UNII:EU52DFC4WJ (BioDeep_00000017096)
代谢物信息卡片
N-Methyl-DL-aspartic acid
化学式: C5H9NO4 (147.0532)
中文名称: N-甲基-L-天冬氨酸, N-甲基天冬氨酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CNC(CC(=O)O)C(=O)O
InChI: InChI=1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)
描述信息
N-Methyl-DL-aspartic acid is a glutamate analogue and a?NMDA?receptor?agonist and can be used for neurological diseases research[1][2].
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:194970
- ChEBI: CHEBI:181378
- KEGG: C75133
- PubChem: 92982
- PubChem: 4376
- ChEMBL: CHEMBL275325
- CAS: 4226-18-0
- CAS: 17833-53-3
- medchemexpress: HY-W017500
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- L D Spate, B K Redel, A N Brown, C N Murphy, R S Prather. Replacement of bovine serum albumin with N-methyl-D-aspartic acid and homocysteine improves development, but not live birth.
Molecular reproduction and development.
2012 May; 79(5):310. doi:
10.1002/mrd.22032. [PMID: 22407887] - Cristiane Busnardo, Carlos C Crestani, Leonardo B M Resstel, Rodrigo F Tavares, José Antunes-Rodrigues, Fernando M A Corrêa. Ionotropic glutamate receptors in hypothalamic paraventricular and supraoptic nuclei mediate vasopressin and oxytocin release in unanesthetized rats.
Endocrinology.
2012 May; 153(5):2323-31. doi:
10.1210/en.2011-2079. [PMID: 22396452] - Rigobert Ayissi Mbomo, Sasha Gartside, Elizabeth Ngo Bum, Njifutie Njikam, Ed Okello, Richard McQuade. Effect of Mimosa pudica (Linn.) extract on anxiety behaviour and GABAergic regulation of 5-HT neuronal activity in the mouse.
Journal of psychopharmacology (Oxford, England).
2012 Apr; 26(4):575-83. doi:
10.1177/0269881111398686. [PMID: 21427203] - Christian Sommerauer, Patrick Rebernik, Harald Reither, Christian Nanoff, Christian Pifl. The noradrenaline transporter as site of action for the anti-Parkinson drug amantadine.
Neuropharmacology.
2012 Mar; 62(4):1708-16. doi:
10.1016/j.neuropharm.2011.11.017. [PMID: 22155208] - Tamra Llewellyn, Hong Zheng, Xuefei Liu, Bo Xu, Kaushik P Patel. Median preoptic nucleus and subfornical organ drive renal sympathetic nerve activity via a glutamatergic mechanism within the paraventricular nucleus.
American journal of physiology. Regulatory, integrative and comparative physiology.
2012 Feb; 302(4):R424-32. doi:
10.1152/ajpregu.00403.2011. [PMID: 22160544] - Pau Gonzalez, Hugo Peluffo, Laia Acarin, Antonio Villaverde, Berta Gonzalez, Bernardo Castellano. Interleukin-10 overexpression does not synergize with the neuroprotective action of RGD-containing vectors after postnatal brain excitotoxicity but modulates the main inflammatory cell responses.
Journal of neuroscience research.
2012 Jan; 90(1):143-59. doi:
10.1002/jnr.22741. [PMID: 21922521] - Marc Gleichmann, Yongqing Zhang, William H Wood, Kevin G Becker, Mohamed R Mughal, Michael J Pazin, Henriette van Praag, Tali Kobilo, Alan B Zonderman, Juan C Troncoso, William R Markesbery, Mark P Mattson. Molecular changes in brain aging and Alzheimer's disease are mirrored in experimentally silenced cortical neuron networks.
Neurobiology of aging.
2012 Jan; 33(1):205.e1-18. doi:
10.1016/j.neurobiolaging.2010.08.012. [PMID: 20947216] - Anja Wellejus, Heidi Elbrønd-Bek, Nicholas M Kelly, Morten S Weidner, Signe H Jørgensen. 4-iodophenyl isothiocyanate: a neuroprotective compound.
Restorative neurology and neuroscience.
2012; 30(1):21-38. doi:
10.3233/rnn-2011-0617. [PMID: 22082767] - Luis A Zarazaga, Irma Celi, José Luis Guzmán, Benoît Malpaux. The effect of nutrition on the neural mechanisms potentially involved in melatonin-stimulated LH secretion in female Mediterranean goats.
The Journal of endocrinology.
2011 Dec; 211(3):263-72. doi:
10.1530/joe-11-0225. [PMID: 21903864] - Alexander Jeans, Richard Malins, Zahid Padamsey, Marcia Reinhart, Nigel Emptage. Increased expression of dysbindin-1A leads to a selective deficit in NMDA receptor signaling in the hippocampus.
Neuropharmacology.
