Exact Mass: 377.1256648
Exact Mass Matches: 377.1256648
Found 463 metabolites which its exact mass value is equals to given mass value 377.1256648
,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
6-(2-Hydroxyethyl)-5,6-dihydrosanguinarine
C22H19NO5 (377.12631640000006)
Imidaprilat
Imidaprilat, is the active metabolite of Imidapril. Imidapril is a prodrug used to treat hypertension, chronic congestive heart failure (CHF), acute myocardial infarction (AMI), and diabetic nephropathy (PMID: 17547476,18192036,12177688, 17094051). Imidapril belongs to a class of long-acting, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitors (PMID: 8851752, 12177688). Imidaprilat competitively binds and inhibits the catalytic activity of ACE, which results in a reduction of peripheral resistance and a reduction in systemic blood pressure (BP) (PMID: 17547476). Imidaprilat is only found in individuals that have used or taken imidapril. D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
JNJ-38877605
C19H13F2N7 (377.12004420000005)
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C164000 - c-Met-targeting Agent C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
Reduced haloperidol
Reduced haloperidol is a metabolite of haloperidol. Haloperidol is a typical antipsychotic. It is in the butyrophenone class of antipsychotic medications and has pharmacological effects similar to the phenothiazines. Haloperidol is an older antipsychotic used in the treatment of schizophrenia and acute psychotic states and delirium. (Wikipedia)
Kinetin-7-N-glucoside
Kinetin-7-N-glucoside belongs to the class of organic compounds known as glycosylamines. Glycosylamines are compounds consisting of an amine with a beta-N-glycosidic bond to a carbohydrate, thus forming a cyclic hemiaminal ether bond (alpha-amino ether). Kinetin-7-N-glucoside is a strong basic compound (based on its pKa). Kinetin-7-N-glucoside is the product of the reaction between kinetin and UDP-D-glucose, with UDP as a co-product. The reaction is catalyzed by a UDP glycosyltransferase. Kinetin-7-N-glucoside is the product of the reaction between kinetin and UDP-D-glucose, with UDP as a co-product. The reaction is catalyzed by a UDP glycosyltransferase. [HMDB]
Kinetin-9-N-glucoside
Kinetin-9-N-glucoside belongs to the class of organic compounds known as glycosylamines. Glycosylamines are compounds consisting of an amine with a beta-N-glycosidic bond to a carbohydrate, thus forming a cyclic hemiaminal ether bond (alpha-amino ether). Kinetin-9-N-glucoside is a strong basic compound (based on its pKa). Kinetin-9-N-glucoside is the product of the reaction between kinetin and UDP-D-glucose, with UDP as a co-product. The reaction is catalyzed by a UDP glycosyltransferase.
7-[(3S,4S)-3-(Benzenesulfonamido)-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acid
C20H27NO4S (377.1660702000001)
3-(2-(N-(1-Carboxy-3-phenylpropyl)amino)propionyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
S-(2-Hydroxy-3-buten-1-yl)glutathione
4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole
7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, N-oxide
C18H20FN3O5 (377.13869220000004)
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
Methyl 4-(2-(2-hydroxy-2-(3-chlorophenyl)ethylamino)propyl)phenoxyacetate
C20H24ClNO4 (377.13937740000006)
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
(2S)-2-(Butanoylamino)-5-[[(1R)-2-(carboxymethylamino)-2-oxo-1-(sulfanylmethyl)ethyl]amino]-5-oxo-pentanoic acid
3-[2-(4-Fluorophenyl)ethylamino]-1-methyl-4-(2-methyl-1H-indol-3-yl)pyrrole-2,5-dione
S-Pyruvylglutathione
Sulfinalol
C20H27NO4S (377.1660702000001)
Talarozole
C21H23N5S (377.16740780000003)
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor C274 - Antineoplastic Agent > C129818 - Antineoplastic Hormonal/Endocrine Agent > C481 - Antiestrogen C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C1740 - Aromatase Inhibitor D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist
(3E,6Z)-3-Benzylidene-6-[[4-[2-(dimethylamino)ethoxy]phenyl]methylidene]piperazine-2,5-dione
Lasmiditan
N - Nervous system > N02 - Analgesics > N02C - Antimigraine preparations > N02CC - Selective serotonin (5ht1) agonists D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists C78272 - Agent Affecting Nervous System > C47794 - Serotonin Agonist
Ethoxysanguinarine
C22H19NO5 (377.12631640000006)
Ethoxysanguinarine is a benzophenanthridine alkaloid natural product that is mainly found in Macleaya cordata. Ethoxysanguinarine is an inhibitor of protein phosphatase 2A (CIP2A). Ethoxysanguinarine induces cell apoptosis and inhibits colorectal cancer cells growth[1]. Ethoxysanguinarine is a benzophenanthridine alkaloid natural product that is mainly found in Macleaya cordata. Ethoxysanguinarine is an inhibitor of protein phosphatase 2A (CIP2A). Ethoxysanguinarine induces cell apoptosis and inhibits colorectal cancer cells growth[1].
