Mycobutin (BioDeep_00000002027)
代谢物信息卡片
72559-06-9
化学式: C46H62N4O11 (846.4415)
中文名称: 利福布汀
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C=CC=C(C(=O)N=C2C(=C3C(=C4C2=NC5(N4)CCN(CC5)CC(C)C)C6=C(C(=C3O)C)OC(C6=O)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)O)C
InChI: InChI=1S/C46H62N4O11/c1-22(2)21-50-18-16-46(17-19-50)48-34-31-32-39(54)28(8)42-33(31)43(56)45(10,61-42)59-20-15-30(58-11)25(5)41(60-29(9)51)27(7)38(53)26(6)37(52)23(3)13-12-14-24(4)44(57)47-36(40(32)55)35(34)49-46/h12-15,20,22-23,25-27,30,37-38,41,48,52-55H,16-19,21H2,1-11H3/b13-12+,20-15+,24-14-,47-36?/t23-,25+,26+,27+,30-,37-,38+,41+,45-/m0/s1
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D000995 - Antitubercular Agents
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D012294 - Rifamycins
C254 - Anti-Infective Agent > C52588 - Antibacterial Agent > C280 - Antitubercular Agent
同义名列表
4 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- KEGG: C07235
- PubChem: 136968143
- PubChem: 135398743
- Metlin: METLIN2304
- DrugBank: DB00615
- MeSH: Rifabutin
- CAS: 72559-06-9
- PMhub: MS000001703
- ChEBI: CHEBI:45367
- PubChem: 9444
- KNApSAcK: C00027872
- PDB-CCD: RBT
- NIKKAJI: J342.306I
- KNApSAcK: 45367
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lorena Valverde-Fraga, Razan Haddad, Nasr Alrabadi, Sandra Sánchez, Carmen Remuñán-López, Noemi Csaba. Design and in vitro assessment of chitosan nanocapsules for the pulmonary delivery of rifabutin.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2023 Aug; 187(?):106484. doi:
10.1016/j.ejps.2023.106484. [PMID: 37268092] - Zhi Kai Guo, Yong Chao Wang, Ying Zi Tan, Ailiman Abulaizi, Zi Jun Xiong, Shi Qing Zhang, Yang Yang, La Ying Yang, Jing Shi. Nagimycins A and B, Antibacterial Ansamycin-Related Macrolactams from Streptomyces sp. NA07423.
Organic letters.
2023 06; 25(22):4203-4207. doi:
10.1021/acs.orglett.3c01539. [PMID: 37232514] - Kevin Antraygues, Mathieu Maingot, Birgit Schellhorn, Vincent Trebosc, Marc Gitzinger, Benoit Deprez, Olivier Defert, Glenn E Dale, Marilyne Bourotte, Sergio Lociuro, Nicolas Willand. Design and synthesis of water-soluble prodrugs of rifabutin for intraveneous administration.
European journal of medicinal chemistry.
2022 Aug; 238(?):114515. doi:
10.1016/j.ejmech.2022.114515. [PMID: 35691174] - Leslie Y Chiang, Brett Baumann, Kamila Romanowski, Divjot Kumar, Jonathon R Campbell, Ognjenka Djurdjev, Muhammad Morshed, Inna Sekirov, Victoria J Cook, Adeera Levin, James C Johnston. Latent Tuberculosis Therapy Outcomes in Dialysis Patients: A Retrospective Cohort.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2021 05; 77(5):696-703. doi:
10.1053/j.ajkd.2020.06.017. [PMID: 32818551] - A Gomila-Grange, S Pérez-Recio, D Camprubí-Ferrer, L Lladó, A Fava, E García-Romero, M D Grijota-Camino, N Sabé, M Santin. Rifabutin for treating tuberculosis in solid organ transplant recipients: A retrospective observational study and literature review.
Transplant infectious disease : an official journal of the Transplantation Society.
2021 Apr; 23(2):e13471. doi:
10.1111/tid.13471. [PMID: 32959494] - Holly E Rawizza, Regina Oladokun, Emeka Ejeliogu, Stephen Oguche, Babatunde O Ogunbosi, Oche Agbaji, Georgina Odaibo, Godwin Imade, David Olaleye, Lubbe Wiesner, Kristin M Darin, Prosper Okonkwo, Phyllis J Kanki, Kimberly K Scarsi, Helen M McIlleron. Rifabutin pharmacokinetics and safety among TB/HIV-coinfected children receiving lopinavir/ritonavir-containing second-line ART.
The Journal of antimicrobial chemotherapy.
2021 02; 76(3):710-717. doi:
10.1093/jac/dkaa512. [PMID: 33294914] - T K Qi, J Chen, R F Zhang, L Liu, Y Z Shen, Z Y Wang, J J Sun, W Song, Y Tang, J R Wang, Y X Ling, S B Xu, J Y Yang, H Z Lu. A retrospective cohort study of early mortality among patients with HIV/TB co-infection in Shanghai municipality.
HIV medicine.
2020 12; 21(11):739-746. doi:
10.1111/hiv.13025. [PMID: 33369033] - Md Sorwer Alam Parvez, Md Adnan Karim, Mahmudul Hasan, Jomana Jaman, Ziaul Karim, Tohura Tahsin, Md Nazmul Hasan, Mohammad Jakir Hosen. Prediction of potential inhibitors for RNA-dependent RNA polymerase of SARS-CoV-2 using comprehensive drug repurposing and molecular docking approach.
International journal of biological macromolecules.
