Edaravone (BioDeep_00000001702)
Secondary id: BioDeep_00000028186
human metabolite blood metabolite
代谢物信息卡片
3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one
化学式: C10H10N2O (174.0793)
中文名称: 1-苯基-3-甲基-5-吡唑啉酮(PMP), 依达拉奉
谱图信息:
最多检出来源 Mus musculus(blood) 5.51%
分子结构信息
SMILES: CC1=NN(C(=O)C1)C1=CC=CC=C1
InChI: InChI=1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3
描述信息
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
D000975 - Antioxidants > D016166 - Free Radical Scavengers
C26170 - Protective Agent > C1509 - Neuroprotective Agent
D020011 - Protective Agents > D000975 - Antioxidants
COVID info from PDB, Protein Data Bank
N - Nervous system
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
24 个代谢物同义名
3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one; 2,4-dihydro-5-Methyl-2-phenyl-3H-pyrazol-3-one; 1-Phenyl-3-methyl-5-oxo-2-pyrazoline; 3 Methyl 1 phenyl 2 pyrazolin 5 one; 3-Methyl-1-phenyl-2-pyrazolin-5-one; 3-Methyl-1-phenyl-5-pyrazolone; 3-Methyl-1-phenylpyrazol-5-one; 1 Phenyl 3 methyl 5 pyrazolone; 1-Phenyl-3-methyl-5-pyrazolone; Phenyl methyl pyrazolone; Methylphenylpyrazolone; Phenylmethylpyrazolone; C.I. developer 1; Norantipyrine; Norphenazone; Developer Z; Edarabone; edaravone; Radicava; MCI-186; Radicut; MCI 186; Edaravone; Edaravone
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:31530
- KEGG: C13008
- PubChem: 4021
- HMDB: HMDB0251697
- Metlin: METLIN44360
- DrugBank: DB12243
- ChEMBL: CHEMBL290916
- Wikipedia: Edaravone
- MeSH: Edaravone
- chemspider: 3881
- CAS: 89-25-8
- PMhub: MS000001008
- ChEBI: CHEBI:190738
- PubChem: 583397
- PDB-CCD: W1P
- NIKKAJI: J37.341I
- KNApSAcK: 31530
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shi-Le Huang, Yin-Li Shen, Wen-Yan Peng, Kun Ye, Hui Zheng. Edaravone for patients with amyotrophic lateral sclerosis: a systematic review and meta-analysis.
Acta neurologica Belgica.
2024 Jun; 124(3):895-904. doi:
10.1007/s13760-024-02476-2. [PMID: 38347315] - Yi Li, Jieying He, Bilan Luo, Qinyang Yu, Ting Cai, Yong Li, Lingling Fan, Xunrong Zhou, Lei Tang. Discovery of Novel Hybrids of Edaravone and 6-Phenyl-4,5-dihydropyridazin-3(2H)-one with Antiplatelet Aggregation and Neuroprotection for Ischemic Stroke Treatment.
Chemistry & biodiversity.
2024 May; 21(5):e202400110. doi:
10.1002/cbdv.202400110. [PMID: 38424689] - Toru Yamashita, Koji Abe. Update on Antioxidant Therapy with Edaravone: Expanding Applications in Neurodegenerative Diseases.
International journal of molecular sciences.
2024 Mar; 25(5):. doi:
10.3390/ijms25052945. [PMID: 38474192] - Cristina Russo, Dario Rusciano, Rosa Santangelo, Lucia Malaguarnera. Options for Topical Treatment of Oxidative Eye Diseases with a Special Focus on Retinopathies.
Medicina (Kaunas, Lithuania).
2024 Feb; 60(3):. doi:
10.3390/medicina60030354. [PMID: 38541080] - Youzhi Wang, Guoqing Yang, Huizhen Shen, Ying Liang, Haijuan Dong, Ximing Guo, Qingjing Hao, Jinxin Wang. Hybrids of selective COX-2 inhibitors and active derivatives of edaravone as COX-2 selective NSAIDs with free radical scavenging activity: Design, synthesis and biological activities.
European journal of medicinal chemistry.
2024 Feb; 266(?):116155. doi:
10.1016/j.ejmech.2024.116155. [PMID: 38266553] - José Manuel Cruz-Rubio, Renate Loeppert, Werner Praznik. Monosaccharide Analysis After One-Pot Derivatization Followed by Reverse-Phase Liquid Chromatography Separation and UV/Vis Detection.
Methods in molecular biology (Clifton, N.J.).
2024; 2788(?):67-79. doi:
10.1007/978-1-0716-3782-1_5. [PMID: 38656509] - Danuta Jantas, Piotr Warszyński, Władysław Lasoń. Carnosic Acid Shows Higher Neuroprotective Efficiency than Edaravone or Ebselen in In Vitro Models of Neuronal Cell Damage.
Molecules (Basel, Switzerland).
2023 Dec; 29(1):. doi:
10.3390/molecules29010119. [PMID: 38202702] - Maria A Lapshina, Elena F Shevtsova, Vladimir V Grigoriev, Aleksey Yu Aksinenko, Aleksey A Ustyugov, Daniil A Steinberg, Grigoriy V Maleev, Elena S Dubrovskaya, Tatiana V Goreva, Tatiana A Epishina, Vladimir L Zamoyski, Galina F Makhaeva, Vladimir P Fisenko, Ivan M Veselov, Daria V Vinogradova, Sergey O Bachurin. New Adamantane-Containing Edaravone Conjugates as Potential Neuroprotective Agents for ALS Treatments.
