Latamoxef (BioDeep_00001868246)
Main id: BioDeep_00000006445
代谢物信息卡片
Latamoxef
化学式: C20H20N6O9S (520.1012430000001)
中文名称: 拉氧头孢
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C(=NN=N1)SCC2=C(N3C(C(C3=O)(NC(=O)C(C4=CC=C(C=C4)O)C(=O)O)OC)OC2)C(=O)O
InChI: InChI=1S/C20H20N6O9S/c1-25-19(22-23-24-25)36-8-10-7-35-18-20(34-2,17(33)26(18)13(10)16(31)32)21-14(28)12(15(29)30)9-3-5-11(27)6-4-9/h3-6,12,18,27H,7-8H2,1-2H3,(H,21,28)(H,29,30)(H,31,32)/t12?,18-,20+/m1/s1
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DD - Third-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
1 个代谢物同义名
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:599928
- KEGG: C07231
- KEGGdrug: D08109
- PubChem: 47499
- DrugBank: DB04570
- ChEMBL: CHEMBL74632
- MeSH: Moxalactam
- CAS: 79120-38-0
- CAS: 64952-97-2
- PubChem: 9440
- PDB-CCD: MXL
- NIKKAJI: J19.504I
- RefMet: Latamoxef
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 7461 Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 7461 Apis cerana: 10.1371/JOURNAL.PONE.0175573
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hui Qi, Chen Kou, Yu-Jie Qi, Bo-Hao Tang, Yue-E Wu, Fei Jin, Xiao-Jing Luo, Yan-Hua Shen, Ya-Jie Guo, Xue Qi, Ya-Cui Wang, Qian Dong, Xing-Kai Chen, Hai-Yan Shi, Yi Zheng, Wei Zhao, A-Dong Shen. Population pharmacokinetics and dosing optimization of latamoxef in neonates and young infants.
International journal of antimicrobial agents.
2019 Mar; 53(3):347-351. doi:
10.1016/j.ijantimicag.2018.11.017. [PMID: 30472290] - Qian Dong, Hai-Yan Shi, Chen Kou, Xin Huang, A-Dong Shen, Wei Zhao. A microscale HPLC-UV method for the determination of latamoxef in plasma: An adapted method for therapeutic drug monitoring in neonates.
Biomedical chromatography : BMC.
2018 Aug; 32(8):e4243. doi:
10.1002/bmc.4243. [PMID: 29573350] - Ken Grime, Stuart W Paine. Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement.
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Journal of medicinal chemistry.
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1995 Mar; 48(3):380-8. doi:
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Urologia internationalis.
1995; 55(2):101-4. doi:
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1993 Jan; 8(1):52-9. doi:
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Nihon Jinzo Gakkai shi.
1991 Aug; 33(8):769-77. doi:
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Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
1991 Feb; 111(2):77-102. doi:
10.1248/yakushi1947.111.2_77. [PMID: 2056448] - Y Suzuki, S Itoh, M Katoh, M Morita, Y Fukushi, S Toyota, S Katoh, K Oikawa, S Orikasa, K Majima. [Clinical study concerning of latamoxef concentration in the obstructed urinary tract].
Hinyokika kiyo. Acta urologica Japonica.
1990 Aug; 36(8):897-902. doi:
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Japanese journal of pharmacology.
1990 May; 53(1):111-20. doi:
10.1254/jjp.53.111. [PMID: 2352376] - N Hashimoto, T Ichihashi, K Hirano, H Yamada. Epimerization kinetics of moxalactam in frozen urine and plasma samples.
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1990 Apr; 7(4):364-9. doi:
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Urology.
1990 Jan; 35(1):93-5. doi:
10.1016/0090-4295(90)80024-h. [PMID: 2404368] - R Kojima, M Ito, Y Suzuki. Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects (7): Effect of latamoxef on binding of tobramycin to brush border membranes isolated from rat kidney cortex.
Japanese journal of pharmacology.
1989 Dec; 51(4):465-73. doi:
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Arzneimittel-Forschung.
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The Journal of toxicological sciences.
1989 Aug; 14(3):165-80. doi:
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Antimicrobial agents and chemotherapy.
1989 Jun; 33(6):857-61. doi:
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1989 Mar; 35(3):501-4. doi:
NULL. [PMID: 2567569] - T Kitaura, S Tsukiai, S Arai, K Miyake, M Kimura, H Fukuchi. Ocular pharmacokinetics of latamoxef and cefaclor in humans. Penetration into aqueous humor.
Journal of pharmacobio-dynamics.
1989 Jan; 12(1):60-6. doi:
10.1248/bpb1978.12.60. [PMID: 2724050] - T Chimura, T Hirayama, T Ogawa, Y Shiina. [Effects of prophylactically used latamoxef with tobramycin against postoperative infections on therapeutic drug monitoring and renal function in the field of obstetrics and gynecology].
