Xylopine (BioDeep_00000001070)

 

Secondary id: BioDeep_00001867594

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


(12R)-16-methoxy-3,5-dioxa-11-azapentacyclo[10.7.1.0{2,6}.0{8,20}.0{14,19}]icosa-1(20),2(6),7,14(19),15,17-hexaene

化学式: C18H17NO3 (295.1208372)
中文名称: 木番荔枝碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 3.85%

分子结构信息

SMILES: COC1=CC2=C(C=C1)C3=C4C(C2)NCCC4=CC5=C3OCO5
InChI: InChI=1S/C18H17NO3/c1-20-12-2-3-13-11(6-12)7-14-16-10(4-5-19-14)8-15-18(17(13)16)22-9-21-15/h2-3,6,8,14,19H,4-5,7,9H2,1H3/t14-/m1/s1

描述信息

Xylopine, also known as (-)-xylopine, is a member of the class of compounds known as aporphines. Aporphines are quinoline alkaloids containing the dibenzo[de,g]quinoline ring system or a dehydrogenated derivative thereof. Xylopine is practically insoluble (in water) and a very strong basic compound (based on its pKa). Xylopine can be found in cherimoya and custard apple, which makes xylopine a potential biomarker for the consumption of these food products. Xylopine is an antimicrobial benzylisoquinoline alkaloid .
Xylopine is an aporphine alkaloid.
Xylopine is a natural product found in Dasymaschalon longiflorum, Annona muricata, and other organisms with data available.

同义名列表

19 个代谢物同义名

(12R)-16-methoxy-3,5-dioxa-11-azapentacyclo[10.7.1.0{2,6}.0{8,20}.0{14,19}]icosa-1(20),2(6),7,14(19),15,17-hexaene; (12R)-16-methoxy-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14(19),15,17-hexaene; (12R)-16-methoxy-3,5-dioxa-11-azapentacyclo[10.7.1.0?,?.0?,??.0??,??]icosa-1(20),2(6),7,14,16,18-hexaene; (12R)-16-methoxy-3,5-dioxa-11-azapentacyclo[10.7.1.0²,⁶.0⁸,²⁰.0¹⁴,¹⁹]icosa-1(20),2(6),7,14,16,18-hexaene; 5H-BENZO(G)-1,3-BENZODIOXOLO(6,5,4-DE)QUINOLINE, 6,7,7A,8-TETRAHYDRO-10-METHOXY-, (7AR)-; 5H-BENZO(G)-1,3-BENZODIOXOLO(6,5,4-DE)QUINOLINE, 6,7,7A,8-TETRAHYDRO-10-METHOXY-, (R)-; (7AR)-6,7,7A,8-TETRAHYDRO-10-METHOXY-5H-BENZO(G)-1,3-BENZODIOXOLO(6,5,4-DE)QUINOLINE; 10-Methoxy-6,7,7a,8-tetrahydro-2H,5H-[1,3]benzodioxolo[6,5,4-de]benzo[g]quinoline; 6A.BETA.-NORAPORPHINE, 9-METHOXY-1,2-(METHYLENEDIOXY)-; 6abeta-Noraporphine, 9-methoxy-1,2-(methylenedioxy)-; Anolobine, O-methyl-; UNII-NNZ7TH999H; Xylopine, (-)-; (+)-Xylopine; (-)-xylopine; NNZ7TH999H; AC1L4NQM; AC1Q6ZQZ; Xylopine



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

20 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ari S Nugraha, Rachada Haritakun, Jacob M Lambert, Carolyn T Dillon, Paul A Keller. Alkaloids from the root of Indonesian Annona muricata L. Natural product research. 2021 Feb; 35(3):481-489. doi: 10.1080/14786419.2019.1638380. [PMID: 31282747]
  • Leociley R A Menezes, Cinara O D Sousa Costa, Ana Carolina B da C Rodrigues, Felipe R do E Santo, Angelita Nepel, Lívia M Dutra, Felipe M A Silva, Milena B P Soares, Andersson Barison, Emmanoel V Costa, Daniel P Bezerra. Cytotoxic Alkaloids from the Stem of Xylopia laevigata. Molecules (Basel, Switzerland). 2016 Jul; 21(7):. doi: 10.3390/molecules21070890. [PMID: 27399666]
  • Su-Sen Chang, Hung-Jin Huang, Calvin Yu-Chian Chen. Two birds with one stone? Possible dual-targeting H1N1 inhibitors from traditional Chinese medicine. PLoS computational biology. 2011 Dec; 7(12):e1002315. doi: 10.1371/journal.pcbi.1002315. [PMID: 22215997]
  • Lídia Sayuri Mori, Shirley Boller, Cândida Aparecida Leite Kassuya, Maria Élida Alves Stefanello, Aleksander Roberto Zampronio. Analgesic effects of the ethanolic extract from Magnolia ovata (Magnoliaceae) trunk bark and of N-acetylxylopine, a semi-synthetic analogue of xylopine. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2011 Jan; 18(2-3):143-7. doi: 10.1016/j.phymed.2010.06.001. [PMID: 20637574]
  • Emmanoel Vilaça Costa, Maria Lúcia B Pinheiro, Andersson Barison, Francinete R Campos, Marcos J Salvador, Beatriz Helena L N S Maia, Elaine C Cabral, Marcos N Eberlin. Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents. Journal of natural products. 2010 Jun; 73(6):1180-3. doi: 10.1021/np100013r. [PMID: 20476748]
  • Chun-yan Fu, Wen-qing Yin, Zhong-liu Zhou. [Studies on the aporphine alkaloids from Fissistigma oldhamii (Hemsl.) Merr]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2007 Apr; 30(4):409-12. doi: . [PMID: 17674790]