Molecules (Basel, Switzerland).
2023 Nov; 28(22):. doi:
10.3390/molecules28227567. [PMID: 38005288] - V V Grigoriev, E F Shevtsova, A Yu Aksinenko, I M Veselov, T V Goreva, A V Gabrelyan, S O Bachurin. New Hybrid Structures Based on Memanthine and Edaravone Molecules.
Doklady. Biochemistry and biophysics.
2023 Oct; 512(1):284-287. doi:
10.1134/s1607672923700461. [PMID: 38093132] - Xiao-Bo Wang, Long-Yun Zhou, Xu-Qing Chen, Ran Li, Bin-Bin Yu, Meng-Xiao Pan, Lu Fang, Jian Li, Xue-Jun Cui, Min Yao, Xiao Lu. Neuroprotective effect and possible mechanism of edaravone in rat models of spinal cord injury: a protocol for a systematic review and meta-analysis.
Systematic reviews.
2023 09; 12(1):177. doi:
10.1186/s13643-023-02306-1. [PMID: 37752580] - Dongli Qi, Huihui Li, Chunxia Liang, Peijin Peng, Zhen Yang, Yanquan Gao, Ziwei Li, Qingqing Zhang, Zhidong Liu. Herb-drug interaction of Xingnaojing injection and Edaravone via pharmacokinetics, mixed inhibition of UGTs, and molecular docking.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Apr; 112(?):154696. doi:
10.1016/j.phymed.2023.154696. [PMID: 36764095] - Liang-Da Li, Yue Zhou, Shan-Fen Shi. Edaravone combined with Shuxuening versus edaravone alone in the treatment of acute cerebral infarction: A systematic review and meta-analysis.
Medicine.
2023 Mar; 102(9):e32929. doi:
10.1097/md.0000000000032929. [PMID: 36862906] - Lucas Matheus Gonçalves de Oliveira, Rodrigo Barreto Carreira, Juciele Valeria Ribeiro de Oliveira, Ravena Pereira do Nascimento, Cleide Dos Santos Souza, Emiliano Trias, Victor Diogenes Amaral da Silva, Silvia Lima Costa. Impact of Plant-Derived Compounds on Amyotrophic Lateral Sclerosis.
Neurotoxicity research.
2023 Feb; ?(?):. doi:
10.1007/s12640-022-00632-1. [PMID: 36800114] - Shenglong Guo, Qi Lei, Hena Guo, Qian Yang, Yanli Xue, Ruili Chen. Edaravone Attenuates Aβ 1-42-Induced Inflammatory Damage and Ferroptosis in HT22 Cells.
Neurochemical research.
2023 Feb; 48(2):570-578. doi:
10.1007/s11064-022-03782-y. [PMID: 36333599] - Mandeep K Arora, Deepika Singh, Ritu Tomar, Ashok Jangra. Neuroprotective Efficacy of Edaravone against Arsenic-Induced Behavioral and Neurochemical Deficits in Rats: Amelioration of Cholinergic and Mitochondrial Functions.
CNS & neurological disorders drug targets.
2023; 22(1):125-136. doi:
10.2174/1871527321666220225112241. [PMID: 35232368] - Mengxia Gao, Lingqun Zhu, Jingling Chang, Tianyu Cao, Lianying Song, Chunli Wen, Yi Chen, Yudi Zhuo, Fei Chen. Safety and Efficacy of Edaravone in Patients with Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-analysis.
Clinical drug investigation.
2023 Jan; 43(1):1-11. doi:
10.1007/s40261-022-01229-4. [PMID: 36462105] - M Oosthoek, A Lili, A Almeida, O van Loosbroek, R van der Geest, I de Greef-van der Sandt, P van Bokhoven, S A M Sikkes, C E Teunissen, E G B Vijverberg. ASURE Clinical Trial Protocol: A Randomized, Placebo-Controlled, Proof-of-Concept Study Aiming to Evaluate Safety and Target Engagement following Administration of TW001 in Early Alzheimer's Disease Patients.
The journal of prevention of Alzheimer's disease.
2023; 10(4):669-674. doi:
10.14283/jpad.2023.107. [PMID: 37874087] - Zhuoyi Su, Shuai Zhang, Ziqiao Yu, Hong Jin, Weichen Sun, Ziqi Yang, Dexi Zhao. Efficacy and safety of blood-activating herbs combined with edaravone in the treatment of acute ischemic stroke: A protocol for systematic review and meta-analysis.
Medicine.
2022 Dec; 101(48):e32162. doi:
10.1097/md.0000000000032162. [PMID: 36482528] - Hee Jo Han, Ha Young Shin, Young-Chul Choi, Seung Min Kim, Seung Woo Kim. Serum uric acid level predicts the progression of amyotrophic lateral sclerosis following treatment with edaravone.
Redox report : communications in free radical research.
2022 Dec; 27(1):79-84. doi:
10.1080/13510002.2022.2051964. [PMID: 35296219] - Lei Zhang, Lingfeng Wang, Peihao Hu, Xiaoming Zhong, Danni Zhang, Fengmei Qiu, Zhen Huang. Pinus massoniana needle extracts attenuate oxidative stress injury in cerebral ischemia reperfusion rats by regulating JNK3/caspase-3 signal transduction.
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences.
2022 Nov; 51(5):563-572. doi:
10.3724/zdxbyxb-2022-0326. [PMID: 36581582] - Jian Jia, Jianbing Wu, Duorui Ji, Weijie Jiao, Xiaoli Wang, Zhangjian Huang, Yihua Zhang. Synthesis and biological evaluation of hybrids from optically active ring-opened 3-N-butylphthalide derivatives and 4-fluro-edaravone as potential anti-acute ischemic stroke agents.