Phellodendrine HCl
C20H24NO4+.Cl- (377.13937740000006)
Phellodendrine chloride is a plant alkaloid found in Phellodendron amurense. Phellodendrine chloride suppresses the proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis [1]. Phellodendrine chloride promotes autophagy by regulating the AMPK/mTOR pathway and reduce the intestinal damage of ulcerative colitis[2]. Phellodendrine chloride is a plant alkaloid found in Phellodendron amurense. Phellodendrine chloride suppresses the proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis [1]. Phellodendrine chloride promotes autophagy by regulating the AMPK/mTOR pathway and reduce the intestinal damage of ulcerative colitis[2].
Phellodendrine
C20H24NO4+.Cl- (377.13937740000006)
Phellodendrine chloride is a plant alkaloid found in Phellodendron amurense. Phellodendrine chloride suppresses the proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis [1]. Phellodendrine chloride promotes autophagy by regulating the AMPK/mTOR pathway and reduce the intestinal damage of ulcerative colitis[2]. Phellodendrine chloride is a plant alkaloid found in Phellodendron amurense. Phellodendrine chloride suppresses the proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis [1]. Phellodendrine chloride promotes autophagy by regulating the AMPK/mTOR pathway and reduce the intestinal damage of ulcerative colitis[2].
Piscerythoxazole
C22H19NO5 (377.12631640000006)
L-gamma-glutamyl-S-3-(1-oxobutyl)-L-cysteinyl-glycine
This record was created by the financial support of MEXT/JSPS KAKENHI Grant Number 16HP2005 to the Mass Spectrometry Society of Japan.
O1-(2-acetylamino-[1]naphthyl)-beta-D-glucopyranuronic acid|O1-(2-Acetylamino-[1]naphthyl)-beta-D-glucopyranuronsaeure
4-methoxyfuro[2,3-b]quinolin-7-yl beta-D-mannopyranoside|dictamnine-7-beta-D-mannopyranoside
(-)-circumdatin J|(S)-(-)-circumdatin J|(S)-2,12-dimethoxy-5b,6,7,8-tetrahydrobenzo[6,7]pyrrolo[2,1:3,4][1,4]diazepino[2,1-b]quinazoline-10,16-dione|circumdatin J
C21H19N3O4 (377.13754940000007)
(2-hydroxy-1-methoxy-12-methyl-12,13-dihydro-[1,3]dioxolo[4,5:4,5]benzo[1,2-c]phenanthridin-13-yl)-acetaldehyde|11-(Formyl-methylenyl)-O-desmethyl-dihydrochelerythrin
C22H19NO5 (377.12631640000006)
6-methoxy-11,12,13,14,14a,15-hexahydro-9H-benzo[h][1,3]dioxolo[4,5:4,5]benzo[1,2-f]pyrido[1,2-b]isoquinolin-12-ol|Cryptopleuridin|Cryptopleuridine
C23H23NO4 (377.16269980000004)
bruceolline K
An indole alkaloid that is 1,2,3,4-tetrahydrocyclopenta[b]indole substituted by geminal-methyl groups at position 3, an oxo group at position 1 and a beta-D-glucopyranosyloxy group at position 2.It has been isolated from the ethanol extract of the stems of Brucea mollis.
O1-(6-acetylamino-[2]naphthyl)-beta-D-glucopyranuronic acid|O1-(6-Acetylamino-[2]naphthyl)-beta-D-glucopyranuronsaeure
16-Methoxycarbonyl-18,19-dihydroxynaufoline
C21H19N3O4 (377.13754940000007)
14-Ethoxy-13-methyl-13,14-dihydro-[1,3]dioxolo[4,5:4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridine
C22H19NO5 (377.12631640000006)
SB 203580
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D000700 - Analgesics D000893 - Anti-Inflammatory Agents D018501 - Antirheumatic Agents C308 - Immunotherapeutic Agent D004791 - Enzyme Inhibitors
Cissamine chloride
C20H24ClNO4 (377.13937740000006)
Cyclanoline (chloride) shows cholinesterase inhibitory activity[1].