The Japanese journal of antibiotics.
1989 Jan; 42(1):189-92. doi:
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The Journal of antimicrobial chemotherapy.
1988 Dec; 22(6):857-61. doi:
10.1093/jac/22.6.857. [PMID: 3243734] - T Kitaura, S Tsukiai, S Arai, K Miyake, M Kimura, H Fukuchi. Ocular pharmacokinetics of latamoxef and cefaclor in rabbits. Penetration into aqueous humor.
Journal of pharmacobio-dynamics.
1988 Oct; 11(10):694-9. doi:
10.1248/bpb1978.11.694. [PMID: 3221302] - M Matsuura, S Satoh, F Kobayashi, T Matsubara, K Uchida. Vitamin K reversible hypoprothrombinemia in rats. II. Efficacy of vitamin K on latamoxef-induced coagulopathy in rats.
Japanese journal of pharmacology.
1988 Aug; 47(4):357-65. doi:
10.1254/jjp.47.357. [PMID: 3184567] - L C Knodel, B R Goldspiel, R S Gibbs. Prospective cost analysis of moxalactam versus clindamycin plus gentamicin for endomyometritis after cesarean section.
Antimicrobial agents and chemotherapy.
1988 Jun; 32(6):853-7. doi:
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La Revue de medecine interne.
1988 Mar; 9(2):223-5. doi:
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The Journal of antibiotics.
1988 Mar; 41(3):316-31. doi:
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Drug intelligence & clinical pharmacy.
1988 Jan; 22(1):58-61. doi:
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Journal of pharmacobio-dynamics.
1988 Jan; 11(1):9-17. doi:
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The Japanese journal of antibiotics.
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Japanese journal of pharmacology.
1987 Nov; 45(3):303-15. doi:
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1987 Aug; 20(2):273-82. doi:
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1987 Aug; 31(8):1169-76. doi:
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The Japanese journal of antibiotics.
1987 Jul; 40(7):1253-8. doi:
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The Japanese journal of antibiotics.
1987 Jul; 40(7):1317-31. doi:
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1987 Jul; 40(7):1243-52. doi:
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1987 Jul; 40(7):1294-8. doi:
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The Journal of dermatology.
1987 Jun; 14(3):237-40. doi:
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Surgery, gynecology & obstetrics.
1987 Jun; 164(6):525-9. doi:
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Pathologie-biologie.
1987 Jun; 35(5 Pt 2):861-4. doi:
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The Journal of hospital infection.
1987 May; 9(3):278-84. doi:
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International journal of clinical pharmacology, therapy, and toxicology.
1987 Mar; 25(3):152-6. doi:
NULL. [PMID: 3557743] - Y Nakata, M Mizunaga, M Morikawa, H Osanai, M Fujisawa, F Inada, S Yachiku. [Study of levels of latamoxef in prostatic tissue and bladder mucosal tissue].
Hinyokika kiyo. Acta urologica Japonica.
1987 Feb; 33(2):289-93. doi:
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The Journal of antimicrobial chemotherapy.
1987 Feb; 19(2):205-10. doi:
10.1093/jac/19.2.205. [PMID: 3471750] - K Uchida, M Nakamura, M Konishi, T Ishigami, T Komeno. Effect of latamoxef on platelet function and prothrombin time in partially nephrectomized rats.
Japanese journal of pharmacology.
1987 Jan; 43(1):9-16. doi:
10.1254/jjp.43.9. [PMID: 3573419] - R Kojima, M Ito, Y Suzuki. Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects (4). Effects of tobramycin alone and in combination with latamoxef on the stability of rat kidney lysosomal membranes.
Japanese journal of pharmacology.
1987 Jan; 43(1):73-80. doi:
10.1254/jjp.43.73. [PMID: 3573418] - J Prokopowicz, M Dabrowska, J Wysocka, N Wołosowicz, A Gabryelewicz. Does ceftazidime or latamoxef affect the phagocytic capabilities of human granulocytes?.
Folia haematologica (Leipzig, Germany : 1928).
1987; 114(3):390-7. doi:
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Folia haematologica (Leipzig, Germany : 1928).
1987; 114(3):398-407. doi:
. [PMID: 2444514] - R P Rapp, J E Connors, W D Hager, E S Donaldson, J R van Nagell. Comparison of single-dose moxalactam and a three-dose regimen of cefoxitin for prophylaxis in vaginal hysterectomy.
Clinical pharmacy.