Bioorganic & medicinal chemistry.
2022 09; 69(?):116891. doi:
10.1016/j.bmc.2022.116891. [PMID: 35764031] - Sen Zhang, De-Wen Kong, Guo-Dong Ma, Cheng-di Liu, Yu-Jiao Yang, Shan Liu, Nan Jiang, Zi-Rong Pan, Wen Zhang, Ling-Lei Kong, Guan-Hua Du. Long-term administration of salvianolic acid A promotes endogenous neurogenesis in ischemic stroke rats through activating Wnt3a/GSK3β/β-catenin signaling pathway.
Acta pharmacologica Sinica.
2022 Sep; 43(9):2212-2225. doi:
10.1038/s41401-021-00844-9. [PMID: 35217812] - Mohammadreza Moslemi, Seyyedeh Mina Hejazian, Molod Shaddelan, Fatemeh Javanali, Alireza Mirghaffari, Armin Sadeghi, Hamed Valizadeh, Akbar Sharifi, Morteza Haramshahi, Mohammadreza Ardalan, Sepideh Zununi Vahed. Evaluating the effect of Edaravone on clinical outcome of patients with severe COVID-19 admitted to ICU: a randomized clinical trial.
Inflammopharmacology.
2022 Aug; 30(4):1277-1282. doi:
10.1007/s10787-022-01001-2. [PMID: 35723849] - Emiliano Laudadio, Cristina Minnelli, Giovanna Mobbili, Giulia Sabbatini, Pierluigi Stipa, Dario Rusciano, Roberta Galeazzi. Salt effects on mixed composition membranes containing an antioxidant lipophilic edaravone derivative: a computational-experimental study.
Organic & biomolecular chemistry.
2022 07; 20(29):5784-5795. doi:
10.1039/d2ob01143c. [PMID: 35822625] - Sanjiv Singh, Upendr Gautam, F V Manvi. Protective Impact of Edaravone Against ZnO NPs-induced Oxidative Stress in the Human Neuroblastoma SH-SY5Y Cell Line.
Cellular and molecular neurobiology.
2022 May; 42(4):1189-1210. doi:
10.1007/s10571-020-01011-0. [PMID: 33222098] - Hui-Qin Yang, Wen-Jun Yin, Kun Liu, Man-Cang Liu, Xiao-Cong Zuo. Renal safety evaluation of aspirin plus edaravone in patients with ischaemic stroke: a retrospective cohort study.
BMJ open.
2022 04; 12(4):e055469. doi:
10.1136/bmjopen-2021-055469. [PMID: 35440453] - Chao Sun, Cuiling Ma, Yu Sun, Lili Ma. Effect of Edaravone Combined with Anticoagulant Therapy on the Serum hs-CRP, IL-6, and TNF-α Levels and Activity of Daily Living in Patients with Acute Cerebral Infarction.
Journal of healthcare engineering.
2022; 2022(?):8603146. doi:
10.1155/2022/8603146. [PMID: 35265308] - Yanxia Fei, Jiali Shao, Ge Huang, Lijuan Wang, Shuangfa Zou, Huiping Sun, Chumei Zheng, Jinfeng Yang. Effect of Edaravone on MicroRNA Expression in Exosomes after Hepatic Ischemia-reperfusion Injury.
Current molecular pharmacology.
2022; 15(6):870-882. doi:
10.2174/1874467214666211130162152. [PMID: 34847855] - Yuliang Zhang, Yi Liu, Qian Cui, Zitong Fu, Haoyu Yu, Ao Liu, Jingjing Liu, Xiude Qin, Shaoqin Ge, Guowei Zhang. Hydroxysafflor Yellow A Alleviates Ischemic Stroke in Rats via HIF-1[Formula: see text], BNIP3, and Notch1-Mediated Inhibition of Autophagy.
The American journal of Chinese medicine.
2022; 50(3):799-815. doi:
10.1142/s0192415x22500331. [PMID: 35300568] - Xiaoyun Lv, Xiaolan Lu. Significance of Edaravone Combined with Emotion Management Model in Promoting the Recovery Process and Improving Negative Psychology in Patients with Type 2 Diabetes Mellitus Combined with Stroke.
BioMed research international.
2022; 2022(?):8099997. doi:
10.1155/2022/8099997. [PMID: 36262976] - Keliang Li, Qiting Zhang, Xuesheng Lu, Shengqi Yao. Effects of Butylphthalide Sodium Chloride Injection Combined with Edaravone Dexborneol on Neurological Function and Serum Inflammatory Factor Levels in Sufferers Having Acute Ischemic Stroke.
Journal of healthcare engineering.
2022; 2022(?):1509407. doi:
10.1155/2022/1509407. [PMID: 35463675] - Hidetoshi Shimizu, Yukiko Nishimura, Yoichi Shiide, Hideaki Matsuda, Makoto Akimoto, Munetomo Matsuda, Yoshinobu Nakamaru, Yuichiro Kato, Kazuoki Kondo. Evaluation of Pharmacokinetics, Safety, and Drug-Drug Interactions of an Oral Suspension of Edaravone in Healthy Adults.
Clinical pharmacology in drug development.
2021 10; 10(10):1174-1187. doi:
10.1002/cpdd.925. [PMID: 33704925] - Hidetoshi Shimizu, Yukiko Nishimura, Youichi Shiide, Kaori Yoshida, Manabu Hirai, Munetomo Matsuda, Yoshinobu Nakamaru, Yuichiro Kato, Kazuoki Kondo. Bioequivalence Study of Oral Suspension and Intravenous Formulation of Edaravone in Healthy Adult Subjects.
