6-Deoxocastasterone (BioDeep_00000010926)

 

Secondary id: BioDeep_00000637035

human metabolite Endogenous


代谢物信息卡片


(1S,2S,4R,5S,7S,10R,11S,14R,15S)-14-[(2S,3R,4R,5S)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecane-4,5-diol

化学式: C28H50O4 (450.37089000000003)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 0.21%

分子结构信息

SMILES: CC(C)C(C)C(C(C(C)C1CCC2C1(CCC3C2CCC4C3(CC(C(C4)O)O)C)C)O)O
InChI: InChI=1S/C28H50O4/c1-15(2)16(3)25(31)26(32)17(4)20-9-10-21-19-8-7-18-13-23(29)24(30)14-28(18,6)22(19)11-12-27(20,21)5/h15-26,29-32H,7-14H2,1-6H3/t16-,17-,18-,19-,20+,21-,22-,23-,24+,25+,26+,27+,28-/m0/s1

描述信息

6-Deoxocastasterone belongs to the class of organic compounds known as tetrahydroxy bile acids, alcohols, and derivatives. These are prenol lipids structurally characterized by a bile acid or alcohol which bears four hydroxyl groups. Thus, 6-deoxocastasterone is considered to be a sterol lipid molecule. 6-Deoxocastasterone is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. 6-Deoxocastasterone is found in common bean and has been isolated from Phaseolus vulgaris (kidney bean).
Isolated from Phaseolus vulgaris (kidney bean). 6-Deoxocastasterone is found in many foods, some of which are jerusalem artichoke, alaska blueberry, sourdough, and yautia.

同义名列表

8 个代谢物同义名

(1S,2S,4R,5S,7S,10R,11S,14R,15S)-14-[(2S,3R,4R,5S)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecane-4,5-diol; (2alpha,3alpha,5alpha,22R,23R,24S)-Ergostane-2,3,22,23-tetrol; (22R,23R)-5alpha-Campestane-2alpha,3alpha,22,23-tetraol; (2α,3α,5α,22R,23R,24S)-Ergostane-2,3,22,23-tetrol; campestan-2alpha,3alpha,22R,23R-tetrol; 6-Deoxo-24-epicastasterone; 6-Deoxocastasterone; ST 28:0;O4



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(4)

