4-Dihydroboldenone (BioDeep_00000010660)
Secondary id: BioDeep_00000637503
human metabolite Endogenous
代谢物信息卡片
化学式: C19H28O2 (288.2089)
中文名称: 1-睾酮
谱图信息:
最多检出来源 Homo sapiens(lipidomics) 92.86%
分子结构信息
SMILES: C1[C@@]2(C)[C@@]([H])(CC[C@@]3([H])[C@]4([H])CC[C@H](O)[C@@]4(C)CC[C@]23[H])CC(=O)C=1
InChI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h7,9,12,14-17,21H,3-6,8,10-11H2,1-2H3/t12-,14+,15+,16+,17+,18+,19+/m1/s1
描述信息
4-Dihydroboldenone is a metabolite of boldenone. Boldenone is an androgenic anabolic steroid (AAS) intensively used for growth promoting purposes in animals destined for meat production and as a performance enhancer in athletics. Therefore its use is officially banned either in animals intended for consumption or in humans. Because most anabolic steroids are completely metabolized and usually no parent steroid is excreted, metabolite identification is crucial to detect the illegal use of anabolic steroids either in humans or in livestock. Androgenic anabolic steroids are defined as natural, synthetic or semi-synthetic drugs chemicals derived from testosterone, used with the aim to improve physical performance by increasing both muscle strength and mass. Despite their reported toxicological effects on the cardiovascular, hepatic and neuro-endocrine systems, the AAS have been extensively used in sports activities. (PMID: 2663904, 16195040, 16292586, 1663826, 16799097, 16888758, 16923823, 9249887) [HMDB]
4-Dihydroboldenone is a metabolite of boldenone. Boldenone is an androgenic anabolic steroid (AAS) intensively used for growth-promoting purposes in animals destined for meat production and as a performance enhancer in athletics. Therefore, its use is officially banned in both humans and in animals intended for human consumption. Because most anabolic steroids are completely metabolized and usually no parent steroid is excreted, metabolite identification is crucial to detect the illegal use of anabolic steroids either in humans or in livestock. Androgenic anabolic steroids are defined as natural, synthetic, or semi-synthetic drugs chemicals derived from testosterone, used with the aim to improve physical performance by increasing both muscle strength and mass. Despite their reported toxicological effects on the cardiovascular, hepatic, and neuroendocrine systems, the AAS has been extensively used in sports activities (PMID: 2663904, 16195040, 16292586, 1663826, 16799097, 16888758, 16923823, 9249887).
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
同义名列表
21 个代谢物同义名
(1S,2R,7R,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-3-en-5-one; (5beta,17beta)-17-Hydroxyandrost-1-en-3-one; 17beta-hydroxy-5alpha-androst-1-en-3-one; 17beta-Hydroxy-5beta-androst-1-en-3-one; (5b,17b)-17-Hydroxyandrost-1-en-3-one; (5Β,17β)-17-hydroxyandrost-1-en-3-one; 5beta-Androst-1-ene-17beta-ol-3-one; 17b-Hydroxy-5b -androst-1-en-3-one; 5beta-Androst-1-en-17beta-ol-3-one; 17b-Hydroxy-5b-androst-1-en-3-one; 17β-Hydroxy-5β-androst-1-en-3-one; 5β-Androst-1-ene-17β-ol-3-one; 5b-Androst-1-ene-17b-ol-3-one; 17-Hydroxyandrost-1-en-3-one; 5β-Androst-1-en-17β-ol-3-one; 5b-Androst-1-en-17b-ol-3-one; Androst-1-en-17-ol-3-one; 4-Dihydroboldenone; 1-Testosterone; ST 19:2;O2; 1-Testosterone
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:59714
- ChEBI: CHEBI:87331
- KEGG: C15377
- PubChem: 12133279
- PubChem: 236666
- PubChem: 579094
- HMDB: HMDB0006035
- Metlin: METLIN58347
- DrugBank: DB01481
- LipidMAPS: LMST02020110
- foodb: FDB023811
- chemspider: 20045328
- CAS: 10529-96-1
- CAS: 65-06-5
- PMhub: MS000024529
- PubChem: 17396374
- NIKKAJI: J108.132B
- KNApSAcK: 59714
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Fu-Chun Yang, Yi-Lung Chen, Sen-Lin Tang, Chang-Ping Yu, Po-Hsiang Wang, Wael Ismail, Chia-Hsiang Wang, Jiun-Yan Ding, Cheng-Yu Yang, Chia-Ying Yang, Yin-Ru Chiang. Integrated multi-omics analyses reveal the biochemical mechanisms and phylogenetic relevance of anaerobic androgen biodegradation in the environment.
