N-Methyl-DL-aspartic acid (BioDeep_00000181324)

   

human metabolite blood metabolite


代谢物信息卡片


2-(methylamino)butanedioic acid

化学式: C5H9NO4 (147.0532)
中文名称: N-甲基天冬氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 89.47%

分子结构信息

SMILES: CNC(CC(=O)O)C(=O)O
InChI: InChI=1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)

描述信息

N-Methyl-DL-aspartic acid is a glutamate analogue and a?NMDA?receptor?agonist and can be used for neurological diseases research[1][2].

同义名列表

6 个代谢物同义名

2-(methylamino)butanedioic acid; 2-(Methylamino)butanedioate; L-aspartic acid, N-methyl-; N-Methyl-DL-aspartic acid; N-Methyl-DL-aspartate; UNII:EU52DFC4WJ



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 CA1, DMD, POMC, PRL
Peripheral membrane protein 1 DMD
Nucleus 3 DMD, FOS, PRL
cytosol 5 AVP, CA1, DMD, FOS, SST
dendrite 2 AVP, HTR1A
nucleoplasm 2 FOS, PRL
RNA polymerase II transcription regulator complex 2 FOS, PRL
Cell membrane 4 GLRA2, GNRHR, GRID1, HTR1A
Cytoplasmic side 1 DMD
Multi-pass membrane protein 5 CACNA1I, GLRA2, GNRHR, GRID1, HTR1A
Synapse 4 CRH, DMD, GLRA2, HTR1A
cell surface 1 DMD
glutamatergic synapse 1 GRID1
Golgi apparatus 1 NPY
Golgi membrane 1 INS
lysosomal membrane 1 AP5B1
neuronal cell body 1 SST
sarcolemma 1 DMD
plasma membrane 7 CACNA1I, DMD, EDNRA, GLRA2, GNRHR, GRID1, HTR1A
terminal bouton 1 GHRH
Membrane 4 CACNA1I, DMD, GLRA2, GNRHR
extracellular exosome 2 CA1, GRID1
endoplasmic reticulum 1 FOS
extracellular space 9 AVP, CRH, GHRH, GNRH1, INS, NPY, POMC, PRL, SST
protein-containing complex 1 DMD
intracellular membrane-bounded organelle 1 GLRA2
filopodium 1 DMD
Secreted 8 AVP, CRH, INS, NPY, POMC, PRL, SST, TRH
extracellular region 10 AVP, CRH, GHRH, GNRH1, INS, NPY, POMC, PRL, SST, TRH
varicosity 1 CRH
neuronal dense core vesicle lumen 1 CRH
perikaryon 2 CRH, GHRH
Z disc 1 DMD
postsynaptic membrane 2 DMD, GRID1
Cell membrane, sarcolemma 1 DMD
Membrane raft 1 DMD
Cytoplasm, cytoskeleton 1 DMD
GABA-ergic synapse 4 GLRA2, GRID1, NPY, SST
secretory granule 3 AVP, POMC, TRH
Nucleus outer membrane 1 DMD
nuclear outer membrane 1 DMD
Postsynaptic cell membrane 3 DMD, GLRA2, GRID1
Late endosome 1 AP5B1
neuron projection 1 GLRA2
chromatin 2 FOS, PRL
cell projection 1 GLRA2
cytoskeleton 1 DMD
transmembrane transporter complex 1 GLRA2
endosome lumen 2 INS, PRL
chloride channel complex 1 GLRA2
Cell projection, dendrite 1 HTR1A
filopodium membrane 1 DMD
secretory granule lumen 2 INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
nuclear matrix 1 FOS
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 GRID1
neuronal dense core vesicle 3 AVP, NPY, SST
Single-pass type IV membrane protein 1 DMD
clathrin-coated endocytic vesicle membrane 1 AVP
costamere 1 DMD
protein-DNA complex 1 FOS
postsynaptic specialization membrane 1 GLRA2
AP-5 adaptor complex 1 AP5B1
AP-type membrane coat adaptor complex 1 AP5B1
dystrophin-associated glycoprotein complex 1 DMD
cell-substrate junction 1 DMD
transcription factor AP-1 complex 1 FOS
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 NPY
glycinergic synapse 1 GLRA2
neuron projection terminus 1 DMD
syntrophin complex 1 DMD
organelle 1 DMD
plasma membrane bounded cell projection 1 DMD


文献列表

  • Gj Amabeoku. Anticonvulsant activity of Nylandtia spinosa L. Dumont (Polygalaceae) aqueous and methanol leaf extracts in mice. Human & experimental toxicology. 2008 Nov; 27(11):811-8. doi: 10.1177/0960327108099538. [PMID: 19244288]
  • G J Amabeoku, I Green, J Kabatende. Anticonvulsant activity of Cotyledon orbiculata L. (Crassulaceae) leaf extract in mice. Journal of ethnopharmacology. 2007 May; 112(1):101-7. doi: 10.1016/j.jep.2007.02.016. [PMID: 17398051]
  • Stephanie B Seminara, Meloni J Dipietro, Suresh Ramaswamy, William F Crowley, Tony M Plant. Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mulatta): a finding with therapeutic implications. Endocrinology. 2006 May; 147(5):2122-6. doi: 10.1210/en.2005-1550. [PMID: 16469799]
  • E Bienvenu, G J Amabeoku, P K Eagles, G Scott, E P Springfield. Anticonvulsant activity of aqueous extract of Leonotis leonurus. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2002 Apr; 9(3):217-23. doi: 10.1078/0944-7113-00103. [PMID: 12046862]
  • C P Phelps, J M Dong, L T Chen, R A Menzies. Plasma interleukin-1beta, prolactin, ACTH and corticosterone responses to endotoxin after damage of the anterior hypothalamic area. Neuroimmunomodulation. 2001; 9(6):340-51. doi: 10.1159/000059392. [PMID: 12045362]
  • G C Palmer, R J Murray, C L Cramer, M L Stagnitto, M K Knowles, L R Freedman, M S Eismann, N Mahmood, M Balestra, A R Borrelli, T J Hudzik, D J McCarthy. [S]-AR-R 15896AR-A novel anticonvulsant: acute safety, pharmacokinetic and pharmacodynamic properties. The Journal of pharmacology and experimental therapeutics. 1999 Jan; 288(1):121-32. doi: . [PMID: 9862762]