Escholine chloride
C20H24ClNO4 (377.13937740000006)
Magnoflorine chloride (Magnoflorine chloride), an aporphine alkaloid found in Magnolia or Aristolochia, reduces the formation of C. albicans biofilm[1]. Magnoflorine chloride has anti-fungal, anti-antidiabetic and anti-oxidative activity[2]. Magnoflorine chloride (Magnoflorine chloride), an aporphine alkaloid found in Magnolia or Aristolochia, reduces the formation of C. albicans biofilm[1]. Magnoflorine chloride has anti-fungal, anti-antidiabetic and anti-oxidative activity[2].
Phellodendrine HCl
C20H24ClNO4 (377.13937740000006)
Phellodendrine chloride is a plant alkaloid found in Phellodendron amurense. Phellodendrine chloride suppresses the proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis [1]. Phellodendrine chloride promotes autophagy by regulating the AMPK/mTOR pathway and reduce the intestinal damage of ulcerative colitis[2]. Phellodendrine chloride is a plant alkaloid found in Phellodendron amurense. Phellodendrine chloride suppresses the proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis [1]. Phellodendrine chloride promotes autophagy by regulating the AMPK/mTOR pathway and reduce the intestinal damage of ulcerative colitis[2].
Phentolamine mesilate
C18H23N3O4S (377.14091980000006)
Phentolamine mesylate (Phentolamine methanesulfonate) is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine mesylate can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction[1][2][3].
Ala Ala Cys Asn
C13H23N5O6S (377.13689780000004)
Ala Ala Asn Cys
C13H23N5O6S (377.13689780000004)
Ala Cys Ala Asn
C13H23N5O6S (377.13689780000004)
Ala Cys Gly Lys
Ala Cys Gly Gln
C13H23N5O6S (377.13689780000004)
Ala Cys Lys Gly
Ala Cys Asn Ala
C13H23N5O6S (377.13689780000004)
Ala Cys Gln Gly
C13H23N5O6S (377.13689780000004)
Ala Gly Cys Lys
Ala Gly Cys Gln
C13H23N5O6S (377.13689780000004)
Ala Gly Lys Cys
Ala Gly Gln Cys
C13H23N5O6S (377.13689780000004)
Ala Lys Cys Gly
Ala Lys Gly Cys
Ala Asn Ala Cys
C13H23N5O6S (377.13689780000004)
Ala Asn Cys Ala
C13H23N5O6S (377.13689780000004)
Ala Asn Ser Ser
Ala Gln Cys Gly
C13H23N5O6S (377.13689780000004)
Ala Gln Gly Cys
C13H23N5O6S (377.13689780000004)
Ala Ser Asn Ser
Ala Ser Ser Asn
Cys Ala Ala Asn
C13H23N5O6S (377.13689780000004)
Cys Ala Gly Lys
Cys Ala Gly Gln
C13H23N5O6S (377.13689780000004)
Cys Ala Lys Gly
Cys Ala Asn Ala
C13H23N5O6S (377.13689780000004)
Cys Ala Gln Gly
C13H23N5O6S (377.13689780000004)
Cys Gly Ala Lys
Cys Gly Ala Gln
C13H23N5O6S (377.13689780000004)
Cys Gly Lys Ala
Cys Gly Gln Ala
C13H23N5O6S (377.13689780000004)
Cys Lys Ala Gly
Cys Lys Gly Ala
Cys Asn Ala Ala
C13H23N5O6S (377.13689780000004)
Cys Gln Ala Gly
C13H23N5O6S (377.13689780000004)
Cys Gln Gly Ala
C13H23N5O6S (377.13689780000004)
Gly Ala Cys Lys
Gly Ala Cys Gln
C13H23N5O6S (377.13689780000004)
Gly Ala Lys Cys
Gly Ala Gln Cys
C13H23N5O6S (377.13689780000004)
Gly Cys Ala Lys
Gly Cys Ala Gln
C13H23N5O6S (377.13689780000004)
Gly Cys Lys Ala
Gly Cys Gln Ala
C13H23N5O6S (377.13689780000004)
Gly Gly Met Asn
C13H23N5O6S (377.13689780000004)
Gly Gly Asn Met
C13H23N5O6S (377.13689780000004)
Gly Lys Ala Cys
Gly Lys Cys Ala
Gly Met Gly Asn
C13H23N5O6S (377.13689780000004)
Gly Met Asn Gly
C13H23N5O6S (377.13689780000004)
Gly Asn Gly Met
C13H23N5O6S (377.13689780000004)
Gly Asn Met Gly
C13H23N5O6S (377.13689780000004)
Gly Asn Ser Thr
Gly Asn Thr Ser
Gly Gln Ala Cys
C13H23N5O6S (377.13689780000004)
Gly Gln Cys Ala
C13H23N5O6S (377.13689780000004)
Gly Gln Ser Ser
Gly Ser Asn Thr
Gly Ser Gln Ser
Gly Ser Ser Gln
Gly Ser Thr Asn
Gly Thr Asn Ser
Gly Thr Ser Asn
Lys Ala Cys Gly
Lys Ala Gly Cys
Lys Cys Ala Gly
Lys Cys Gly Ala
Lys Gly Ala Cys
Lys Gly Cys Ala
Met Gly Gly Asn
C13H23N5O6S (377.13689780000004)
