SB 203580 (BioDeep_00000391340)
代谢物信息卡片
4-[4-(4-fluorophenyl)-2-[4-methylsulfinyl)phenyl]-1H-imidazol-5-yl]-pyridine
化学式: C21H16FN3OS (377.0998058)
中文名称: SB 203580(DMSO溶液), 4-(4-氟苯基)-2-(4-甲基亚磺酰基苯基)-5-(4-吡啶基)-1H-咪唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F
InChI: InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
描述信息
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
C308 - Immunotherapeutic Agent
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:90705
- PubChem: 176155
- Metlin: METLIN45450
- ChEMBL: CHEMBL10
- CAS: 152121-47-6
- PMhub: MS000241537
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hao Chai, Fangfang Xu, Jixia Wang, Yuxin Zhang, Xiaomin Xie, Han Zhou, Yanfang Liu, Xinmiao Liang, Aoxue Wang. Profiling CCR3 target pathways for discovering novel antagonists from natural products using label-free cell phenotypic assays.
Chemico-biological interactions.
2023 Nov; 385(?):110732. doi:
10.1016/j.cbi.2023.110732. [PMID: 37788752] - Ruyang Yu, Jia Zhong, Qilyu Zhou, Wei Ren, Zhongjie Liu, Yifei Bian. Kaempferol prevents angiogenesis of rat intestinal microvascular endothelial cells induced by LPS and TNF-α via inhibiting VEGF/Akt/p38 signaling pathways and maintaining gut-vascular barrier integrity.
Chemico-biological interactions.
2022 Oct; 366(?):110135. doi:
10.1016/j.cbi.2022.110135. [PMID: 36049518] - Yanli Liu, Xia Gong, Juan Wang, Yongxiang Wang, Yong Zhang, Tao Li, Juan Yan, Min Zhou, Benzhong Zhang. Investigation of nickel sulfate-induced cytotoxicity and underlying toxicological mechanisms in human umbilical vein endothelial cells through oxidative stress, inflammation, apoptosis, and MAPK signaling pathways.
Environmental toxicology.
2022 Aug; 37(8):2058-2071. doi:
10.1002/tox.23550. [PMID: 35499276] - Yuan Lin, Kanjana Wongkrajang, Xiaofei Shen, Ping Wang, Zongyuan Zhou, Thipphawan Chuprajob, Nilubon Sornkaew, Na Yang, Lijuan Yang, Xiaoxia Lu, Ratchanaporn Chokchaisiri, Apichart Suksamrarn, Guolin Zhang, Fei Wang. Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo.
Bioorganic & medicinal chemistry.
2022 07; 66(?):116811. doi:
10.1016/j.bmc.2022.116811. [PMID: 35576655] - Meng-Yuan Qin, Song-Qing Huang, Xiao-Qin Zou, Xiao-Bin Zhong, Yu-Fang Yang, Yu-Ting Zhang, Zheng-Cheng Mi, Yan-Song Zhang, Zhen-Guang Huang. Drug-containing serum of rhubarb-astragalus capsule inhibits the epithelial-mesenchymal transformation of HK-2 by downregulating TGF-β1/p38MAPK/Smad2/3 pathway.
Journal of ethnopharmacology.
2021 Nov; 280(?):114414. doi:
10.1016/j.jep.2021.114414. [PMID: 34314804] - Ziyin Li, Huiqin Chi, Wei Zhu, Guangyu Yang, Jia Song, Lijun Mo, Yitian Zhang, Yudi Deng, Feifei Xu, Jiani Yang, Zhini He, Xingfen Yang. Cadmium induces renal inflammation by activating the NLRP3 inflammasome through ROS/MAPK/NF-κB pathway in vitro and in vivo.
Archives of toxicology.
2021 Nov; 95(11):3497-3513. doi:
10.1007/s00204-021-03157-2. [PMID: 34510229] - Chin-Yi Cheng, Hui-Chi Huang, Shung-Te Kao, Yu-Chen Lee. Angelica sinensis extract promotes neuronal survival by enhancing p38 MAPK-mediated hippocampal neurogenesis and dendritic growth in the chronic phase of transient global cerebral ischemia in rats.