2020 Nov; 163(?):1787-1797. doi:
10.1016/j.ijbiomac.2020.09.098. [PMID: 32950529] - Bernardo Guevara, Asha Gupta Cogdill. Helicobacter pylori: A Review of Current Diagnostic and Management Strategies.
Digestive diseases and sciences.
2020 07; 65(7):1917-1931. doi:
10.1007/s10620-020-06193-7. [PMID: 32170476] - Seni Kouanda, Henri Gautier Ouedraogo, Kadari Cisse, Tegwinde Rebeca Compaoré, Giorgia Sulis, Serge Diagbouga, Alberto Roggi, Grissoum Tarnagda, Paola Villani, Lassana Sangare, Jacques Simporé, Mario Regazzi, Alberto Matteelli. Pharmacokinetic study of two different rifabutin doses co-administered with lopinavir/ritonavir in African HIV and tuberculosis co-infected adult patients.
BMC infectious diseases.
2020 Jun; 20(1):449. doi:
10.1186/s12879-020-05169-2. [PMID: 32590942] - Lingjie Wu, Zhenjie Ye, Hui Liu, Hongliang Guo, Jing Lin, Ling Zheng, Nannan Chu, Xiaolong Liu. Rapid and highly sensitive quantification of the anti-tuberculosis agents isoniazid, ethambutol, pyrazinamide, rifampicin and rifabutin in human plasma by UPLC-MS/MS.
Journal of pharmaceutical and biomedical analysis.
2020 Feb; 180(?):113076. doi:
10.1016/j.jpba.2019.113076. [PMID: 31896523] - Ana Grenha, Ana D Alves, Filipa Guerreiro, Jacinta Pinho, Sandra Simões, António José Almeida, Maria Manuela Gaspar. Inhalable locust bean gum microparticles co-associating isoniazid and rifabutin: Therapeutic assessment in a murine model of tuberculosis infection.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2020 Feb; 147(?):38-44. doi:
10.1016/j.ejpb.2019.11.009. [PMID: 31790800] - Henri Gautier Ouedraogo, Alberto Matteelli, Giorgia Sulis, Tegwinde Rebeca Compaore, Serge Diagbouga, Simon Tiendrebeogo, Alberto Roggi, Kadari Cisse, Pier Francesco Giorgetti, Paola Villani, Lassana Sangare, Jacques Simpore, Mario Regazzi, Seni Kouanda. Pharmacokinetics of plasma lopinavir and ritonavir in tuberculosis-HIV co-infected African adult patients also receiving rifabutin 150 or 300 mg three times per week.
Annals of clinical microbiology and antimicrobials.
2020 Jan; 19(1):3. doi:
10.1186/s12941-020-0345-6. [PMID: 31969147] - Wesley A Gray, Byron Waldorf, Manasa Geeta Rao, Brenda L Stiles, J McLeod Griffiss, Robert A Salata, Jeffrey L Blumer. Development and validation of an LC-MS/MS method for the simultaneous determination of bedaquiline and rifabutin in human plasma.
Journal of pharmaceutical and biomedical analysis.
2019 Nov; 176(?):112775. doi:
10.1016/j.jpba.2019.07.023. [PMID: 31446299] - Ruchika Dadhich, Abhishek Singh, Anjana P Menon, Manjari Mishra, C D Athul, Shobhna Kapoor. Biophysical characterization of mycobacterial model membranes and their interaction with rifabutin: Towards lipid-guided drug screening in tuberculosis.
Biochimica et biophysica acta. Biomembranes.
2019 06; 1861(6):1213-1227. doi:
10.1016/j.bbamem.2019.04.004. [PMID: 31002767] - M Ghannad, M Dennehy, C la Porte, I Seguin, D Tardiff, R Mallick, E Sabri, G Zhang, S Kanji, D W Cameron. A drug interaction study investigating the effect of Rifabutin on the pharmacokinetics of Maraviroc in healthy subjects.
PloS one.
2019; 14(10):e0223969. doi:
10.1371/journal.pone.0223969. [PMID: 31647836] - Geetha Ramachandran, A K Hemanth Kumar, T Kannan, R Sridhar, S K Guha, Deelip Kadam, N Poorana Gangadevi, T Rajapandian. Pharmacokinetics of rifabutin during atazanavir/ritonavir co-administration in HIV-infected TB patients.
The Indian journal of tuberculosis.
2019 Jan; 66(1):129-133. doi:
10.1016/j.ijtb.2018.06.009. [PMID: 30797270] - Susan L Ford, Yu Lou, Nicole Lewis, Michalis Kostapanos, Ronald D'Amico, William Spreen, Parul Patel. Effect of rifabutin on the pharmacokinetics of oral cabotegravir in healthy subjects.
Antiviral therapy.
2019; 24(4):301-308. doi:
10.3851/imp3306. [PMID: 30896438] - Helena Rouco, Patricia Diaz-Rodriguez, Santiago Rama-Molinos, Carmen Remuñán-López, Mariana Landin. Delimiting the knowledge space and the design space of nanostructured lipid carriers through Artificial Intelligence tools.
International journal of pharmaceutics.
2018 Dec; 553(1-2):522-530. doi:
10.1016/j.ijpharm.2018.10.058. [PMID: 30442594] - Guoyan Zhang, Shiliang Gui, Weiqun Wang, Dexin Meng, Qingmin Meng, Haiyan Luan, Rixin Zhao, Jiatian Zhang, Hongyu Sui. Acute stimulatory effect of tumor necrosis factor on the basolateral 50 pS K channels in the thick ascending limb of the rat kidney.