Clinical pharmacology in drug development.
2021 10; 10(10):1188-1197. doi:
10.1002/cpdd.952. [PMID: 33955162] - Dong Wang, Xiaoyan Peng, Aiguo Yang, Ying He, Li Dong, Huajie Lu. Edaravone promotes nerve function recovery after acute cerebral infarction in rats via targeting Keap1-Nrf2/ARE.
Panminerva medica.
2021 Sep; 63(3):384-385. doi:
10.23736/s0031-0808.19.03694-2. [PMID: 31355603] - Sheng-Rui Fan, Teng-Teng Ren, Miao-Ying Yun, Rongfeng Lan, Xiao-Yan Qin. Edaravone attenuates cadmium-induced toxicity by inhibiting oxidative stress and inflammation in ICR mice.
Neurotoxicology.
2021 09; 86(?):1-9. doi:
10.1016/j.neuro.2021.06.003. [PMID: 34174317] - Bertan B Bayrak, Sebahat Yilmaz, Neziha Hacihasanoglu Cakmak, Refiye Yanardag. The effects of edaravone, a free-radical scavenger in lung injury induced by valproic acid demonstrated via different biochemical parameters.
Journal of biochemical and molecular toxicology.
2021 Sep; 35(9):e22847. doi:
10.1002/jbt.22847. [PMID: 34309930] - Natsumi Koike, Ayaka Sasaki, Tomoaki Murakami, Kazuhiko Suzuki. Effect of edaravone against cisplatin-induced chronic renal injury.
Drug and chemical toxicology.
2021 Jul; 44(4):437-446. doi:
10.1080/01480545.2019.1604740. [PMID: 31064223] - Hai-Hui Xie, Hong-Yan Ma, Shu Zhang, Jian-Wen Li, Qi Han, Hui-Qun Chen, Bo-Qin Su, Jian-Ping Zhou. Impact of edaravone on serum CXC chemokine ligand-13 levels and perioperative neurocognitive disorders in elderly patients with hip replacement.
Chinese medical journal.
2021 Jun; 134(13):1610-1615. doi:
10.1097/cm9.0000000000001492. [PMID: 34133348] - Asako Kakimoto, Masatoshi Ishizaki, Hidetsugu Ueyama, Yasushi Maeda, Mitsuharu Ueda. Renal function in amyotrophic lateral sclerosis patients on long-term treatment with edaravone.
Medicine.
2021 May; 100(21):e26127. doi:
10.1097/md.0000000000026127. [PMID: 34032759] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Hailei Shan, Guangmei Jiao, Xi Cheng, Zhijie Dou. Safety and efficacy of edaravone for patients with acute stroke: A protocol for randomized clinical trial.
Medicine.
2021 Feb; 100(8):e24811. doi:
10.1097/md.0000000000024811. [PMID: 33663100] - Marwa Atallah, Toru Yamashita, Koji Abe. Effect of edaravone on pregnant mice and their developing fetuses subjected to placental ischemia.
Reproductive biology and endocrinology : RB&E.
2021 Feb; 19(1):19. doi:
10.1186/s12958-021-00707-2. [PMID: 33549111] - Lianfeng Dang, Xin Dong, Jie Yang. Influence of Nanoparticle-Loaded Edaravone on Postoperative Effects in Patients with Cerebral Hemorrhage.
Journal of nanoscience and nanotechnology.
2021 02; 21(2):1202-1211. doi:
10.1166/jnn.2021.18668. [PMID: 33183463] - Lin Guo, Junlu Pan, Fang Li, Liang Zhao, Yijie Shi. A novel brain targeted plasma exosomes enhance the neuroprotective efficacy of edaravone in ischemic stroke.
IET nanobiotechnology.
2021 Feb; 15(1):107-116. doi:
10.1049/nbt2.12003. [PMID: 34694723] - Kenta Arai, Yuumi Sato, Ikumi Nakajima, Manami Saito, Moeka Sasaki, Akiko Kanamori, Michio Iwaoka. Glutathione peroxidase-like functions of 1,2-diselenane-4,5-diol and its amphiphilic derivatives: Switchable catalytic cycles depending on peroxide substrates.
Bioorganic & medicinal chemistry.
2021 01; 29(?):115866. doi:
10.1016/j.bmc.2020.115866. [PMID: 33203607] - Jie Yin, Hong Chang, Dongmei Wang, Haifei Li, Aibing Yin. Fuzzy C-Means Clustering Algorithm-Based Magnetic Resonance Imaging Image Segmentation for Analyzing the Effect of Edaravone on the Vascular Endothelial Function in Patients with Acute Cerebral Infarction.
Contrast media & molecular imaging.
2021; 2021(?):4080305. doi:
10.1155/2021/4080305. [PMID: 34354551] - Takeshi Terada, Jayesh A Kulkarni, Ariel Huynh, Yuen Yi C Tam, Pieter Cullis. Protective Effect of Edaravone against Cationic Lipid-Mediated Oxidative Stress and Apoptosis.
Biological & pharmaceutical bulletin.
2021; 44(1):144-149. doi:
10.1248/bpb.b20-00679. [PMID: 33390543] - Sandra E Reznik, Amit K Tiwari, Charles R Ashby. Edaravone: A potential treatment for the COVID-19-induced inflammatory syndrome?.
Pharmacological research.
