • Tao Ke, Caihua Dong, Han Mao, Yingzhong Zhao, Hong Chen, Hongyan Liu, Xuyan Dong, Chaobo Tong, Shengyi Liu. Analysis of expression sequence tags from a full-length-enriched cDNA library of developing sesame seeds (Sesamum indicum). BMC plant biology. 2011 Dec; 11(?):180. doi: 10.1186/1471-2229-11-180. [PMID: 22195973]
  • Saki Kakutani, Yoshiyuki Ishikura, Norifumi Tateishi, Chika Horikawa, Hisanori Tokuda, Masanori Kontani, Hiroshi Kawashima, Yutaka Sakakibara, Yoshinobu Kiso, Hiroshi Shibata, Ikuo Morita. Supplementation of arachidonic acid-enriched oil increases arachidonic acid contents in plasma phospholipids, but does not increase their metabolites and clinical parameters in Japanese healthy elderly individuals: a randomized controlled study. Lipids in health and disease. 2011 Dec; 10(?):241. doi: 10.1186/1476-511x-10-241. [PMID: 22188761]
  • Janine Hellenbrand, Eva-Maria Biester, Jens Gruber, Mats Hamberg, Margrit Frentzen. Fatty acyl-CoA reductases of birds. BMC biochemistry. 2011 Dec; 12(?):64. doi: 10.1186/1471-2091-12-64. [PMID: 22151413]
  • Huifen Wang, Lyn M Steffen, Bengt Vessby, Samar Basu, Julia Steinberger, Antoinette Moran, David R Jacobs, Ching-Ping Hong, Alan R Sinaiko. Obesity modifies the relations between serum markers of dairy fats and inflammation and oxidative stress among adolescents. Obesity (Silver Spring, Md.). 2011 Dec; 19(12):2404-10. doi: 10.1038/oby.2011.234. [PMID: 21779090]
  • Jinah Hwang, Yun-Hee Chang, Jung Hwa Park, Soo Yeon Kim, Haeyon Chung, Eugene Shim, Hye Jin Hwang. Dietary saturated and monounsaturated fats protect against acute acetaminophen hepatotoxicity by altering fatty acid composition of liver microsomal membrane in rats. Lipids in health and disease. 2011 Oct; 10(?):184. doi: 10.1186/1476-511x-10-184. [PMID: 22011590]
  • Jennifer T Smilowitz, Michelle M Wiest, Dorothy Teegarden, Michael B Zemel, J Bruce German, Marta D Van Loan. Dietary fat and not calcium supplementation or dairy product consumption is associated with changes in anthropometrics during a randomized, placebo-controlled energy-restriction trial. Nutrition & metabolism. 2011 Oct; 8(?):67. doi: 10.1186/1743-7075-8-67. [PMID: 21970320]
  • Jason W Holder, Jil C Ulrich, Anthony C DeBono, Paul A Godfrey, Christopher A Desjardins, Jeremy Zucker, Qiandong Zeng, Alex L B Leach, Ion Ghiviriga, Christine Dancel, Thomas Abeel, Dirk Gevers, Chinnappa D Kodira, Brian Desany, Jason P Affourtit, Bruce W Birren, Anthony J Sinskey. Comparative and functional genomics of Rhodococcus opacus PD630 for biofuels development. PLoS genetics. 2011 Sep; 7(9):e1002219. doi: 10.1371/journal.pgen.1002219. [PMID: 21931557]
  • Vincent J T van Ginneken, Johannes P F G Helsper, Willem de Visser, Herman van Keulen, Willem A Brandenburg. Polyunsaturated fatty acids in various macroalgal species from North Atlantic and tropical seas. Lipids in health and disease. 2011 Jun; 10(?):104. doi: 10.1186/1476-511x-10-104. [PMID: 21696609]
  • Xiao-Hong Yu, Richa Rawat, John Shanklin. Characterization and analysis of the cotton cyclopropane fatty acid synthase family and their contribution to cyclopropane fatty acid synthesis. BMC plant biology. 2011 May; 11(?):97. doi: 10.1186/1471-2229-11-97. [PMID: 21612656]
