Pyrrolidine, 1,5-dimethyl-3,3-diphenyl-2-ethylidene- (BioDeep_00001883756)
代谢物信息卡片
Pyrrolidine, 1,5-dimethyl-3,3-diphenyl-2-ethylidene-
化学式: C20H23N (277.183)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC=C1C(CC(N1C)C)(C2=CC=CC=C2)C3=CC=CC=C3
InChI: InChI=1S/C20H23N/c1-4-19-20(15-16(2)21(19)3,17-11-7-5-8-12-17)18-13-9-6-10-14-18/h4-14,16H,15H2,1-3H3
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Katharina Feld, Patrick Dahm, Tobias Kieliba, Axel Klee, Markus A Rothschild, Hilke Andresen-Streichert, Justus Beike. Evidence for the transfer of methadone and EDDP by sweat to children's hair.
International journal of legal medicine.
2021 Sep; 135(5):1799-1811. doi:
10.1007/s00414-021-02576-1. [PMID: 33821333] - Mohamed Abou El Hassan, David Colantonio, Sergei Likhodii, Bassam A Nassar. The analytical performance of six urine drug screens on cobas 6000 and ARCHITECT i2000 compared to LC-MS/MS gold standard.
Clinical biochemistry.
2021 Jul; 93(?):99-103. doi:
10.1016/j.clinbiochem.2021.04.003. [PMID: 33844982] - Ingrid F Metzger, Anna E Thomas, Cindy A Evrard, David R Jones, Andrea R Masters, David M Haas, Laura S Haneline, Sara K Quinney. Stereoselective Analysis of Methadone and EDDP in Laboring Women and Neonates in Plasma and Dried Blood Spots and Association with Neonatal Abstinence Syndrome.
American journal of perinatology.
2021 07; 38(9):968-975. doi:
10.1055/s-0040-1701505. [PMID: 32052397] - Karolina Nowak, Paweł Szpot, Tomasz Jurek, Marcin Zawadzki. Quantification of methadone and its metabolites: EDDP and EMDP determined in autopsy cases using LC-MS/MS.
Journal of forensic sciences.
2021 May; 66(3):1003-1012. doi:
10.1111/1556-4029.14674. [PMID: 33512019] - Dheepthi Arakonam Ravishankar, Erin Calhoun, Roopa Sethi, Amad Din. Urine toxicology screen negative for Methadone metabolite but positive for Methadone in a patient on Methadone maintenance therapy (MMT).
Asian journal of psychiatry.
2020 Apr; 50(?):101969. doi:
10.1016/j.ajp.2020.101969. [PMID: 32109808] - Regula Theurillat, Friederike A Sandbaumhüter, Claudia Gittel, M Paula Larenza Menzies, Christina Braun, Wolfgang Thormann. Enantioselective capillary electrophoresis for pharmacokinetic analysis of methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine in equines anesthetized with ketamine and isoflurane.
Electrophoresis.
2019 08; 40(15):1959-1965. doi:
10.1002/elps.201900044. [PMID: 30900259] - Željko Ključević, Benjamin Benzon, Nikola Ključević, Maja Veršić Bratinčević, Davorka Sutlović. Liver damage indices as a tool for modifying methadone maintenance treatment: a cross-sectional study.
Croatian medical journal.
2018 Dec; 59(6):298-306. doi:
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Journal of analytical toxicology.
2018 Jul; 42(6):365-374. doi:
10.1093/jat/bky017. [PMID: 29579266] - Taryn M Guinan, Declan Neldner, Peter Stockham, Hilton Kobus, Christopher B Della Vedova, Nicolas H Voelcker. Porous silicon mass spectrometry as an alternative confirmatory assay for compliance testing of methadone.
Drug testing and analysis.
2017 May; 9(5):769-777. doi:
10.1002/dta.2033. [PMID: 27364015] - Nicola Mastroianni, Maria Jose Bleda, Miren López de Alda, Damià Barceló. Occurrence of drugs of abuse in surface water from four Spanish river basins: Spatial and temporal variations and environmental risk assessment.
Journal of hazardous materials.
2016 10; 316(?):134-42. doi:
10.1016/j.jhazmat.2016.05.025. [PMID: 27232724] - Brandon Stamper, Waseem Gul, Murrell Godfrey, Shahbaz W Gul, Mahmoud A ElSohly. LC-MS-MS Method for the Analysis of Miscellaneous Drugs in Wastewater During Football Games III.