Journal of ethnopharmacology.
2021 Oct; 278(?):114301. doi:
10.1016/j.jep.2021.114301. [PMID: 34090910] - Tomoyuki Hioki, Haruhiko Tokuda, Kumiko Tanabe, Woo Kim, Junko Tachi, Shinobu Yamaguchi, Rie Matsushima-Nishiwaki, Osamu Kozawa, Hiroki Iida. Amplification by tramadol of PGD2-induced osteoprotegerin synthesis in osteoblasts: Involvement of μ-opioid receptor and 5-HT transporter.
Prostaglandins, leukotrienes, and essential fatty acids.
2021 09; 172(?):102323. doi:
10.1016/j.plefa.2021.102323. [PMID: 34392133] - Yinan Guo, Weikai Hu, Xueyan Wang, Chunyun Li, Tianyu Cui, Ruixia Liu, Junqi He, Chenghong Yin. PSD-95 protects the pancreas against pathological damage through p38 MAPK signaling pathway in acute pancreatitis.
Experimental biology and medicine (Maywood, N.J.).
2021 07; 246(13):1473-1482. doi:
10.1177/15353702211003293. [PMID: 33794695] - Nivedita Banerjee, Hui Wang, Gangduo Wang, Paul J Boor, M Firoze Khan. Redox-sensitive Nrf2 and MAPK signaling pathways contribute to trichloroethene-mediated autoimmune disease progression.
Toxicology.
2021 06; 457(?):152804. doi:
10.1016/j.tox.2021.152804. [PMID: 33930529] - Jiacheng Zhang, Fangchao Mei, Liang Zhao, Teng Zuo, Yupu Hong, Man Li, Jia Yu, Weixing Wang. Inhibition of the p38 MAPK pathway attenuates renal injury in pregnant rats with acute necrotizing pancreatitis.
Immunologic research.
2021 06; 69(3):295-306. doi:
10.1007/s12026-021-09195-3. [PMID: 33988814] - Xueshan Wen, Xing Zhang, Shulan Qu, Xugang Chen, Cheng Liu, Yifu Yang. Coptisine induces G2/M arrest in esophageal cancer cell via the inhibition of p38/ERK1/2/claudin-2 signaling pathway.
Die Pharmazie.
2021 05; 76(5):202-207. doi:
10.1691/ph.2021.1353. [PMID: 33964993] - Jinyu Li, Qi Sun, Chenying Zheng, Chunxiao Bai, Chuyin Liu, Xueqian Zhao, Peiying Deng, Limin Chai, Yusong Jia. Lipoxin A4-Mediated p38 MAPK Signaling Pathway Protects Mice Against Collagen-Induced Arthritis.
Biochemical genetics.
2021 Feb; 59(1):346-365. doi:
10.1007/s10528-020-10016-9. [PMID: 33221976] - Alexandre Bergeron, Andra Brezai, Rami Shukr, Louis Villeneuve, Bruce G Allen, Wasay M S Qureshi, Kathryn E Hentges, Angelino Calderone. Filamentous nestin and nonmuscle myosin IIB are associated with a migratory phenotype in neonatal rat cardiomyocytes.
Journal of cellular physiology.
2021 02; 236(2):1281-1294. doi:
10.1002/jcp.29934. [PMID: 32654195] - Qiongtao Song, Ying Zhao, Yanrong Yang, Xue Han, Junguo Duan. Astragaloside IV protects against retinal iron overload toxicity through iron regulation and the inhibition of MAPKs and NF-κB activation.
Toxicology and applied pharmacology.
2021 01; 410(?):115361. doi:
10.1016/j.taap.2020.115361. [PMID: 33285147] - Xiaobin Fang, Jingyi Li, Xuechao Hao, Weiyi Zhang, Jie Zhong, Tao Zhu, Ren Liao. Exosomes From Packed Red Cells Induce Human Mast Cell Activation and the Production of Multiple Inflammatory Mediators.
Frontiers in immunology.