2011 Dec; 61(8):1345-53. doi:
10.1016/j.neuropharm.2011.08.007. [PMID: 21856316] - Stanley I Rapoport, Epolia Ramadan, Mireille Basselin. Docosahexaenoic acid (DHA) incorporation into the brain from plasma, as an in vivo biomarker of brain DHA metabolism and neurotransmission.
Prostaglandins & other lipid mediators.
2011 Nov; 96(1-4):109-13. doi:
10.1016/j.prostaglandins.2011.06.003. [PMID: 21704722] - Kyung-A Kim, Kui Dong Kang, Eun Ha Lee, Chu Won Nho, Sang Hoon Jung. Edible wild vegetable, Gymnaster koraiensis protects retinal ganglion cells against oxidative stress.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2011 Sep; 49(9):2131-43. doi:
10.1016/j.fct.2011.05.028. [PMID: 21664221] - Marco D Brockmann, Beatrice Pöschel, Nicole Cichon, Ileana L Hanganu-Opatz. Coupled oscillations mediate directed interactions between prefrontal cortex and hippocampus of the neonatal rat.
Neuron.
2011 Jul; 71(2):332-47. doi:
10.1016/j.neuron.2011.05.041. [PMID: 21791291] - Carolyn O'Driscoll, Francesca Doonan, Nuria Sanvicens, Angel Messeguer, Thomas G Cotter. A novel free radical scavenger rescues retinal cells in vivo.
Experimental eye research.
2011 Jul; 93(1):65-74. doi:
10.1016/j.exer.2011.04.007. [PMID: 21635890] - Veronica Musante, Maria Summa, Rodrigo A Cunha, Maurizio Raiteri, Anna Pittaluga. Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions.
Journal of neurochemistry.
2011 May; 117(3):516-27. doi:
10.1111/j.1471-4159.2011.07223.x. [PMID: 21348870] - A M Dolga, N Terpolilli, F Kepura, I M Nijholt, H-G Knaus, B D'Orsi, J H M Prehn, U L M Eisel, T Plant, N Plesnila, C Culmsee. KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia.
Cell death & disease.
2011 Apr; 2(?):e147. doi:
10.1038/cddis.2011.30. [PMID: 21509037] - R Russo, L Berliocchi, A Adornetto, G P Varano, F Cavaliere, C Nucci, D Rotiroti, L A Morrone, G Bagetta, M T Corasaniti. Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo.
Cell death & disease.
2011 Apr; 2(?):e144. doi:
10.1038/cddis.2011.29. [PMID: 21490676] - Muriel Noetzli, Eva Choong, Nicolas Ansermot, Chin B Eap. Simultaneous determination of antidementia drugs in human plasma for therapeutic drug monitoring.
Therapeutic drug monitoring.
2011 Apr; 33(2):227-38. doi:
10.1097/ftd.0b013e31821126cf. [PMID: 21383648] - Heidi M Mitchell, David M White, Miriam S Domowicz, Richard P Kraig. Cold pre-conditioning neuroprotection depends on TNF-α and is enhanced by blockade of interleukin-11.
Journal of neurochemistry.
2011 Apr; 117(2):187-96. doi:
10.1111/j.1471-4159.2010.07103.x. [PMID: 21070241] - Xiaoqian Yu, Jiabin Guo, Houhua Fang, Shuangqing Peng. Basal metallothionein-I/II protects against NMDA-mediated oxidative injury in cortical neuron/astrocyte cultures.
Toxicology.
2011 Mar; 282(1-2):16-22. doi:
10.1016/j.tox.2010.12.008. [PMID: 21215786] - O O Krupko, A S Tarasenko, N H Himmelreich. [Activation of presynaptic ionotropic glutamate receptors stimulates GABA release from hippocampal and cortical nerve terminals in rats].
Ukrains'kyi biokhimichnyi zhurnal (1999 ).
2011 Mar; 83(2):45-52. doi:
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The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.
2011 Mar; 12(2):89-98. doi:
10.3109/15622975.2010.506927. [PMID: 20735156] - Silmara Aparecida Faggion, Alexandra Olimpio Siqueira Cunha, Helene Aparecida Fachim, Amanda Salomão Gavin, Wagner Ferreira dos Santos, Ana Maria Soares Pereira, Renê Oliveira Beleboni. Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-α-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae-Papilionaceae).
Epilepsy & behavior : E&B.
2011 Mar; 20(3):441-6. doi:
10.1016/j.yebeh.2010.12.037. [PMID: 21277832] - Andrea Matteucci, Roberta Cammarota, Silvia Paradisi, Monica Varano, Maria Balduzzi, Lanfranco Leo, Gian C Bellenchi, Chiara De Nuccio, Giovanna Carnovale-Scalzo, Giovanni Scorcia, Claudio Frank, Cinzia Mallozzi, Annamaria M Di Stasi, Sergio Visentin, Fiorella Malchiodi-Albedi. Curcumin protects against NMDA-induced toxicity: a possible role for NR2A subunit.
