6-Thiourate (BioDeep_00001875925)

Main id: BioDeep_00000011305

 


代谢物信息卡片


6-Thiouric acid

化学式: C5H4N4O2S (184.0055)
中文名称:
谱图信息: 最多检出来源 Mus musculus(not specific) 0.46%

分子结构信息

SMILES: C12=C(NC(=O)N1)NC(=O)NC2=S
InChI: InChI=1S/C5H4N4O2S/c10-4-6-1-2(7-4)8-5(11)9-3(1)12/h(H4,6,7,8,9,10,11,12)

描述信息

同义名列表

3 个代谢物同义名

6-Thiouric acid; 6-Thiourate; 6-Thiourate



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(2)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Blanka Stiburkova, Katerina Pavelcova, Lenka Petru, Jakub Krijt. Thiopurine-induced toxicity is associated with dysfunction variant of the human molybdenum cofactor sulfurase gene (xanthinuria type II). Toxicology and applied pharmacology. 2018 08; 353(?):102-108. doi: 10.1016/j.taap.2018.06.015. [PMID: 29935280]
  • William J Sandborn. State-of-the-art: Immunosuppression and biologic therapy. Digestive diseases (Basel, Switzerland). 2010; 28(3):536-42. doi: 10.1159/000320413. [PMID: 20926883]
  • Ahmed F Hawwa, Jeff S Millership, Paul S Collier, Anthony McCarthy, Sid Dempsey, Carole Cairns, James C McElnay. The development of an objective methodology to measure medication adherence to oral thiopurines in paediatric patients with acute lymphoblastic leukaemia--an exploratory study. European journal of clinical pharmacology. 2009 Nov; 65(11):1105-12. doi: 10.1007/s00228-009-0700-1. [PMID: 19636546]
  • A Ansari, Z Aslam, A De Sica, M Smith, K Gilshenan, L Fairbanks, A Marinaki, J Sanderson, J Duley. Influence of xanthine oxidase on thiopurine metabolism in Crohn's disease. Alimentary pharmacology & therapeutics. 2008 Sep; 28(6):749-57. doi: 10.1111/j.1365-2036.2008.03768.x. [PMID: 18557988]
  • Sukirti Kalra, Gopabandhu Jena, Kulbhushan Tikoo, Anup Kumar Mukhopadhyay. Preferential inhibition of xanthine oxidase by 2-amino-6-hydroxy-8-mercaptopurine and 2-amino-6-purine thiol. BMC biochemistry. 2007 May; 8(?):8. doi: 10.1186/1471-2091-8-8. [PMID: 17511860]
  • S Weller, P Thürmann, N Rietbrock, J Gossmann, E H Scheuermann. HPLC analysis of azathioprine metabolites in red blood cells, plasma and urine in renal transplant recipients. International journal of clinical pharmacology and therapeutics. 1995 Dec; 33(12):639-45. doi: . [PMID: 8963480]
  • A A Elfarra, I Y Hwang. Targeting of 6-mercaptopurine to the kidneys. Metabolism and kidney-selectivity of S-(6-purinyl)-L-cysteine analogs in rats. Drug metabolism and disposition: the biological fate of chemicals. 1993 Sep; 21(5):841-5. doi: . [PMID: 7902246]
  • I Y Hwang, A A Elfarra. Detection and mechanisms of formation of S-(6-purinyl)glutathione and 6-mercaptopurine in rats given 6-chloropurine. The Journal of pharmacology and experimental therapeutics. 1993 Jan; 264(1):41-6. doi: . [PMID: 8423540]
  • M Jeebhay, S Mbuli, R Uebel. Assessment of exposure to chloramphenicol and azathioprine among workers in a South African pharmaceutical plant. International archives of occupational and environmental health. 1993; 65(1 Suppl):S119-22. doi: 10.1007/bf00381321. [PMID: 8406906]
  • K T Lin, F Varin, G E Rivard, J M Leclerc. Isolation of 6-mercaptopurine in human plasma by aluminum ion complexation for high-performance liquid chromatographic analysis. Journal of chromatography. 1991 Jan; 536(1-2):349-55. doi: 10.1016/s0021-9673(01)89269-4. [PMID: 2050774]
  • V Kurowski, H Iven. Plasma concentrations and organ distribution of thiopurines after oral application of azathioprine in mice. Cancer chemotherapy and pharmacology. 1991; 28(1):7-14. doi: 10.1007/bf00684949. [PMID: 2040036]
  • G L Chan, G R Erdmann, S A Gruber, A J Matas, D M Canafax. Azathioprine metabolism: pharmacokinetics of 6-mercaptopurine, 6-thiouric acid and 6-thioguanine nucleotides in renal transplant patients. Journal of clinical pharmacology. 1990 Apr; 30(4):358-63. doi: 10.1002/j.1552-4604.1990.tb03606.x. [PMID: 2341582]
  • I Bruunshuus, K Schmiegelow. Analysis of 6-mercaptopurine, 6-thioguanine nucleotides, and 6-thiouric acid in biological fluids by high-performance liquid chromatography. Scandinavian journal of clinical and laboratory investigation. 1989 Dec; 49(8):779-84. doi: 10.3109/00365518909091557. [PMID: 2617134]
  • G L Chan, G R Erdmann, S A Gruber, P Stock, S Chen, N L Ascher, D M Canafax. Pharmacokinetics of 6-thiouric acid and 6-mercaptopurine in renal allograft recipients after oral administration of azathioprine. European journal of clinical pharmacology. 1989; 36(3):265-71. doi: 10.1007/bf00558158. [PMID: 2526020]
  • K G Vanscoik, C A Johnson, W R Porter. Sensitive and specific high-performance liquid chromatographic assay for 6-thiouric acid. Journal of chromatography. 1987 Jun; 417(1):183-9. doi: 10.1016/0378-4347(87)80106-8. [PMID: 3624395]
  • R Tawa, S Takeshima, S Hirose. The use of xanthine oxidase for a specific and sensitive fluorimetric determination of 6-mercaptopurine in serum. Biochemical medicine. 1984 Dec; 32(3):303-10. doi: 10.1016/0006-2944(84)90035-8. [PMID: 6549126]
  • P J Jackson. Determination of 6-thiouric acid in human urine. Clinical biochemistry. 1983 Oct; 16(5):285-6. doi: 10.1016/s0009-9120(83)94053-5. [PMID: 6652883]
  • A H Chalmers. A spectrophotometric method for the estimation of urinary azathioprine, 6-mercaptopurine, and 6-thiouric acid. Biochemical medicine. 1975 Mar; 12(3):234-41. doi: 10.1016/0006-2944(75)90125-8. [PMID: 1137584]