  • Maria E Estrany, Ana M Proenza, Isabel Lladó, Magdalena Gianotti. Isocaloric intake of a high-fat diet modifies adiposity and lipid handling in a sex dependent manner in rats. Lipids in health and disease. 2011 Apr; 10(?):52. doi: 10.1186/1476-511x-10-52. [PMID: 21486445]
  • Michael J Shipston. Ion channel regulation by protein palmitoylation. The Journal of biological chemistry. 2011 Mar; 286(11):8709-16. doi: 10.1074/jbc.r110.210005. [PMID: 21216969]
  • Miki Sagara, Marina Njelekela, Takanori Teramoto, Takashi Taguchi, Mari Mori, Lesley Armitage, Nina Birt, Christopher Birt, Yukio Yamori. Effects of docosahexaenoic Acid supplementation on blood pressure, heart rate, and serum lipids in Scottish men with hypertension and hypercholesterolemia. International journal of hypertension. 2011 Mar; 2011(?):809198. doi: 10.4061/2011/809198. [PMID: 21423683]
  • David P Macfarlane, Xiantong Zou, Ruth Andrew, Nicholas M Morton, Dawn E W Livingstone, Rebecca L Aucott, Moffat J Nyirenda, John P Iredale, Brian R Walker. Metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency: implications for the pathogenesis of steatohepatitis. American journal of physiology. Endocrinology and metabolism. 2011 Feb; 300(2):E402-9. doi: 10.1152/ajpendo.00331.2010. [PMID: 21119028]
  • Mélanie Plourde, Raphaël Chouinard-Watkins, Milène Vandal, Ying Zhang, Peter Lawrence, J Thomas Brenna, Stephen C Cunnane. Plasma incorporation, apparent retroconversion and β-oxidation of 13C-docosahexaenoic acid in the elderly. Nutrition & metabolism. 2011 Jan; 8(?):5. doi: 10.1186/1743-7075-8-5. [PMID: 21272363]
  • Fatma Hümeyra Yerlikaya, Idris Mehmetoglu, Sevil Kurban, Zeki Tonbul. Plasma fatty acid composition in continuous ambulatory peritoneal dialysis patients: an increased omega-6/omega-3 ratio and deficiency of essential fatty acids. Renal failure. 2011; 33(8):819-23. doi: 10.3109/0886022x.2011.601831. [PMID: 21793790]
  • Oliver Fiehn, W Timothy Garvey, John W Newman, Kerry H Lok, Charles L Hoppel, Sean H Adams. Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. PloS one. 2010 Dec; 5(12):e15234. doi: 10.1371/journal.pone.0015234. [PMID: 21170321]
  • Bibi Rafeiza Khan, Bethany K Zolman. pex5 Mutants that differentially disrupt PTS1 and PTS2 peroxisomal matrix protein import in Arabidopsis. Plant physiology. 2010 Dec; 154(4):1602-15. doi: 10.1104/pp.110.162479. [PMID: 20974890]
  • Pasqualina Magliano, Dominique Sanglard, Yves Poirier. Repercussion of a deficiency in mitochondrial ß-oxidation on the carbon flux of short-chain fatty acids to the peroxisomal ß-oxidation cycle in Aspergillus nidulans. Biochimica et biophysica acta. 2010 Dec; 1801(12):1386-92. doi: 10.1016/j.bbalip.2010.08.008. [PMID: 20736083]
  • Pere Domingo, Javier Torres-Torronteras, Virginia Pomar, Marta Giralt, Joan Carles Domingo, Maria Del Mar Gutierrez, José M Gallego-Escuredo, Maria Gracia Mateo, Pedro Cano-Soldado, Irene Fernandez, Marçal Pastor-Anglada, Francesc Vidal, Francesc Villarroya, Antoni Andreu, Ramon Marti. Uridine metabolism in HIV-1-infected patients: effect of infection, of antiretroviral therapy and of HIV-1/ART-associated lipodystrophy syndrome. PloS one. 2010 Nov; 5(11):e13896. doi: 10.1371/journal.pone.0013896. [PMID: 21085568]