Met Gly Asn Gly
C13H23N5O6S (377.13689780000004)
Met Asn Gly Gly
C13H23N5O6S (377.13689780000004)
Asn Ala Ala Cys
C13H23N5O6S (377.13689780000004)
Asn Ala Cys Ala
C13H23N5O6S (377.13689780000004)
Asn Ala Ser Ser
Asn Cys Ala Ala
C13H23N5O6S (377.13689780000004)
Asn Gly Gly Met
C13H23N5O6S (377.13689780000004)
Asn Gly Met Gly
C13H23N5O6S (377.13689780000004)
Asn Gly Ser Thr
Asn Gly Thr Ser
Asn Met Gly Gly
C13H23N5O6S (377.13689780000004)
Asn Ser Ala Ser
Asn Ser Gly Thr
Asn Ser Ser Ala
Asn Ser Thr Gly
Asn Thr Gly Ser
Asn Thr Ser Gly
Gln Ala Cys Gly
C13H23N5O6S (377.13689780000004)
Gln Ala Gly Cys
C13H23N5O6S (377.13689780000004)
Gln Cys Ala Gly
C13H23N5O6S (377.13689780000004)
Gln Cys Gly Ala
C13H23N5O6S (377.13689780000004)
Gln Gly Ala Cys
C13H23N5O6S (377.13689780000004)
Gln Gly Cys Ala
C13H23N5O6S (377.13689780000004)
Gln Gly Ser Ser
Gln Ser Gly Ser
Gln Ser Ser Gly
Ser Ala Asn Ser
Ser Ala Ser Asn
Ser Gly Asn Thr
Ser Gly Gln Ser
Ser Gly Ser Gln
Ser Gly Thr Asn
Ser Asn Ala Ser
Ser Asn Gly Thr
Ser Asn Ser Ala
Ser Asn Thr Gly
Ser Gln Gly Ser
Ser Gln Ser Gly
Ser Ser Ala Asn
Ser Ser Gly Gln
Ser Ser Asn Ala
Ser Ser Gln Gly
Ser Thr Gly Asn
Ser Thr Asn Gly
Thr Gly Asn Ser
Thr Gly Ser Asn
Thr Asn Gly Ser
Thr Asn Ser Gly
Thr Ser Gly Asn
Thr Ser Asn Gly
Imidaprilat
A member of the class of imidazolidines that is imidapril in which the ethyl ester group has been hydrolysed to the corresponding acid group. It is the active metabolite of imidapril used to treat hypertension. D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
3-[[2-(4-phenylmethoxyphenoxy)acetyl]amino]benzoic acid
C22H19NO5 (377.12631640000006)
[4-(3-Methoxyphenyl)-1-piperazinyl](5-methyl-3-phenyl-1,2-oxazol- 4-yl)methanone
disperse blue 124
C16H19N5O4S (377.11576940000003)
1,3,3-trimethyl-2-[(methyl-2-naphthylhydrazono)methyl]-3H-indolium chloride
C23H24ClN3 (377.16586540000003)
4-Phenylpiperidine-4-carboxylic acid, compound with toluene-p-sulphonic acid
C19H23NO5S (377.12968680000006)
3-AMINO-3-(3,4-DIBENZYLOXY-PHENYL)-PROPIONIC ACID
C23H23NO4 (377.16269980000004)
diethyl (6-chloro-2,3,4,9-tetrahydro-1H-carbazol-2-yl)methylmalonate
C20H24ClNO4 (377.13937740000006)
3-(4-Methoxybenzyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridinehydrochloride
C19H25BClNO4 (377.1565070000001)
1-(4-nitrophenyl)-1,2,2-triphenylethylene
C26H19NO2 (377.14157140000003)
Urea, N-cyclopropyl-N-[(1,2-dihydro-6-methyl-2-oxo-3-quinolinyl)methyl]-N-(2-methoxyphenyl)- (9CI)
2-Carboxy-5-fluoro-1-[(1-naphthalenyl)methyl]-1H-indole-3-acetic acid
dibutyl [[(diethylamino)thioxomethyl]thio]succinate
tert-Butyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate
Methanone, [4-(4-methoxyphenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)-
Ronifibrate
C19H20ClNO5 (377.1029940000001)
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent > C98150 - Fibrate Antilipidemic Agent C - Cardiovascular system > C10 - Lipid modifying agents > C10A - Lipid modifying agents, plain > C10AB - Fibrates
Sulfinalol
C20H27NO4S (377.1660702000001)
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
5-(4-TERT-BUTYLPHENYL)-4-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-TRIAZOLE-3-THIOL
C19H18F3N3S (377.11734640000003)
(4-(N-Butyl-N-(4-methoxybenzyl)sulfamoyl)phenyl)boronic acid
C18H24BNO5S (377.14681640000003)
tert-Butyl 5-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate
C19H25BClNO4 (377.1565070000001)
tert-Butyl 7-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate
C19H25BClNO4 (377.1565070000001)
1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline hydrochloride
C20H24ClNO4 (377.13937740000006)
CH5132799
C15H19N7O3S (377.12700240000004)