Molecular medicine reports.
2018 Nov; 18(5):4733-4738. doi:
10.3892/mmr.2018.9475. [PMID: 30221721] - Tapinder Kaur Grewal, Shahnawaz Majeed, Sadhna Sharma. Therapeutic implications of nano-encapsulated rifabutin, azithromycin & ethambutol against experimental Mycobacterium avium infection in mice.
The Indian journal of medical research.
2018 06; 147(6):594-602. doi:
10.4103/ijmr.ijmr_2004_15. [PMID: 30168492] - Robert S Wallis, Caryn E Good, Mary A O'Riordan, Jeffrey L Blumer, Michael R Jacobs, J McLeod Griffiss, Amanda Healan, Robert A Salata. Mycobactericidal activity of bedaquiline plus rifabutin or rifampin in ex vivo whole blood cultures of healthy volunteers: A randomized controlled trial.
PloS one.
2018; 13(5):e0196756. doi:
10.1371/journal.pone.0196756. [PMID: 29718967] - Amanda M Healan, J McLeod Griffiss, Howard M Proskin, Mary Ann O'Riordan, Wesley A Gray, Robert A Salata, Jeffrey L Blumer. Impact of Rifabutin or Rifampin on Bedaquiline Safety, Tolerability, and Pharmacokinetics Assessed in a Randomized Clinical Trial with Healthy Adult Volunteers.
Antimicrobial agents and chemotherapy.
2018 01; 62(1):. doi:
10.1128/aac.00855-17. [PMID: 29061739] - Diana P Gaspar, Maria Manuela Gaspar, Carla V Eleutério, Ana Grenha, Mateo Blanco, Lídia M D Gonçalves, Pablo Taboada, António J Almeida, Carmen Remuñán-López. Microencapsulated Solid Lipid Nanoparticles as a Hybrid Platform for Pulmonary Antibiotic Delivery.
Molecular pharmaceutics.
2017 09; 14(9):2977-2990. doi:
10.1021/acs.molpharmaceut.7b00169. [PMID: 28809501] - Seong Mi Moon, Byung Woo Jhun, Hyun Lee, Hye Yun Park, Kyeongman Jeon, Soo-Youn Lee, Won-Jung Koh. Effect of a 150 mg dose of rifabutin on serum itraconazole levels in patients with coexisting chronic pulmonary aspergillosis and Mycobacterium avium complex lung disease.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2017 Sep; 23(9):658-660. doi:
10.1016/j.jiac.2017.02.004. [PMID: 28284662] - Susana Rodrigues, Ana D Alves, Joana S Cavaco, Jorge F Pontes, Filipa Guerreiro, Ana M Rosa da Costa, Francesca Buttini, Ana Grenha. Dual antibiotherapy of tuberculosis mediated by inhalable locust bean gum microparticles.
International journal of pharmaceutics.
2017 Aug; 529(1-2):433-441. doi:
10.1016/j.ijpharm.2017.06.088. [PMID: 28669623] - Michael Czapka, Shuchin Shukla, Magdalena Slosar-Cheah. Urine trouble: genitourinary tuberculosis and subsequent DRESS syndrome.
BMJ case reports.
2017 Aug; 2017(?):. doi:
10.1136/bcr-2017-220440. [PMID: 28784884] - Swati Jaiswal, Abhisheak Sharma, Mahendra Shukla, Jawahar Lal. Simultaneous LC-MS-MS Determination of Lopinavir and Rifabutin in Human Plasma.
Journal of chromatographic science.
2017 Jul; 55(6):617-624. doi:
10.1093/chromsci/bmx016. [PMID: 28334925] - Yu Ermolenko, A Anshakova, N Osipova, M Kamentsev, O Maksimenko, V Balabanyan, S Gelperina. Simultaneous determination of rifabutin and human serum albumin in pharmaceutical formulations by capillary electrophoresis.
Journal of pharmacological and toxicological methods.
2017 May; 85(?):55-60. doi:
10.1016/j.vascn.2017.01.003. [PMID: 28137656] - Pradip Nirbhavane, Nalini Vemuri, Neeraj Kumar, Gopal Krishan Khuller. Lipid Nanocarrier-Mediated Drug Delivery System to Enhance the Oral Bioavailability of Rifabutin.
AAPS PharmSciTech.
2017 Apr; 18(3):829-837. doi:
10.1208/s12249-016-0559-2. [PMID: 27350276] - Syed Q Shah, Mamoona Alam. Synthesis of 99mTc-Rifabutin: A Potential Tuberculosis Radiodiagnostic Agent.
Infectious disorders drug targets.
2017; 17(3):185-191. doi:
10.2174/1871526517666170606114650. [PMID: 28595542] - Christian Wagner, Yuzhuo Pan, Vicky Hsu, Vikram Sinha, Ping Zhao. Predicting the Effect of CYP3A Inducers on the Pharmacokinetics of Substrate Drugs Using Physiologically Based Pharmacokinetic (PBPK) Modeling: An Analysis of PBPK Submissions to the US FDA.
Clinical pharmacokinetics.
2016 Apr; 55(4):475-83. doi:
10.1007/s40262-015-0330-y. [PMID: 26369776] - Diana P Gaspar, Vasco Faria, Lídia M D Gonçalves, Pablo Taboada, Carmen Remuñán-López, António J Almeida. Rifabutin-loaded solid lipid nanoparticles for inhaled antitubercular therapy: Physicochemical and in vitro studies.
