Paromomycin I (BioDeep_00000171733)
human metabolite blood metabolite natural product
代谢物信息卡片
5-amino-2-(aminomethyl)-6-({5-[(3,5-diamino-2-{[3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-hydroxycyclohexyl)oxy]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl}oxy)oxane-3,4-diol
化学式: C23H45N5O14 (615.296287)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N
InChI: InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
同义名列表
24 个代谢物同义名
5-amino-2-(aminomethyl)-6-({5-[(3,5-diamino-2-{[3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-hydroxycyclohexyl)oxy]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl}oxy)oxane-3,4-diol; Paromomycin, beta D glucopyranosyl isomer; Paromomycin, beta-D-glucopyranosyl-isomer; beta-D-Glucopyranosyl-isomer paromomycin; Parke davis brand OF paromomycin sulfate; Cheminova brand OF paromomycin sulfate; Monarch brand OF paromomycin sulfate; Pfizer brand OF paromomycin sulfate; Paromomycin sulfate (1:1); Paromomycin sulfate (2:5); Phosphate, paromomycin; Paromomycin phosphate; Sulfate, paromomycin; Paromomycin sulfate; Paromomycin I; Hydroxymycin; Gabbromycin; Paromomycin; Paramomycin; Aminosidine; Neomycin e; Catenulin; Estomycin; Humatin
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 4689
- HMDB: HMDB0242512
- MeSH: Paromomycin
- KNApSAcK: C00018808
- chemspider: 4527
- LOTUS: LTS0142951
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
6 个相关的物种来源信息
- 2 - Bacteria: LTS0142951
- 9606 - Homo sapiens: -
- 1883 - Streptomyces: LTS0142951
- 1906 - Streptomyces fradiae: 10.1039/B808734B
- 1906 - Streptomyces fradiae: LTS0142951
- 2062 - Streptomycetaceae: LTS0142951
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mingxiao Liu, Di Zhang, Dongqiang Wang, Xiaodong Wu, Ying Zhang, Jigang Yin, Guan Zhu. Cost-effective In vivo and In vitro Mouse Models for Evaluating Anti-Cryptosporidial Drug Efficacy: Assessing Vorinostat, Docetaxel and Baicalein.
The Journal of infectious diseases.
2023 Jul; ?(?):. doi:
10.1093/infdis/jiad243. [PMID: 37418629] - Yiğit Kaçar, Ahmet Tarık Baykal, Levent Aydin, Hasan Batmaz. Evaluation of the efficacy of cow colostrum in the treatment and its effect on serum proteomes in calves with cryptosporidiosis.
Veterinary immunology and immunopathology.
2022 Jun; 248(?):110429. doi:
10.1016/j.vetimm.2022.110429. [PMID: 35500421] - Shipra Gupta, Layne Smith, Adriana Diakiw. Amebiasis and Amebic Liver Abscess in Children.
Pediatric clinics of North America.
2022 02; 69(1):79-97. doi:
10.1016/j.pcl.2021.08.003. [PMID: 34794678] - Luka Verrest, Monique Wasunna, Gilbert Kokwaro, Rashid Aman, Ahmed M Musa, Eltahir A G Khalil, Mahmoud Mudawi, Brima M Younis, Asrat Hailu, Zewdu Hurissa, Workagegnehu Hailu, Samson Tesfaye, Eyasu Makonnen, Yalemtsehay Mekonnen, Alwin D R Huitema, Jos H Beijnen, Smita A Kshirsagar, Jaya Chakravarty, Madhukar Rai, Shyam Sundar, Fabiana Alves, Thomas P C Dorlo. Geographical Variability in Paromomycin Pharmacokinetics Does Not Explain Efficacy Differences between Eastern African and Indian Visceral Leishmaniasis Patients.
Clinical pharmacokinetics.
2021 11; 60(11):1463-1473. doi:
10.1007/s40262-021-01036-8. [PMID: 34105063] - Aschalew Tamiru, Rezika Mohammed, Saba Atnafu, Girmay Medhin, Asrat Hailu. Efficacy and safety of a combined treatment of sodium stibogluconate at 20mg/kg/day with upper maximum daily dose limit of 850mg and Paromomycin 15mg/kg/day in HIV negative visceral leishmaniasis patients. A retrospective study, northwest Ethiopia.
PLoS neglected tropical diseases.
2021 08; 15(8):e0009713. doi:
10.1371/journal.pntd.0009713. [PMID: 34464401] - Sapna Jain Chowdhary, Amit Chowdhary, Govind Prasad Agrawal, Ashish Jain. A Formulation of Paromomycin Sulphate as a Promising Fucose-Conjugated Nanostructured Lipid Carrier for Antileishmanial Drug Delivery.
ACS biomaterials science & engineering.
2021 01; 7(1):157-165. doi:
10.1021/acsbiomaterials.0c01165. [PMID: 33350804] - Tiget Ayelgn Mengstie, Hiwot Tezera Endale, Tadele Mulaw, Aman Mossa Abdella, Rezika Mohammed, Tabarak Malik, Gashaw Dessie. Assessment of serum amylase, lipase and associated factors among patients with visceral leishmaniasis treated with sodium stibogluconate/paromomycin at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.