2021; 12(?):677905. doi:
10.3389/fimmu.2021.677905. [PMID: 34025676] - Takato Takenouchi, Takeya Morozumi, Emi Wada, Shunichi Suzuki, Yasutaka Nishiyama, Shin Sukegawa, Hirohide Uenishi. Dexamethasone enhances CD163 expression in porcine IPKM immortalized macrophages.
In vitro cellular & developmental biology. Animal.
2021 Jan; 57(1):10-16. doi:
10.1007/s11626-020-00535-5. [PMID: 33447967] - Dongya Chai, Jiaqi Yuan, Xiang Zhu, Yueqin Zeng, Rongrong Yang, Yingjie Chen, Yuehu Wang, Yiping Zhou. Total Saponins from Paris forrestii Reverse Multidrug Resistance of MCF-7/ADM Cells by Suppression of P-gp via ERK Signaling Pathway.
Biological & pharmaceutical bulletin.
2020 Dec; 43(12):1823-1830. doi:
10.1248/bpb.b20-00014. [PMID: 32963175] - Asres Berhan, Trudi Harris, Jade Jaffar, Fernando Jativa, Shenna Langenbach, Ingrid Lönnstedt, Monther Alhamdoosh, Milica Ng, Peter Lee, Glen Westall, Nick Wilson, Michael Wilson, Alastair G Stewart. Cellular Microenvironment Stiffness Regulates Eicosanoid Production and Signaling Pathways.
American journal of respiratory cell and molecular biology.
2020 12; 63(6):819-830. doi:
10.1165/rcmb.2020-0227oc. [PMID: 32926636] - Jue Jia, Fan Yu, Yuyun Xiong, Weiping Wei, Hong Ma, Fulvio Nisi, Xu Song, Ling Yang, Dong Wang, Guoyue Yuan, Hongwen Zhou. Chemerin enhances the adhesion and migration of human endothelial progenitor cells and increases lipid accumulation in mice with atherosclerosis.
Lipids in health and disease.
2020 Sep; 19(1):207. doi:
10.1186/s12944-020-01378-5. [PMID: 32951592] - Changyan Xiao, Chang Xu, Ningning He, Yang Liu, Yan Wang, Manman Zhang, Kaihua Ji, Liqing Du, Jinhan Wang, Qin Wang, Qiang Liu. Atractylenolide II prevents radiation damage via MAPKp38/Nrf2 signaling pathway.
Biochemical pharmacology.
2020 07; 177(?):114007. doi:
10.1016/j.bcp.2020.114007. [PMID: 32360309] - Bharath Kumar Velmurugan, Jen-Tsun Lin, B Mahalakshmi, Yi-Ching Chuang, Chia-Chieh Lin, Yu-Sheng Lo, Ming-Ju Hsieh, Mu-Kuan Chen. Luteolin-7-O-Glucoside Inhibits Oral Cancer Cell Migration and Invasion by Regulating Matrix Metalloproteinase-2 Expression and Extracellular Signal-Regulated Kinase Pathway.
Biomolecules.
2020 03; 10(4):. doi:
10.3390/biom10040502. [PMID: 32224968] - Yuting Cheng, Fang Sun, Luyao Wang, Minjun Gao, Youli Xie, Yu Sun, Huan Liu, Yufeng Yuan, Wei Yi, Zan Huang, Huan Yan, Ke Peng, Yingliang Wu, Zhijian Cao. Virus-induced p38 MAPK activation facilitates viral infection.
Theranostics.
2020; 10(26):12223-12240. doi:
10.7150/thno.50992. [PMID: 33204339] - Jung Hyun Park, Ji-Young Choi, Chulman Jo, Young Ho Koh. Involvement of ADAM10 in acrolein-induced astrocytic inflammation.
Toxicology letters.
2020 Jan; 318(?):44-49. doi:
10.1016/j.toxlet.2019.10.005. [PMID: 31639409] - Mohammed I El-Gamal, Hanan S Anbar, Hamadeh Tarazi, Chang-Hyun Oh. Discovery of a potent p38α/MAPK14 kinase inhibitor: Synthesis, in vitro/in vivo biological evaluation, and docking studies.
European journal of medicinal chemistry.