Investigative ophthalmology & visual science.
2011 Feb; 52(2):1070-7. doi:
10.1167/iovs.10-5966. [PMID: 20861489] - Fabrizio Gardoni, Mariaserena Boraso, Elisa Zianni, Emanuela Corsini, Corrado L Galli, Flaminio Cattabeni, Marina Marinovich, Monica Di Luca, Barbara Viviani. Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1β and NMDA stimulation.
Journal of neuroinflammation.
2011 Feb; 8(1):14. doi:
10.1186/1742-2094-8-14. [PMID: 21314939] - J C Rostain, C Lavoute, J J Risso, N Vallée, M Weiss. A review of recent neurochemical data on inert gas narcosis.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc.
2011 Jan; 38(1):49-59. doi:
". [PMID: 21384763] - Shao Li, Jie Luo, Xi Wang, Bing-Cai Guan, Chang-Kai Sun. Effects of Ginkgo biloba extracts on NMDA-activated currents in acutely isolated hippocampal neurons of the rat.
Phytotherapy research : PTR.
2011 Jan; 25(1):137-41. doi:
10.1002/ptr.3235. [PMID: 20632296] - Liliana L Jorge, Caroline C Feres, Vitor Ep Teles. Topical preparations for pain relief: efficacy and patient adherence.
Journal of pain research.
2010 Dec; 4(?):11-24. doi:
10.2147/jpr.s9492. [PMID: 21386951] - Daniel del Toro, Xavier Xifró, Albert Pol, Sandrine Humbert, Frédéric Saudou, Josep M Canals, Jordi Alberch. Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease.
Journal of neurochemistry.
2010 Oct; 115(1):153-67. doi:
10.1111/j.1471-4159.2010.06912.x. [PMID: 20663016] - Hyo-Jin Jeong, Robert J Vandenberg, Christopher W Vaughan. N-arachidonyl-glycine modulates synaptic transmission in superficial dorsal horn.
British journal of pharmacology.
2010 Oct; 161(4):925-35. doi:
10.1111/j.1476-5381.2010.00935.x. [PMID: 20860669] - Pierre J Deviche, Laura L Hurley, H Bobby Fokidis, Benjamin Lerbour, Bengt Silverin, Björg Silverin, John Sabo, Peter J Sharp. Acute stress rapidly decreases plasma testosterone in a free-ranging male songbird: potential site of action and mechanism.
General and comparative endocrinology.
2010 Oct; 169(1):82-90. doi:
10.1016/j.ygcen.2010.07.009. [PMID: 20691650] - Chun Zhang, Fan Yi, Min Xia, Krishna M Boini, Qing Zhu, Laura A Laperle, Justine M Abais, Christopher A Brimson, Pin-Lan Li. NMDA receptor-mediated activation of NADPH oxidase and glomerulosclerosis in hyperhomocysteinemic rats.
Antioxidants & redox signaling.
2010 Oct; 13(7):975-86. doi:
10.1089/ars.2010.3091. [PMID: 20406136] - Maria A Brito, Ana R Vaz, Sandra L Silva, Ana S Falcão, Adelaide Fernandes, Rui F M Silva, Dora Brites. N-methyl-aspartate receptor and neuronal nitric oxide synthase activation mediate bilirubin-induced neurotoxicity.
Molecular medicine (Cambridge, Mass.).
2010 Sep; 16(9-10):372-80. doi:
10.2119/molmed.2009.00152. [PMID: 20593111] - Shoshiro Okada, Naoko Yamaguchi. Alpha1-adrenoceptor activation is involved in the central N-methyl-D-aspartate-induced adrenomedullary outflow in rats.
European journal of pharmacology.
2010 Aug; 640(1-3):55-62. doi:
10.1016/j.ejphar.2010.04.038. [PMID: 20450908] - Epolia Ramadan, Angelo O Rosa, Lisa Chang, Mei Chen, Stanley I Rapoport, Mireille Basselin. Extracellular-derived calcium does not initiate in vivo neurotransmission involving docosahexaenoic acid.
Journal of lipid research.
2010 Aug; 51(8):2334-40. doi:
10.1194/jlr.m006262. [PMID: 20388940] - Nathan Knutson, Charles E Wood. Interaction of PGHS-2 and glutamatergic mechanisms controlling the ovine fetal hypothalamus-pituitary-adrenal axis.
American journal of physiology. Regulatory, integrative and comparative physiology.
2010 Jul; 299(1):R365-70. doi:
10.1152/ajpregu.00163.2010. [PMID: 20445154] - Xiang Jun Zeng, Shan Ping Yu, Like Zhang, Ling Wei. Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons.
Experimental cell research.