PloS one.
2021; 16(10):e0257229. doi:
10.1371/journal.pone.0257229. [PMID: 34597312] - Kerem Teralı, Buket Baddal, Hayrettin Ozan Gülcan. Prioritizing potential ACE2 inhibitors in the COVID-19 pandemic: Insights from a molecular mechanics-assisted structure-based virtual screening experiment.
Journal of molecular graphics & modelling.
2020 11; 100(?):107697. doi:
10.1016/j.jmgm.2020.107697. [PMID: 32739642] - Asma Tariq, Rana Muhammad Mateen, Muhammad Sohail Afzal, Mahjabeen Saleem. Paromomycin: A potential dual targeted drug effectively inhibits both spike (S1) and main protease of COVID-19.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2020 Sep; 98(?):166-175. doi:
10.1016/j.ijid.2020.06.063. [PMID: 32579907] - Shabi Parvez, Ganesh Yadagiri, Aakriti Singh, Archana Karole, Om Prakash Singh, Shyam Sundar, Shyam Lal Mudavath. Improvising anti-leishmanial activity of amphotericin B and paromomycin using co-delivery in d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) tailored nano-lipid carrier system.
Chemistry and physics of lipids.
2020 09; 231(?):104946. doi:
10.1016/j.chemphyslip.2020.104946. [PMID: 32621810] - Shabi Parvez, Ganesh Yadagiri, Mallikarjuna Rao Gedda, Aakriti Singh, Om Prakash Singh, Anurag Verma, Shyam Sundar, Shyam Lal Mudavath. Modified solid lipid nanoparticles encapsulated with Amphotericin B and Paromomycin: an effective oral combination against experimental murine visceral leishmaniasis.
Scientific reports.
2020 07; 10(1):12243. doi:
10.1038/s41598-020-69276-5. [PMID: 32699361] - D Kasabalis, M K Chatzis, K Apostolidis, T Petanides, L V Athanasiou, P G Xenoulis, A Mataragka, J Ikonomopoulos, L S Leontides, M N Saridomichelakis. A randomized, blinded, controlled clinical trial comparing the efficacy of aminosidine (paromomycin)-allopurinol combination with the efficacy of meglumine antimoniate-allopurinol combination for the treatment of canine leishmaniosis due to Leishmania infantum.
Experimental parasitology.
2020 Jul; 214(?):107903. doi:
10.1016/j.exppara.2020.107903. [PMID: 32360142] - Ignace C Roseboom, Bas Thijssen, Hilde Rosing, Jane Mbui, Jos H Beijnen, Thomas P C Dorlo. Highly sensitive UPLC-MS/MS method for the quantification of paromomycin in human plasma.
Journal of pharmaceutical and biomedical analysis.
2020 Jun; 185(?):113245. doi:
10.1016/j.jpba.2020.113245. [PMID: 32199328] - Md Shahiduzzaman, Refaat Ras, Giovanni Widmer. Effect of Ginsenoside-Rh2 and Curcurbitacin-B on Cryptosporidium parvum in vitro.
Experimental parasitology.
2020 May; 212(?):107873. doi:
10.1016/j.exppara.2020.107873. [PMID: 32165146] - Albert Bernet Sánchez, Alba Bellés Bellés, Jesus Aramburu Arnuelos, Alfredo Jover Sanz, Eva Sesé Abizanda, Montserrat Vallverdú Vidal, Mercè García González. Entamoeba histolytica liver abscess case: could stool PCR avoid it?.
Diagnosis (Berlin, Germany).
2020 01; 7(1):69-73. doi:
10.1515/dx-2019-0006. [PMID: 31256063] - Mojdeh Khosravi, Hanieh Mohammad Rahimi, Delaram Doroud, Elnaz Sadat Mirsamadi, Hamed Mirjalali, Mohammad Reza Zali. In vitro Evaluation of Mannosylated Paromomycin-Loaded Solid Lipid Nanoparticles on Acute Toxoplasmosis.
Frontiers in cellular and infection microbiology.
2020; 10(?):33. doi:
10.3389/fcimb.2020.00033. [PMID: 32117807] - Shabi Parvez, Ganesh Yadagiri, Archana Karole, Om Prakash Singh, Anurag Verma, Shyam Sundar, Shyam Lal Mudavath. Recuperating Biopharmaceutical Aspects of Amphotericin B and Paromomycin Using a Chitosan Functionalized Nanocarrier via Oral Route for Enhanced Anti-leishmanial Activity.
Frontiers in cellular and infection microbiology.
2020; 10(?):570573. doi:
10.3389/fcimb.2020.570573. [PMID: 33178626] - Arijit Bhattacharya, Philippe Leprohon, Sophia Bigot, Prasad Kottayil Padmanabhan, Angana Mukherjee, Gaétan Roy, Hélène Gingras, Anais Mestdagh, Barbara Papadopoulou, Marc Ouellette. Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania.
Nature communications.