International journal of pharmaceutics.
2016 Jan; 497(1-2):199-209. doi:
10.1016/j.ijpharm.2015.11.050. [PMID: 26656946] - Marina Pinheiro, Ricardo Ribeiro, Alexandre Vieira, Fernanda Andrade, Salette Reis. Design of a nanostructured lipid carrier intended to improve the treatment of tuberculosis.
Drug design, development and therapy.
2016; 10(?):2467-75. doi:
10.2147/dddt.s104395. [PMID: 27536067] - Tetsuo Hasegawa, Tsunoda Yuya, Yukihiro Yoshimura, Yuichiro Amano, Yohei Sakamoto, Natsuo Tachikawa. Image of the month: Disseminated Nontuberculous Mycobacteriosis.
The American journal of gastroenterology.
2015 Dec; 110(12):1654. doi:
10.1038/ajg.2015.136. [PMID: 26673493] - Marina Pinheiro, Ana Sofia Silva, Salette Reis. Molecular interactions of rifabutin with membrane under acidic conditions.
International journal of pharmaceutics.
2015 Feb; 479(1):63-9. doi:
10.1016/j.ijpharm.2014.12.042. [PMID: 25542991] - Lee C Winchester, Anthony T Podany, Joshua S Baldwin, Brian L Robbins, Courtney V Fletcher. Determination of the rifamycin antibiotics rifabutin, rifampin, rifapentine and their major metabolites in human plasma via simultaneous extraction coupled with LC/MS/MS.
Journal of pharmaceutical and biomedical analysis.
2015 Feb; 104(?):55-61. doi:
10.1016/j.jpba.2014.11.011. [PMID: 25481085] - Payam Tabarsi, Maham Farshidpour, Majid Marjani, Parvaneh Baghaei, Amir Yousefzadeh, Katayoon Najafizadeh, Babak Sharifkashani, Pedram Javanmard, Davood Mansouri, Mohammadreza Masjedi, Aliakbar Velayati. Mycobacterial infection and the impact of rifabutin treatment in organ transplant recipients: a single-center study.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
2015 Jan; 26(1):6-11. doi:
10.4103/1319-2442.148710. [PMID: 25579709] - I G Kuznetsova, E G Dubovik, N S Dubovik, T N Komarov, Y V Medvedev, L A Menshikova, S E Severin, I E Shohin, T A Yarushok. [Biodistribution of Rifabutin Polymeric Transport Form].
Vestnik Rossiiskoi akademii meditsinskikh nauk.
2015; ?(3):366-71. doi:
10.15690/vramn.v70i3.1335. [PMID: 26495727] - Seong Mi Moon, Hye Yun Park, Byeong-Ho Jeong, Kyeongman Jeon, Soo-Youn Lee, Won-Jung Koh. Effect of rifampin and rifabutin on serum itraconazole levels in patients with chronic pulmonary aspergillosis and coexisting nontuberculous mycobacterial infection.
Antimicrobial agents and chemotherapy.
2015 Jan; 59(1):663-5. doi:
10.1128/aac.04075-14. [PMID: 25313207] - Enzo Ierardi, Antonio Giangaspero, Giuseppe Losurdo, Floriana Giorgio, Annacinzia Amoruso, Vincenzo De Francesco, Alfredo Di Leo, Mariabeatrice Principi. Quadruple rescue therapy after first and second line failure for Helicobacter pylori treatment: comparison between two tetracycline-based regimens.
Journal of gastrointestinal and liver diseases : JGLD.
2014 Dec; 23(4):367-70. doi:
10.15403/jgld.2014.1121.234.qrth. [PMID: 25531993] - Suhashni Naiker, Cathy Connolly, Lubbe Wiesner, Tracey Kellerman, Tarylee Reddy, Anthony Harries, Helen McIlleron, Christian Lienhardt, Alexander Pym. Randomized pharmacokinetic evaluation of different rifabutin doses in African HIV- infected tuberculosis patients on lopinavir/ritonavir-based antiretroviral therapy.
BMC pharmacology & toxicology.
2014 Nov; 15(?):61. doi:
10.1186/2050-6511-15-61. [PMID: 25406657] - Ji Yeun Chang, Eun Gyo Jeong, Ji Hyun Yu, Byung Ha Chung, Chul Woo Yang. Recurrent neutropenia induced by rifabutin in a renal transplant recipient.
The Korean journal of internal medicine.
2014 Jul; 29(4):532-4. doi:
10.3904/kjim.2014.29.4.532. [PMID: 25045303] - Nguyen Thi Ngoc Lan, Nguyen Thi Nguyet Thu, Aurélie Barrail-Tran, Nguyen Hong Duc, Nguyen Ngoc Lan, Didier Laureillard, Truong Thi Xuan Lien, Laurence Borand, Catherine Quillet, Catherine Connolly, Dominique Lagarde, Alexander Pym, Christian Lienhardt, Nguyen Huy Dung, Anne-Marie Taburet, Anthony D Harries. Randomised pharmacokinetic trial of rifabutin with lopinavir/ritonavir-antiretroviral therapy in patients with HIV-associated tuberculosis in Vietnam.
PloS one.