2019 Dec; 183(?):111684. doi:
10.1016/j.ejmech.2019.111684. [PMID: 31520926] - Hui-Ning Fan, Wei Chen, Li-Na Fan, Jing-Tong Wu, Jin-Shui Zhu, Jing Zhang. Macrophages-derived p38α promotes the experimental severe acute pancreatitis by regulating inflammation and autophagy.
International immunopharmacology.
2019 Dec; 77(?):105940. doi:
10.1016/j.intimp.2019.105940. [PMID: 31655340] - Juan P García-López, Cristian Vilos, Carmen G Feijóo. Zebrafish, a model to develop nanotherapeutics that control neutrophils response during inflammation.
Journal of controlled release : official journal of the Controlled Release Society.
2019 11; 313(?):14-23. doi:
10.1016/j.jconrel.2019.10.005. [PMID: 31622693] - Minhong Xiang, Lijuan Mo, Yueping Zhan, Hang Wen, Huanming Zhou, Wanhong Miao. P38-Mediated Cellular Senescence in Conjunctivochalasis Fibroblasts.
Investigative ophthalmology & visual science.
2019 11; 60(14):4643-4651. doi:
10.1167/iovs.19-27617. [PMID: 31682715] - Shuqing Cui, Qing Nian, Gang Chen, Xingyong Wang, Jinying Zhang, Jianqing Qiu, Zhiqiang Zhang. Ghrelin ameliorates A549 cell apoptosis caused by paraquat via p38-MAPK regulated mitochondrial apoptotic pathway.
Toxicology.
2019 10; 426(?):152267. doi:
10.1016/j.tox.2019.152267. [PMID: 31381934] - Yang Ding, Xiaoqiang Li. Resistin Promotes Thrombosis in Rats with Deep Vein Thrombosis via Up-Regulating MMP-2, MMP-9, and PAI-1.
Clinical laboratory.
2019 Oct; 65(10):. doi:
10.7754/clin.lab.2019.181119. [PMID: 31625370] - Nian Zhang, Yi Jiang, Fangxiang Mu, Hong Wu, Qingxia You. Gentiopicrin exerts anti-rheumatic effect in human fibroblast-like synoviocytes via inhibition of p38MAPK/NF-κB pathway.
Cellular and molecular biology (Noisy-le-Grand, France).
2019 Aug; 65(6):85-90. doi:
. [PMID: 31472052] - Woo Kim, Haruhiko Tokuda, Tetsu Kawabata, Kazuhiko Fujita, Go Sakai, Daiki Nakashima, Junko Tachi, Gen Kuroyanagi, Rie Matsushima-Nishiwaki, Kumiko Tanabe, Takanobu Otsuka, Hiroki Iida, Osamu Kozawa. Enhancement by HSP90 inhibitor of PGD2-stimulated HSP27 induction in osteoblasts: Suppression of SAPK/JNK and p38 MAP kinase.
Prostaglandins & other lipid mediators.
2019 08; 143(?):106327. doi:
10.1016/j.prostaglandins.2019.03.002. [PMID: 30946899] - Wenxia Zhong, Bin Fan, Huiying Cong, Tianyu Wang, Jianqiu Gu. Oleic acid-induced perilipin 5 expression and lipid droplets formation are regulated by the PI3K/PPARα pathway in HepG2 cells.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.
2019 Aug; 44(8):840-848. doi:
10.1139/apnm-2018-0729. [PMID: 31274012] - Ganlin Zhu, Yiming Liu, Ye Zhi, Yang Jin, Jinlong Li, Weiwei Shi, Yuting Liu, Yu Han, Shali Yu, Junkang Jiang, Xinyuan Zhao. PKA- and Ca2+-dependent p38 MAPK/CREB activation protects against manganese-mediated neuronal apoptosis.
Toxicology letters.
2019 Jul; 309(?):10-19. doi:
10.1016/j.toxlet.2019.04.004. [PMID: 30951808] - Phi-Long Tran, Okwha Kim, Huynh Nguyen Khanh Tran, Manh Hung Tran, Byung-Sun Min, Cheol Hwangbo, Jeong-Hyung Lee. Protective effects of extract of Cleistocalyx operculatus flower buds and its isolated major constituent against LPS-induced endotoxic shock by activating the Nrf2/HO-1 pathway.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2019 Jul; 129(?):125-137. doi:
10.1016/j.fct.2019.04.035. [PMID: 31029725] - You-Dong Wan, Rui-Xue Zhu, Zhong-Zheng Bian, Xin-Ting Pan. Improvement of Gut Microbiota by Inhibition of P38 Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Rats with Severe Acute Pancreatitis.