2010 Jul; 316(11):1773-83. doi:
10.1016/j.yexcr.2010.02.005. [PMID: 20152832] - Xavier d'Anglemont de Tassigny, Karen J Ackroyd, Emmanouella E Chatzidaki, William H Colledge. Kisspeptin signaling is required for peripheral but not central stimulation of gonadotropin-releasing hormone neurons by NMDA.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2010 Jun; 30(25):8581-90. doi:
10.1523/jneurosci.5486-09.2010. [PMID: 20573904] - Agnes Simonyi, Yan He, Wenwen Sheng, Albert Y Sun, W Gibson Wood, Gary A Weisman, Grace Y Sun. Targeting NADPH oxidase and phospholipases A2 in Alzheimer's disease.
Molecular neurobiology.
2010 Jun; 41(2-3):73-86. doi:
10.1007/s12035-010-8107-7. [PMID: 20195796] - Mikael E Pedersen, Roger A Baldwin, Jerome Niquet, Gary I Stafford, Johannes van Staden, Claude G Wasterlain, Anna K Jäger. Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats.
Phytotherapy research : PTR.
2010 Jun; 24(6):924-7. doi:
10.1002/ptr.3016. [PMID: 19953526] - Allison C Kleiber, Hong Zheng, Neeru M Sharma, Kaushik P Patel. Chronic AT1 receptor blockade normalizes NMDA-mediated changes in renal sympathetic nerve activity and NR1 expression within the PVN in rats with heart failure.
American journal of physiology. Heart and circulatory physiology.
2010 May; 298(5):H1546-55. doi:
10.1152/ajpheart.01006.2009. [PMID: 20173042] - Andy J Fischer, Melissa A Scott, Christopher Zelinka, Patrick Sherwood. A novel type of glial cell in the retina is stimulated by insulin-like growth factor 1 and may exacerbate damage to neurons and Müller glia.
Glia.
2010 Apr; 58(6):633-49. doi:
10.1002/glia.20950. [PMID: 19941335] - Maria Letizia Cucchiaroni, Maria Teresa Viscomi, Giorgio Bernardi, Marco Molinari, Ezia Guatteo, Nicola B Mercuri. Metabotropic glutamate receptor 1 mediates the electrophysiological and toxic actions of the cycad derivative beta-N-Methylamino-L-alanine on substantia nigra pars compacta DAergic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2010 Apr; 30(15):5176-88. doi:
10.1523/jneurosci.5351-09.2010. [PMID: 20392940] - Hsien-Yu Peng, Gin-Den Chen, Cheng-Yuan Lai, Ming-Chun Hsieh, Hsao-Hsun Hsu, Hsi-Chin Wu, Tzer-Bin Lin. PI3K modulates estrogen-dependent facilitation of colon-to-urethra cross-organ reflex sensitization in ovariectomized female rats.
Journal of neurochemistry.
2010 Apr; 113(1):54-66. doi:
10.1111/j.1471-4159.2010.06577.x. [PMID: 20067569] - S L Stvolinsky, E R Bulygina, T N Fedorova, K Meguro, T Sato, O V Tyulina, H Abe, A A Boldyrev. Biological activity of novel synthetic derivatives of carnosine.
Cellular and molecular neurobiology.
2010 Apr; 30(3):395-404. doi:
10.1007/s10571-009-9462-7. [PMID: 19798566] - Lin Xiao, Chunzhi Feng, Yizhang Chen. Glucocorticoid rapidly enhances NMDA-evoked neurotoxicity by attenuating the NR2A-containing NMDA receptor-mediated ERK1/2 activation.
Molecular endocrinology (Baltimore, Md.).
2010 Mar; 24(3):497-510. doi:
10.1210/me.2009-0422. [PMID: 20160127] - F Schoonenberg Kegel, B M Rietman, A R D Verliefde. Reverse osmosis followed by activated carbon filtration for efficient removal of organic micropollutants from river bank filtrate.
Water science and technology : a journal of the International Association on Water Pollution Research.
2010; 61(10):2603-10. doi:
10.2166/wst.2010.166. [PMID: 20453334] - Dong Liu, Michael Pitta, Jong-Hwan Lee, Balmiki Ray, Debomoy K Lahiri, Katsutoshi Furukawa, Mohamed Mughal, Haiyang Jiang, Julissa Villarreal, Roy G Cutler, Nigel H Greig, Mark P Mattson. The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD.
2010; 22(2):443-57. doi:
10.3233/jad-2010-101017. [PMID: 20847430] - Brian T Reed, Steven J Sullivan, Guochuan Tsai, Joseph T Coyle, Manuel Esguerra, Robert F Miller. The glycine transporter GlyT1 controls N-methyl-D-aspartic acid receptor coagonist occupancy in the mouse retina.
The European journal of neuroscience.