Journal of analytical toxicology.
2016 Oct; 40(8):694-699. doi:
10.1093/jat/bkw081. [PMID: 27562966] - Phong K Thai, Foon Yin Lai, Raimondo Bruno, Emma van Dyken, Wayne Hall, Jake O'Brien, Jeremy Prichard, Jochen F Mueller. Refining the excretion factors of methadone and codeine for wastewater analysis - Combining data from pharmacokinetic and wastewater studies.
Environment international.
2016 Sep; 94(?):307-314. doi:
10.1016/j.envint.2016.05.033. [PMID: 27295047] - Pascal Kintz, François Mathiaux, Pierre Villéger, Jean-Michel Gaulier. Testing for Drugs in Exhaled Breath Collected With ExaBreath in a Drug Dependence Population: Comparison With Data Obtained in Urine After Liquid Chromatographic-Tandem Mass Spectrometric Analyses.
Therapeutic drug monitoring.
2016 Feb; 38(1):135-9. doi:
10.1097/ftd.0000000000000228. [PMID: 26222873] - John F Carlquist, David E Moody, Stacey Knight, Eric G Johnson, Wenfang B Fang, John A Huntinghouse, Jeffrey S Rollo, Lynn R Webster, Jeffrey L Anderson. A Possible Mechanistic Link Between the CYP2C19 Genotype, the Methadone Metabolite Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidene (EDDP), and Methadone-Induced Corrected QT Interval Prolongation in a Pilot Study.
Molecular diagnosis & therapy.
2015 Apr; 19(2):131-8. doi:
10.1007/s40291-015-0137-4. [PMID: 25903311] - Régis Bouquié, Hélène Hernando, Guillaume Deslandes, Amina Ben Mostefa Daho, Christian Renaud, Marie Grall-Bronnec, Eric Dailly, Pascale Jolliet. Chiral on-line solid phase extraction coupled to liquid chromatography-tandem mass spectrometry assay for quantification of (R) and (S) enantiomers of methadone and its main metabolite in plasma.
Talanta.
2015 Mar; 134(?):373-378. doi:
10.1016/j.talanta.2014.11.052. [PMID: 25618682] - Shiau Hui Diong, Nor Shuhadah Mohd Yusoff, Maw Shin Sim, Raja Elina Raja Aziddin, Zamri Chik, Poppy Rajan, Rusdi Abdul Rashid, Norliza Chemi, Zahurin Mohamed. Quantitation of methadone and metabolite in patients under maintenance treatment.
Journal of analytical toxicology.
2014 Nov; 38(9):660-6. doi:
10.1093/jat/bku096. [PMID: 25106416] - Carl E Wolf, Ashley Goldstein, Justin L Poklis, Alphonse Poklis. Evaluation of an enzyme immunoassay for the detection of methadone metabolite EDDP [2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine] in urine.
Journal of clinical laboratory analysis.
2014 Mar; 28(2):136-40. doi:
10.1002/jcla.21657. [PMID: 24395735] - Marie K K Nielsen, Sys S Johansen, Kristian Linnet. Evaluation of metabolite/drug ratios in blood and urine as a tool for confirmation of a reduced tolerance in methadone-related deaths in Denmark.
Drug and alcohol dependence.
2013 Dec; 133(2):447-51. doi:
10.1016/j.drugalcdep.2013.07.001. [PMID: 23891033] - Ya-Ching Hsu, Bud-Gen Chen, Shu-Ching Yang, Yu-Shan Wang, Shiao-Ping Huang, Mei-Han Huang, Tai-Jui Chen, Hsu-Chun Liu, Dong-Liang Lin, Ray H Liu, A Wayne Jones. Methadone concentrations in blood, plasma, and oral fluid determined by isotope-dilution gas chromatography-mass spectrometry.
Analytical and bioanalytical chemistry.
2013 May; 405(12):3921-8. doi:
10.1007/s00216-012-6460-2. [PMID: 23090648] - Nunziata Barbera, Francesco Paolo Busardò, Francesca Indorato, Guido Romano. The pathogenetic role of adulterants in 5 cases of drug addicts with a fatal outcome.
Forensic science international.