2014; 9(1):e84866. doi:
10.1371/journal.pone.0084866. [PMID: 24465443] - G Ramachandran, P K Bhavani, A K Hemanth Kumar, R Srinivasan, K Raja, V Sudha, S Venkatesh, C Chandrasekaran, S Swaminathan. Pharmacokinetics of rifabutin during atazanavir/ritonavir co-administration in HIV-infected TB patients in India.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
2013 Dec; 17(12):1564-8. doi:
10.5588/ijtld.13.0390. [PMID: 24200269] - Marina Pinheiro, Mariana Arêde, João M Caio, Cristina Moiteiro, Marlene Lúcio, Salette Reis. Drug-membrane interaction studies applied to N'-acetyl-rifabutin.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2013 Nov; 85(3 Pt A):597-603. doi:
10.1016/j.ejpb.2013.02.015. [PMID: 23523541] - Marina Pinheiro, Cláudia Nunes, João M Caio, Cristina Moiteiro, Gerald Brezesinski, Salette Reis. Interactions of N'-acetyl-rifabutin and N'-butanoyl-rifabutin with lipid bilayers: a synchrotron X-ray study.
International journal of pharmaceutics.
2013 Sep; 453(2):560-8. doi:
10.1016/j.ijpharm.2013.06.018. [PMID: 23796838] - Marina Pinheiro, Catarina Pereira-Leite, Mariana Arêde, Cláudia Nunes, João M Caio, Cristina Moiteiro, Juan J Giner-Casares, Marlene Lúcio, Gerald Brezesinski, Luis Camacho, Salette Reis. Evaluation of the structure-activity relationship of rifabutin and analogs: a drug-membrane study.
Chemphyschem : a European journal of chemical physics and physical chemistry.
2013 Aug; 14(12):2808-16. doi:
10.1002/cphc.201300262. [PMID: 23821530] - Marina Pinheiro, Mariana Arêde, Juan J Giner-Casares, Cláudia Nunes, João M Caio, Cristina Moiteiro, Marlene Lúcio, Luis Camacho, Salette Reis. Effects of a novel antimycobacterial compound on the biophysical properties of a pulmonary surfactant model membrane.
International journal of pharmaceutics.
2013 Jun; 450(1-2):268-77. doi:
10.1016/j.ijpharm.2013.03.062. [PMID: 23603451] - Marina Pinheiro, Cláudia Nunes, João M Caio, Cristina Moiteiro, Marlene Lúcio, Gerald Brezesinski, Salette Reis. The influence of rifabutin on human and bacterial membrane models: implications for its mechanism of action.
The journal of physical chemistry. B.
2013 May; 117(20):6187-93. doi:
10.1021/jp403073v. [PMID: 23617457] - Matthew D Hickey, David J Quan, Peter V Chin-Hong, John P Roberts. Use of rifabutin for the treatment of a latent tuberculosis infection in a patient after solid organ transplantation.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.
2013 Apr; 19(4):457-61. doi:
10.1002/lt.23622. [PMID: 23526600] - Hanzhou Feng, Limei Zhang, Chunyan Zhu. Genipin crosslinked ethyl cellulose-chitosan complex microspheres for anti-tuberculosis delivery.
Colloids and surfaces. B, Biointerfaces.
2013 Mar; 103(?):530-7. doi:
10.1016/j.colsurfb.2012.11.007. [PMID: 23266829] - Marina Pinheiro, Juan J Giner-Casares, Marlene Lúcio, João M Caio, Cristina Moiteiro, José L F C Lima, Salette Reis, Luis Camacho. Interplay of mycolic acids, antimycobacterial compounds and pulmonary surfactant membrane: a biophysical approach to disease.
Biochimica et biophysica acta.
2013 Feb; 1828(2):896-905. doi:
10.1016/j.bbamem.2012.09.015. [PMID: 23022131] - Marina Pinheiro, Mariana Arêde, Cláudia Nunes, João M Caio, Cristina Moiteiro, Marlene Lúcio, Salette Reis. Differential interactions of rifabutin with human and bacterial membranes: implication for its therapeutic and toxic effects.
Journal of medicinal chemistry.
2013 Jan; 56(2):417-26. doi:
10.1021/jm301116j. [PMID: 23215016] - Junko Tanuma, Kazumi Sano, Katsuji Teruya, Koji Watanabe, Takahiro Aoki, Haruhito Honda, Hirohisa Yazaki, Kunihisa Tsukada, Hiroyuki Gatanaga, Yoshimi Kikuchi, Shinichi Oka. Pharmacokinetics of rifabutin in Japanese HIV-infected patients with or without antiretroviral therapy.
PloS one.
2013; 8(8):e70611. doi:
10.1371/journal.pone.0070611. [PMID: 23940604] - Anne M Baciewicz, Cary R Chrisman, Christopher K Finch, Timothy H Self. Update on rifampin, rifabutin, and rifapentine drug interactions.
Current medical research and opinion.
2013 Jan; 29(1):1-12. doi:
10.1185/03007995.2012.747952. [PMID: 23136913] - Won-Jung Koh, Byeong-Ho Jeong, Kyeongman Jeon, Soo-Youn Lee, Sung Jae Shin. Therapeutic drug monitoring in the treatment of Mycobacterium avium complex lung disease.
American journal of respiratory and critical care medicine.
2012 Oct; 186(8):797-802. doi:
10.1164/rccm.201206-1088oc. [PMID: 22878282] - Alberto Matteelli, Paola Villani, Anna Cristina C Carvalho, Issa El-Hamad, Maria Cusato, Alessandra Apostoli, Claudio Marcantoni, Alessandra Calabresi, Sarah Dal Zoppo, Sara Bigoni, Mario Regazzi. Lopinavir pharmacokinetic profiles in HIV-infected patients during rifabutin-based anti-mycobacterial therapy.
