Afalanine (BioDeep_00001875820)

   


代谢物信息卡片


N-Acetyl-DL-phenylalanine

化学式: C11H13NO3 (207.0895)
中文名称: N-乙酰基-DL-苯丙氨酸, N-乙酰-DL-苯丙氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)NC(CC1=CC=CC=C1)C(=O)O
InChI: InChI=1S/C11H13NO3/c1-8(13)12-10(11(14)15)7-9-5-3-2-4-6-9/h2-6,10H,7H2,1H3,(H,12,13)(H,14,15)

描述信息

C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent

同义名列表

3 个代谢物同义名

N-Acetyl-DL-phenylalanine; ac-dl-phe-oh; Afalanine



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ACY3, ALB, AR, GAL, MYLK, MYLK3
Peripheral membrane protein 1 ACY3
Nucleus 4 ALB, AR, KLK3, SEMG1
cytosol 7 ACY3, ALB, AR, GPT, MYLK, MYLK3, PRKCQ
centrosome 1 ALB
nucleoplasm 1 AR
Cell membrane 3 C5AR1, GAL, NPHS1
Cleavage furrow 1 MYLK
lamellipodium 1 MYLK
Multi-pass membrane protein 1 C5AR1
Synapse 1 MYLK
cell surface 1 C3
Golgi apparatus 1 ALB
neuronal cell body 1 GAL
plasma membrane 9 AR, C3, C5AR1, GAL, KLK3, KNG1, MYLK, NPHS1, PRKCQ
Membrane 1 AR
apical plasma membrane 1 ACY3
basolateral plasma membrane 1 C5AR1
extracellular exosome 8 ACY3, ALB, C3, GPT, KLK3, KNG1, NPHS1, SEMG1
endoplasmic reticulum 1 ALB
extracellular space 7 ALB, C3, CTRL, GAL, KLK3, KNG1, SEMG1
protein-containing complex 5 ALB, AR, C3, KLK3, SEMG1
Single-pass type I membrane protein 1 NPHS1
Secreted 4 ALB, C3, GAL, SEMG1
extracellular region 6 ALB, C3, GAL, KLK3, KNG1, SEMG1
anchoring junction 1 ALB
centriolar satellite 1 PRKCQ
actin cytoskeleton 2 MYLK, MYLK3
slit diaphragm 1 NPHS1
cytoplasmic vesicle 1 C5AR1
apical part of cell 1 C5AR1
cell-cell junction 1 NPHS1
Apical cell membrane 1 ACY3
Cell projection, lamellipodium 1 MYLK
focal adhesion 1 NPHS1
collagen-containing extracellular matrix 1 KNG1
secretory granule 2 GAL, KLK3
nuclear speck 1 AR
ciliary basal body 1 ALB
chromatin 1 AR
cell projection 1 NPHS1
centriole 1 ALB
Secreted, extracellular space 1 KNG1
spindle pole 1 ALB
blood microparticle 3 ALB, C3, KNG1
stress fiber 1 MYLK
secretory granule lumen 1 C3
secretory granule membrane 1 C5AR1
endoplasmic reticulum lumen 3 ALB, C3, KNG1
platelet alpha granule lumen 2 ALB, KNG1
azurophil granule lumen 1 C3
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
ciliary transition fiber 1 ALB


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Vahid Hosseininaveh, Alireza Bandani, Fatemeh Hosseininaveh. Digestive proteolytic activity in the Sunn pest, Eurygaster integriceps. Journal of insect science (Online). 2009; 9(?):1-11. doi: 10.1673/031.009.7001. [PMID: 20053125]
  • Magnus Stödeman, Frederick P Schwarz. Importance of product inhibition in the kinetics of the acylase hydrolysis reaction by differential stopped flow microcalorimetry. Analytical biochemistry. 2002 Sep; 308(2):285-93. doi: 10.1016/s0003-2697(02)00339-1. [PMID: 12419341]
  • K Y Xu. Acid dissociation constant and apparent nucleophilicity of lysine-501 of the alpha-polypeptide of sodium and potassium ion activated adenosinetriphosphatase. Biochemistry. 1989 Aug; 28(17):6894-9. doi: 10.1021/bi00443a018. [PMID: 2554957]
  • E Jellum, L Horn, O Thoresen, E A Kvittingen, O Stokke. Urinary excretion of N-acetyl amino acids in patients with some inborn errors of amino acid metabolism. Scandinavian journal of clinical and laboratory investigation. Supplementum. 1986; 184(?):21-6. doi: . [PMID: 3473611]
  • K Okajima, M Inoue, Y Morino. Studies on the mechanism for renal elimination of N-acetylphenylalanine: its pathophysiologic significance in phenylketonuria. The Journal of laboratory and clinical medicine. 1985 Jan; 105(1):132-8. doi: . [PMID: 4038506]