Cilazprilat (BioDeep_00000011644)

 

Secondary id: BioDeep_00001869487


代谢物信息卡片


(4S,7S)-7-[[(1S)-1-carboxy-3-phenylpropyl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid

化学式: C20H27N3O5 (389.19506120000005)
中文名称: 西拉扎普利拉
谱图信息: 最多检出来源 Viridiplantae(plant) 66.67%

分子结构信息

SMILES: C1CC(C(=O)N2C(CCCN2C1)C(=O)O)NC(CCC3=CC=CC=C3)C(=O)O
InChI: InChI=1S/C20H27N3O5/c24-18-15(8-4-12-22-13-5-9-17(20(27)28)23(18)22)21-16(19(25)26)11-10-14-6-2-1-3-7-14/h1-3,6-7,15-17,21H,4-5,8-13H2,(H,25,26)(H,27,28)/t15-,16-,17-/m0/s1

描述信息

D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents

同义名列表

4 个代谢物同义名

(4S,7S)-7-[[(1S)-1-carboxy-3-phenylpropyl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid; SCHEMBL14287316; Cilazaprilat; Cilazprilat



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Filomila Kolocouri, Yannis Dotsikas, Constantinos Apostolou, Constantinos Kousoulos, Georgios-Stefanos Soumelas, Yannis L Loukas. Advantages of automation in plasma sample preparation prior to HPLC/MS/MS quantification: application to the determination of cilazapril and cilazaprilat in a bioequivalence study. Journal of AOAC International. 2011 May; 94(3):758-64. doi: . [PMID: 21797003]
  • Leszek Tylicki, Przemysław Rutkowski, Marcin Renke, Wojciech Larczyński, Ewa Aleksandrowicz, Wiesława Lysiak-Szydlowska, Bolesław Rutkowski. Triple pharmacological blockade of the renin-angiotensin-aldosterone system in nondiabetic CKD: an open-label crossover randomized controlled trial. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2008 Sep; 52(3):486-93. doi: 10.1053/j.ajkd.2008.02.297. [PMID: 18423812]
  • Hiroto Matsuda, Koichi Hayashi, Shu Wakino, Eiji Kubota, Masanori Honda, Hirobumi Tokuyama, Ichiro Takamatsu, Satoru Tatematsu, Takao Saruta. Role of endothelium-derived hyperpolarizing factor in ACE inhibitor-induced renal vasodilation in vivo. Hypertension (Dallas, Tex. : 1979). 2004 Mar; 43(3):603-9. doi: 10.1161/01.hyp.0000118053.42262.71. [PMID: 14769805]
  • Hirobumi Tokuyama, Koichi Hayashi, Hiroto Matsuda, Eiji Kubota, Masanori Honda, Ken Okubo, Ichiro Takamatsu, Satoru Tatematsu, Yuri Ozawa, Shu Wakino, Takao Saruta. Differential regulation of elevated renal angiotensin II in chronic renal ischemia. Hypertension (Dallas, Tex. : 1979). 2002 Jul; 40(1):34-40. doi: 10.1161/01.hyp.0000022060.13995.ed. [PMID: 12105135]
  • Kohji Takara, Mikio Kakumoto, Yusuke Tanigawara, Junko Funakoshi, Toshiyuki Sakaeda, Katsuhiko Okumura. Interaction of digoxin with antihypertensive drugs via MDR1. Life sciences. 2002 Feb; 70(13):1491-500. doi: 10.1016/s0024-3205(01)01494-1. [PMID: 11895100]
  • J A Prieto, R M Jiménez, R M Alonso, E Ortiz. Determination of the antihypertensive drug cilazapril and its active metabolite cilazaprilat in pharmaceuticals and urine by solid-phase extraction and high-performance liquid chromatography with photometric detection. Journal of chromatography. B, Biomedical sciences and applications. 2001 Apr; 754(1):23-34. doi: 10.1016/s0378-4347(00)00580-6. [PMID: 11318420]
  • J A Prieto, R M Jiménez, R M Alonso. Quantitative determination of the angiotensin-converting enzyme inhibitor cilazapril and its active metabolite cilazaprilat in pharmaceuticals and urine by high-performance liquid chromatography with amperometric detection. Journal of chromatography. B, Biomedical sciences and applications. 1998 Sep; 714(2):285-92. doi: 10.1016/s0378-4347(98)00226-6. [PMID: 9766868]
  • A W Hahn, R Schmidt, F Kern, T J Resink, F R Bühler. Endothelium-modulated proliferation of medial smooth muscle cells: influence of angiotensin II and converting enzyme inhibition. European heart journal. 1995 May; 16 Suppl C(?):29-32. doi: 10.1093/eurheartj/16.suppl_c.29. [PMID: 7556269]
  • G S Lloyd, A J Turner. Aminopeptidase P: cation activation and inhibitor sensitivity are substrate-dependent. Biochemical Society transactions. 1995 Feb; 23(1):60S. doi: 10.1042/bst023060s. [PMID: 7538950]