The Journal of antimicrobial chemotherapy.
2012 Oct; 67(10):2470-3. doi:
10.1093/jac/dks218. [PMID: 22678727] - J-H Cho, C-H Yu, M-K Jin, O Kwon, K-D Hong, J-Y Choi, S-H Yoon, S-H Park, C-D Kim, Y-L Kim. Mycobacterium kansasii pericarditis in a kidney transplant recipient: a case report and comprehensive review of the literature.
Transplant infectious disease : an official journal of the Transplantation Society.
2012 Oct; 14(5):E50-5. doi:
10.1111/j.1399-3062.2012.00767.x. [PMID: 22823928] - Jakko van Ingen, Eric F Egelund, Adrah Levin, Sarah E Totten, Martin J Boeree, Johan W Mouton, Rob E Aarnoutse, Leonid B Heifets, Charles A Peloquin, Charles L Daley. The pharmacokinetics and pharmacodynamics of pulmonary Mycobacterium avium complex disease treatment.
American journal of respiratory and critical care medicine.
2012 Sep; 186(6):559-65. doi:
10.1164/rccm.201204-0682oc. [PMID: 22744719] - Rabia Ahmed, Ryan Cooper, Michelle Foisy, Evelina Der, Dennis Kunimoto. Factors associated with reduced antituberculous serum drug concentrations in patients with HIV-TB coinfection.
Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002).
2012 Sep; 11(5):273-6. doi:
10.1177/1545109712454454. [PMID: 22875581] - Ya A Sheremet, A I Yemets, A Azmi, K Vissenberg, J P Verbelen, Ya B Blume. Effects of tyrosine kinase and phosphatase inhibitors on mitosis progression in synchronized tobacco BY-2 cells.
TSitologiia i genetika.
2012 Sep; 46(5):3-11. doi:
. [PMID: 23342643] - Manoli Vourvahis, John Davis, Rong Wang, Gary Layton, Heng Wee Choo, Chew-Lan Chong, Margaret Tawadrous. Effect of rifampin and rifabutin on the pharmacokinetics of lersivirine and effect of lersivirine on the pharmacokinetics of rifabutin and 25-O-desacetyl-rifabutin in healthy subjects.
Antimicrobial agents and chemotherapy.
2012 Aug; 56(8):4303-9. doi:
10.1128/aac.06282-11. [PMID: 22644026] - Rahul Kumar Verma, Jatinder Kaur Mukker, Ravi Shankar Prasad Singh, Kaushlendra Kumar, Priya Ranjan Prasad Verma, Amit Misra. Partial biodistribution and pharmacokinetics of isoniazid and rifabutin following pulmonary delivery of inhalable microparticles to rhesus macaques.
Molecular pharmaceutics.
2012 Apr; 9(4):1011-6. doi:
10.1021/mp300043f. [PMID: 22397370] - Jun-ichi Kusaba, Noriko Kajikawa, Hiromu Kawasaki, Yuji Kurosaki, Tetsuya Aiba. Comparative study on altered hepatic metabolism of CYP3A substrates in rats with glycerol-induced acute renal failure.
Biopharmaceutics & drug disposition.
2012 Jan; 33(1):22-9. doi:
10.1002/bdd.1774. [PMID: 22351566] - Ya A Sheremet, A I Yemets, Ya B Blume. Inhibitors of tyrosine kinases and phosphatases as a tool for the investigation of microtubule role in plant cold response.
TSitologiia i genetika.
2012 Jan; 46(1):3-9. doi:
. [PMID: 22420214] - Elinore F McCance-Katz, David E Moody, Sudha Prathikanti, Gerald Friedland, Petrie M Rainey. Rifampin, but not rifabutin, may produce opiate withdrawal in buprenorphine-maintained patients.
Drug and alcohol dependence.
2011 Nov; 118(2-3):326-34. doi:
10.1016/j.drugalcdep.2011.04.013. [PMID: 21596492] - Aylin Babalik, Aylin Babalik, Sharyn Mannix, Denis Francis, Dick Menzies. Therapeutic drug monitoring in the treatment of active tuberculosis.
Canadian respiratory journal.
2011 Jul; 18(4):225-9. doi:
10.1155/2011/307150. [PMID: 22059181] - Diana M Brainard, Kelem Kassahun, Larissa A Wenning, Amelia S Petry, Chengcheng Liu, Jared Lunceford, Niresh Hariparsad, Roy Eisenhandler, Alisha Norcross, Emanuel P DeNoia, Julie A Stone, John A Wagner, Marian Iwamoto. Lack of a clinically meaningful pharmacokinetic effect of rifabutin on raltegravir: in vitro/in vivo correlation.
Journal of clinical pharmacology.
2011 Jun; 51(6):943-50. doi:
10.1177/0091270010375959. [PMID: 20852006] - Xiaoping Zhang, Scott Fettner, Elke Zwanziger, Lucy Rowell, Miklos Salgo. Pharmacokinetic interaction study of ritonavir-boosted saquinavir in combination with rifabutin in healthy subjects.
Antimicrobial agents and chemotherapy.
2011 Feb; 55(2):680-7. doi:
10.1128/aac.00992-10. [PMID: 21135186] - Vanitha Sekar, Ludo Lavreys, Tom Van de Casteele, Cindy Berckmans, Sabrina Spinosa-Guzman, Tony Vangeneugden, Martine De Pauw, Richard Hoetelmans. Pharmacokinetics of darunavir/ritonavir and rifabutin coadministered in HIV-negative healthy volunteers.