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C2152 - Phosphatidylinositide 3-Kinase Inhibitor C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor
Setiptiline maleate
C23H23NO4 (377.16269980000004)
Setiptiline maleate (MO-8282 maleate) is a serotonin receptor antagonist. Setiptiline maleate is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline maleate acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine[1][2][3][4].
Domitroban
C20H27NO4S (377.1660702000001)
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D011448 - Prostaglandin Antagonists C78275 - Agent Affecting Blood or Body Fluid > C29750 - Thrombolytic Agent D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
1,2-di-o-acetyl-3-azido-3-deoxy-5-o-toluoyl-d-ribofuranose
tert-Butyl 6-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate
C19H25BClNO4 (377.1565070000001)
Selurampanel
C16H19N5O4S (377.11576940000003)
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate
C18H20FN3O3S (377.1209342000001)
(4-(N-(tert-Butyl)-N-(4-methoxybenzyl)sulfamoyl)phenyl)boronic acid
C18H24BNO5S (377.14681640000003)
N-Fmoc-2-amino-2-(2-propenyl)-4-Pentenoic acid
C23H23NO4 (377.16269980000004)
4-[[2-methoxy-4-[(4-nitrophenyl)azo]phenyl]azo]phenol
C19H15N5O4 (377.11239900000004)
Pyridine, 4-(4-(4-fluorophenyl)-2-(5-((R)-methylsulfinyl)phenyl)-1H-imidazol-4-yl)-
Glufanide disodium
D006133 - Growth Substances > D043924 - Angiogenesis Modulating Agents D000970 - Antineoplastic Agents > D020533 - Angiogenesis Inhibitors D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor D006133 - Growth Substances > D006131 - Growth Inhibitors D020011 - Protective Agents > D000931 - Antidotes C308 - Immunotherapeutic Agent D007155 - Immunologic Factors
3-((4-(2-(Dimethylamino)ethoxy)phenyl)methylene)-6-(phenylmethylene)-2,5-piperazinedione
Acridine half-mustard
D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds D009676 - Noxae > D009153 - Mutagens
6-(4-Hydroxyphenyl)-5-(4-methoxyphenyl)-1,3-dimethylpyrrolo[3,4-d]pyrimidine-2,4-dione
C21H19N3O4 (377.13754940000007)
2-(4-morpholinyl)-N-[(2-nitrophenyl)-oxomethyl]-4-thiazolecarbohydrazide
C15H15N5O5S (377.07938600000006)
Dasolampanel
C17H20ClN5O3 (377.1254600000001)
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant
N-(2-methoxydibenzofuran-3-yl)-2-(4-methoxyphenoxy)acetamide
C22H19NO5 (377.12631640000006)
Ofloxacin N-oxide
C18H20FN3O5 (377.13869220000004)
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
4-benzyl-N-[4-(difluoromethoxy)phenyl]piperazine-1-carbothioamide
N-(1,3-benzodioxol-5-yl)-3-methyl-6-phenyl-2-imidazo[2,1-b]thiazolecarboxamide
C20H15N3O3S (377.0834080000001)
2-[2-Amino-5-(4-methoxyphenyl)-6-methylpyrimidin-4-yl]-5-[(2-methylprop-2-en-1-yl)oxy]phenol
5-benzoyl-6-methyl-4-[4-(4-morpholinyl)phenyl]-3,4-dihydro-1H-pyrimidin-2-one
7-Pyridin-2-Yl-N-(3,4,5-Trimethoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-2-Amine
C20H19N5O3 (377.1487824000001)
(3s)-1-(1,3-Benzodioxol-5-Ylmethyl)-3-[4-(1h-Imidazol-1-Yl)phenoxy]piperidine
[2-Amino-6-(2,6-difluoro-benzoyl)-imidazo[1,2-A]pyridin-3-YL]-phenyl-methanone
C21H13F2N3O2 (377.09757820000004)
2-[(2-methoxyethyl)amino]-4-(4-oxo-1,2,3,4-tetrahydro-9H-carbazol-9-yl)benzamide
6-Carbamimidoyl-4-(3-hydroxy-2-methyl-benzoylamino)-naphthalene-2-carboxylic acid methyl ester
C21H19N3O4 (377.13754940000007)
[4-({5-(Aminocarbonyl)-4-[(3-Methylphenyl)amino]pyrimidin-2-Yl}amino)phenyl]acetic Acid
C20H19N5O3 (377.1487824000001)
Phentolamine mesylate
C18H23N3O4S (377.14091980000006)
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents Phentolamine mesylate (Phentolamine methanesulfonate) is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine mesylate can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction[1][2][3].