2013 Apr; 227(1-3):74-6. doi:
10.1016/j.forsciint.2012.08.041. [PMID: 23000137] - Shiow-Ling Wu, Sheng-Chang Wang, Hsiao-Hui Tsou, Hsiang-Wei Kuo, Ing-Kang Ho, Sheng-Wen Liu, Ya-Ting Hsu, Yao-Sheng Chang, Yu-Li Liu. Hepatitis C virus infection influences the S-methadone metabolite plasma concentration.
PloS one.
2013; 8(7):e69310. doi:
10.1371/journal.pone.0069310. [PMID: 23935979] - Cristiana Gambelunghe, Riccardo Rossi, Kyriaki Aroni, Mauro Bacci, Andrea Lazzarini, Nadia De Giovanni, Paola Carletti, Nadia Fucci. Sweat testing to monitor drug exposure.
Annals of clinical and laboratory science.
2013; 43(1):22-30. doi:
NULL. [PMID: 23462602] - Mathew George, Joseph P Kitzmiller, Michele Burns Ewald, Katherine A O'Donell, Melissa Lai Becter, Steve Salhanick. Methadone toxicity and possible induction and enhanced elimination in a premature neonate.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2012 Dec; 8(4):432-5. doi:
10.1007/s13181-012-0249-8. [PMID: 22898875] - Béla Kiss, Catalina Bogdan, Anca Pop, Felicia Loghin. A rapid UPLC-MS/MS method for simultaneous determination of flunitrazepam, 7-aminoflunitrazepam, methadone and EDDP in human, rat and rabbit plasma.
Talanta.
2012 Sep; 99(?):649-59. doi:
10.1016/j.talanta.2012.06.070. [PMID: 22967607] - Jia-Ni Tian, Ing-Kang Ho, Hsiao-Hui Tsou, Chiu-Ping Fang, Chin-Fu Hsiao, Chia-Hui Chen, Happy Kuy-Lok Tan, Linen Lin, Chi-Shin Wu, Lien-Wen Su, Chieh-Liang Huang, Yi-Hong Yang, Ming-Lun Liu, Yu-Ting Chen, Shu Chih Liu, Ya-Ting Hsu, Hsiang-Wei Kuo, Chen Ting Liu, Yi-Ting Yang, Andrew Ch Chen, Yu-Huei Shih, Yu-Li Liu. UGT2B7 genetic polymorphisms are associated with the withdrawal symptoms in methadone maintenance patients.
Pharmacogenomics.
2012 Jun; 13(8):879-88. doi:
10.2217/pgs.12.69. [PMID: 22676193] - Edijs Leimanis, Brookie M Best, Rabia S Atayee, Amadeo J Pesce. Evaluating the relationship of methadone concentrations and EDDP formation in chronic pain patients.
Journal of analytical toxicology.
2012 May; 36(4):239-49. doi:
10.1093/jat/bks020. [PMID: 22511698] - Igor Botello, Francesc Borrull, Marta Calull, Carme Aguilar, Govert W Somsen, Gerhardus J de Jong. In-line solid-phase extraction-capillary electrophoresis coupled with mass spectrometry for determination of drugs of abuse in human urine.
Analytical and bioanalytical chemistry.
2012 May; 403(3):777-84. doi:
10.1007/s00216-012-5872-3. [PMID: 22370589] - Wenjie J Lu, Weidong Zhou, Yvonne Kreutz, David A Flockhart. Methadone adverse reaction presenting with large increase in plasma methadone binding: a case series.
Journal of medical case reports.
2011 Oct; 5(?):513. doi:
10.1186/1752-1947-5-513. [PMID: 21985665] - Chun-Chi Wang, Cheng-Chung Chen, Shang-Jang Wang, Shou-Mei Wu. Cation-selective exhaustive injection and sweeping micellar electrokinetic chromatography for the analysis of methadone and its metabolites in serum of heroin addicts.
Journal of chromatography. A.
2011 Sep; 1218(38):6832-7. doi:
10.1016/j.chroma.2011.07.086. [PMID: 21862022] - Ana de Castro, Hendreé E Jones, Rolley E Johnson, Teresa R Gray, Diaa M Shakleya, Marilyn A Huestis. Methadone, cocaine, opiates, and metabolite disposition in umbilical cord and correlations to maternal methadone dose and neonatal outcomes.