Antimicrobial agents and chemotherapy.
2010 Oct; 54(10):4440-5. doi:
10.1128/aac.01749-09. [PMID: 20660678] - Oliver Hsu, Catherine J Hill, Mina Kim, Benny Tan, John G O'Brien. Decreased plasma efavirenz concentrations in a patient receiving rifabutin.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2010 Oct; 67(19):1611-4. doi:
10.2146/ajhp090516. [PMID: 20852162] - Atsuyuki Kurashima, Toru Mori, Yoshiro Tomono, Sadahiro Abe, Makoto Nagaoka, Masaaki Abe. [A new anti-mycobacterial agent, rifabutin].
Kekkaku : [Tuberculosis].
2010 Oct; 85(10):743-56. doi:
. [PMID: 21061564] - Bhagwat Prasad, Saranjit Singh. Identification of rat urinary metabolites of rifabutin using LC-MSn and LC-HR-MS.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2010 Sep; 41(1):173-88. doi:
10.1016/j.ejps.2010.06.006. [PMID: 20558285] - Wolfgang Stöhr, David Back, David Dunn, Caroline Sabin, Alan Winston, Richard Gilson, Deenan Pillay, Teresa Hill, Jonathan Ainsworth, Brian Gazzard, Clifford Leen, Loveleen Bansi, Martin Fisher, Chloe Orkin, Jane Anderson, Margaret Johnson, Philippa Easterbrook, Sara Gibbons, Saye Khoo. Factors influencing lopinavir and atazanavir plasma concentration.
The Journal of antimicrobial chemotherapy.
2010 Jan; 65(1):129-37. doi:
10.1093/jac/dkp408. [PMID: 19897506] - Navneet Nimje, Abhinav Agarwal, Gaurav Kant Saraogi, Narendra Lariya, Gopal Rai, Himanshu Agrawal, G P Agrawal. Mannosylated nanoparticulate carriers of rifabutin for alveolar targeting.
Journal of drug targeting.
2009 Dec; 17(10):777-87. doi:
10.3109/10611860903115308. [PMID: 19938949] - Catherine Boulanger, Elena Hollender, Karen Farrell, Jerry Jean Stambaugh, Diane Maasen, David Ashkin, Stephen Symes, Luis A Espinoza, Rafael O Rivero, Jenny J Graham, Charles A Peloquin. Pharmacokinetic evaluation of rifabutin in combination with lopinavir-ritonavir in patients with HIV infection and active tuberculosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2009 Nov; 49(9):1305-11. doi:
10.1086/606056. [PMID: 19807276] - David P Holland, Carol D Hamilton, Amy C Weintrob, John J Engemann, Ellen R Fortenberry, Charles A Peloquin, Jason E Stout. Therapeutic drug monitoring of antimycobacterial drugs in patients with both tuberculosis and advanced human immunodeficiency virus infection.
Pharmacotherapy.
2009 May; 29(5):503-10. doi:
10.1592/phco.29.5.503. [PMID: 19397460] - Anna Cardiakidis Myers, Sten Kjellström, Anitha Bruun, Björn Isaksson, Fredrik Ghosh, Sten Andréasson, Vesna Ponjavic. Rifabutin accumulates in the lens and reduces retinal function in the rabbit eye.
Retina (Philadelphia, Pa.).
2009 Jan; 29(1):106-11. doi:
10.1097/iae.0b013e318180ab3c. [PMID: 18685541] - Charles J L la Porte, John P Sabo, Mabrouk Elgadi, D William Cameron. Interaction studies of tipranavir-ritonavir with clarithromycin, fluconazole, and rifabutin in healthy volunteers.
Antimicrobial agents and chemotherapy.
2009 Jan; 53(1):162-73. doi:
10.1128/aac.00534-08. [PMID: 19015362] - Janine Voyer, John J Heikkila. Comparison of the effect of heat shock factor inhibitor, KNK437, on heat shock- and chemical stress-induced hsp30 gene expression in Xenopus laevis A6 cells.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2008 Oct; 151(2):253-61. doi:
10.1016/j.cbpa.2008.07.004. [PMID: 18675372] - G Daoud, F Le bellego, J Lafond. PP2 regulates human trophoblast cells differentiation by activating p38 and ERK1/2 and inhibiting FAK activation.
Placenta.
2008 Oct; 29(10):862-70. doi:
10.1016/j.placenta.2008.07.011. [PMID: 18783823] - Rahul Kumar Verma, Jatinder Kaur, Kaushlendra Kumar, Awadh Bihari Yadav, Amit Misra. Intracellular time course, pharmacokinetics, and biodistribution of isoniazid and rifabutin following pulmonary delivery of inhalable microparticles to mice.
Antimicrobial agents and chemotherapy.
2008 Sep; 52(9):3195-201. doi:
10.1128/aac.00153-08. [PMID: 18591268] - Joshua N Schwiesow, Michael D Iseman, Charles A Peloquin. Concomitant use of voriconazole and rifabutin in a patient with multiple infections.
Pharmacotherapy.
2008 Aug; 28(8):1076-80. doi:
10.1592/phco.28.8.1076. [PMID: 18657024] - Mike O Karl, Wolfram Kroeger, Soenke Wimmers, Vladimir M Milenkovic, Monika Valtink, Katrin Engelmann, Olaf Strauss. Endogenous Gas6 and Ca2+ -channel activation modulate phagocytosis by retinal pigment epithelium.