2009 Dec; 30(12):2308-17. doi:
10.1111/j.1460-9568.2009.07020.x. [PMID: 20092573] - Stefano Rufini, Daniele Grossi, Paolo Luly, Virginia Tancredi, Claudio Frank, Giovanna D'Arcangelo. Cholesterol depletion inhibits electrophysiological changes induced by anoxia in CA1 region of rat hippocampal slices.
Brain research.
2009 Nov; 1298(?):178-85. doi:
10.1016/j.brainres.2009.08.037. [PMID: 19699721] - Zongren Wang, Wen Wang, Zhongjun Shao, Bifeng Gao, Junchang Li, Jing Ma, Jinghua Li, Honglei Che, Wei Zhang. Eukaryotic expression and purification of anti-epilepsy peptide of Buthus martensii Karsch and its protein interactions.
Molecular and cellular biochemistry.
2009 Oct; 330(1-2):97-104. doi:
10.1007/s11010-009-0104-7. [PMID: 19370317] - S Ramaswamy, R B Gibbs, T M Plant. Studies of the localisation of kisspeptin within the pituitary of the rhesus monkey (Macaca mulatta) and the effect of kisspeptin on the release of non-gonadotropic pituitary hormones.
Journal of neuroendocrinology.
2009 Oct; 21(10):795-804. doi:
10.1111/j.1365-2826.2009.01905.x. [PMID: 19686451] - Jerome H Pagani, Jeffrey B Rosen. The medial hypothalamic defensive circuit and 2,5-dihydro-2,4,5-trimethylthiazoline (TMT) induced fear: comparison of electrolytic and neurotoxic lesions.
Brain research.
2009 Aug; 1286(?):133-46. doi:
10.1016/j.brainres.2009.06.062. [PMID: 19559688] - E Ngo Bum, G S Taiwe, F C O Moto, G T Ngoupaye, G C N Nkantchoua, M M Pelanken, S V Rakotonirina, A Rakotonirina. Anticonvulsant, anxiolytic, and sedative properties of the roots of Nauclea latifolia Smith in mice.
Epilepsy & behavior : E&B.
2009 Aug; 15(4):434-40. doi:
10.1016/j.yebeh.2009.05.014. [PMID: 19560975] - Zhenyu Sheng, Zhong Liang, James H Geiger, Mary Prorok, Francis J Castellino. The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B.
Neuropharmacology.
2009 Aug; 57(2):127-36. doi:
10.1016/j.neuropharm.2009.04.014. [PMID: 19427876] - Sheng-Chun Mao, Hui-Ching Lin, Po-Wu Gean. Augmentation of fear extinction by infusion of glycine transporter blockers into the amygdala.
Molecular pharmacology.
2009 Aug; 76(2):369-78. doi:
10.1124/mol.108.053728. [PMID: 19411609] - Juliano R Guerreiro, Claudiana Lameu, Eduardo F Oliveira, Clécio F Klitzke, Robson L Melo, Edlaine Linares, Ohara Augusto, Jay W Fox, Ivo Lebrun, Solange M T Serrano, Antonio C M Camargo. Argininosuccinate synthetase is a functional target for a snake venom anti-hypertensive peptide: role in arginine and nitric oxide production.
The Journal of biological chemistry.
2009 Jul; 284(30):20022-33. doi:
10.1074/jbc.m109.021089. [PMID: 19491403] - Nozomu Matsunaga, Shunsuke Imai, Yuta Inokuchi, Masamitsu Shimazawa, Shigeru Yokota, Yoko Araki, Hideaki Hara. Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo.
Molecular nutrition & food research.
2009 Jul; 53(7):869-77. doi:
10.1002/mnfr.200800394. [PMID: 19415665] - David J Koss, Gernot Riedel, Bettina Platt. Intracellular Ca2+ stores modulate SOCCs and NMDA receptors via tyrosine kinases in rat hippocampal neurons.
Cell calcium.
2009 Jul; 46(1):39-48. doi:
10.1016/j.ceca.2009.04.001. [PMID: 19423160] - Hai Xia Zhang, Krzysztof Hyrc, Liu Lin Thio. The glycine transport inhibitor sarcosine is an NMDA receptor co-agonist that differs from glycine.
The Journal of physiology.
2009 Jul; 587(Pt 13):3207-20. doi:
10.1113/jphysiol.2009.168757. [PMID: 19433577] - Yaoming Wang, Meenakshisundaram Thiyagarajan, Nienwen Chow, Itender Singh, Huang Guo, Thomas P Davis, Berislav V Zlokovic. Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity.
Stroke.
2009 May; 40(5):1864-9. doi:
10.1161/strokeaha.108.536680. [PMID: 19057019] - Michael J Ferragamo, Jessica L Reinardy, Stanley A Thayer. Ca2+-dependent, stimulus-specific modulation of the plasma membrane Ca2+ pump in hippocampal neurons.
Journal of neurophysiology.