2020 10; 160(?):105055. doi:
10.1016/j.phrs.2020.105055. [PMID: 32619723] - Yasuyuki Ohta, Toru Yamashita, Emi Nomura, Nozomi Hishikawa, Ken Ikegami, Yosuke Osakada, Namiko Matsumoto, Yuko Kawahara, Taijun Yunoki, Yoshiaki Takahashi, Motonori Takamiya, Koh Tadokoro, Ryo Sasaki, Yumiko Nakano, Keiichiro Tsunoda, Kota Sato, Yoshio Omote, Mami Takemoto, Koji Abe. Improvement of a decreased anti-oxidative activity by edaravone in amyotrophic lateral sclerosis patients.
Journal of the neurological sciences.
2020 Aug; 415(?):116906. doi:
10.1016/j.jns.2020.116906. [PMID: 32446009] - Fadime Demir, Mustafa Demir, Hatice Aygun. Evaluation of the protective effect of edaravone on doxorubicin nephrotoxicity by [99mTc]DMSA renal scintigraphy and biochemical methods.
Naunyn-Schmiedeberg's archives of pharmacology.
2020 08; 393(8):1383-1390. doi:
10.1007/s00210-020-01832-2. [PMID: 32036411] - Nan-Nan Zhang, Long Sun, Wen-Ting Chen, Yang-Liang Yang, Yi-Ming Wu. Effects of edaravone on postoperative cognitive function in elderly patients undergoing hip joint replacement surgery: A randomized controlled trial.
International journal of surgery (London, England).
2020 Aug; 80(?):13-18. doi:
10.1016/j.ijsu.2020.05.092. [PMID: 32535263] - Xiaoying Zhao, Erfei Zhang, Xiaofen Ren, Xiaoli Bai, Dongming Wang, Ling Bai, Danlei Luo, Zheng Guo, Qiang Wang, Jianxin Yang. Edaravone alleviates cell apoptosis and mitochondrial injury in ischemia-reperfusion-induced kidney injury via the JAK/STAT pathway.
Biological research.
2020 Jul; 53(1):28. doi:
10.1186/s40659-020-00297-0. [PMID: 32620154] - Md Quamrul Hassan, Md Sayeed Akhtar, Obaid Afzal, Ibraheem Hussain, Mohd Akhtar, Syed Ehtaishamul Haque, Abul Kalam Najmi. Edaravone and benidipine protect myocardial damage by regulating mitochondrial stress, apoptosis signalling and cardiac biomarkers against doxorubicin-induced cardiotoxicity.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2020 Jul; 42(5):381-392. doi:
10.1080/10641963.2019.1676770. [PMID: 31630586] - Le Li, Shunbo Zhao, Lingyan Xu, Yuwen Su, Li Ding. Two high-performance liquid chromatography-tandem mass spectrometry methods for determination of edaravone and taurine in human plasma: Application to drug-drug interaction and pharmacokinetic studies.
Journal of separation science.
2020 Jun; 43(12):2279-2289. doi:
10.1002/jssc.201901322. [PMID: 32175680] - Cunfu Liang, Qiang He, Fengxiao Ge, Xin Yin. Effects of edaravone on pancreatic and renal injury in rats with severe acute pancreatitis.
Panminerva medica.
2020 06; 62(2):119-121. doi:
10.23736/s0031-0808.19.03630-9. [PMID: 31089082] - Zhaohong Kong, Jian Jiang, Ming Deng, Zhaohui Zhang, Gaohua Wang. Edaravone reduces depression severity in patients with symptomatic intracranial stenosis and is associated with the serum expression of sex hormones.
Medicine.
2020 Feb; 99(8):e19316. doi:
10.1097/md.0000000000019316. [PMID: 32080148] - Xiushan Li, Dongzhou Ma, Guozhu Sun. Effects of Edaravone on Neurological Function and Tumor Necrosis Factor Alpha and Interleukin 8 Levels in Patients with Cerebral Infarction.
European neurology.
2020; 83(1):73-79. doi:
10.1159/000505776. [PMID: 32114586] - Zhao-Yin Fu, Zhi-Jiang Wu, Jun-Hui Zheng, Nuo Li, Jun-Yu Lu, Meng-Hua Chen. Edaravone Ameliorates Renal Warm Ischemia-Reperfusion Injury by Downregulating Endoplasmic Reticulum Stress in a Rat Resuscitation Model.
Drug design, development and therapy.
2020; 14(?):175-183. doi:
10.2147/dddt.s211906. [PMID: 32021102] - Snežana Spasić, Aleksandra Nikolić-Kokić, Srđan Miletić, Zorana Oreščanin-Dušić, Mihajlo B Spasić, Duško Blagojević, Zorica Stević. Edaravone May Prevent Ferroptosis in ALS.
Current drug targets.
2020; 21(8):776-780. doi:
10.2174/1389450121666200220123305. [PMID: 32077821] - Emad H M Hassanein, Omnia A M Abd El-Ghafar, Marwa A Ahmed, Ahmed M Sayed, Wail M Gad-Elrab, Jamaan S Ajarem, Ahmed A Allam, Ayman M Mahmoud. Edaravone and Acetovanillone Upregulate Nrf2 and PI3K/Akt/mTOR Signaling and Prevent Cyclophosphamide Cardiotoxicity in Rats.
Drug design, development and therapy.