1986 Dec; 5(12):988-93. doi:
. [PMID: 3542346] - N Takeuchi, T Kinukawa, O Matsuura, R Hattori, S Hasegawa, S Ohshima, Y Ono. [A study of prostatic tissue levels of latamoxef, cefoperazone and cefotaxime].
Hinyokika kiyo. Acta urologica Japonica.
1986 Dec; 32(12):1831-41. doi:
. [PMID: 2435132] - F Carpentier, P Granier, J Croize, F Serre-Debeauvais, D Barnoud, M Guignier. [Latamoxef in resuscitation in acute renal failure. Measurement of plasma levels].
Therapie.
1986 Nov; 41(6):487-92. doi:
NULL. [PMID: 3810544] - R Kojima, M Ito, Y Suzuki. Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects (3). Protective effect of latamoxef against tobramycin nephrotoxicity and its protective mechanism.
Japanese journal of pharmacology.
1986 Nov; 42(3):397-404. doi:
10.1254/jjp.42.397. [PMID: 3820859] - J R Sharman, A Howarth. Modified method for the determination of moxalactam in plasma by high-performance liquid chromatography.
Journal of chromatography.
1986 Sep; 381(2):447-52. doi:
10.1016/s0378-4347(00)83613-0. [PMID: 3760101] - J L Axelrod, R M Klein, R L Bergen, M Z Sheikh. Human vitreous levels of cefamandole and moxalactam.
American journal of ophthalmology.
1986 Jun; 101(6):684-7. doi:
10.1016/0002-9394(86)90769-5. [PMID: 3717251] - M G Bergeron, P Simard. Influence of three modes of administration on the penetration of latamoxef into interstitial fluid and fibrin clots and its in-vivo activity against Haemophilus influenzae.
The Journal of antimicrobial chemotherapy.
1986 Jun; 17(6):775-84. doi:
10.1093/jac/17.6.775. [PMID: 3488309] - C A De Jongh, J H Joshi, B W Thompson, K A Newman, R S Finley, M R Moody, P C Salvatore, J H Tenney, G L Drusano, S C Schimpff. A double beta-lactam combination versus an aminoglycoside-containing regimen as empiric antibiotic therapy for febrile granulocytopenic cancer patients.
The American journal of medicine.
1986 May; 80(5C):101-11. doi:
NULL. [PMID: 3521269] - Y Matsuura, M Tamura, H Yamashina, M Higo, T Fujii, M Yamamoto, H Shimamoto, H Yamada, T Oguma, K Shimamura. [The prophylactic effects of latamoxef against the postoperative infections to open heart surgery. Studies on the penetration of latamoxef into the pericardial fluid and the auricle of heart].
The Japanese journal of antibiotics.
1986 May; 39(5):1241-9. doi:
NULL. [PMID: 3761554] - D Charles, B Larsen. Pharmacokinetics of cefotaxime, moxalactam, and cefoperazone in the early puerperium.
Antimicrobial agents and chemotherapy.
1986 May; 29(5):873-6. doi:
10.1128/aac.29.5.873. [PMID: 3729345] - S H Zinner, J Blaser. In-vitro studies of antibiotic combinations with special emphasis on the evaluation of newly developed methods.
The Journal of antimicrobial chemotherapy.
1986 Mar; 17 Suppl A(?):1-5. doi:
10.1093/jac/17.suppl_a.1. [PMID: 3086275] - H C Standiford, G L Drusano, C I Bustamante, G Rivera, A Forrest, B Tatem, J Leslie, M Moody. Imipenem coadministered with cilastatin compared with moxalactam: integration of serum pharmacokinetics and microbiologic activity following single-dose administration to normal volunteers.
Antimicrobial agents and chemotherapy.
1986 Mar; 29(3):412-7. doi:
10.1128/aac.29.3.412. [PMID: 3459390] - D E Fry, L Trachtenberg, H C Polk. Serum kinetics of intraperitoneal moxalactam.
Archives of surgery (Chicago, Ill. : 1960).
1986 Mar; 121(3):282-4. doi:
10.1001/archsurg.1986.01400030036005. [PMID: 3947227] - I Cho, J M Bertoni, L Hopkins. Moxalactam myoclonus, seizures, and encephalopathy.
Drug intelligence & clinical pharmacy.
1986 Mar; 20(3):223-4. doi:
10.1177/106002808602000310. [PMID: 3956381] - G Fradet, S Brister, G K Richards, J Prentis, R A Brown, R C Chiu, D S Mulder. Antibiotic prophylaxis in vascular surgery: pharmacokinetic study of four commonly used cephalosporins.
Journal of vascular surgery.
1986 Mar; 3(3):535-9. doi:
10.1067/mva.1986.avs0030535. [PMID: 3512862] - A Contrepois, J M Vallois, J J Garaud, B Pangon, J Mohler, A Meulemans, C Carbon. Kinetics and bactericidal effect of gentamicin and latamoxef (moxalactam) in experimental Escherichia coli endocarditis.