2009 May; 101(5):2563-71. doi:
10.1152/jn.90774.2008. [PMID: 19244356] - J-H Tao-Cheng, A Dosemeci, P E Gallant, S Miller, J A Galbraith, C A Winters, R Azzam, T S Reese. Rapid turnover of spinules at synaptic terminals.
Neuroscience.
2009 Apr; 160(1):42-50. doi:
10.1016/j.neuroscience.2009.02.031. [PMID: 19248820] - Pau Gonzalez, Ferran Burgaya, Laia Acarin, Hugo Peluffo, Bernardo Castellano, Berta Gonzalez. Interleukin-10 and interleukin-10 receptor-I are upregulated in glial cells after an excitotoxic injury to the postnatal rat brain.
Journal of neuropathology and experimental neurology.
2009 Apr; 68(4):391-403. doi:
10.1097/nen.0b013e31819dca30. [PMID: 19287312] - Reymundo Dominguez, Eric Hu, Miou Zhou, Michel Baudry. 17beta-estradiol-mediated neuroprotection and ERK activation require a pertussis toxin-sensitive mechanism involving GRK2 and beta-arrestin-1.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2009 Apr; 29(13):4228-38. doi:
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Bioorganic & medicinal chemistry letters.
2009 Mar; 19(5):1492-5. doi:
10.1016/j.bmcl.2009.01.015. [PMID: 19181525] - Moshe Parnas, Ben Katz, Shaya Lev, Vered Tzarfaty, Daniela Dadon, Ariela Gordon-Shaag, Henry Metzner, Rami Yaka, Baruch Minke. Membrane lipid modulations remove divalent open channel block from TRP-like and NMDA channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2009 Feb; 29(8):2371-83. doi:
10.1523/jneurosci.4280-08.2009. [PMID: 19244513] - Dennis J Goebel. Selective blockade of CaMKII-alpha inhibits NMDA-induced caspase-3-dependent cell death but does not arrest PARP-1 activation or loss of plasma membrane selectivity in rat retinal neurons.
Brain research.
2009 Feb; 1256(?):190-204. doi:
10.1016/j.brainres.2008.12.051. [PMID: 19135986] - Theodore Yu, Gert Cauwenberghs. Biophysical synaptic dynamics in an analog VLSI network of Hodgkin-Huxley neurons.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference.
2009; 2009(?):3335-8. doi:
10.1109/iembs.2009.5333272. [PMID: 19964071] - Nuray Yazihan, Kubilay Uzuner, Bulent Salman, Murat Vural, Tulay Koken, Ali Arslantas. Erythropoietin improves oxidative stress following spinal cord trauma in rats.
Injury.
2008 Dec; 39(12):1408-13. doi:
10.1016/j.injury.2008.03.010. [PMID: 18635178] - Hongmei Shen, Ying Yuan, Fei Ding, Jie Liu, Xiaosong Gu. The protective effects of Achyranthes bidentata polypeptides against NMDA-induced cell apoptosis in cultured hippocampal neurons through differential modulation of NR2A- and NR2B-containing NMDA receptors.
Brain research bulletin.
2008 Nov; 77(5):274-81. doi:
10.1016/j.brainresbull.2008.08.002. [PMID: 18765272] - Raymond S Roginski, Farida Goubaeva, Maya Mikami, Emma Fried-Cassorla, Mohan R Nair, Jay Yang. GRINL1A colocalizes with N-methyl D-aspartate receptor NR1 subunit and reduces N-methyl D-aspartate toxicity.
Neuroreport.
2008 Nov; 19(17):1721-6. doi:
10.1097/wnr.0b013e328317f05f. [PMID: 18849881] - Xiao-Dong Jiang, Xu-Long Wang, Yan Sun, Hai-Qing Gong, Pei-Ji Liang. NMDA modulation of GABA transporter current in carp retinal horizontal cells.
Brain research.
2008 Nov; 1240(?):105-10. doi:
10.1016/j.brainres.2008.08.094. [PMID: 18822275] - Gj Amabeoku. Anticonvulsant activity of Nylandtia spinosa L. Dumont (Polygalaceae) aqueous and methanol leaf extracts in mice.
Human & experimental toxicology.
2008 Nov; 27(11):811-8. doi:
10.1177/0960327108099538. [PMID: 19244288] - Denis Boulay, Philippe Pichat, Gihad Dargazanli, Genevieve Estenne-Bouhtou, Jean Paul Terranova, Nancy Rogacki, Jeanne Stemmelin, Annick Coste, Christophe Lanneau, Christophe Desvignes, Caroline Cohen, Richard Alonso, Xavier Vigé, Bruno Biton, Régis Steinberg, Mireille Sevrin, Florence Oury-Donat, Pascal George, Olivier Bergis, Guy Griebel, Patrick Avenet, Bernard Scatton. Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia.
Pharmacology, biochemistry, and behavior.