Cellular signalling.
2008 Jun; 20(6):1159-68. doi:
10.1016/j.cellsig.2008.02.005. [PMID: 18395422] - Alla Yemets, Yarina Sheremet, Kris Vissenberg, Jürgen Van Orden, Jean-Pierre Verbelen, Yaroslav B Blume. Effects of tyrosine kinase and phosphatase inhibitors on microtubules in Arabidopsis root cells.
Cell biology international.
2008 Jun; 32(6):630-7. doi:
10.1016/j.cellbi.2008.01.013. [PMID: 18343165] - Jatinder Kaur, Pavan Muttil, Rahul Kumar Verma, Kaushlendra Kumar, Awadh Bihari Yadav, Rolee Sharma, Amit Misra. A hand-held apparatus for 'nose-only' exposure of mice to inhalable microparticles as a dry powder inhalation targeting lung and airway macrophages.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2008 May; 34(1):56-65. doi:
10.1016/j.ejps.2008.02.008. [PMID: 18387284] - Daohong Lin, Erik-Jan Kamsteeg, Yan Zhang, Yan Jin, Hyacinth Sterling, Peng Yue, Marcel Roos, Amy Duffield, Joanna Spencer, Michael Caplan, Wen-Hui Wang. Expression of tetraspan protein CD63 activates protein-tyrosine kinase (PTK) and enhances the PTK-induced inhibition of ROMK channels.
The Journal of biological chemistry.
2008 Mar; 283(12):7674-81. doi:
10.1074/jbc.m705574200. [PMID: 18211905] - Anne M Baciewicz, Cary R Chrisman, Christopher K Finch, Timothy H Self. Update on rifampin and rifabutin drug interactions.
The American journal of the medical sciences.
2008 Feb; 335(2):126-36. doi:
10.1097/maj.0b013e31814a586a. [PMID: 18277121] - Susan L Ford, Ya-Chi Chen, Yu Lou, Julie Borland, Sherene S Min, Geoffrey J Yuen, Mark J Shelton. Pharmacokinetic interaction between fosamprenavir-ritonavir and rifabutin in healthy subjects.
Antimicrobial agents and chemotherapy.
2008 Feb; 52(2):534-8. doi:
10.1128/aac.00724-07. [PMID: 18056271] - Winfried Goettsch, Corina Gryczka, Thomas Korff, Evelyn Ernst, Claudia Goettsch, Jochen Seebach, Hans-Joachim Schnittler, Hellmut G Augustin, Henning Morawietz. Flow-dependent regulation of angiopoietin-2.
Journal of cellular physiology.
2008 Feb; 214(2):491-503. doi:
10.1002/jcp.21229. [PMID: 17960565] - Vitaly V Vostrikov, Alla A Selishcheva, Galina M Sorokoumova, Yulia N Shakina, Vitaly I Shvets, Oleg Yu Savel'ev, Vladimir I Polshakov. Distribution coefficient of rifabutin in liposome/water system as measured by different methods.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2008 Feb; 68(2):400-5. doi:
10.1016/j.ejpb.2007.05.014. [PMID: 17614265] - Chunhua Lu, Yuemao Shen. A novel ansamycin, naphthomycin K from Streptomyces sp.
The Journal of antibiotics.
2007 Oct; 60(10):649-53. doi:
10.1038/ja.2007.84. [PMID: 17965482] - Gregory D Rushing, L D Britt. Inhibition of NF-KB does not induce c-Jun N-terminal kinase-mediated apoptosis in reperfusion injury.
Journal of the American College of Surgeons.
2007 May; 204(5):964-7; discussion 967. doi:
10.1016/j.jamcollsurg.2007.01.029. [PMID: 17481520] - Hung Bae Chang, Jae-Heon Kim. Antioxidant properties of dihydroherbimycin A from a newly isolated Streptomyces sp.
Biotechnology letters.
2007 Apr; 29(4):599-603. doi:
10.1007/s10529-006-9288-z. [PMID: 17206369] - Esther L W Barrow, William W Barrow, Debra C Quenelle, Louise Westbrook, Gary A Winchester, Jay K Staas. Efficacy of rifabutin-loaded microspheres for treatment of Mycobacterium avium-infected macrophages and mice.
Drug delivery.
2007 Mar; 14(3):119-27. doi:
10.1080/10717540600739815. [PMID: 17454031] - G Krishna, A Parsons, B Kantesaria, T Mant. Evaluation of the pharmacokinetics of posaconazole and rifabutin following co-administration to healthy men.
Current medical research and opinion.
2007 Mar; 23(3):545-52. doi:
10.1185/030079906x167507. [PMID: 17355736] - Shin-ichiro Nakagawa, Takuya Umehara, Chiho Matsuda, Shusuke Kuge, Masayuki Sudoh, Michinori Kohara. Hsp90 inhibitors suppress HCV replication in replicon cells and humanized liver mice.
Biochemical and biophysical research communications.
2007 Feb; 353(4):882-8. doi:
10.1016/j.bbrc.2006.12.117. [PMID: 17196931] - P R Sudhakaran, A Radhika, S S Jacob. Monocyte macrophage differentiation in vitro: Fibronectin-dependent upregulation of certain macrophage-specific activities.
Glycoconjugate journal.
2007 Jan; 24(1):49-55. doi:
10.1007/s10719-006-9011-2. [PMID: 17115276]