2020; 14(?):5275-5288. doi:
10.2147/dddt.s281854. [PMID: 33299300] - Wen-Xi Zhang, Hui Wang, He-Rong Cui, Wen-Bo Guo, Fei Zhou, De-Sheng Cai, Bing Xu, Xiao-Hui Jia, Xue-Mei Huang, Yu-Qin Yang, Hong-Shan Chen, Jin-Chai Qi, Peng-Long Wang, Hai-Min Lei. Design, synthesis and biological evaluation of cinnamic acid derivatives with synergetic neuroprotection and angiogenesis effect.
European journal of medicinal chemistry.
2019 Dec; 183(?):111695. doi:
10.1016/j.ejmech.2019.111695. [PMID: 31541868] - Min Shi, Yuan Zhou, Yadi Li, Yuting Zhu, Bing Yang, Li Zhong, Rui Pan, Dongdong Yang. Young male with syphilitic cerebral arteritis presents with signs of acute progressive stroke: A case report.
Medicine.
2019 Nov; 98(48):e18147. doi:
10.1097/md.0000000000018147. [PMID: 31770254] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Takujiro Homma, Sho Kobayashi, Hideyo Sato, Junichi Fujii. Edaravone, a free radical scavenger, protects against ferroptotic cell death in vitro.
Experimental cell research.
2019 11; 384(1):111592. doi:
10.1016/j.yexcr.2019.111592. [PMID: 31479686] - Lindsey Y K Suh, Dinesh Babu, Lusine Tonoyan, Béla Reiz, Randy Whittal, S Amirhossein Tabatabaei-Dakhili, Andrew G Morgan, Carlos A Velázquez-Martínez, Arno G Siraki. Myeloperoxidase-mediated oxidation of edaravone produces an apparent non-toxic free radical metabolite and modulates hydrogen peroxide-mediated cytotoxicity in HL-60 cells.
Free radical biology & medicine.
2019 11; 143(?):422-432. doi:
10.1016/j.freeradbiomed.2019.08.021. [PMID: 31445206] - Nursah Basol, Hatice Aygun, Serdar Savas Gul. Beneficial effects of edaravone in experimental model of amitriptyline-induced cardiotoxicity in rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2019 11; 392(11):1447-1453. doi:
10.1007/s00210-019-01683-6. [PMID: 31273393] - Maria Bandookwala, Amit Kumar Sahu, Disha Thakkar, Monika Sharma, Amit Khairnar, Pinaki Sengupta. Edaravone-caffeine combination for the effective management of rotenone induced Parkinson's disease in rats: An evidence based affirmative from a comparative analysis of behavior and biomarker expression.
Neuroscience letters.
2019 10; 711(?):134438. doi:
10.1016/j.neulet.2019.134438. [PMID: 31422100] - Hirokazu Yokoyama, Masaya Tsujii, Takahiro Iino, Tomoki Nakamura, Akihiro Sudo. Inhibitory effect of edaravone on systemic inflammation and local damage in skeletal muscles following long-term ischemia to murine hind limb.
Journal of orthopaedic surgery (Hong Kong).
2019 Sep; 27(3):2309499019874470. doi:
10.1177/2309499019874470. [PMID: 31549573] - Zi-Yue Zhang, Nan Ma, Li-Jun Tao, Xue-Ying Gong, Wen-Cai Ye, Lei Wang. Linear Peptides Containing d-Leucine with Neuroprotective Activities from the Leech Whitmania pigra Whitman.
Journal of natural products.
2019 08; 82(8):2349-2353. doi:
10.1021/acs.jnatprod.9b00322. [PMID: 31361480] - Ren Yi, Yang Zhizhou, Sun Zhaorui, Zhang Wei, Chen Xin, Nie Shinan. Retrospective study of clinical features and prognosis of edaravone in the treatment of paraquat poisoning.
Medicine.
2019 May; 98(19):e15441. doi:
10.1097/md.0000000000015441. [PMID: 31083174] - Liang-Min Liu, Ning Wang, Yan Lu, Wei-Ping Wang. Edaravone acts as a potential therapeutic drug against pentylenetetrazole-induced epilepsy in male albino rats by downregulating cyclooxygenase-II.
Brain and behavior.
2019 01; 9(1):e01156. doi:
10.1002/brb3.1156. [PMID: 30506635] - Thangarajan Sumathi, Aishwariya Vedagiri, Surekha Ramachandran, Bhagyalakshmi Purushothaman. Quinolinic Acid-Induced Huntington Disease-Like Symptoms Mitigated by Potent Free Radical Scavenger Edaravone-a Pilot Study on Neurobehavioral, Biochemical, and Histological Approach in Male Wistar Rats.
Journal of molecular neuroscience : MN.
2018 Nov; 66(3):322-341. doi:
10.1007/s12031-018-1168-1. [PMID: 30284227] - Sungwoo Hyung, Yoo-Seong Jeong, Jungmin Yeo, Yoo-Kyung Song, Min-Soo Kim, Young-Jae Im, Han-Joo Maeng, Suk-Jae Chung. Identification of the primary determining factor(s) governing the oral absorption of edaravone in rats.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2018 Oct; 123(?):312-320. doi:
10.1016/j.ejps.2018.07.052. [PMID: 30056192] - Jiaqing Wang, Xia Chen, Baoshi Yuan, Weicong Wang, Chunmin Xu, Weiwei Zhao, Pengpeng Zhao, Yilong Wang, Xingquan Zhao, Yongjun Wang. Bioavailability of Edaravone Sublingual Tablet Versus Intravenous Infusion in Healthy Male Volunteers.
Clinical therapeutics.