代谢反应

253 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(3)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(249)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Se-Hwan Joo, Tae-Wuk Kim, Seung-Hyun Son, Woo Sung Lee, Takao Yokota, Seong-Ki Kim. Biosynthesis of a cholesterol-derived brassinosteroid, 28-norcastasterone, in Arabidopsis thaliana. Journal of experimental botany. 2012 Mar; 63(5):1823-33. doi: 10.1093/jxb/err354. [PMID: 22170941]
  • Katja Schneider, Christian Breuer, Ayako Kawamura, Yusuke Jikumaru, Atsushi Hanada, Shozo Fujioka, Takanari Ichikawa, Youichi Kondou, Minami Matsui, Yuji Kamiya, Shinjiro Yamaguchi, Keiko Sugimoto. Arabidopsis PIZZA has the capacity to acylate brassinosteroids. PloS one. 2012; 7(10):e46805. doi: 10.1371/journal.pone.0046805. [PMID: 23071642]
  • Ana M Fortes, Patricia Agudelo-Romero, Marta S Silva, Kashif Ali, Lisete Sousa, Federica Maltese, Young H Choi, Jerome Grimplet, José M Martinez-Zapater, Robert Verpoorte, Maria S Pais. Transcript and metabolite analysis in Trincadeira cultivar reveals novel information regarding the dynamics of grape ripening. BMC plant biology. 2011 Nov; 11(?):149. doi: 10.1186/1471-2229-11-149. [PMID: 22047180]
  • Sigrid Husar, Franz Berthiller, Shozo Fujioka, Wilfried Rozhon, Mamoona Khan, Florian Kalaivanan, Luisa Elias, Gillian S Higgins, Yi Li, Rainer Schuhmacher, Rudolf Krska, Hideharu Seto, Fabian E Vaistij, Dianna Bowles, Brigitte Poppenberger. Overexpression of the UGT73C6 alters brassinosteroid glucoside formation in Arabidopsis thaliana. BMC plant biology. 2011 Mar; 11(?):51. doi: 10.1186/1471-2229-11-51. [PMID: 21429230]
  • Brigitte Poppenberger, Wilfried Rozhon, Mamoona Khan, Sigrid Husar, Gerhard Adam, Christian Luschnig, Shozo Fujioka, Tobias Sieberer. CESTA, a positive regulator of brassinosteroid biosynthesis. The EMBO journal. 2011 Mar; 30(6):1149-61. doi: 10.1038/emboj.2011.35. [PMID: 21336258]
  • Andrzej Bajguz. Isolation and characterization of brassinosteroids from algal cultures of Chlorella vulgaris Beijerinck (Trebouxiophyceae). Journal of plant physiology. 2009 Nov; 166(17):1946-9. doi: 10.1016/j.jplph.2009.05.003. [PMID: 19535168]
  • Bo Kyung Kim, Shozo Fujioka, Suguru Takatsuto, Masafumi Tsujimoto, Sunghwa Choe. Castasterone is a likely end product of brassinosteroid biosynthetic pathway in rice. Biochemical and biophysical research communications. 2008 Oct; 374(4):614-9. doi: 10.1016/j.bbrc.2008.07.073. [PMID: 18656444]
  • Corinne E Jager, Gregory M Symons, Takahito Nomura, Yumiko Yamada, Jennifer J Smith, Shinjiro Yamaguchi, Yuji Kamiya, James L Weller, Takao Yokota, James B Reid. Characterization of two brassinosteroid C-6 oxidase genes in pea. Plant physiology. 2007 Apr; 143(4):1894-904. doi: 10.1104/pp.106.093088. [PMID: 17322341]
  • Toshiyuki Ohnishi, Takahito Nomura, Bunta Watanabe, Daisaku Ohta, Takao Yokota, Hisashi Miyagawa, Kanzo Sakata, Masaharu Mizutani. Tomato cytochrome P450 CYP734A7 functions in brassinosteroid catabolism. Phytochemistry. 2006 Sep; 67(17):1895-906. doi: 10.1016/j.phytochem.2006.05.042. [PMID: 16872648]
  • Takahito Nomura, Tetsuo Kushiro, Takao Yokota, Yuji Kamiya, Gerard J Bishop, Shinjiro Yamaguchi. The last reaction producing brassinolide is catalyzed by cytochrome P-450s, CYP85A3 in tomato and CYP85A2 in Arabidopsis. The Journal of biological chemistry. 2005 May; 280(18):17873-9. doi: 10.1074/jbc.m414592200. [PMID: 15710611]
  • Young-Soo Kim, Tae-Wuk Kim, Seong-Ki Kim. Brassinosteroids are inherently biosynthesized in the primary roots of maize, Zea mays L. Phytochemistry. 2005 May; 66(9):1000-6. doi: 10.1016/j.phytochem.2005.03.007. [PMID: 15896368]
  • Gregory M Symons, James B Reid. Hormone levels and response during de-etiolation in pea. Planta. 2003 Jan; 216(3):422-31. doi: 10.1007/s00425-002-0860-z. [PMID: 12520333]
  • T Nomura, T Sato, G J Bishop, Y Kamiya, S Takatsuto, T Yokota. Accumulation of 6-deoxocathasterone and 6-deoxocastasterone in Arabidopsis, pea and tomato is suggestive of common rate-limiting steps in brassinosteroid biosynthesis. Phytochemistry. 2001 May; 57(2):171-8. doi: 10.1016/s0031-9422(00)00440-4. [PMID: 11382232]
  • R Yamamoto, S Fujioka, T Demura, S Takatsuto, S Yoshida, H Fukuda. Brassinosteroid levels increase drastically prior to morphogenesis of tracheary elements. Plant physiology. 2001 Feb; 125(2):556-63. doi: 10.1104/pp.125.2.556. [PMID: 11161013]
  • . . . . doi: . [PMID: 9927639]
  • . . . . doi: . [PMID: 11402205]
  • . . . . doi: . [PMID: 14502988]