The Journal of antimicrobial chemotherapy.
1986 Feb; 17(2):227-37. doi:
10.1093/jac/17.2.227. [PMID: 3516963] - T Inoue, K Sakaguchi, K Yoshida, T Imai, Y Kajimoto, D Shirai. [Effect of latamoxef on platelet aggregation in hemodialysis and continuous ambulatory peritoneal dialysis (CAPD) patients].
Nihon Jinzo Gakkai shi.
1986 Feb; 28(2):177-83. doi:
NULL. [PMID: 3735768] - G Drusano, H Standiford, P Ryan, W McNamee, B Tatem, S Schimpff. Correlation of predicted serum bactericidal activities and values measured in volunteers.
European journal of clinical microbiology.
1986 Feb; 5(1):88-92. doi:
10.1007/bf02013475. [PMID: 3084247] - Y Kumasaka, H Nakahata, Y Hirai, K Imamura, K Takebe, I Suzuki, H Senda. [In vivo antibacterial activity of cefbuperazone. Synergy of cefbuperazone for bactericidal effect with human polymorphonuclear leukocytes].
The Japanese journal of antibiotics.
1986 Jan; 39(1):154-8. doi:
NULL. [PMID: 3517405] - Y Benno, N Shiragami, K Uchida, T Yoshida, T Mitsuoka. Effect of moxalactam on human fecal microflora.
Antimicrobial agents and chemotherapy.
1986 Jan; 29(1):175-8. doi:
10.1128/aac.29.1.175. [PMID: 3729329] - D R Branch, B G Beatty, A L Hian, W G Vlahos, A W Hawksworth, L D Petz. Immune response to moxalactam in rabbits and in humans.
The Journal of laboratory and clinical medicine.
1986 Jan; 107(1):15-22. doi:
NULL. [PMID: 3941291] - R Kojima, M Ito, Y Suzuki. Protective effect of latamoxef on aminoglycoside nephrotoxicity in rats.
Developments in toxicology and environmental science.
1986; 14(?):31-4. doi:
NULL. [PMID: 3829982] - H Albin, J M Ragnaud, F Demotes-Mainard, G Vincon, C Wone. Pharmacokinetics of intravenous and intraperitoneal moxalactam in chronic ambulatory peritoneal dialysis.
European journal of clinical pharmacology.
1986; 30(3):299-302. doi:
10.1007/bf00541532. [PMID: 3732364] - R J Creger, R I Cowan, H S Nearman, J L Blumer, W R Selman, L H Danziger. Cerebrospinal fluid penetration of moxalactam in ventriculostomy patients.
Antimicrobial agents and chemotherapy.
1985 Dec; 28(6):839-41. doi:
10.1128/aac.28.6.839. [PMID: 4083867] - S Miyake, M Tanigawa, T Manabe, T Asano, H Niimi, I Kamata. [Clinical experience of latamoxef in the field of neurosurgery on the penetration into the cerebrospinal fluid in the patients with postoperative meningitis].
The Japanese journal of antibiotics.
1985 Dec; 38(12):3464-70. doi:
NULL. [PMID: 3834129] - N Seno, S Matsumoto, H Yamamoto. [Clinical study on the penetration of latamoxef into the pulmonary tissue in surgery of the chest].
The Japanese journal of antibiotics.
1985 Dec; 38(12):3471-6. doi:
NULL. [PMID: 3834130] - A L Kerremans, J J Lipsky, J Van Loon, M O Gallego, R M Weinshilboum. Cephalosporin-induced hypoprothrombinemia: possible role for thiol methylation of 1-methyltetrazole-5-thiol and 2-methyl-1,3,4-thiadiazole-5-thiol.
The Journal of pharmacology and experimental therapeutics.
1985 Nov; 235(2):382-8. doi:
NULL. [PMID: 2865352] - T J Louie, H Chubb, E J Bow, J M Conly, G K Harding, E Rayner, M James. Preservation of colonization resistance parameters during empiric therapy with aztreonam in the febrile neutropenic patient.
Reviews of infectious diseases.
1985 Nov; 7 Suppl 4(?):S747-61. doi:
10.1093/clinids/7.supplement_4.s747. [PMID: 3909333] - W Y Lau, S T Fan, K W Chu, H C Suen, T F Yiu, K K Wong. Randomized, prospective, and double-blind trial of new beta-lactams in the treatment of appendicitis.
Antimicrobial agents and chemotherapy.
1985 Nov; 28(5):639-42. doi:
10.1128/aac.28.5.639. [PMID: 3911877]