2019 12; 10(1):5627. doi:
10.1038/s41467-019-13344-6. [PMID: 31819054] - Ander Burgaña, Rosa Abellana, Stanislav Zlatanov Yordanov, Rabee Kazan, A Mauricio Pérez Ortiz, Cristina Castillo Ramos, Christian Garavito Hernández, Miriam Molina Rivero, Alessandra Queiroga Gonçalves, Emma Padilla, Josefa Pérez, Roger García-Puig, Tomas M Perez-Porcuna. Paromomycin is superior to metronidazole in Dientamoeba fragilis treatment.
International journal for parasitology. Drugs and drug resistance.
2019 12; 11(?):95-100. doi:
10.1016/j.ijpddr.2019.10.005. [PMID: 31759244] - Dipti Debnath, Md Akil Hossain, Munny Das, Asma Kabir, Md Ibrahim, Mohammad Nurul Amin, Amrita Chowdhury, Rokeya Pervin. Characterization of Transplasma Membrane Electron Transport Chain in Wild and Drug-Resistant Leishmania donovani Promastigote and Amastigote.
Acta parasitologica.
2019 Dec; 64(4):710-719. doi:
10.2478/s11686-019-00050-y. [PMID: 30941668] - D Kasabalis, M K Chatzis, K Apostolidis, P G Xenoulis, A Buono, T Petanides, L S Leontides, Z S Polizopoulou, J M Steiner, J S Suchodolski, M N Saridomichelakis. Evaluation of nephrotoxicity and ototoxicity of aminosidine (paromomycin)-allopurinol combination in dogs with leishmaniosis due to Leishmania infantum: A randomized, blinded, controlled study.
Experimental parasitology.
2019 Nov; 206(?):107768. doi:
10.1016/j.exppara.2019.107768. [PMID: 31539540] - Shinichiro Nakamura, Iori Itagaki, Takahiro Nakagawa, Ikuo Kawamoto, Takahiro Asano, Daichi Arakawa, Hideaki Tsuchiya. Paromomycin sulfate is an effective treatment for balantidiasis in captive cynomolgus monkeys.
Experimental animals.
2019 Aug; 68(3):285-292. doi:
10.1538/expanim.18-0133. [PMID: 30814394] - Clare F Collett, Carl Kitson, Nicola Baker, Heather B Steele-Stallard, Marie-Victoire Santrot, Sebastian Hutchinson, David Horn, Sam Alsford. Chemogenomic Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei.
Antimicrobial agents and chemotherapy.
2019 08; 63(8):. doi:
10.1128/aac.00795-19. [PMID: 31160283] - Anne E Rivas, Donal M Boyer, Kevin Torregrosa, William J Orrico, Jean A Paré. TREATMENT OF CRYPTOSPORIDIUM SERPENTIS INFECTION IN A KING COBRA ( OPHIOPHAGUS HANNAH) WITH PAROMOMYCIN.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2018 12; 49(4):1061-1063. doi:
10.1638/2018-0080.1. [PMID: 30592920] - Huawen Lin, Paul F Cliften, Susan K Dutcher. MAPINS, a Highly Efficient Detection Method That Identifies Insertional Mutations and Complex DNA Rearrangements.
Plant physiology.
2018 12; 178(4):1436-1447. doi:
10.1104/pp.18.00474. [PMID: 30206105] - Mohammad Asadpour, Fatemeh Namazi, Seyed Mostafa Razavi, Saeed Nazifi. Curcumin: A promising treatment for Cryptosporidium parvum infection in immunosuppressed BALB/c mice.
Experimental parasitology.
2018 Dec; 195(?):59-65. doi:
10.1016/j.exppara.2018.10.008. [PMID: 30385266] - Md Sakhawat Hossain, Amresh Kumar, A F M Akhtar Hossain, Md Mahshin, Abhijit Sharma, Md Akter Hossain, Varun Sharma, Rashidul Haque, A K M Shamsuzzaman, Shomik Maruf, Prakash Ghosh, Vivek Ahuja, Dinesh Mondal. Using focused pharmacovigilance for ensuring patient safety against antileishmanial drugs in Bangladesh's National Kala-azar Elimination Programme.
Infectious diseases of poverty.
2018 Aug; 7(1):80. doi:
10.1186/s40249-018-0461-0. [PMID: 30099967] - Mohammad Asadpour, Fatemeh Namazi, Seyed Mostafa Razavi, Saeed Nazifi. Comparative efficacy of curcumin and paromomycin against Cryptosporidium parvum infection in a BALB/c model.
Veterinary parasitology.
2018 Jan; 250(?):7-14. doi:
10.1016/j.vetpar.2017.12.008. [PMID: 29329627] - Muslim Raza, Yang Jiang, Yun Wei, Aftab Ahmad, Ajmal Khan, Yuan Qipeng. Insights from spectroscopic and in-silico techniques for the exploitation of biomolecular interactions between Human serum albumin and Paromomycin.
Colloids and surfaces. B, Biointerfaces.
2017 Sep; 157(?):242-253. doi:
10.1016/j.colsurfb.2017.05.076. [PMID: 28601753] - Christina Petridou, Adnan Al-Badri, Anjana Dua, Matthew Dryden, Kordo Saeed. Learning points from a case of severe amoebic colitis.