  • Owen Jeffries, Nina Geiger, Iain C M Rowe, Lijun Tian, Heather McClafferty, Lie Chen, Danlei Bi, Hans Guenther Knaus, Peter Ruth, Michael J Shipston. Palmitoylation of the S0-S1 linker regulates cell surface expression of voltage- and calcium-activated potassium (BK) channels. The Journal of biological chemistry. 2010 Oct; 285(43):33307-33314. doi: 10.1074/jbc.m110.153940. [PMID: 20693285]
  • Frédéric Domergue, Sollapura J Vishwanath, Jérôme Joubès, Jasmine Ono, Jennifer A Lee, Matthieu Bourdon, Reem Alhattab, Christine Lowe, Stéphanie Pascal, René Lessire, Owen Rowland. Three Arabidopsis fatty acyl-coenzyme A reductases, FAR1, FAR4, and FAR5, generate primary fatty alcohols associated with suberin deposition. Plant physiology. 2010 Aug; 153(4):1539-54. doi: 10.1104/pp.110.158238. [PMID: 20571114]
  • Etienne Croteau, Eric Lavallée, Sébastien M Labbe, Laurent Hubert, Fabien Pifferi, Jacques A Rousseau, Stephen C Cunnane, André C Carpentier, Roger Lecomte, François Bénard. Image-derived input function in dynamic human PET/CT: methodology and validation with 11C-acetate and 18F-fluorothioheptadecanoic acid in muscle and 18F-fluorodeoxyglucose in brain. European journal of nuclear medicine and molecular imaging. 2010 Aug; 37(8):1539-50. doi: 10.1007/s00259-010-1443-z. [PMID: 20437239]
  • Yunbao Liu, Muraleedharan G Nair. An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds. Journal of natural products. 2010 Jul; 73(7):1193-5. doi: 10.1021/np1000945. [PMID: 20565070]
  • Daniel Hess, Jeffrey W Chisholm, R Ariel Igal. Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells. PloS one. 2010 Jun; 5(6):e11394. doi: 10.1371/journal.pone.0011394. [PMID: 20613975]
  • Teresa Domínguez, M Luisa Hernández, Joyce C Pennycooke, Pedro Jiménez, José Manuel Martínez-Rivas, Carlos Sanz, Eric J Stockinger, José J Sánchez-Serrano, Maite Sanmartín. Increasing omega-3 desaturase expression in tomato results in altered aroma profile and enhanced resistance to cold stress. Plant physiology. 2010 Jun; 153(2):655-65. doi: 10.1104/pp.110.154815. [PMID: 20382895]
  • Wenjuan Xu, Yuhong Huang, Longxing Wang, Qianxu Yang, Hongbin Xiao, Deqin Zhang. [Classification of diabetes deficiency syndromes based on plasma fatty acid metabolic profilings using precolumn derivatization quantitative method]. Se pu = Chinese journal of chromatography. 2010 Jun; 28(6):547-50. doi: 10.3724/sp.j.1123.2010.00547. [PMID: 20873573]
  • Martin Hajduch, Leonard B Hearne, Jan A Miernyk, Jill E Casteel, Trupti Joshi, Ganesh K Agrawal, Zhao Song, Mingyi Zhou, Dong Xu, Jay J Thelen. Systems analysis of seed filling in Arabidopsis: using general linear modeling to assess concordance of transcript and protein expression. Plant physiology. 2010 Apr; 152(4):2078-87. doi: 10.1104/pp.109.152413. [PMID: 20118269]
  • Laurent Beck, Christine Leroy, Sarah Beck-Cormier, Anne Forand, Christine Salaün, Nadine Paris, Adeline Bernier, Pablo Ureña-Torres, Dominique Prié, Mario Ollero, Laure Coulombel, Gérard Friedlander. The phosphate transporter PiT1 (Slc20a1) revealed as a new essential gene for mouse liver development. PloS one. 2010 Feb; 5(2):e9148. doi: 10.1371/journal.pone.0009148. [PMID: 20161774]