Naltrexone Hydrochloride
C20H24ClNO4 (377.13937740000006)
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D009292 - Narcotic Antagonists D002491 - Central Nervous System Agents > D000427 - Alcohol Deterrents C78272 - Agent Affecting Nervous System > C681 - Opiate Antagonist Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS
Lasmiditan
N - Nervous system > N02 - Analgesics > N02C - Antimigraine preparations > N02CC - Selective serotonin (5ht1) agonists D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists C78272 - Agent Affecting Nervous System > C47794 - Serotonin Agonist
Talarozole
C21H23N5S (377.16740780000003)
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor C274 - Antineoplastic Agent > C129818 - Antineoplastic Hormonal/Endocrine Agent > C481 - Antiestrogen C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C1740 - Aromatase Inhibitor D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist
Kinetin-7-N-glucoside
Kinetin-7-N-glucoside belongs to the class of organic compounds known as glycosylamines. Glycosylamines are compounds consisting of an amine with a beta-N-glycosidic bond to a carbohydrate, thus forming a cyclic hemiaminal ether bond (alpha-amino ether). Kinetin-7-N-glucoside is a strong basic compound (based on its pKa). Kinetin-7-N-glucoside is the product of the reaction between kinetin and UDP-D-glucose, with UDP as a co-product. The reaction is catalyzed by a UDP glycosyltransferase. Kinetin-7-N-glucoside is the product of the reaction between kinetin and UDP-D-glucose, with UDP as a co-product. The reaction is catalyzed by a UDP glycosyltransferase. [HMDB]
Protuboxepin A
An organic heterotricyclic compound that is 10,11-dihydro-6H-oxepino[2,3-d]pyrazino[1,2-a]pyrimidine-6,9(8H)-dione substituted by a benzyl group at position 8 and a butan-2-yl group at position 11. It has been isolated from Aspergillus species.
2-[(2-methyl-4-benzofuro[3,2-d]pyrimidinyl)thio]-N-(2-phenylethyl)acetamide
C21H19N3O2S (377.11979140000005)
3-methoxy-N-[4-methyl-2-(4-morpholinyl)-6-quinolinyl]benzamide
1-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl]-N-(5-methyl-2-pyridinyl)-4-piperidinecarboxamide
C17H23N5O3S (377.15215280000007)
3,4-Dimethyl-6-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-1,6-dihydropyrimidine-5-carboxylic acid propyl ester
1-[4-(3,4,5-Trimethoxyphenyl)-2-thiazolyl]-4-piperidinecarboxamide
C18H23N3O4S (377.14091980000006)
4-allyl-1-anilino-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one
C20H19N5OS (377.13102440000006)
N-[[4-(dimethylsulfamoyl)anilino]-sulfanylidenemethyl]-2-phenylacetamide
4-benzyl-N-(3,5-dichlorophenyl)-1,4-diazepane-1-carboxamide
5-[(5-Tert-butyl-2,3-dimethylphenyl)sulfonylamino]-2-hydroxybenzoic acid
C19H23NO5S (377.12968680000006)
1-(2,5-Dimethoxyphenyl)-3-[5-(2-methylpiperidin-1-yl)-1,3,4-thiadiazol-2-yl]urea
C17H23N5O3S (377.15215280000007)
1-phenylspiro[1,3-diazinane-5,5-2,4,4a,6-tetrahydro-1H-[1,4]oxazino[4,3-a]quinoline]-2,4,6-trione
C21H19N3O4 (377.13754940000007)