2018 10; 40(10):1683-1691. doi:
10.1016/j.clinthera.2018.08.009. [PMID: 30241688] - Shu Wang, Shintaro Fumoto, Hirotaka Miyamoto, Masakazu Tanaka, Koyo Nishida. Edaravone, a cytoprotective drug, enhances transgene expression mediated by lipoplexes in HepG2 cells and mice.
International journal of pharmaceutics.
2018 Sep; 548(1):173-181. doi:
10.1016/j.ijpharm.2018.06.068. [PMID: 29969708] - Hideaki Ishii, Andrey B Petrenko, Mika Sasaki, Yukio Satoh, Yoshinori Kamiya, Toshiyuki Tobita, Kenta Furutani, Mari Matsuhashi, Tatsuro Kohno, Hiroshi Baba. Free radical scavenger edaravone produces robust neuroprotection in a rat model of spinal cord injury.
Brain research.
2018 03; 1682(?):24-35. doi:
10.1016/j.brainres.2017.12.035. [PMID: 29294349] - Chizu Oba, Mitsuru Kashiwagi, Takuya Tanabe, Shohei Nomura, Motoko Ogino, Takuya Matsuda, Shinya Murata, Michiko Nakamura, Akihiko Shirasu, Keisuke Inoue, Keisuke Okasora, Hiroshi Tamai. Prognostic factors in the early phase of acute encephalopathy.
Pediatrics international : official journal of the Japan Pediatric Society.
2018 Mar; 60(3):270-275. doi:
10.1111/ped.13492. [PMID: 29280262] - P Tsounapi, M Honda, F Dimitriadis, S Shimizu, T Shiomi, K Hikita, M Saito, S Tomita, N Sofikitis, A Takenaka. Antioxidant treatment ameliorates diabetes-induced dysfunction of the vas deferens in a rat model.
Andrologia.
2018 Feb; 50(1):. doi:
10.1111/and.12795. [PMID: 28224697] - Chao He, Wei Zhang, Suobei Li, Wei Ruan, Junmei Xu, Feng Xiao. Edaravone Improves Septic Cardiac Function by Inducing an HIF-1α/HO-1 Pathway.
Oxidative medicine and cellular longevity.
2018; 2018(?):5216383. doi:
10.1155/2018/5216383. [PMID: 29765498] - Y Chen, Y Zhao. Curative efficacy of penehyclidine combined with edaravone on acute cerebral infarction and their effects on serum TNF-α and NDS score in rats.
European review for medical and pharmacological sciences.
2018 01; 22(1):223-228. doi:
10.26355/eurrev_201801_14121. [PMID: 29364497] - Katsunori Tsuda, Licht Miyamoto, Shuichi Hamano, Yuri Morimoto, Yumi Kangawa, Chika Fukue, Yoko Kagawa, Yuya Horinouchi, Wenting Xu, Yasumasa Ikeda, Toshiaki Tamaki, Koichiro Tsuchiya. Mechanisms of the pH- and Oxygen-Dependent Oxidation Activities of Artesunate.
Biological & pharmaceutical bulletin.
2018; 41(4):555-563. doi:
10.1248/bpb.b17-00855. [PMID: 29607928] - Yingda Zang, Xiuyun Song, Chuangjun Li, Jie Ma, Shifeng Chu, Dandan Liu, Qian Ren, Yan Li, Naihong Chen, Dongming Zhang. Pyrano[3,2-a]carbazole alkaloids as effective agents against ischemic stroke in vitro and in vivo.
European journal of medicinal chemistry.
2018 Jan; 143(?):438-448. doi:
10.1016/j.ejmech.2017.11.084. [PMID: 29202406] - Xiong Zhang, Fang Xu, Li Liu, Lili Feng, Xuefeng Wu, Yan Shen, Yang Sun, Xudong Wu, Qiang Xu. (+)-Borneol improves the efficacy of edaravone against DSS-induced colitis by promoting M2 macrophages polarization via JAK2-STAT3 signaling pathway.
International immunopharmacology.
2017 Dec; 53(?):1-10. doi:
10.1016/j.intimp.2017.10.002. [PMID: 29028547] - Panagiota Tsounapi, Masashi Honda, Fotios Dimitriadis, Bunya Kawamoto, Katsuya Hikita, Kuniyasu Muraoka, Motoaki Saito, Nikolaos Sofikitis, Atsushi Takenaka. Impact of antioxidants on seminal vesicles function and fertilizing potential in diabetic rats.
Asian journal of andrology.
2017 Nov; 19(6):639-646. doi:
10.4103/1008-682x.186871. [PMID: 27748317] - Ankit Parikh, Krishna Kathawala, Chun Chuan Tan, Sanjay Garg, Xin-Fu Zhou. Lipid-based nanosystem of edaravone: development, optimization, characterization and in vitro/in vivo evaluation.
Drug delivery.
2017 Nov; 24(1):962-978. doi:
10.1080/10717544.2017.1337825. [PMID: 28633547] - Alexander Kalin, Elvia Medina-Paraiso, Kaoru Ishizaki, Alex Kim, Yannong Zhang, Takanori Saita, Masahiko Wasaki. A safety analysis of edaravone (MCI-186) during the first six cycles (24 weeks) of amyotrophic lateral sclerosis (ALS) therapy from the double-blind period in three randomized, placebo-controlled studies.
Amyotrophic lateral sclerosis & frontotemporal degeneration.
2017 Oct; 18(sup1):71-79. doi:
10.1080/21678421.2017.1362440. [PMID: 28872919] - Zhengping Zhang, Zhaowen Luo, Aijing Bi, Weidong Yang, Wenji An, Xiaoliang Dong, Rong Chen, Shibao Yang, Huifang Tang, Xiaodong Han, Lan Luo. Compound edaravone alleviates lipopolysaccharide (LPS)-induced acute lung injury in mice.