  • Kelly M Wynalda, Robert C Murphy. Low-concentration ozone reacts with plasmalogen glycerophosphoethanolamine lipids in lung surfactant. Chemical research in toxicology. 2010 Jan; 23(1):108-17. doi: 10.1021/tx900306p. [PMID: 19916514]
  • Long Nam Nguyen, David Trofa, Joshua D Nosanchuk. Fatty acid synthase impacts the pathobiology of Candida parapsilosis in vitro and during mammalian infection. PloS one. 2009 Dec; 4(12):e8421. doi: 10.1371/journal.pone.0008421. [PMID: 20027295]
  • Mario Kallenbach, Ian T Baldwin, Gustavo Bonaventure. A rapid and sensitive method for the simultaneous analysis of aliphatic and polar molecules containing free carboxyl groups in plant extracts by LC-MS/MS. Plant methods. 2009 Nov; 5(?):17. doi: 10.1186/1746-4811-5-17. [PMID: 19939243]
  • Jedrzej Szymanski, Szymon Jozefczuk, Zoran Nikoloski, Joachim Selbig, Victoria Nikiforova, Gareth Catchpole, Lothar Willmitzer. Stability of metabolic correlations under changing environmental conditions in Escherichia coli--a systems approach. PloS one. 2009 Oct; 4(10):e7441. doi: 10.1371/journal.pone.0007441. [PMID: 19829699]
  • Natalia Scaglia, Jeffrey W Chisholm, R Ariel Igal. Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK. PloS one. 2009 Aug; 4(8):e6812. doi: 10.1371/journal.pone.0006812. [PMID: 19710915]
  • Amandine Brochot, Marine Guinot, Daniel Auchere, Jean-Paul Macaire, Pierre Weill, Alain Grynberg, Delphine Rousseau-Ralliard. Effects of alpha-linolenic acid vs. docosahexaenoic acid supply on the distribution of fatty acids among the rat cardiac subcellular membranes after a short- or long-term dietary exposure. Nutrition & metabolism. 2009 Mar; 6(?):14. doi: 10.1186/1743-7075-6-14. [PMID: 19320987]
  • Adelheid Kratzer, Marlene Buchebner, Thomas Pfeifer, Tatjana M Becker, Georg Uray, Makoto Miyazaki, Shinobu Miyazaki-Anzai, Birgit Ebner, Prakash G Chandak, Rajendra S Kadam, Emine Calayir, Nora Rathke, Helmut Ahammer, Branislav Radovic, Michael Trauner, Gerald Hoefler, Uday B Kompella, Guenter Fauler, Moshe Levi, Sanja Levak-Frank, Gerhard M Kostner, Dagmar Kratky. Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia. Journal of lipid research. 2009 Feb; 50(2):312-26. doi: 10.1194/jlr.m800376-jlr200. [PMID: 18812595]
  • Cinzia Scambi, Lucia De Franceschi, Patrizia Guarini, Fabio Poli, Angela Siciliano, Patrizia Pattini, Andrea Biondani, Valentina La Verde, Oscar Bortolami, Francesco Turrini, Franco Carta, Ciro D'Orazio, Baroukh M Assael, Giovanni Faccini, Lisa M Bambara. Preliminary evidence for cell membrane amelioration in children with cystic fibrosis by 5-MTHF and vitamin B12 supplementation: a single arm trial. PloS one. 2009; 4(3):e4782. doi: 10.1371/journal.pone.0004782. [PMID: 19277125]
  • Suzan Wopereis, Carina M Rubingh, Marjan J van Erk, Elwin R Verheij, Trinette van Vliet, Nicole H P Cnubben, Age K Smilde, Jan van der Greef, Ben van Ommen, Henk F J Hendriks. Metabolic profiling of the response to an oral glucose tolerance test detects subtle metabolic changes. PloS one. 2009; 4(2):e4525. doi: 10.1371/journal.pone.0004525. [PMID: 19242536]