  • V Gross, E Treher, K Haag, W Neis, U Wiegand, J Schölmerich. Angiotensin-converting enzyme (ACE)-inhibition in cirrhosis. Pharmacokinetics and dynamics of the ACE-inhibitor cilazapril (Ro 31-2848). Journal of hepatology. 1993 Jan; 17(1):40-7. doi: 10.1016/s0168-8278(05)80519-7. [PMID: 8445218]
  • P E Williams, A N Brown, S Rajaguru, R J Francis, A J Bell, P M Dewland. Pharmacokinetics of cilazapril during repeated oral dosing in healthy young volunteers. European journal of drug metabolism and pharmacokinetics. 1990 Jan; 15(1):63-7. doi: 10.1007/bf03190129. [PMID: 2166672]
  • E M Whitehead, G E Walters, P E Williams, G D Johnston. Pharmacokinetics of intravenous cilazaprilat in normal volunteers. British journal of clinical pharmacology. 1989 Jun; 27(6):873-5. doi: 10.1111/j.1365-2125.1989.tb03453.x. [PMID: 2757899]
  • J F Waterfall. A review of the preclinical cardiovascular pharmacology of cilazapril, a new angiotensin converting enzyme inhibitor. British journal of clinical pharmacology. 1989; 27 Suppl 2(?):139S-150S. doi: 10.1111/j.1365-2125.1989.tb03475.x. [PMID: 2527528]
  • J P Fillastre, B Moulin, M Godin, P E Williams, A N Brown, R J Francis, P Pinta, R Manfredi. Pharmacokinetics of cilazapril in patients with renal failure. British journal of clinical pharmacology. 1989; 27 Suppl 2(?):275S-282S. doi: 10.1111/j.1365-2125.1989.tb03492.x. [PMID: 2527539]
  • P A Meredith, H L Elliott, J L Reid, R J Francis. The pharmacokinetics and angiotensin converting enzyme inhibition dynamics of cilazapril in essential hypertension. British journal of clinical pharmacology. 1989; 27 Suppl 2(?):263S-266S. doi: 10.1111/j.1365-2125.1989.tb03490.x. [PMID: 2548553]
  • C J Doorenbos, P van Brummelen. The effect of acute ACE inhibition on atrial natriuretic peptide. British journal of clinical pharmacology. 1989; 27 Suppl 2(?):243S-247S. doi: 10.1111/j.1365-2125.1989.tb03488.x. [PMID: 2527537]
  • J W Massarella, T M DeFeo, A N Brown, A Lin, R J Wills. The influence of food on the pharmacokinetics and ACE inhibition of cilazapril. British journal of clinical pharmacology. 1989; 27 Suppl 2(?):205S-209S. doi: 10.1111/j.1365-2125.1989.tb03483.x. [PMID: 2527534]
  • P E Williams, A N Brown, S Rajaguru, G E Walters, J McEwen, C Durnin. A pharmacokinetic study of cilazapril in elderly and young volunteers. British journal of clinical pharmacology. 1989; 27 Suppl 2(?):211S-215S. doi: 10.1111/j.1365-2125.1989.tb03484.x. [PMID: 2527535]
  • J Massarella, T DeFeo, A Lin, R Limjuco, A Brown. The pharmacokinetics and dose proportionality of cilazapril. British journal of clinical pharmacology. 1989; 27 Suppl 2(?):199S-204S. doi: 10.1111/j.1365-2125.1989.tb03482.x. [PMID: 2527533]
  • S Satoh, T Matsuoka, M Suzuki-Kusaba, K Chiba. Inhibitory effect of cilazaprilat on norepinephrine release induced by renal nerve stimulation in anesthetized dogs. Japanese journal of pharmacology. 1988 Oct; 48(2):287-9. doi: 10.1254/jjp.48.287. [PMID: 3210452]
  • B Jackson, R Cubela, C I Johnston. Measurement of angiotensin converting enzyme inhibitors in serum by radioinhibitor binding displacement assay. Biochemical pharmacology. 1987 Apr; 36(8):1357-60. doi: 10.1016/0006-2952(87)90094-3. [PMID: 3036166]
  • H Tanaka, Y Yoneyama, M Sugawara, I Umeda, Y Ohta. Enzyme immunoassay discrimination of a new angiotensin-converting enzyme (ACE) inhibitor, cilazapril, and its active metabolite. Journal of pharmaceutical sciences. 1987 Mar; 76(3):224-7. doi: 10.1002/jps.2600760308. [PMID: 3035170]
  • I L Natoff, J S Nixon, R J Francis, L R Klevans, M Brewster, J Budd, A T Patel, J Wenger, E Worth. Biological properties of the angiotensin-converting enzyme inhibitor cilazapril. Journal of cardiovascular pharmacology. 1985 May; 7(3):569-80. doi: 10.1097/00005344-198505000-00025. [PMID: 2410692]