Therapeutic drug monitoring.
2011 Aug; 33(4):443-52. doi:
10.1097/ftd.0b013e31822724f0. [PMID: 21743375] - Sheng-Chang Wang, Ing-Kang Ho, Hsiao-Hui Tsou, Jia-Ni Tian, Chin-Fu Hsiao, Chia-Hui Chen, Happy Kuy-Lok Tan, Linen Lin, Chi-Shin Wu, Lien-Wen Su, Chieh-Liang Huang, Yi-Hong Yang, Ming-Lun Liu, Keh-Ming Lin, Chun-Yu Chen, Shu Chih Liu, Hsiao-Yu Wu, Hsiu-Wen Chan, Ming-Hsien Tsai, Pei-Sheng Lin, Yu-Li Liu. CYP2B6 polymorphisms influence the plasma concentration and clearance of the methadone S-enantiomer.
Journal of clinical psychopharmacology.
2011 Aug; 31(4):463-9. doi:
10.1097/jcp.0b013e318222b5dd. [PMID: 21694616] - Francina Fonseca, Rafael de la Torre, Laura Díaz, Antonio Pastor, Elisabet Cuyàs, Nieves Pizarro, Olha Khymenets, Magí Farré, Marta Torrens. Contribution of cytochrome P450 and ABCB1 genetic variability on methadone pharmacokinetics, dose requirements, and response.
PloS one.
2011 May; 6(5):e19527. doi:
10.1371/journal.pone.0019527. [PMID: 21589866] - Marta Pedrouzo, Francesc Borrull, Eva Pocurull, Rosa Maria Marcé. Drugs of abuse and their metabolites in waste and surface waters by liquid chromatography-tandem mass spectrometry.
Journal of separation science.
2011 May; 34(10):1091-101. doi:
10.1002/jssc.201100043. [PMID: 21491600] - Alexander L N van Nuijs, Jean-François Mougel, Isabela Tarcomnicu, Lieven Bervoets, Ronny Blust, Philippe G Jorens, Hugo Neels, Adrian Covaci. A one year investigation of the occurrence of illicit drugs in wastewater from Brussels, Belgium.
Journal of environmental monitoring : JEM.
2011 Apr; 13(4):1008-16. doi:
10.1039/c0em00686f. [PMID: 21331424] - Ana de Castro, Hendreé E Jones, Rolley E Johnson, Teresa R Gray, Diaa M Shakleya, Marilyn A Huestis. Maternal methadone dose, placental methadone concentrations, and neonatal outcomes.
Clinical chemistry.
2011 Mar; 57(3):449-58. doi:
10.1373/clinchem.2010.154864. [PMID: 21245372] - Teresa R Gray, Robin E Choo, Marta Concheiro, Erica Williams, Andrea Elko, Lauren M Jansson, Hendreé E Jones, Marilyn A Huestis. Prenatal methadone exposure, meconium biomarker concentrations and neonatal abstinence syndrome.
Addiction (Abingdon, England).
2010 Dec; 105(12):2151-9. doi:
10.1111/j.1360-0443.2010.03097.x. [PMID: 20854338] - Geraldine Dowling, Liam Regan, Julie Tierney, Michael Nangle. A hybrid liquid chromatography-mass spectrometry strategy in a forensic laboratory for opioid, cocaine and amphetamine classes in human urine using a hybrid linear ion trap-triple quadrupole mass spectrometer.
Journal of chromatography. A.
2010 Oct; 1217(44):6857-66. doi:
10.1016/j.chroma.2010.08.043. [PMID: 20855077] - Sheng-Chang Wang, Ing-Kang Ho, Shiow-Ling Wu, Shu Chih Liu, Hsiang-Wei Kuo, Keh-Ming Lin, Yu-Li Liu. Development of a method to measure methadone enantiomers and its metabolites without enantiomer standard compounds for the plasma of methadone maintenance patients.
Biomedical chromatography : BMC.
2010 Jul; 24(7):782-8. doi:
10.1002/bmc.1363. [PMID: 19904716] - Anders Buchard, Kristian Linnet, Sys Stybe Johansen, Julie Munkholm, Michael Fregerslev, Niels Morling. Postmortem blood concentrations of R- and S-enantiomers of methadone and EDDP in drug users: influence of co-medication and p-glycoprotein genotype.