  • Antonis Kourtidis, Rekha Srinivasaiah, Richard D Carkner, M Julia Brosnan, Douglas S Conklin. Peroxisome proliferator-activated receptor-gamma protects ERBB2-positive breast cancer cells from palmitate toxicity. Breast cancer research : BCR. 2009; 11(2):R16. doi: 10.1186/bcr2240. [PMID: 19298655]
  • Helen J Atherton, Melanie K Gulston, Nigel J Bailey, Kian-Kai Cheng, Wen Zhang, Kieran Clarke, Julian L Griffin. Metabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse. Molecular systems biology. 2009; 5(?):259. doi: 10.1038/msb.2009.18. [PMID: 19357638]
  • Xiaohui Yuan, Tuong Chi Ta, Min Lin, Jane R Evans, Yinchen Dong, Eugene Bolotin, Mark A Sherman, Barry M Forman, Frances M Sladek. Identification of an endogenous ligand bound to a native orphan nuclear receptor. PloS one. 2009; 4(5):e5609. doi: 10.1371/journal.pone.0005609. [PMID: 19440305]
  • Chizuko Maruyama, Megumi Yoneyama, Noriko Suyama, Kasuya Yoshimi, Ai Teramoto, Yuka Sakaki, Yasuyo Suto, Kei Takahashi, Risa Araki, Yuko Ishizaka, Minoru Yamakado, Tamio Teramoto. Differences in serum phospholipid fatty acid compositions and estimated desaturase activities between Japanese men with and without metabolic syndrome. Journal of atherosclerosis and thrombosis. 2008 Dec; 15(6):306-13. doi: 10.5551/jat.e564. [PMID: 19060426]
  • Marina Moraitou, Evangelia Dimitriou, Dimitrios Zafeiriou, Constantina Reppa, Theodoros Marinakis, Jasmin Sarafidou, Helen Michelakakis. Plasmalogen levels in Gaucher disease. Blood cells, molecules & diseases. 2008 Sep; 41(2):196-9. doi: 10.1016/j.bcmd.2008.03.007. [PMID: 18501647]
  • Stefanie Wienkoop, Katja Morgenthal, Florian Wolschin, Matthias Scholz, Joachim Selbig, Wolfram Weckwerth. Integration of metabolomic and proteomic phenotypes: analysis of data covariance dissects starch and RFO metabolism from low and high temperature compensation response in Arabidopsis thaliana. Molecular & cellular proteomics : MCP. 2008 Sep; 7(9):1725-36. doi: 10.1074/mcp.m700273-mcp200. [PMID: 18445580]
  • Kevin S Jones, Alexander P Alimov, Horacio L Rilo, Ronald J Jandacek, Laura A Woollett, W Todd Penberthy. A high throughput live transparent animal bioassay to identify non-toxic small molecules or genes that regulate vertebrate fat metabolism for obesity drug development. Nutrition & metabolism. 2008 Aug; 5(?):23. doi: 10.1186/1743-7075-5-23. [PMID: 18752667]
  • Andrew Rowland, David J Elliot, Kathleen M Knights, Peter I Mackenzie, John O Miners. The 'albumin effect' and in vitro-in vivo extrapolation: sequestration of long-chain unsaturated fatty acids enhances phenytoin hydroxylation by human liver microsomal and recombinant cytochrome P450 2C9. Drug metabolism and disposition: the biological fate of chemicals. 2008 May; 36(5):870-7. doi: 10.1124/dmd.107.019885. [PMID: 18256202]
  • Naomi E Allen, Philip B Grace, Annette Ginn, Ruth C Travis, Andrew W Roddam, Paul N Appleby, Timothy Key. Phytanic acid: measurement of plasma concentrations by gas-liquid chromatography-mass spectrometry analysis and associations with diet and other plasma fatty acids. The British journal of nutrition. 2008 Mar; 99(3):653-9. doi: 10.1017/s000711450782407x. [PMID: 17868488]