Le infezioni in medicina.
2017 Sep; 25(3):281-284. doi:
NULL. [PMID: 28956549] - Laura Escolà-Vergé, Maider Arando, Martí Vall, Roger Rovira, Mateu Espasa, Elena Sulleiro, Pere Armengol, Francesc Zarzuela, María-Jesús Barberá. Outbreak of intestinal amoebiasis among men who have sex with men, Barcelona (Spain), October 2016 and January 2017.
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.
2017 Jul; 22(30):. doi:
10.2807/1560-7917.es.2017.22.30.30581. [PMID: 28797327] - Gilles Darcis, Gert Van der Auwera, Jean-Baptiste Giot, Marie-Pierre Hayette, Françoise Tassin, Jorge Arrese Estrada, Lieselotte Cnops, Michel Moutschen, Laurence de Leval, Philippe Leonard. Recurrence of visceral and muco-cutaneous leishmaniasis in a patient under immunosuppressive therapy.
BMC infectious diseases.
2017 07; 17(1):478. doi:
10.1186/s12879-017-2571-x. [PMID: 28687071] - M Jakir S K Pinjari, Rahul Somani, Ritu M Gilhotra. Investigation of in vitro absorption, distribution, metabolism, and excretion and in vivo pharmacokinetics of paromomycin: Influence on oral bioavailability.
Indian journal of pharmacology.
2017 Jul; 49(4):297-303. doi:
10.4103/ijp.ijp_651_16. [PMID: 29326490] - M Heidari-Kharaji, T Taheri, D Doroud, S Habibzadeh, A Badirzadeh, S Rafati. Enhanced paromomycin efficacy by solid lipid nanoparticle formulation against Leishmania in mice model.
Parasite immunology.
2016 Oct; 38(10):599-608. doi:
10.1111/pim.12340. [PMID: 27213964] - Maryam Heidari Kharaji, Delaram Doroud, Tahereh Taheri, Sima Rafati. Drug Targeting to Macrophages With Solid Lipid Nanoparticles Harboring Paromomycin: an In Vitro Evaluation Against L. major and L. tropica.
AAPS PharmSciTech.
2016 Oct; 17(5):1110-9. doi:
10.1208/s12249-015-0439-1. [PMID: 26552399] - Kotnala Balaraju, Chang-Jin Kim, Dong-Jin Park, Ki-Woong Nam, Kecheng Zhang, Mee Kyung Sang, Kyungseok Park. Paromomycin Derived from Streptomyces sp. AG-P 1441 Induces Resistance against Two Major Pathogens of Chili Pepper.
Journal of microbiology and biotechnology.
2016 Sep; 26(9):1542-50. doi:
10.4014/jmb.1603.03019. [PMID: 27291677] - Maryam Heidari-Kharaji, Tahereh Taheri, Delaram Doroud, Sima Habibzadeh, Sima Rafati. Solid lipid nanoparticle loaded with paromomycin: in vivo efficacy against Leishmania tropica infection in BALB/c mice model.
Applied microbiology and biotechnology.
2016 Aug; 100(16):7051-60. doi:
10.1007/s00253-016-7422-y. [PMID: 26960322] - Maria Manuela Gaspar, Susana Calado, Joana Pereira, Helena Ferronha, Ivone Correia, Helena Castro, Ana M Tomás, Maria Eugénia Meirinhos Cruz. Targeted delivery of paromomycin in murine infectious diseases through association to nano lipid systems.
Nanomedicine : nanotechnology, biology, and medicine.
2015 Oct; 11(7):1851-60. doi:
10.1016/j.nano.2015.06.008. [PMID: 26169150] - Femke-Anouska Heinsen, Henrik Knecht, Sven C Neulinger, Ruth A Schmitz, Carolin Knecht, Tanja Kühbacher, Philip C Rosenstiel, Stefan Schreiber, Anette K Friedrichs, Stephan J Ott. Dynamic changes of the luminal and mucosa-associated gut microbiota during and after antibiotic therapy with paromomycin.
Gut microbes.
2015 Jul; 6(4):243-54. doi:
10.1080/19490976.2015.1062959. [PMID: 26178862] - L V Athanasiou, G C Batzias, M N Saridomichelakis, G Delis, N Soubasis, V I Kontos, T S Rallis. Pharmacokinetics and tolerability of aminosidine after repeated administrations using an optimal dose regimen in healthy dogs and in dogs with leishmaniosis.
Veterinary parasitology.
2014 Sep; 205(1-2):365-70. doi:
10.1016/j.vetpar.2014.06.019. [PMID: 24998095] - Dominique Wakefield, Louise Thompson, Stuart Bruce. A Lilliputian army under the floorboards: persistent delirium with complete though prolonged recovery.
BMJ case reports.
2014 May; 2014(?):. doi:
10.1136/bcr-2013-202639. [PMID: 24792019] - Agnes Kurniawan, Sri W Dwintasari, Lisa Connelly, Rosely A B Nichols, Evy Yunihastuti, Teguh Karyadi, Samsuridjal Djauzi. Cryptosporidium species from human immunodeficiency-infected patients with chronic diarrhea in Jakarta, Indonesia.