Medical science monitor : international medical journal of experimental and clinical research.
2019 06; 25(?):4609-4616. doi:
10.12659/msm.914538. [PMID: 31226101] - Yiming Qian, Fenghua Qian, Weiwei Zhang, Lei Zhao, Mengwen Shen, Chunlei Ding, Jian Guo. Shengjiang Powder ameliorates myocardial injury in septic rats by downregulating the phosphorylation of P38-MAPK.
Journal of biosciences.
2019 Jun; 44(2):. doi:
10.1007/s12038-019-9857-7. [PMID: 31180053] - Kyoung-Jae Won, Joo-Seop Park, Hyunyoung Jeong. Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid.
Journal of lipid research.
2019 04; 60(4):794-804. doi:
10.1194/jlr.m088880. [PMID: 30709899] - Katsuhiro Uzawa, Atsushi Kasamatsu, Tomoaki Saito, Akihiro Kita, Yuki Sawai, Yuriko Toeda, Kazuyuki Koike, Dai Nakashima, Yosuke Endo, Masashi Shiiba, Yuichi Takiguchi, Hideki Tanzawa. Growth suppression of human oral cancer cells by candidate agents for cetuximab-side effects.
Experimental cell research.
2019 03; 376(2):210-220. doi:
10.1016/j.yexcr.2019.01.016. [PMID: 30690028] - Hsin-Hung Lin, Yu-Chi King, Yu-Chi Li, Chih-Ching Lin, Yu-Chi Chen, Jeng-Shane Lin, Shih-Tong Jeng. The p38-like MAP kinase modulated H2O2 accumulation in wounding signaling pathways of sweet potato.
Plant science : an international journal of experimental plant biology.
2019 Mar; 280(?):305-313. doi:
10.1016/j.plantsci.2018.12.011. [PMID: 30824008] - Xiaoyang Xia, Xia Xiang, Fenghong Huang, Mingming Zheng, Zhen Zhang, Ling Han. Dietary canolol induces apoptosis in human cervical carcinoma HeLa cells through ROS-MAPK mediated mitochondrial signaling pathway: In vitro and in vivo.
Chemico-biological interactions.
2019 Feb; 300(?):138-150. doi:
10.1016/j.cbi.2019.01.016. [PMID: 30653946] - Shao-Hui Hu, Yi Guang, Wei-Xing Wang. Protective Effects of Calcitonin Gene-Related Peptide-Mediated p38 Mitogen-Activated Protein Kinase Pathway on Severe Acute Pancreatitis in Rats.
Digestive diseases and sciences.
2019 02; 64(2):447-455. doi:
10.1007/s10620-018-5345-4. [PMID: 30370491] - Yu Zhou, Hongmiao Xia, Liang Zhao, Fangchao Mei, Man Li, Yundong You, Kailiang Zhao, Weixing Wang. SB203580 attenuates acute lung injury and inflammation in rats with acute pancreatitis in pregnancy.
Inflammopharmacology.
2019 Feb; 27(1):99-107. doi:
10.1007/s10787-018-0522-9. [PMID: 30094758] - Ji Hye Yang, Moon-Hee Choi, Chang-Su Na, Sam Seok Cho, Jae Hoon Kim, Sae Kwang Ku, Il Je Cho, Hyun-Jae Shin, Sung Hwan Ki. Bamboo Stems (Phyllostachys nigra variety henosis) Containing Polyphenol Mixtures Activate Nrf2 and Attenuate Phenylhydrazine-Induced Oxidative Stress and Liver Injury.
Nutrients.
2019 Jan; 11(1):. doi:
10.3390/nu11010114. [PMID: 30626086] - H-D Lu, Z-C Liu, L-Y Zhou, J Zhou, X-R Feng, B Wang. Influence of the TLR4-mediated p38MAPK signaling pathway on chronic intermittent hypoxic-induced rat's oxidative stress and inflammatory cytokines in rats.