1-(2-Methoxyphenyl)-4-{[5-(4-methylphenyl)-3-isoxazolyl]carbonyl}piperazine
N2-phenyl-6-[[(1-phenyl-5-tetrazolyl)thio]methyl]-1,3,5-triazine-2,4-diamine
C17H15N9S (377.11710700000003)
3-(2,5-dioxo-1-pyrrolidinyl)-N-(2-methyl-1,3-dioxo-5-isoindolyl)benzamide
C20H15N3O5 (377.10116600000003)
1-(3-Chlorophenyl)-3-(9-cyclopentyl-9-azabicyclo[3.3.1]nonan-3-yl)thiourea
C20H28ClN3S (377.1692358000001)
2-cyano-N-(2-furanylmethyl)-2-[3-(4-morpholinyl)-2-quinoxalinyl]acetamide
C20H19N5O3 (377.1487824000001)
N-ethyl-8-methyl-4-oxo-N-(phenylmethyl)-2-thieno[3,2-c][1]benzopyrancarboxamide
C22H19NO3S (377.1085584000001)
6-amino-5-cyano-2-(4-methoxyphenyl)-4-(3-pyridinyl)-4H-pyran-3-carboxylic acid ethyl ester
C21H19N3O4 (377.13754940000007)
3-(4-methylphenyl)-5-oxo-N-propyl-8-thiazolo[2,3-b]quinazolinecarboxamide
C21H19N3O2S (377.11979140000005)
1-(3,4-dihydro-1H-isoquinolin-2-yl)-2-[(2-propyl-4-quinazolinyl)thio]ethanone
C22H23N3OS (377.15617480000003)
2-[[2-Oxo-2-[4-[5-(trifluoromethyl)-2-pyridinyl]-1,4-diazepan-1-yl]ethyl]thio]acetic acid
C15H18F3N3O3S (377.10209140000006)
N-methyl-N-(3-pyridinylmethyl)-5-(5,6,7,8-tetrahydronaphthalen-2-yloxymethyl)-3-isoxazolecarboxamide
(15S)-13-[(4-Fluorophenyl)methyl]-10,10-dimethyl-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
(15S)-13-[(2-Fluorophenyl)methyl]-10,10-dimethyl-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
(15R)-13-[(4-Fluorophenyl)methyl]-10,10-dimethyl-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
(15S)-13-[(3-Fluorophenyl)methyl]-10,10-dimethyl-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
(15R)-13-[(2-Fluorophenyl)methyl]-10,10-dimethyl-8,11,13-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraene-12,14-dione
(5E)-5-[[1-(4-chloro-2-fluorophenyl)-2,5-dimethylpyrrol-3-yl]methylidene]-3-methyl-2-methylimino-1,3-thiazolidin-4-one
C18H17ClFN3OS (377.07648340000003)
4-[(2E)-2-(2,4,5-trimethoxybenzylidene)hydrazinyl]-5H-pyrimido[5,4-b]indole
C20H19N5O3 (377.1487824000001)
2-(3,5-dimethylphenoxy)acetic acid [3-(1H-benzimidazol-2-yl)-3-cyano-2-oxopropyl] ester
C21H19N3O4 (377.13754940000007)
(1R,5S)-N-(1,3-benzodioxol-5-yl)-7-[4-[(E)-prop-1-enyl]phenyl]-3,6-diazabicyclo[3.1.1]heptane-6-carboxamide
(6R,7R,8S)-8-(hydroxymethyl)-7-[4-[(E)-prop-1-enyl]phenyl]-4-(pyridine-4-carbonyl)-1,4-diazabicyclo[4.2.0]octan-2-one
(6R,7S,8R)-8-(hydroxymethyl)-7-[4-[(E)-prop-1-enyl]phenyl]-4-(pyridine-4-carbonyl)-1,4-diazabicyclo[4.2.0]octan-2-one
(6S,7S,8R)-8-(hydroxymethyl)-7-[4-[(E)-prop-1-enyl]phenyl]-4-(pyridine-4-carbonyl)-1,4-diazabicyclo[4.2.0]octan-2-one
2-[[(1S,5R)-7-[4-(2-methoxyphenyl)phenyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]methyl]thiazole
C22H23N3OS (377.15617480000003)
(1S,5R)-N-(1,3-benzodioxol-5-yl)-7-[4-[(E)-prop-1-enyl]phenyl]-3,6-diazabicyclo[3.1.1]heptane-3-carboxamide
(6R,7R,8R)-8-(hydroxymethyl)-7-[4-[(E)-prop-1-enyl]phenyl]-4-(pyridine-4-carbonyl)-1,4-diazabicyclo[4.2.0]octan-2-one
(6R,7S,8S)-8-(hydroxymethyl)-7-[4-[(E)-prop-1-enyl]phenyl]-4-(pyridine-4-carbonyl)-1,4-diazabicyclo[4.2.0]octan-2-one
