Vaporole (BioDeep_00000019545)
Main id: BioDeep_00000006503
human metabolite
代谢物信息卡片
化学式: C5H11NO2 (117.079)
中文名称: 亚硝酸异戊酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CCON=O
InChI: InChI=1S/C5H11NO2/c1-5(2)3-4-8-6-7/h5H,3-4H2,1-2H3
描述信息
Isoamyl nitrite (IAN) has been used as antianginal agents for more than 100 years. It is now established that IAN cause direct vasorelaxation through vascular generation of NO and relaxation via a cyclic guanosine monophosphate-dependent process. (PMID: 8996213). IAN is a member of the family of volatile organic nitrites that exert vasodilatory effects and have recently exhibited a considerable potential for inhalation abuse. (PMID: 9829558). All nitrovasodilators act intracellularly by a common molecular mechanism. This is characterized by the release of nitric oxide (NO). This process basically depends on the presence of oxygen as electron acceptor from the sydnonimine molecule. Organic nitrites (such as IAN) require the interaction with a mercapto group to form a S-nitrosothiol intermediate, from which finally NO radicals are liberated. In the presence of thiol compounds organic nitrites (e.g., IAN) and nitrosothiols may act as intermediary products of NO generation. (PMID: 1683227).
Isoamyl nitrite (IAN) has been used as antianginal agents for more than 100 years. It is now established that IAN cause direct vasorelaxation through vascular generation of NO and relaxation via a cyclic guanosine monophosphate-dependent process. (PMID: 8996213)
C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
同义名列表
25 个代谢物同义名
Nitrous acid, 3-methylbutyl ester; Nitrous acid 3-methylbutyl ester; Nitrous acid, isopentyl ester; Isopentyl ester nitrous acid; Amyl nitrite(mixed isomers); Nitrite isopentyl alcohol; 3-Methylbutanol nitrite; Amyl nitrite (JP15/usp); 3-methylbutyl nitrite; Vaporole amyl nitrite; Isopentyl nitrite; Pentanoli nitris; ISOAMYL NITRITE; Pentyl nitrite; Amyl nitrite I; Amyl nitrosum; Amyl nitrite; Amyl nitrit; Amilnitrite; Nitramyl; Vaporole; Aspiral; IPN; Amyl nitrite; Isoamyl nitrite
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:2691
- KEGG: C07457
- PubChem: 8053
- HMDB: HMDB0001382
- ChEMBL: CHEMBL1535371
- Wikipedia: Vaporole
- foodb: FDB022593
- chemspider: 7762
- CAS: 110-46-3
- PMhub: MS000019552
- PubChem: 9660
- NIKKAJI: J5.092J
- KNApSAcK: 2691
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Ruri Kikura-Hanajiri, Nahoko Uchiyama, Maiko Kawamura, Jun Ogata, Yukihiro Goda. [Prevalence of new designer drugs and their legal status in Japan].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2013; 133(1):31-40. doi:
10.1248/yakushi.12-00247-6. [PMID: 23292017] - Ioannis S Minas, Georgia Tanou, Maya Belghazi, Dominique Job, George A Manganaris, Athanassios Molassiotis, Miltiadis Vasilakakis. Physiological and proteomic approaches to address the active role of ozone in kiwifruit post-harvest ripening.
Journal of experimental botany.
2012 Apr; 63(7):2449-64. doi:
10.1093/jxb/err418. [PMID: 22268155] - Ming J Wu, Patrick J O'Doherty, Patricia A Murphy, Victoria Lyons, Melinda Christophersen, Peter J Rogers, Trevor D Bailey, Vincent J Higgins. Different reactive oxygen species lead to distinct changes of cellular metal ions in the eukaryotic model organism Saccharomyces cerevisiae.
International journal of molecular sciences.
2011; 12(11):8119-32. doi:
10.3390/ijms12118119. [PMID: 22174654] - Yu Ishima, Takaaki Akaike, Ulrich Kragh-Hansen, Shuichi Hiroyama, Tomohiro Sawa, Ayaka Suenaga, Toru Maruyama, Toshiya Kai, Masaki Otagiri. S-nitrosylated human serum albumin-mediated cytoprotective activity is enhanced by fatty acid binding.
The Journal of biological chemistry.
2008 Dec; 283(50):34966-75. doi:
10.1074/jbc.m807009200. [PMID: 18940810] - Naohisa Katayama, Keisuke Nakajou, Hisakazu Komori, Kunitoshi Uchida, Jun-Ichi Yokoe, Norikiyo Yasui, Hisashi Yamamoto, Toshiya Kai, Makoto Sato, Takenobu Nakagawa, Motohiro Takeya, Toru Maruyama, Masaki Otagiri. Design and evaluation of S-nitrosylated human serum albumin as a novel anticancer drug.
The Journal of pharmacology and experimental therapeutics.
2008 Apr; 325(1):69-76. doi:
10.1124/jpet.107.132100. [PMID: 18218831] - Adrian C Nicolescu, James N Reynolds, L Ross C Barclay, Gregory R J Thatcher. Organic nitrites and NO: inhibition of lipid peroxidation and radical reactions.
Chemical research in toxicology.
2004 Feb; 17(2):185-96. doi:
10.1021/tx034097p. [PMID: 14967006] - Adrian C Nicolescu, Sergei I Zavorin, Nicholas J Turro, James N Reynolds, Gregory R J Thatcher. Inhibition of lipid peroxidation in synaptosomes and liposomes by nitrates and nitrites.
Chemical research in toxicology.
2002 Jul; 15(7):985-98. doi:
10.1021/tx025529j. [PMID: 12119011] - V M Ramanathan, T G Reigle, S Muralidhara, C E Dallas. Effects of acute inhalation exposure to isoamyl nitrite on the hypothalamo-pituitary-adrenal axis in male Sprague-Dawley rats.
Journal of toxicology and environmental health. Part A.
1998 Nov; 55(5):345-58. doi:
10.1080/009841098158395. [PMID: 9829558]