Annals of epidemiology.
2013 Nov; 23(11):720-3. doi:
10.1016/j.annepidem.2013.07.019. [PMID: 23972618] - William R Ravis, Alejandro Llanos-Cuentas, Nestor Sosa, Mara Kreishman-Deitrick, Karen M Kopydlowski, Carl Nielsen, Kirsten S Smith, Philip L Smith, Janet H Ransom, Yuh-Jing Lin, Max Grogl. Pharmacokinetics and absorption of paromomycin and gentamicin from topical creams used to treat cutaneous leishmaniasis.
Antimicrobial agents and chemotherapy.
2013 Oct; 57(10):4809-15. doi:
10.1128/aac.00628-13. [PMID: 23877689] - Chelsea Marie, William Arthur Petri. Amoebic dysentery.
BMJ clinical evidence.
2013 Aug; 2013(?):. doi:
. [PMID: 23991750] - Wahid Khan, Shyam S Sharma, Neeraj Kumar. Bioanalytical method development, pharmacokinetics, and toxicity studies of paromomycin and paromomycin loaded in albumin microspheres.
Drug testing and analysis.
2013 Jun; 5(6):453-60. doi:
10.1002/dta.339. [PMID: 22447374] - Christopher J Pantazis, Sarah Fisk, Kerri Mills, Barry S Flinn, Vladimir Shulaev, Richard E Veilleux, Yinghui Dan. Development of an efficient transformation method by Agrobacterium tumefaciens and high throughput spray assay to identify transgenic plants for woodland strawberry (Fragaria vesca) using NPTII selection.
Plant cell reports.
2013 Mar; 32(3):329-37. doi:
10.1007/s00299-012-1366-1. [PMID: 23160638] - Irina Sizova, Andre Greiner, Mayanka Awasthi, Suneel Kateriya, Peter Hegemann. Nuclear gene targeting in Chlamydomonas using engineered zinc-finger nucleases.
The Plant journal : for cell and molecular biology.
2013 Mar; 73(5):873-82. doi:
10.1111/tpj.12066. [PMID: 23137232] - Thomas Krahn, Christie Gilmour, Justin Tilak, Sebastien Fraud, Nicholas Kerr, Calvin Ho-Fung Lau, Keith Poole. Determinants of intrinsic aminoglycoside resistance in Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy.
2012 Nov; 56(11):5591-602. doi:
10.1128/aac.01446-12. [PMID: 22908149] - Guilherme Carneiro, Marta Gontijo Aguiar, Ana Paula Fernandes, Lucas Antônio Miranda Ferreira. Drug delivery systems for the topical treatment of cutaneous leishmaniasis.
Expert opinion on drug delivery.
2012 Sep; 9(9):1083-97. doi:
10.1517/17425247.2012.701204. [PMID: 22724539] - Yonca Acikgoz, Ozan Ozkaya, Kenan Bek, Gurkan Genc, Sema Gulnar Sensoy, Murat Hokelek. Cryptosporidiosis: a rare and severe infection in a pediatric renal transplant recipient.
Pediatric transplantation.
2012 Jun; 16(4):E115-9. doi:
10.1111/j.1399-3046.2011.01473.x. [PMID: 21320246] - Nisha Singh, Manish Kumar, Rakesh Kumar Singh. Leishmaniasis: current status of available drugs and new potential drug targets.
Asian Pacific journal of tropical medicine.
2012 Jun; 5(6):485-97. doi:
10.1016/s1995-7645(12)60084-4. [PMID: 22575984] - Katja Herzog, Henryk Flachowsky, Holger B Deising, Magda-Viola Hanke. Heat-shock-mediated elimination of the nptII marker gene in transgenic apple (Malus×domestica Borkh.).
Gene.
2012 Apr; 498(1):41-9. doi:
10.1016/j.gene.2012.01.074. [PMID: 22349025] - Joline Goossens, Virginie Vandenbroucke, Frank Pasmans, Siegrid De Baere, Mathias Devreese, Ann Osselaere, Elin Verbrugghe, Freddy Haesebrouck, Sarah De Saeger, Mia Eeckhout, Kris Audenaert, Geert Haesaert, Patrick De Backer, Siska Croubels. Influence of mycotoxins and a mycotoxin adsorbing agent on the oral bioavailability of commonly used antibiotics in pigs.
Toxins.
2012 04; 4(4):281-95. doi:
10.3390/toxins4040281. [PMID: 22606377] - Mathieu Mével, Matthieu Sainlos, Benoît Chatin, Noufissa Oudrhiri, Michèle Hauchecorne, Olivier Lambert, Jean-Pierre Vigneron, Pierre Lehn, Bruno Pitard, Jean-Marie Lehn. Paromomycin and neomycin B derived cationic lipids: synthesis and transfection studies.
Journal of controlled release : official journal of the Controlled Release Society.
