Chlorzoxazone (BioDeep_00000001857)
Secondary id: BioDeep_00000408943
human metabolite blood metabolite
代谢物信息卡片
5-chloro-2,3-dihydro-1,3-benzoxazol-2-one
化学式: C7H4ClNO2 (168.9930554)
中文名称: 氯唑沙宗
谱图信息:
最多检出来源 Homo sapiens(blood) 1.15%
分子结构信息
SMILES: C1=CC2=C(C=C1Cl)NC(=O)O2
InChI: InChI=1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)
描述信息
A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
M - Musculo-skeletal system > M03 - Muscle relaxants > M03B - Muscle relaxants, centrally acting agents > M03BB - Oxazol, thiazine, and triazine derivatives
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
C78281 - Agent Affecting Musculoskeletal System > C29696 - Muscle Relaxant
D002491 - Central Nervous System Agents
COVID info from PDB, Protein Data Bank
Corona-virus
KEIO_ID C042
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
20 个代谢物同义名
5-chloro-2,3-dihydro-1,3-benzoxazol-2-one; McNeil brand OF chlorzoxazone; 5-Chloro-2-hydroxybenzoxazole; 2-Hydroxy-5-chlorobenzoxazole; 5-Chloro-2(3H)-benzoxazolone; Ortho brand OF chlorzoxazone; 5-Chloro-2-benzoxazolinone; 5-Chlorobenzoxazolin-2-one; 5-Chloro-2-benzoxazolone; 5-Chlorobenzoxazolidone; 5-Chloro-2-benzoxazolol; Parafon forte DSC; Chlorzoxazonum; Chlorzoxazona; chlorzoxazone; Chlorzoxazon; Chloroxazone; Chlorzoxane; Paraflex; Parafon
数据库引用编号
23 个数据库交叉引用编号
- ChEBI: CHEBI:3655
- KEGG: C07931
- KEGGdrug: D78096
- KEGGdrug: D00771
- PubChem: 2733
- HMDB: HMDB0014500
- Metlin: METLIN3960
- DrugBank: DB00356
- ChEMBL: CHEMBL1371
- Wikipedia: Chlorzoxazone
- MeSH: Chlorzoxazone
- chemspider: 2632
- CAS: 95-25-0
- MoNA: KO000452
- MoNA: KO000455
- MoNA: KO000453
- MoNA: KO000451
- MoNA: KO000454
- PMhub: MS000001308
- PubChem: 10133
- PDB-CCD: CLW
- NIKKAJI: J3.950K
- RefMet: Chlorzoxazone
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(1)
- chlorzoxazone degradation:
2-amino-5-chlorophenyl carbonate + H+ ⟶ 2-amino-5-chlorophenol + CO2
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hui-Lin Yang, Ying Li, Yi Chen, Si-Ying Chen, Yue-Ting Li, Yong Huang, Lin Zheng, Jing Huang, Yong-Lin Wang, Zi-Peng Gong. [Effect of Laportea bulbifera extract on CYP450 enzyme activities in rats by Cocktail probe drug method].
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Biochimica et biophysica acta. Biomembranes.
2022 09; 1864(9):183954. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
2021 Jun; 51(6):625-635. doi:
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Cell reports.
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Acta chimica Slovenica.
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Planta medica.
2010 Feb; 76(3):245-50. doi:
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Environmental health perspectives.
2010 Feb; 118(2):278-83. doi:
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Toxicology letters.
2010 Jan; 192(1):29-33. doi:
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Biopharmaceutics & drug disposition.
2009 Nov; 30(8):485-93. doi:
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Basic & clinical pharmacology & toxicology.
2009 Oct; 105(4):249-56. doi:
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2009 Aug; 34(16):2079-82. doi:
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Prostaglandins & other lipid mediators.
2009 Jun; 89(1-2):16-9. doi:
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Bioorganic & medicinal chemistry.
2009 May; 17(10):3665-70. doi:
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Journal of cell science.
2009 Apr; 122(Pt 8):1126-33. doi:
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Biological & pharmaceutical bulletin.
2009 Apr; 32(4):717-20. doi:
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The Biochemical journal.
2009 Jan; 417(1):43-54. doi:
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2009; 69(13):1777-98. doi:
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Journal of chromatography. A.
2008 Dec; 1215(1-2):107-15. doi:
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The Journal of biological chemistry.
2008 Nov; 283(46):31385-93. doi:
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Toxicology and industrial health.
2008 Nov; 24(10):625-34. doi:
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Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.
2008 Aug; 26(8):496-7. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1233-41. doi:
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Journal of ethnopharmacology.
2008 May; 117(3):420-6. doi:
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Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2008 May; 91(5):733-8. doi:
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Methods and findings in experimental and clinical pharmacology.
2008 Apr; 30(3):215-20. doi:
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Chemico-biological interactions.
2008 Mar; 172(1):1-10. doi:
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Drug metabolism and drug interactions.
2008; 23(3-4):311-21. doi:
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Critical care (London, England).
2008; 12(6):235. doi:
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European journal of drug metabolism and pharmacokinetics.
2008 Jan; 33(1):1-7. doi:
10.1007/bf03191012. [PMID: 18543578] - Phisit Khemawoot, Kousuke Nishino, Junko Ishizaki, Koichi Yokogawa, Ken-ichi Miyamoto. Circadian rhythm of cytochrome P4502E1 and its effect on disposition kinetics of chlorzoxazone in rats.
European journal of pharmacology.
2007 Nov; 574(1):71-6. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2007 Oct; 35(10):1754-8. doi:
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European journal of drug metabolism and pharmacokinetics.
2007 Oct; 32(4):189-96. doi:
10.1007/bf03191003. [PMID: 18348467] - Xin Wang, Xuan Zhao, Dan Li, Ya-Qing Lou, Zhi-Bin Lin, Guo-Liang Zhang. Effects of Ganoderma lucidum polysaccharide on CYP2E1, CYP1A2 and CYP3A activities in BCG-immune hepatic injury in rats.
Biological & pharmaceutical bulletin.
2007 Sep; 30(9):1702-6. doi:
10.1248/bpb.30.1702. [PMID: 17827724] - Lawrence H Lash, David A Putt, Paul Huang, Sarah E Hueni, Jean C Parker. Modulation of hepatic and renal metabolism and toxicity of trichloroethylene and perchloroethylene by alterations in status of cytochrome P450 and glutathione.
Toxicology.
2007 Jun; 235(1-2):11-26. doi:
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Current drug metabolism.
2007 Jun; 8(5):493-8. doi:
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Fundamental & clinical pharmacology.
2007 Jun; 21(3):307-16. doi:
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BMC medicine.
2007 May; 5(?):13. doi:
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Toxicology in vitro : an international journal published in association with BIBRA.
2007 Feb; 21(1):109-15. doi:
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Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2007 Jan; 90(1):160-6. doi:
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Biochemical pharmacology.
2007 Jan; 73(1):155-62. doi:
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European journal of clinical pharmacology.
2007 Jan; 63(1):43-50. doi:
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Life sciences.
2006 Nov; 79(23):2179-86. doi:
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Journal of pharmaceutical sciences.
2006 Nov; 95(11):2452-62. doi:
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Life sciences.
2006 Oct; 79(20):1913-20. doi:
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Clinical pharmacology and therapeutics.
2006 Sep; 80(3):235-45. doi:
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Clinical pharmacology and therapeutics.
2006 Sep; 80(3):257-63. doi:
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