Journal of forensic sciences.
2010 Mar; 55(2):457-63. doi:
10.1111/j.1556-4029.2009.01278.x. [PMID: 20102450] - Edward Goucher, Andrew Kicman, Kim Wolff, Norman Smith, Sue Jickells. Hydrophilic stationary phases: a practical approach for the co-analysis of compounds with varying polarity in biological matrices.
Journal of separation science.
2010 Mar; 33(6-7):955-65. doi:
10.1002/jssc.200900727. [PMID: 20183825] - Christine L H Snozek, Matthew W Bjergum, Loralie J Langman. Gas chromatography-mass spectrometry method for the determination of methadone and 2-ethylidene-1,5-dimethyl-3, 3-diphenylpyrrolidine (EDDP).
Methods in molecular biology (Clifton, N.J.).
2010; 603(?):351-8. doi:
10.1007/978-1-60761-459-3_33. [PMID: 20077086] - Michael E M Larson, Thomas M Richards. Quantification of a methadone metabolite (EDDP) in urine: assessment of compliance.
Clinical medicine & research.
2009 Dec; 7(4):134-41. doi:
10.3121/cmr.2009.859. [PMID: 19920164] - Sys Stybe Johansen, Kristian Linnet. Chiral analysis of methadone and its main metabolite EDDP in postmortem blood by liquid chromatography-mass spectrometry.
Journal of analytical toxicology.
2008 Sep; 32(7):499-504. doi:
10.1093/jat/32.7.499. [PMID: 18713518] - Salvatore De Fazio, Luca Gallelli, Antonella De Siena, Giovambattista De Sarro, Maria Gabriella Scordo. Role of CYP3A5 in abnormal clearance of methadone.
The Annals of pharmacotherapy.
2008 Jun; 42(6):893-7. doi:
10.1345/aph.1k539. [PMID: 18460585] - Panagiota D Nikolaou, Ioannis I Papoutsis, Julia Atta-Politou, Sotiris A Athanaselis, Chara A Spiliopoulou, Antony C Calokerinos, Constantinos P Maravelias. Validated method for the simultaneous determination of methadone and its main metabolites (EDDP and EMDP) in plasma of umbilical cord blood by gas chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 May; 867(2):219-25. doi:
10.1016/j.jchromb.2008.04.006. [PMID: 18436488] - David E Moody, Shen-Nan Lin, Yan Chang, Lolita Lamm, Mark K Greenwald, Mahmoud S Ahmed. An enantiomer-selective liquid chromatography-tandem mass spectrometry method for methadone and EDDP validated for use in human plasma, urine, and liver microsomes.
Journal of analytical toxicology.
2008 Apr; 32(3):208-19. doi:
10.1093/jat/32.3.208. [PMID: 18397572] - Pai-Sheng Cheng, Choung-Huei Lee, Chiareiy Liu, Chun-Sheng Chien. Simultaneous determination of ketamine, tramadol, methadone, and their metabolites in urine by gas chromatography-mass spectrometry.
Journal of analytical toxicology.
2008 Apr; 32(3):253-9. doi:
10.1093/jat/32.3.253. [PMID: 18397578] - Liliane F Martins, Michel Yegles, Robert Wennig. Simultaneous enantioselective quantification of methadone and of 2-ethylidene-1,5-dimethyl-3,3-diphenyl-pyrrolidine in oral fluid using capillary electrophoresis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Feb; 862(1-2):79-85. doi:
10.1016/j.jchromb.2007.11.001. [PMID: 18155972] - N Fucci, N De Giovanni, S Scarlata. Sweat testing in addicts under methadone treatment: an Italian experience.
Forensic science international.
2008 Jan; 174(2-3):107-10. doi:
10.1016/j.forsciint.2007.03.010. [PMID: 17428631] - Marta Concheiro, Ana De Castro, Oscar Quintela, Angelines Cruz, Manuel López-Rivadulla. Determination of illicit drugs and their metabolites in human urine by liquid chromatography tandem mass spectrometry including relative ion intensity criterion.
Journal of analytical toxicology.
2007 Nov; 31(9):573-80. doi:
10.1093/jat/31.9.573. [PMID: 18093416] - Purificación Fernández, Marta Lago, Rosa Antonia Lorenzo, Antonia María Carro, Ana María Bermejo, María Jesús Tabernero. Microwave-assisted extraction and HPLC-DAD determination of drugs of abuse in human plasma.