2012 Mar; 158(3):461-9. doi:
10.1016/j.jconrel.2011.12.019. [PMID: 22226775] - Maryam Ghadiri, Shohreh Fatemi, Alireza Vatanara, Delaram Doroud, Abdolhossein Rouholamini Najafabadi, Majid Darabi, Amir Abbas Rahimi. Loading hydrophilic drug in solid lipid media as nanoparticles: statistical modeling of entrapment efficiency and particle size.
International journal of pharmaceutics.
2012 Mar; 424(1-2):128-37. doi:
10.1016/j.ijpharm.2011.12.037. [PMID: 22227603] - Olivier Vandenberg, Françoise Robberecht, Nicolas Dauby, Catherine Moens, Hana Talabani, Eddy Dupont, Jean Menotti, Tom van Gool, Jack Levy. Management of a Cryptosporidium hominis outbreak in a day-care center.
The Pediatric infectious disease journal.
2012 Jan; 31(1):10-5. doi:
10.1097/inf.0b013e318235ab64. [PMID: 22094626] - Olivier Le Bihan, Raphaël Chèvre, Stéphane Mornet, Boris Garnier, Bruno Pitard, Olivier Lambert. Probing the in vitro mechanism of action of cationic lipid/DNA lipoplexes at a nanometric scale.
Nucleic acids research.
2011 Mar; 39(4):1595-609. doi:
10.1093/nar/gkq921. [PMID: 21078679] - Nina E Hahn, Saverio V Capuano. Successful treatment of cryptosporidiosis in 2 common marmosets (Callithrix jacchus) by using paromomycin.
Journal of the American Association for Laboratory Animal Science : JAALAS.
2010 Nov; 49(6):873-5. doi:
. [PMID: 21205457] - Priya Joyce, Melissa Kuwahata, Nicole Turner, Prakash Lakshmanan. Selection system and co-cultivation medium are important determinants of Agrobacterium-mediated transformation of sugarcane.
Plant cell reports.
2010 Feb; 29(2):173-83. doi:
10.1007/s00299-009-0810-3. [PMID: 20041254] - Hafez M Hafez, Rüdiger Hauck, Wael Gad, Koen De Gussem, Abdulrahman Lotfi. Pilot study on the efficacy of paromomycin as a histomonostatic feed additive in turkey poults experimentally infected with Histomonas meleagridis.
Archives of animal nutrition.
2010 Feb; 64(1):77-84. doi:
10.1080/17450390903478851. [PMID: 20496863] - K Róna, G Klausz, E Keller, M Szakay, P Laczay, M Shem-Tov, P Székely-Körmöczy. Determination of paromomycin residues in turkey tissues by liquid chromatography/mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Nov; 877(30):3792-8. doi:
10.1016/j.jchromb.2009.09.018. [PMID: 19801206] - J El-On, L Ozer, J Gopas, R Sneir, A Golan-Goldhirsh. Nuphar lutea: in vitro anti-leishmanial activity against Leishmania major promastigotes and amastigotes.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2009 Aug; 16(8):788-92. doi:
10.1016/j.phymed.2009.01.011. [PMID: 19303752] - J El-On, L Ozer, J Gopas, R Sneir, H Enav, N Luft, G Davidov, A Golan-Goldhirsh. Antileishmanial activity in Israeli plants.
Annals of tropical medicine and parasitology.
2009 Jun; 103(4):297-306. doi:
10.1179/136485909x440827. [PMID: 19508747] - Sujata Agarwal, Star Loar, Camille Steber, Janice Zale. Floral transformation of wheat.
Methods in molecular biology (Clifton, N.J.).
2009; 478(?):105-13. doi:
10.1007/978-1-59745-379-0_6. [PMID: 19009441] - Ahmed M A Massoud, Adel O Hafez, Abdel-Gawad E Abdel-Gawad, Atef M El-Shazly, Tosson A Morsy. Mirazid alone or combined with Paromomycin in treating cryptosporidiosis parvum in immunocompetent hospitalized patients.
Journal of the Egyptian Society of Parasitology.
2008 Aug; 38(2):399-418. doi:
. [PMID: 18853615] - César Petri, Hong Wang, Nuria Alburquerque, Mohamed Faize, Lorenzo Burgos. Agrobacterium-mediated transformation of apricot (Prunus armeniaca L.) leaf explants.
Plant cell reports.
2008 Aug; 27(8):1317-24. doi:
10.1007/s00299-008-0550-9. [PMID: 18449544] - C P Thakur. Tetany in kala azar patients treated with paromomycin.
The Indian journal of medical research.
2008 May; 127(5):489-93. doi:
. [PMID: 18653914] - David Gonzalez-Ballester, Steve V Pollock, Wirulda Pootakham, Arthur R Grossman. The central role of a SNRK2 kinase in sulfur deprivation responses.
Plant physiology.
2008 May; 147(1):216-27. doi:
10.1104/pp.108.116137. [PMID: 18326790] - K Mørch, K Hanevik, L J Robertson, E A Strand, N Langeland. Treatment-ladder and genetic characterisation of parasites in refractory giardiasis after an outbreak in Norway.
The Journal of infection.
