Alprazolam (BioDeep_00000001423)

 

Secondary id: BioDeep_00000397506

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


12-chloro-3-methyl-9-phenyl-2,4,5,8-tetraazatricyclo[8.4.0.0²,⁶]tetradeca-1(10),3,5,8,11,13-hexaene

化学式: C17H13ClN4 (308.0829)
中文名称: 阿普唑仑
谱图信息: 最多检出来源 Homo sapiens(blood) 20.85%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Alprazolam. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/alprazolam (retrieved 2024-12-31) (BioDeep RN: BioDeep_00000001423). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC1=NN=C2CN=C(C3=CC=CC=C3)C3=C(C=CC(Cl)=C3)N12
InChI: InChI=1S/C17H13ClN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3

描述信息

Alprazolam is only found in individuals that have used or taken this drug. It is a triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of panic disorders, with or without agoraphobia, and in generalized anxiety disorders. (From AMA Drug Evaluations Annual, 1994, p238)Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics > N05BA - Benzodiazepine derivatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent

同义名列表

44 个代谢物同义名

12-chloro-3-methyl-9-phenyl-2,4,5,8-tetraazatricyclo[8.4.0.0²,⁶]tetradeca-1(10),3,5,8,11,13-hexaene; 8-Chloro-1-methyl-6-phenyl-4H-S-triazolo(4,3-a)(1,4)benzodiazepine; Arzneimittelwerk dresden brand OF alprazolam; Alphapharm brand OF alprazolam; Novopharm brand OF alprazolam; Nu-pharm brand OF alprazolam; Nu pharm brand OF alprazolam; Alprazolam alphapharm brand; Temmler brand OF alprazolam; Apotex brand OF alprazolam; Pfizer brand OF alprazolam; Alprazolam novopharm brand; Kenral brand OF alprazolam; Alprazolam nu-pharm brand; Orion brand OF alprazolam; Alprazolam temmler brand; Alprazolam apotex brand; Alprazolam kenral brand; Alprazolam pfizer brand; Alprazolam orion brand; Novo alprazol; Novo-alprazol; NovoAlprazol; Trankimazin; Apo-alpraz; alprazolam; Alprazolan; Apo alpraz; Nu alpraz; Nu-alpraz; ApoAlpraz; Cassadan; NuAlpraz; Ralozam; Esparon; Alprox; D-65MT; neurol; Tafil; D65MT; TUS-1; Xanax; Kalma; Alprazolam



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 CAT, CYP2C19, CYP2C9, CYP2D6, CYP3A4, POMC, PRL
Peripheral membrane protein 1 CYP1B1
Endoplasmic reticulum membrane 7 CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5
Mitochondrion membrane 1 TSPO
Nucleus 1 PRL
cytosol 5 AVP, CAT, GPT, SCLY, TSPO
dendrite 2 AVP, HTR1A
mitochondrial membrane 1 TSPO
nucleoplasm 1 PRL
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 2 HTR1A, OPRD1
Multi-pass membrane protein 4 CACNA1I, HTR1A, OPRD1, TSPO
Synapse 2 CRH, HTR1A
Golgi apparatus 1 SCLY
Golgi membrane 1 INS
presynaptic membrane 1 OPRD1
Cytoplasm, cytosol 1 SCLY
plasma membrane 5 CACNA1I, CYP2C19, CYP2C9, HTR1A, OPRD1
synaptic vesicle membrane 1 OPRD1
Membrane 8 CACNA1I, CAT, CYP1B1, CYP2D6, CYP3A4, CYP3A5, OPRD1, TSPO
extracellular exosome 3 CAT, GPT, TSPO
endoplasmic reticulum 2 CYP2D6, TSPO
extracellular space 6 AVP, CRH, IL2, INS, POMC, PRL
mitochondrion 4 CAT, CYP1B1, CYP2D6, TSPO
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 9 CAT, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5, TSPO
Microsome membrane 6 CYP1A2, CYP1B1, CYP2C9, CYP2D6, CYP3A4, CYP3A5
Secreted 6 AVP, CRH, IL2, INS, POMC, PRL
extracellular region 7 AVP, CAT, CRH, IL2, INS, POMC, PRL
Single-pass membrane protein 1 CYP2D6
mitochondrial outer membrane 1 TSPO
mitochondrial matrix 1 CAT
varicosity 1 CRH
neuronal dense core vesicle lumen 1 CRH
perikaryon 1 CRH
focal adhesion 1 CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
secretory granule 2 AVP, POMC
neuron projection 1 OPRD1
chromatin 1 PRL
endosome lumen 2 INS, PRL
Cell projection, dendrite 1 HTR1A
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 3 CAT, INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
axon terminus 1 OPRD1
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 OPRD1
neuronal dense core vesicle 2 AVP, OPRD1
clathrin-coated endocytic vesicle membrane 1 AVP
dendrite membrane 1 OPRD1
catalase complex 1 CAT
catalytic complex 1 SCLY
spine apparatus 1 OPRD1


文献列表

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