2008 Nov; 91(1):47-58. doi:
10.1016/j.pbb.2008.06.009. [PMID: 18621075] - Yoshimi Nakajima, Yuta Inokuchi, Masamitsu Shimazawa, Kazumasa Otsubo, Takashi Ishibashi, Hideaki Hara. Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in-vitro and in mice in-vivo.
The Journal of pharmacy and pharmacology.
2008 Oct; 60(10):1365-74. doi:
10.1211/jpp/60.10.0013. [PMID: 18812030] - Larry S Zweifel, Emanuela Argilli, Antonello Bonci, Richard D Palmiter. Role of NMDA receptors in dopamine neurons for plasticity and addictive behaviors.
Neuron.
2008 Aug; 59(3):486-96. doi:
10.1016/j.neuron.2008.05.028. [PMID: 18701073] - Allison C Kleiber, Hong Zheng, Harold D Schultz, Jacob D Peuler, Kaushik P Patel. Exercise training normalizes enhanced glutamate-mediated sympathetic activation from the PVN in heart failure.
American journal of physiology. Regulatory, integrative and comparative physiology.
2008 Jun; 294(6):R1863-72. doi:
10.1152/ajpregu.00757.2007. [PMID: 18385465] - Takayuki Ohnishi, Emiko Okuda-Ashitaka, Shinji Matsumura, Tayo Katano, Mikio Nishizawa, Seiji Ito. Characterization of signaling pathway for the translocation of neuronal nitric oxide synthase to the plasma membrane by PACAP.
Journal of neurochemistry.
2008 Jun; 105(6):2271-85. doi:
10.1111/j.1471-4159.2008.05325.x. [PMID: 18331476] - Shoshiro Okada, Naoko Yamaguchi-Shima, Takahiro Shimizu, Junichi Arai, Mieko Yorimitsu, Kunihiko Yokotani. Centrally administered N-methyl-d-aspartate evokes the adrenal secretion of noradrenaline and adrenaline by brain thromboxane A2-mediated mechanisms in rats.
European journal of pharmacology.
2008 May; 586(1-3):145-50. doi:
10.1016/j.ejphar.2008.02.069. [PMID: 18374330] - Bruno Silva, Paulo J Oliveira, Alberto Dias, Joao O Malva. Quercetin, kaempferol and biapigenin from Hypericum perforatum are neuroprotective against excitotoxic insults.
Neurotoxicity research.
2008 May; 13(3-4):265-79. doi:
10.1007/bf03033510. [PMID: 18522906] - Eloi F Rosa, Edna Freymüller, Silvia S M Ihara, Jeannine Aboulafia, Viviane L A Nouailhetas. Damaging effects of intense repetitive treadmill running on murine intestinal musculature.
Journal of applied physiology (Bethesda, Md. : 1985).
2008 May; 104(5):1410-7. doi:
10.1152/japplphysiol.00377.2007. [PMID: 18309097] - Hsien-Yu Peng, Ya-Wen Cheng, Shin-Da Lee, Yen-Chun Ho, Dylan Chou, Gin-Den Chen, Chen-Li Cheng, Tien-Huan Hsu, Kwong-Chung Tung, Tzer-Bin Lin. Glutamate-mediated spinal reflex potentiation involves ERK 1/2 phosphorylation in anesthetized rats.
Neuropharmacology.
2008 Mar; 54(4):686-98. doi:
10.1016/j.neuropharm.2007.11.017. [PMID: 18191957] - Miho Oyasu, Mineko Fujimiya, Kaori Kashiwagi, Shiho Ohmori, Hirotsugu Imaeda, Naoaki Saito. Immunogold electron microscopic demonstration of distinct submembranous localization of the activated gammaPKC depending on the stimulation.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
2008 Mar; 56(3):253-65. doi:
10.1369/jhc.7a7291.2007. [PMID: 18040079] - Ju Yeon Ban, Soon Ock Cho, Sun-Ha Choi, Hyun Soo Ju, Ju Yeon Kim, KiHwan Bae, Kyung-Sik Song, Yeon Hee Seong. Neuroprotective effect of Smilacis chinae rhizome on NMDA-induced neurotoxicity in vitro and focal cerebral ischemia in vivo.
Journal of pharmacological sciences.
2008 Jan; 106(1):68-77. doi:
10.1254/jphs.fp0071206. [PMID: 18202548] - Henry Sershen, Andrea Balla, John M Aspromonte, Shan Xie, Thomas B Cooper, Daniel C Javitt. Characterization of interactions between phencyclidine and amphetamine in rodent prefrontal cortex and striatum: implications in NMDA/glycine-site-mediated dopaminergic dysregulation and dopamine transporter function.
Neurochemistry international.
2008 Jan; 52(1-2):119-29. doi:
10.1016/j.neuint.2007.07.011. [PMID: 17716783] - Ho-Joo Lee, Jagadeesh S Rao, Lisa Chang, Stanley I Rapoport, Richard P Bazinet. Chronic N-methyl-D-aspartate administration increases the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat.