2008 Apr; 56(4):268-73. doi:
10.1016/j.jinf.2008.01.013. [PMID: 18328567] - Su-Chiung Fang, James G Umen. A suppressor screen in chlamydomonas identifies novel components of the retinoblastoma tumor suppressor pathway.
Genetics.
2008 Mar; 178(3):1295-310. doi:
10.1534/genetics.107.085977. [PMID: 18385113] - Khalil-ur-Rahman, Abdullah Al-Amoudi, Samar Badreddine, Abdulraheem M Al-Shehri, Hassan Kanaan, Saedd M G Al-Ghamdi. Cryptosporidiosis in a renal transplant patient treated with paromomycin.
Annals of Saudi medicine.
2007 Sep; 27(5):373-4. doi:
10.5144/0256-4947.2007.373. [PMID: 17921689] - Shyam Sundar, T K Jha, Chandreshwar P Thakur, Prabhat K Sinha, Sujit K Bhattacharya. Injectable paromomycin for Visceral leishmaniasis in India.
The New England journal of medicine.
2007 Jun; 356(25):2571-81. doi:
10.1056/nejmoa066536. [PMID: 17582067] - Ewan P Plant, Phuc Nguyen, Jonathan R Russ, Yvette R Pittman, Thai Nguyen, Jack T Quesinberry, Terri Goss Kinzy, Jonathan D Dinman. Differentiating between near- and non-cognate codons in Saccharomyces cerevisiae.
PloS one.
2007 Jun; 2(6):e517. doi:
10.1371/journal.pone.0000517. [PMID: 17565370] - Stephen Hanessian, Janek Szychowski, Susanta Sekhar Adhikari, Guillermo Vasquez, Pachamuthu Kandasamy, Eric E Swayze, Michael T Migawa, Ray Ranken, Boris François, Julia Wirmer-Bartoschek, Jiro Kondo, Eric Westhof. Structure-based design, synthesis, and A-site rRNA cocrystal complexes of functionally novel aminoglycoside antibiotics: C2' ether analogues of paromomycin.
Journal of medicinal chemistry.
2007 May; 50(10):2352-69. doi:
10.1021/jm061200+. [PMID: 17458946] - Ahmad-Reza Meamar, Mostafa Rezaian, Sasan Rezaie, Minoo Mohraz, Eshrat B Kia, Eric R Houpt, Shahram Solaymani-Mohammadi. Cryptosporidium parvum bovine genotype oocysts in the respiratory samples of an AIDS patient: efficacy of treatment with a combination of azithromycin and paromomycin.
Parasitology research.
2006 May; 98(6):593-5. doi:
10.1007/s00436-005-0097-4. [PMID: 16416289] - Theodoros C Konstantinidis, Nikolaos Patsoukis, Christos D Georgiou, Dennis Synetos. Translational fidelity mutations in 18S rRNA affect the catalytic activity of ribosomes and the oxidative balance of yeast cells.
Biochemistry.
2006 Mar; 45(11):3525-33. doi:
10.1021/bi052505d. [PMID: 16533033] - R K Singh, H P Pandey, S Sundar. Visceral leishmaniasis (kala-azar): challenges ahead.
The Indian journal of medical research.
2006 Mar; 123(3):331-44. doi:
". [PMID: 16778314] - T Geurden, E Claerebout, L Dursin, A Deflandre, F Bernay, V Kaltsatos, J Vercruysse. The efficacy of an oral treatment with paromomycin against an experimental infection with Giardia in calves.
Veterinary parasitology.
2006 Feb; 135(3-4):241-7. doi:
10.1016/j.vetpar.2005.09.006. [PMID: 16256274] - A Baishanbo, G Gargala, C Duclos, A François, J-F Rossignol, J J Ballet, L Favennec. Efficacy of nitazoxanide and paromomycin in biliary tract cryptosporidiosis in an immunosuppressed gerbil model.
The Journal of antimicrobial chemotherapy.
2006 Feb; 57(2):353-5. doi:
10.1093/jac/dki456. [PMID: 16361328] - Julie A Chitty, Robert S Allen, Philip J Larkin. Opium Poppy (Papaver somniferum).
Methods in molecular biology (Clifton, N.J.).
2006; 344(?):383-91. doi:
10.1385/1-59745-131-2:383. [PMID: 17033080] - H B Lee, Y Kim, J C Kim, G J Choi, S-H Park, C-J Kim, H S Jung. Activity of some aminoglycoside antibiotics against true fungi, Phytophthora and Pythium species.
Journal of applied microbiology.
2005; 99(4):836-43. doi:
10.1111/j.1365-2672.2005.02684.x. [PMID: 16162234] - Jiro Kondo, Boris François, Alexandre Urzhumtsev, Eric Westhof. Crystallographic studies of Homo sapiens ribosomal decoding A site complexed with aminoglycosides.
Nucleic acids symposium series (2004).
2005; ?(49):253-4. doi:
10.1093/nass/49.1.253. [PMID: 17150729] - W M Edeling, J J Verweij, C Ij Ponsioen, L G Visser. [Outbreak of amoebiasis in a Dutch family; tropics unexpectedly nearby].
Nederlands tijdschrift voor geneeskunde.