(6S,7S,8S)-8-(hydroxymethyl)-7-[4-[(E)-prop-1-enyl]phenyl]-4-(pyridine-4-carbonyl)-1,4-diazabicyclo[4.2.0]octan-2-one
(6S,7R,8R)-8-(hydroxymethyl)-7-[4-[(E)-prop-1-enyl]phenyl]-4-(pyridine-4-carbonyl)-1,4-diazabicyclo[4.2.0]octan-2-one
(2S)-2-[[(2-chlorophenyl)-oxomethyl]amino]-3-methylbutanoic acid (3-cyano-4-imino-2-oxopentyl) ester
C18H20ClN3O4 (377.1142270000001)
ethyl 2-[(4E)-4-[[4-(dimethylamino)phenyl]methylidene]-5-oxo-1-phenylpyrazol-3-yl]acetate
(8aR)-2-(1-benzothiophen-2-ylmethyl)-7-benzyl-5,6,8,8a-tetrahydro-1H-imidazo[1,5-a]pyrazin-3-one
C22H23N3OS (377.15617480000003)
4,7-DI(Para-ethoxyphenyl)-1,2,5-thiadiazolo(3,4-C)pyridine
C21H19N3O2S (377.11979140000005)
2-(2-Trimethylsilyloxyethoxy)-4-quinolinecarboxylic acid trimethylsilyl ester
3-[2-(4-Fluorophenyl)ethylamino]-1-methyl-4-(2-methyl-1H-indol-3-yl)pyrrole-2,5-dione
Adaptaquin
Adaptaquin is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PHD2), with an IC50 of 2 μM. Adaptaquin can inhibit lipid peroxidation and maintain mitochondrial function[1][2].
CBiPES
C21H19N3O2S (377.11979140000005)
CBiPES is a potent mGlu2 positive allosteric modulator with an EC50 value of 92.8 nM. CBiPES attenuates stress-induced hyperthermia and Phencyclidine-induced hyperlocomotor activity. CBiPES can be used for research of neurological diseases[1][2].
CCT128930 (hydrochloride)
CCT128930 hydrochloride is a potent and selective inhibitor of AKT (IC50=6 nM). CCT128930 hydrochloride has 28-fold selectivity over the closely related PKA kinase (IC50=168 nM) through the targeting of Met282 of AKT (Met173 of PKA-AKT chimera), as well as 20-fold selectivity over p70S6K (IC50=120 nM). CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. Antitumor activity[1][2].
H3R antagonist 1 (hydrochloride)
H3R antagonist 1 hydrochloride is a histamine receptor 3 (H3R) inverse agonist extracted from patent WO2013107336A1, compound example 2.
mGluR2 antagonist 1
C21H16FN3O3 (377.11756379999997)
mGluR2 antagonist 1 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC50 of 9 nM) with excellent brain permeability[1].
MLS-573151
C21H19N3O2S (377.11979140000005)
MLS-573151 (MLS000573151) is a selective GTPase Cdc42 inhibitor with an EC50 of 2 μM. MLS-573151 is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2 and RhoA wild-type. MLS-573151 acts by blocking the binding of GTP to Cdc42[1][2].
n-{2-[5-(4-hydroxyphenyl)-1-methyl-4,8-dioxo-7h-pyrrolo[3,2-f]indol-3-yl]ethyl}-n-methylformamide
C21H19N3O4 (377.13754940000007)
(23r)-12,13-dimethoxy-5,7-dioxa-19-azahexacyclo[15.7.0.0²,¹⁰.0⁴,⁸.0¹¹,¹⁶.0¹⁹,²³]tetracosa-1(17),2(10),3,8,11(16),12,14-heptaene
C23H23NO4 (377.16269980000004)
(1s,4r)-4-benzyl-3,10-dihydroxy-1-(sec-butyl)-1h,4h-pyrazino[2,1-b]quinazolin-6-one
(2s,3r,4r,5r,6s)-2-({6-[(z)-(hydroxyimino)methyl]-[2,2'-bipyridin]-3-yl}oxy)-6-methyloxane-3,4,5-triol
2-[(23s)-24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.0²,¹⁰.0⁴,⁸.0¹⁴,²².0¹⁷,²¹]tetracosa-1(13),2,4(8),9,11,14,16,21-octaen-23-yl]ethanol
C22H19NO5 (377.12631640000006)