eupatoriopicrin (BioDeep_00001869203)

Main id: BioDeep_00000007378

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


eupatoriopicrin

化学式: C20H26O6 (362.1729)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=C1C(=O)O[C@@H]2/C=C(\C)CC/C=C(\C)C[C@@H](OC(=O)/C(=C/CO)CO)[C@@H]12
InChI: InChI=1S/C20H26O6/c1-12-5-4-6-13(2)10-17(26-20(24)15(11-22)7-8-21)18-14(3)19(23)25-16(18)9-12/h6-7,9,16-18,21-22H,3-5,8,10-11H2,1-2H3/b12-9+,13-6+,15-7+/t16-,17-,18+/m1/s1

描述信息

同义名列表

2 个代谢物同义名

eupatoriopicrin; Eupatoriopicrin



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

51 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 AIMP2, CASP3, GAPDH, PKM
Nucleus 4 AIMP2, CASP3, GAPDH, PKM
cytosol 4 AIMP2, CASP3, GAPDH, PKM
nucleoplasm 1 CASP3
Cell membrane 2 ITGAM, TNF
cell surface 2 ITGAM, TNF
glutamatergic synapse 1 CASP3
neuronal cell body 2 CASP3, TNF
Cytoplasm, cytosol 2 AIMP2, GAPDH
plasma membrane 3 GAPDH, ITGAM, TNF
Membrane 3 AIMP2, GAPDH, ITGAM
extracellular exosome 3 GAPDH, ITGAM, PKM
extracellular space 3 CXCL8, ITGAM, TNF
perinuclear region of cytoplasm 1 GAPDH
mitochondrion 1 PKM
intracellular membrane-bounded organelle 1 GAPDH
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 ITGAM
Secreted 1 CXCL8
extracellular region 3 CXCL8, PKM, TNF
nuclear membrane 1 GAPDH
external side of plasma membrane 2 ITGAM, TNF
Extracellular vesicle 1 PKM
microtubule cytoskeleton 1 GAPDH
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 2 GAPDH, PKM
Cytoplasm, perinuclear region 1 GAPDH
Membrane raft 2 ITGAM, TNF
Cytoplasm, cytoskeleton 1 GAPDH
collagen-containing extracellular matrix 1 PKM
cilium 1 PKM
phagocytic cup 1 TNF
cytoskeleton 1 GAPDH
Lipid droplet 1 GAPDH
specific granule membrane 1 ITGAM
tertiary granule membrane 1 ITGAM
plasma membrane raft 1 ITGAM
ficolin-1-rich granule lumen 1 PKM
secretory granule lumen 1 PKM
ribonucleoprotein complex 1 GAPDH
death-inducing signaling complex 1 CASP3
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
Rough endoplasmic reticulum 1 PKM
GAIT complex 1 GAPDH
integrin complex 1 ITGAM
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
integrin alphaM-beta2 complex 1 ITGAM
[Isoform M2]: Cytoplasm 1 PKM
[Isoform M1]: Cytoplasm 1 PKM
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Orlando G Elso, Vanesa Puente, Patricia Barrera, Miguel A Sosa-Escudero, Valeria P Sülsen, María E Lombardo. Mode of action of the sesquiterpene lactones eupatoriopicrin and estafietin on Trypanosoma cruzi. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Feb; 96(?):153900. doi: 10.1016/j.phymed.2021.153900. [PMID: 35026518]
  • Hiroyuki Yamazaki, Hayato Tsuge, Ohgi Takahashi, Ryuji Uchida. Germacrane sesquiterpenes from leaves of Eupatorium chinense inhibit protein tyrosine phosphatase. Bioorganic & medicinal chemistry letters. 2021 12; 53(?):128422. doi: 10.1016/j.bmcl.2021.128422. [PMID: 34710624]
  • Barbara Michalak, Jakub P Piwowarski, Sebastian Granica, Birgit Waltenberger, Atanas G Atanasov, Shafaat Y Khan, Johannes M Breuss, Pavel Uhrin, Barbara Żyżyńska-Granica, Anna Stojakowska, Hermann Stuppner, Anna K Kiss. Eupatoriopicrin Inhibits Pro-inflammatory Functions of Neutrophils via Suppression of IL-8 and TNF-alpha Production and p38 and ERK 1/2 MAP Kinases. Journal of natural products. 2019 02; 82(2):375-385. doi: 10.1021/acs.jnatprod.8b00939. [PMID: 30653318]
  • Njogu M Kimani, Josphat C Matasyoh, Marcel Kaiser, Reto Brun, Thomas J Schmidt. Antiprotozoal Sesquiterpene Lactones and Other Constituents from Tarchonanthus camphoratus and Schkuhria pinnata. Journal of natural products. 2018 01; 81(1):124-130. doi: 10.1021/acs.jnatprod.7b00747. [PMID: 29244495]
  • H J Woerdenbag, A C Edwards, E J Budé, T M Malingré, A W Konings. Eupatoriopicrin-induced lipid peroxidation in liver and tumour tissue of the mouse. Biochemical pharmacology. 1989 Sep; 38(18):3115-8. doi: 10.1016/0006-2952(89)90023-3. [PMID: 2783165]