The ISME journal.
2016 08; 10(8):1967-83. doi:
10.1038/ismej.2015.255. [PMID: 26872041] - W H Kwok, Emmie N M Ho, Gary N W Leung, Francis P W Tang, Terence S M Wan, Henry N C Wong, John H K Yeung. Metabolic studies of 1-testosterone in horses.
Drug testing and analysis.
2013 Feb; 5(2):81-8. doi:
10.1002/dta.1380. [PMID: 22715048] - Maria K Parr, Christina Blatt, Oliver Zierau, Cornelius Hess, Michael Gütschow, Gregor Fusshöller, Georg Opfermann, Wilhelm Schänzer, Patrick Diel. Endocrine characterization of the designer steroid methyl-1-testosterone: investigations on tissue-specific anabolic-androgenic potency, side effects, and metabolism.
Endocrinology.
2011 Dec; 152(12):4718-28. doi:
10.1210/en.2011-1164. [PMID: 21990312] - Li-Ping Zou, Ying Wang, Li-Ping Zhang, Jian-Bo Zhao, Jin-Fang Lu, Qun Liu, Hang-Yan Wang. Tourette syndrome and excitatory substances: is there a connection?.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery.
2011 May; 27(5):793-802. doi:
10.1007/s00381-010-1318-4. [PMID: 21057956] - Maria K Parr, Georg Opfermann, Hans Geyer, Folker Westphal, Frank D Sönnichsen, Josef Zapp, Dorota Kwiatkowska, Wilhelm Schänzer. Seized designer supplement named "1-Androsterone": identification as 3β-hydroxy-5α-androst-1-en-17-one and its urinary elimination.
Steroids.
2011 May; 76(6):540-7. doi:
10.1016/j.steroids.2011.02.001. [PMID: 21310167] - M Galesio, R Rial-Otero, J Simal-Gándara, X de la Torre, F Botrè, J L Capelo-Martínez. Improved ultrasonic-based sample treatment for the screening of anabolic steroids by gas chromatography/mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2010 Aug; 24(16):2375-85. doi:
10.1002/rcm.4654. [PMID: 20635322] - Thomas Piper, Hans Geyer, Vassilios Gougoulidis, Ulrich Flenker, Wilhelm Schänzer. Determination of (13)C/(12)C ratios of urinary excreted boldenone and its main metabolite 5beta-androst-1-en-17beta-ol-3-one.
Drug testing and analysis.
2010 May; 2(5):217-24. doi:
10.1002/dta.124. [PMID: 20468009] - Oliver Zierau, Sylvi Lehmann, Günter Vollmer, Willhelm Schänzer, Patrick Diel. Detection of anabolic steroid abuse using a yeast transactivation system.
Steroids.
2008 Oct; 73(11):1143-7. doi:
10.1016/j.steroids.2008.04.015. [PMID: 18550137] - Oscar J Pozo, Koen Deventer, Peter Van Eenoo, Frans T Delbeke. Presence of endogenous interferences in the urinary detection of selected anabolic steroids by liquid chromatography/electrospray tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2007; 21(17):2785-96. doi:
10.1002/rcm.3140. [PMID: 17661313] - Mario Thevis, Hans Geyer, Ute Mareck, Wilhelm Schänzer. Screening for unknown synthetic steroids in human urine by liquid chromatography-tandem mass spectrometry.
Journal of mass spectrometry : JMS.
2005 Jul; 40(7):955-62. doi:
10.1002/jms.873. [PMID: 15934041]