  • Raja Noor Zaliha Raja Abd Rahman, Thean Chor Leow, Abu Bakar Salleh, Mahiran Basri. Geobacillus zalihae sp. nov., a thermophilic lipolytic bacterium isolated from palm oil mill effluent in Malaysia. BMC microbiology. 2007 Aug; 7(?):77. doi: 10.1186/1471-2180-7-77. [PMID: 17692114]
  • Trent Stellingwerff, Hanneke Boon, Annemie P Gijsen, Jos H C H Stegen, Harm Kuipers, Luc J C van Loon. Carbohydrate supplementation during prolonged cycling exercise spares muscle glycogen but does not affect intramyocellular lipid use. Pflugers Archiv : European journal of physiology. 2007 Jul; 454(4):635-47. doi: 10.1007/s00424-007-0236-0. [PMID: 17333244]
  • Melanie G Cree, Bradley R Newcomer, David N Herndon, Ting Qian, Dayoung Sun, Beatrice Morio, Jennifer J Zwetsloot, G Lynis Dohm, Ricki Y Fram, Ronald P Mlcak, Asle Aarsland, Robert R Wolfe. PPAR-alpha agonism improves whole body and muscle mitochondrial fat oxidation, but does not alter intracellular fat concentrations in burn trauma children in a randomized controlled trial. Nutrition & metabolism. 2007 Apr; 4(?):9. doi: 10.1186/1743-7075-4-9. [PMID: 17451602]
  • Amy E Griel, Penny M Kris-Etherton, Kirsten F Hilpert, Guixiang Zhao, Sheila G West, Rebecca L Corwin. An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans. Nutrition journal. 2007 Jan; 6(?):2. doi: 10.1186/1475-2891-6-2. [PMID: 17227589]
  • Seiichi Shirasawa, Makoto Shiota, Hiroshi Arakawa, Yasuhiko Shigematsu, Kazuhisa Yokomizo, Noriko Shionoya, Takahisa Okamoto, Yousuke Miyazaki, Shigeyuki Takahashi, Katsuichi Himata. [Quantitative determination of trans-fatty acids in oils and fats by capillary gas chromatography: results of a JOCS collaborative study]. Journal of oleo science. 2007; 56(8):405-15. doi: 10.5650/jos.56.405. [PMID: 17898507]
  • Ibrahim A Alsarra, William G Brockmann, Michael L Cunningham, Mostafa Z Badr. Hepatocellular proliferation in response to agonists of peroxisome proliferator-activated receptor alpha: a role for Kupffer cells?. Journal of carcinogenesis. 2006 Nov; 5(?):26. doi: 10.1186/1477-3163-5-26. [PMID: 17129391]
  • Yan-Qing Gong, Hong Yang, Yun Liu, Ai-Qun Liang, Zheng-Tao Wang, Luo-Shan Xu, Zhi-Bi Hu. [Studies on chemical constituents in stem of Dendrobium chrysotoxum]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2006 Feb; 31(4):304-6. doi: ". [PMID: 16706020]
  • A Brevik, M B Veierød, C A Drevon, L F Andersen. Evaluation of the odd fatty acids 15:0 and 17:0 in serum and adipose tissue as markers of intake of milk and dairy fat. European journal of clinical nutrition. 2005 Dec; 59(12):1417-22. doi: 10.1038/sj.ejcn.1602256. [PMID: 16118654]
  • Mohamed Fayaz, K K Namitha, K N Chidambara Murthy, M Mahadeva Swamy, R Sarada, Salma Khanam, P V Subbarao, G A Ravishankar. Chemical composition, iron bioavailability, and antioxidant activity of Kappaphycus alvarezzi (Doty). Journal of agricultural and food chemistry. 2005 Feb; 53(3):792-7. doi: 10.1021/jf0493627. [PMID: 15686435]
  • Yong-Qiang Zhang, Matthias Brock, Nancy P Keller. Connection of propionyl-CoA metabolism to polyketide biosynthesis in Aspergillus nidulans. Genetics. 2004 Oct; 168(2):785-94. doi: 10.1534/genetics.104.027540. [PMID: 15514053]