European journal of pharmacology.
2017 Sep; 811(?):1-11. doi:
10.1016/j.ejphar.2017.05.047. [PMID: 28552343] - Feng Shao, Xiao-Ling Hu, Xin Liu, Mang-Ting Shan. A Novel LC-MS-MS Method With an Effective Antioxidant for the Determination of Edaravone, a Free-Radical Scavenger in Dog Plasma and its Application to a Pharmacokinetic Study.
Journal of chromatographic science.
2017 Jul; 55(6):595-602. doi:
10.1093/chromsci/bmx012. [PMID: 28335025] - S Zhang, Z X Chen, Y Y Jiang, Q Q Cai, Z H Yang, C R Wang, X Y Wu, P Ying, Z Q Lu. [Intervention of edaravone against renal injury induced by acute paraquat poisoning in rats].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.
2017 Jun; 35(6):408-413. doi:
10.3760/cma.j.issn.1001-9391.2017.06.003. [PMID: 28780814] - Xiaoming Qiang, Yan Li, Xia Yang, Li Luo, Rui Xu, Yunxiaozhu Zheng, Zhongcheng Cao, Zhenghuai Tan, Yong Deng. DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.
Bioorganic & medicinal chemistry letters.
2017 02; 27(4):718-722. doi:
10.1016/j.bmcl.2017.01.050. [PMID: 28131710] - Dong-Yi Zhang, Shen-Song Kang, Zheng-Wen Zhang, Rui Wu. Edaravone enhances the viability of ischemia/reperfusion flaps.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.
2017 Feb; 37(1):51-56. doi:
10.1007/s11596-017-1693-0. [PMID: 28224430] - Kiyoshi Kikuchi, Kentaro Setoyama, Ko-Ichi Kawahara, Tomoka Nagasato, Takuto Terashi, Koki Ueda, Kazuki Nakanishi, Shotaro Otsuka, Naoki Miura, Hisayo Sameshima, Kazuya Hosokawa, Yoichiro Harada, Binita Shrestha, Mika Yamamoto, Yoko Morimoto-Yamashita, Haruna Kikuchi, Ryoji Kiyama, Chinatsu Kamikokuryo, Salunya Tancharoen, Harutoshi Sakakima, Motohiro Morioka, Eiichiro Tanaka, Takashi Ito, Ikuro Maruyama. Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombolysis.
Oxidative medicine and cellular longevity.
2017; 2017(?):6873281. doi:
10.1155/2017/6873281. [PMID: 29259732] - Mayuko Morita, Yuji Naito, Toshikazu Yoshikawa, Etsuo Niki. Inhibition of plasma lipid oxidation induced by peroxyl radicals, peroxynitrite, hypochlorite, 15-lipoxygenase, and singlet oxygen by clinical drugs.
Bioorganic & medicinal chemistry letters.
2016 11; 26(22):5411-5417. doi:
10.1016/j.bmcl.2016.10.033. [PMID: 27777006] - Norio Fujiwara, Angel T Som, Loc-Duyen D Pham, Brian J Lee, Emiri T Mandeville, Eng H Lo, Ken Arai. A free radical scavenger edaravone suppresses systemic inflammatory responses in a rat transient focal ischemia model.
Neuroscience letters.
2016 10; 633(?):7-13. doi:
10.1016/j.neulet.2016.08.048. [PMID: 27589890] - Tianjiao Zhang, Chuanbao Zhang, Haijian Zhao, Jie Zeng, Jiangtao Zhang, Weiyan Zhou, Ying Yan, Yufei Wang, Mo Wang, Wenxiang Chen. Determination of serum glucose by isotope dilution liquid chromatography-tandem mass spectrometry: a candidate reference measurement procedure.
Analytical and bioanalytical chemistry.
2016 Oct; 408(26):7403-11. doi:
10.1007/s00216-016-9817-0. [PMID: 27481169] - Guang-Wei Zhang, Tian-Xiang Gu, Xue-Jun Sun, Chunyue Wang, Xun Qi, Xiao-Bing Wang, Jesse Li-Ling. Edaravone promotes activation of resident cardiac stem cells by transplanted mesenchymal stem cells in a rat myocardial infarction model.
The Journal of thoracic and cardiovascular surgery.
2016 08; 152(2):570-82. doi:
10.1016/j.jtcvs.2016.02.071. [PMID: 27056755] - Melda Apaydin, Oytun Erbas, Dilek Taskiran. Protection by Edaravone, a Radical Scavenger, against Manganese-Induced Neurotoxicity in Rats.
Journal of biochemical and molecular toxicology.
2016 May; 30(5):217-23. doi:
10.1002/jbt.21780. [PMID: 26778341] - Midori Nagase, Yorihiro Yamamoto, Yusuke Miyazaki, Hiide Yoshino. Increased oxidative stress in patients with amyotrophic lateral sclerosis and the effect of edaravone administration.
Redox report : communications in free radical research.
2016 May; 21(3):104-12. doi:
10.1179/1351000215y.0000000026. [PMID: 26191780] - Akio Fujisawa, Yorihiro Yamamoto. Edaravone, a potent free radical scavenger, reacts with peroxynitrite to produce predominantly 4-NO-edaravone.
Redox report : communications in free radical research.
2016 May; 21(3):98-103. doi:
10.1179/1351000215y.0000000025. [PMID: 26196041]