Journal of analytical toxicology.
2007 Sep; 31(7):388-93. doi:
10.1093/jat/31.7.388. [PMID: 17725887] - Diaa M Shakleya, Lauren M Jansson, Marilyn A Huestis. Validation of a LC-APCI-MS/MS method for quantification of methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3,3-diphenylpyraline (EMDP) in infant plasma following protein precipitation.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Sep; 856(1-2):267-72. doi:
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European journal of clinical pharmacology.
2007 Aug; 63(8):777-82. doi:
10.1007/s00228-007-0314-4. [PMID: 17576548] - Nadia Fucci, Nadia De Giovanni. Methadone in hair and sweat from patients in long-term maintenance therapy.
Therapeutic drug monitoring.
2007 Aug; 29(4):452-4. doi:
10.1097/ftd.0b013e31811f1bbe. [PMID: 17667800] - Elena Arroyo, Belén Valenzuela, Joaquín Portilla, Eduardo Climent-Grana, Juan José Pérez-Ruixo, Esperanza Merino. Pharmacokinetics of methadone in human-immunodeficiency-virus-infected patients receiving nevirapine once daily.
European journal of clinical pharmacology.
2007 Jul; 63(7):669-75. doi:
10.1007/s00228-007-0299-z. [PMID: 17473920] - Purificación Fernández, Marta Lago, Rosa Antonia Lorenzo, Antonia María Carro, Ana María Bermejo, María Jesús Tabernero. Microwave assisted extraction of drugs of abuse from human urine.
Journal of applied toxicology : JAT.
2007 Jul; 27(4):373-9. doi:
10.1002/jat.1216. [PMID: 17265433] - Ivano Marchi, Serge Rudaz, Maurice Selman, Jean-Luc Veuthey. Evaluation of the influence of protein precipitation prior to on-line SPE-LC-API/MS procedures using multivariate data analysis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jan; 845(2):244-52. doi:
10.1016/j.jchromb.2006.08.045. [PMID: 17030156] - Séverine Crettol, Patricia Digon, Kerry Powell Golay, Marlyse Brawand, Chin B Eap. In vitro P-glycoprotein-mediated transport of (R)-, (S)-, (R,S)-methadone, LAAM and their main metabolites.
Pharmacology.
2007; 80(4):304-11. doi:
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Critical care (London, England).
2007; 11(1):R5. doi:
10.1186/cc5150. [PMID: 17224045] - Sara Castiglioni, Ettore Zuccato, Elisabetta Crisci, Chiara Chiabrando, Roberto Fanelli, Renzo Bagnati. Identification and measurement of illicit drugs and their metabolites in urban wastewater by liquid chromatography-tandem mass spectrometry.
Analytical chemistry.
2006 Dec; 78(24):8421-9. doi:
10.1021/ac061095b. [PMID: 17165835] - Niccoló Di Pietro, Giorgio Placanica, Italbo Fiorini, Clementina Manera, Caterina Orlando, Flaminia Palombo, Giuseppe Saccomanni, Vittorio Salotti, Marco Macchia. Use of capillary electrophoresis and poly(ethylene oxide) as the coating agent for the determination of substances related to heroin addiction and treatment.
Journal of analytical toxicology.
2006 Nov; 30(9):679-82. doi:
10.1093/jat/30.9.679. [PMID: 17137528] - P Fernández, L Morales, C Vázquez, A M Bermejo, M J Tabernero. HPLC-DAD determination of opioids, cocaine and their metabolites in plasma.
Forensic science international.
2006 Aug; 161(1):31-5. doi:
10.1016/j.forsciint.2005.10.016. [PMID: 16300917] - O Quintela, P López, A M Bermejo, M López-Rivadulla. Determination of methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine and alprazolam in human plasma by liquid chromatography-electrospray ionization mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Apr; 834(1-2):188-94. doi:
10.1016/j.jchromb.2006.02.013. [PMID: 16517229] - M L Etter, S George, K Graybiel, J Eichhorst, D C Lehotay. Determination of free and protein-bound methadone and its major metabolite EDDP: enantiomeric separation and quantitation by LC/MS/MS.
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