  • Eva Warensjö, Jan-Håkan Jansson, Lars Berglund, Kurt Boman, Bo Ahrén, Lars Weinehall, Bernt Lindahl, Göran Hallmans, Bengt Vessby. Estimated intake of milk fat is negatively associated with cardiovascular risk factors and does not increase the risk of a first acute myocardial infarction. A prospective case-control study. The British journal of nutrition. 2004 Apr; 91(4):635-42. doi: 10.1079/bjn20041080. [PMID: 15035691]
  • Xing-Jie Liang, Jun-Jie Yin, Jien-Wei Zhou, Paul C Wang, Barbara Taylor, Carol Cardarelli, Michael Kozar, Raynard Forte, Adorjan Aszalos, Michael M Gottesman. Changes in biophysical parameters of plasma membranes influence cisplatin resistance of sensitive and resistant epidermal carcinoma cells. Experimental cell research. 2004 Feb; 293(2):283-91. doi: 10.1016/j.yexcr.2003.10.012. [PMID: 14729466]
  • Michiyo Tomita, Rodney C Baker, Soichiro Ando, Thomas J Santoro. Arachidonoyl-phospholipid remodeling in proliferating murine T cells. Lipids in health and disease. 2004 Jan; 3(?):1. doi: 10.1186/1476-511x-3-1. [PMID: 14754461]
  • D L Sparkes, G L Robinson, H Dunstan, T K Roberts. Plasma cholesterol levels and Irlen syndrome: preliminary study of 10- to 17-yr.-old students. Perceptual and motor skills. 2003 Dec; 97(3 Pt 1):743-52. doi: 10.2466/pms.2003.97.3.743. [PMID: 14738334]
  • José M Hernández-Pérez, Eduard Cabré, Lourdes Fluvià, Agata Motos, Cruz Pastor, August Corominas, Miquel A Gassull. Improved method for gas chromatographic-mass spectrometric analysis of 1-(13)C-labeled long-chain fatty acids in plasma samples. Clinical chemistry. 2002 Jun; 48(6 Pt 1):906-12. doi: 10.1093/clinchem/48.6.906. [PMID: 12029007]
  • L Byberg, A Smedman, B Vessby, H Lithell. Plasminogen activator inhibitor-1 and relations to fatty acid composition in the diet and in serum cholesterol esters. Arteriosclerosis, thrombosis, and vascular biology. 2001 Dec; 21(12):2086-92. doi: 10.1161/hq1201.100224. [PMID: 11742889]
  • A Wolk, M Furuheim, B Vessby. Fatty acid composition of adipose tissue and serum lipids are valid biological markers of dairy fat intake in men. The Journal of nutrition. 2001 Mar; 131(3):828-33. doi: 10.1093/jn/131.3.828. [PMID: 11238766]
  • L Allenbach, Y Poirier. Analysis of the alternative pathways for the beta-oxidation of unsaturated fatty acids using transgenic plants synthesizing polyhydroxyalkanoates in peroxisomes. Plant physiology. 2000 Nov; 124(3):1159-68. doi: 10.1104/pp.124.3.1159. [PMID: 11080293]
  • M I Vega, M R Cuenca, E Rodríguez, D Callieri. Identification of heptadecanoic and C19 cyclopropane fatty acids in the lipid fraction of Zymomonas mobilis. Current microbiology. 2000 Oct; 41(4):305-6. doi: 10.1007/s002840010139. [PMID: 10977901]
  • N Araki, S Horiuchi, A T Rahim, K Takata, Y Morino. Microquantification of cholesterol and cholesteryl esters in rat peritoneal macrophages by reverse-phase high-performance liquid chromatography. Analytical biochemistry. 1990 Mar; 185(2):339-45. doi: 10.1016/0003-2697(90)90305-s. [PMID: 2339790]
  • A Dasgupta, M A Kenny, S Ahmad. Abnormal fatty acid profile in chronic hemodialysis patients: possible deficiency of essential fatty acids. Clinical physiology and biochemistry. 1990; 8(5):238-43. doi: NULL. [PMID: 2129482]