2004 Sep; 148(37):1830-4. doi:
NULL. [PMID: 15495513] - A L Pasqui, E Savini, M Saletti, C Guzzo, L Puccetti, A Auteri. Chronic urticaria and blastocystis hominis infection: a case report.
European review for medical and pharmacological sciences.
2004 May; 8(3):117-20. doi:
NULL. [PMID: 15368795] - Henry W Murray. Progress in the treatment of a neglected infectious disease: visceral leishmaniasis.
Expert review of anti-infective therapy.
2004 Apr; 2(2):279-92. doi:
10.1586/14787210.2.2.279. [PMID: 15482193] - P Montoro, W Rattana, V Pujade-Renaud, N Michaux-Ferrière, Y Monkolsook, R Kanthapura, S Adunsadthapong. Production of Hevea brasiliensis transgenic embryogenic callus lines by Agrobacterium tumefaciens: roles of calcium.
Plant cell reports.
2003 Jul; 21(11):1095-102. doi:
10.1007/s00299-003-0632-7. [PMID: 12836004] - Maha M M Abou Gamra, Laila M el-Hosseiny. Comparative study of the prophylactic and therapeutic effects of paromomycin, recombinant IL-12 alone or in combination against Cryptosporidium parvum infection in immunosuppressed mice.
Journal of the Egyptian Society of Parasitology.
2003 Apr; 33(1):109-22. doi:
NULL. [PMID: 12739805] - Xunde Li, Philippe Brasseur, Patrice Agnamey, Denis Leméteil, Loïc Favennec, Jean-Jacques Ballet, Jean-François Rossignol. Long-lasting anticryptosporidial activity of nitazoxanide in an immunosuppressed rat model.
Folia parasitologica.
2003 Mar; 50(1):19-22. doi:
10.14411/fp.2003.003. [PMID: 12735719] - P Angelet, M T Compte, J L Cid, T Soriano, J Vilaseca, J Bartolomé. [Recurrent episodes of acidosis with encephalopathy in a hemodialysis program patient with short bowel syndrome].
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.
2002; 22(2):196-8. doi:
NULL. [PMID: 12085421] - J C Harris, S Plummer, D Lloyd. Antigiardial drugs.
Applied microbiology and biotechnology.
2001 Dec; 57(5-6):614-9. doi:
10.1007/s002530100720. [PMID: 11778868] - S Sundar. Treatment of visceral leishmaniasis.
Medical microbiology and immunology.
2001 Nov; 190(1-2):89-92. doi:
10.1007/s004300100088. [PMID: 11770119] - S Sundar. Drug resistance in Indian visceral leishmaniasis.
Tropical medicine & international health : TM & IH.
2001 Nov; 6(11):849-54. doi:
10.1046/j.1365-3156.2001.00778.x. [PMID: 11703838] - T E Nash. Treatment of Giardia lamblia infections.
The Pediatric infectious disease journal.
2001 Feb; 20(2):193-5. doi:
10.1097/00006454-200102000-00015. [PMID: 11224841] - T B Gardner, D R Hill. Treatment of giardiasis.
Clinical microbiology reviews.
2001 Jan; 14(1):114-28. doi:
10.1128/cmr.14.1.114-128.2001. [PMID: 11148005] - R G Hewitt, C T Yiannoutsos, E S Higgs, J T Carey, P J Geiseler, R Soave, R Rosenberg, G J Vazquez, L J Wheat, R J Fass, Z Antoninievic, A L Walawander, T P Flanigan, J F Bender. Paromomycin: no more effective than placebo for treatment of cryptosporidiosis in patients with advanced human immunodeficiency virus infection. AIDS Clinical Trial Group.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2000 Oct; 31(4):1084-92. doi:
10.1086/318155. [PMID: 11049793] - A Tromm, T Griga, I Greving, H Hilden, D Hüppe, U Schwegler, G H Micklefield, B May. Orthograde whole gut irrigation with mannite versus paromomycine + lactulose as prophylaxis of hepatic encephalopathy in patients with cirrhosis and upper gastrointestinal bleeding: results of a controlled randomized trial.
Hepato-gastroenterology.
2000 Mar; 47(32):473-7. doi:
. [PMID: 10791216] - E H Johnson, J J Windsor, D E Muirhead, G J King, R Al-Busaidy. Confirmation of the prophylactic value of paromomycin in a natural outbreak of caprine cryptosporidiosis.
Veterinary research communications.
2000 Feb; 24(1):63-7. doi:
10.1023/a:1006381522986. [PMID: 10703755] - J Kamińska, A Tobiasz, M Gniewosz, T Zoładek. The growth of mdp1/rsp5 mutants of Saccharomyces cerevisiae is affected by mutations in the ATP-binding domain of the plasma membrane H+ -ATPase.
Gene.
2000 Jan; 242(1-2):133-40. doi:
10.1016/s0378-1119(99)00535-1. [PMID: 10721705] - H W Murray . Treatment of visceral leishmaniasis (kala-azar): a decade of progress and future approaches.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2000; 4(3):158-77. doi:
10.1016/s1201-9712(00)90078-x. [PMID: 11179920]