Journal of lipid research.
2008 Jan; 49(1):162-8. doi:
10.1194/jlr.m700406-jlr200. [PMID: 17957090] - Samuel Vandresen-Filho, Bruno de Araújo Herculano, Jeferson Luis Franco, Carina Rodrigues Boeck, Alcir Luiz Dafre, Carla Inês Tasca. Evaluation of glutathione metabolism in NMDA preconditioning against quinolinic acid-induced seizures in mice cerebral cortex and hippocampus.
Brain research.
2007 Dec; 1184(?):38-45. doi:
10.1016/j.brainres.2007.09.091. [PMID: 17980354] - George C-T Jiang, Kristen Tidwell, Beth Ann McLaughlin, Jiyang Cai, Ramesh C Gupta, Dejan Milatovic, Richard Nass, Michael Aschner. Neurotoxic potential of depleted uranium effects in primary cortical neuron cultures and in Caenorhabditis elegans.
Toxicological sciences : an official journal of the Society of Toxicology.
2007 Oct; 99(2):553-65. doi:
10.1093/toxsci/kfm171. [PMID: 17636247] - H S Cui, L S Huang, D-E Sok, J Shin, B-M Kwon, U J Youn, K Bae. Protective action of honokiol, administered orally, against oxidative stress in brain of mice challenged with NMDA.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2007 Oct; 14(10):696-700. doi:
10.1016/j.phymed.2007.03.005. [PMID: 17470388] - Consalvo Mattia, Flaminia Coluzzi. Indantadol, a novel NMDA antagonist and nonselective MAO inhibitor for the potential treatment of neuropathic pain.
IDrugs : the investigational drugs journal.
2007 Sep; 10(9):636-44. doi:
NULL. [PMID: 17786847] - Shao Li, Chang-Kai Sun, Xin-Cai Ji, Jian Zhang. [Effects of ginkgo biloba extracts on NMDA-activated currents in acutely isolated rat hippocampal neurons].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2007 Aug; 23(3):305-8. doi:
". [PMID: 21162271] - Zhenyu Sheng, Qiuyun Dai, Mary Prorok, Francis J Castellino. Subtype-selective antagonism of N-methyl-D-aspartate receptor ion channels by synthetic conantokin peptides.
Neuropharmacology.
2007 Jul; 53(1):145-56. doi:
10.1016/j.neuropharm.2007.04.016. [PMID: 17588620] - Elisa A Waxman, Isabelle Baconguis, David R Lynch, Michael B Robinson. N-methyl-D-aspartate receptor-dependent regulation of the glutamate transporter excitatory amino acid carrier 1.
The Journal of biological chemistry.
2007 Jun; 282(24):17594-607. doi:
10.1074/jbc.m702278200. [PMID: 17459877] - M T Corasaniti, J Maiuolo, S Maida, V Fratto, M Navarra, R Russo, D Amantea, L A Morrone, G Bagetta. Cell signaling pathways in the mechanisms of neuroprotection afforded by bergamot essential oil against NMDA-induced cell death in vitro.
British journal of pharmacology.
2007 Jun; 151(4):518-29. doi:
10.1038/sj.bjp.0707237. [PMID: 17401440] - G J Amabeoku, I Green, J Kabatende. Anticonvulsant activity of Cotyledon orbiculata L. (Crassulaceae) leaf extract in mice.
Journal of ethnopharmacology.
2007 May; 112(1):101-7. doi:
10.1016/j.jep.2007.02.016. [PMID: 17398051] - X-D Dong, M K Mann, U Kumar, P Svensson, L Arendt-Nielsen, J W Hu, B J Sessle, B E Cairns. Sex-related differences in NMDA-evoked rat masseter muscle afferent discharge result from estrogen-mediated modulation of peripheral NMDA receptor activity.
Neuroscience.
2007 May; 146(2):822-32. doi:
10.1016/j.neuroscience.2007.01.051. [PMID: 17382479] - Atsushi Yamamoto, Hiroyuki Tanaka, Tetsuo Ishida, Kihachiro Horiike. Functional and structural characterization of D-aspartate oxidase from porcine kidney: non-Michaelis kinetics due to substrate activation.
Journal of biochemistry.
2007 Mar; 141(3):363-76. doi:
10.1093/jb/mvm041. [PMID: 17234685] - Susanne Kreutz, Marco Koch, Chalid Ghadban, Horst-Werner Korf, Faramarz Dehghani. Cannabinoids and neuronal damage: differential effects of THC, AEA and 2-AG on activated microglial cells and degenerating neurons in excitotoxically lesioned rat organotypic hippocampal slice cultures.
Experimental neurology.
2007 Jan; 203(1):246-57. doi:
10.1016/j.expneurol.2006.08.010. [PMID: 17010339]