European review for medical and pharmacological sciences.
2019 Jan; 23(1):352-360. doi:
10.26355/eurrev_201901_16783. [PMID: 30657577] - Hyun-Keun Kim, Seonung Lim, Min-Jung Bae, Wonwoo Lee, Sunyoung Kim. PG102 Upregulates IL-37 through p38, ERK, and Smad3 Pathways in HaCaT Keratinocytes.
Mediators of inflammation.
2019; 2019(?):6085801. doi:
10.1155/2019/6085801. [PMID: 30918469] - Tawfik Addi, Stéphane Poitevin, Nathalie McKay, Kamel Eddine El Mecherfi, Omar Kheroua, Noémie Jourde-Chiche, Alix de Macedo, Bertrand Gondouin, Claire Cerini, Philippe Brunet, Françoise Dignat-George, Stéphane Burtey, Laetitia Dou. Mechanisms of tissue factor induction by the uremic toxin indole-3 acetic acid through aryl hydrocarbon receptor/nuclear factor-kappa B signaling pathway in human endothelial cells.
Archives of toxicology.
2019 01; 93(1):121-136. doi:
10.1007/s00204-018-2328-3. [PMID: 30324315] - Xiaxia Wu, Hongwei Gao, Ying Hou, Jie Yu, Wen Sun, Ying Wang, Xiaoyan Chen, Yulin Feng, Qiong-Ming Xu, Xiuping Chen. Dihydronortanshinone, a natural product, alleviates LPS-induced inflammatory response through NF-κB, mitochondrial ROS, and MAPK pathways.
Toxicology and applied pharmacology.
2018 09; 355(?):1-8. doi:
10.1016/j.taap.2018.06.007. [PMID: 29906494] - Guorong Wen, Shili Deng, Wenfeng Song, Hai Jin, Jingyu Xu, Xuemei Liu, Rui Xie, Penghong Song, Biguang Tuo. Helicobacter pylori infection downregulates duodenal CFTR and SLC26A6 expressions through TGFβ signaling pathway.
BMC microbiology.
2018 08; 18(1):87. doi:
10.1186/s12866-018-1230-8. [PMID: 30119655] - Congrui Fu, Na Li, Yujia Yuan, Ri Wang, Jinting Chen, Jing Yang, Zan Guo, Sheng Wang, Yi Zhang, Yixian Liu, Jinghui Dong. Chronic intermittent hypobaric hypoxia provides vascular protection in the aorta of the 2-kidney, 1-clip rat model of hypertension.
Canadian journal of physiology and pharmacology.
2018 Aug; 96(8):807-814. doi:
10.1139/cjpp-2017-0356. [PMID: 29400080] - Marie-Christin Schulz, Luise Schumann, Ulrike Rottkord, Hans-Ulrich Humpf, Michael Gekle, Gerald Schwerdt. Synergistic action of the nephrotoxic mycotoxins ochratoxin A and citrinin at nanomolar concentrations in human proximal tubule-derived cells.
Toxicology letters.
2018 Jul; 291(?):149-157. doi:
10.1016/j.toxlet.2018.04.014. [PMID: 29673704] - Liming Hong, Sha Peng, Ying Li, Ying Fang, Qin Wang, Christian Klausen, Chenghong Yin, Shuyu Wang, Peter C K Leung, Xiaokui Yang. miR-106a Increases Granulosa Cell Viability and Is Downregulated in Women With Diminished Ovarian Reserve.
The Journal of clinical endocrinology and metabolism.
2018 06; 103(6):2157-2166. doi:
10.1210/jc.2017-02344. [PMID: 29590425] - Liying Shi, Haihong Qin, Xudong Jin, Xiuxiu Yang, Xuan Lu, Huiguo Wang, Ruoyu Wang, Dayong Yu, Baomin Feng. The natural phenolic peperobtusin A induces apoptosis of lymphoma U937 cells via the Caspase dependent and p38 MAPK signaling pathways.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jun; 102(?):772-781. doi:
10.1016/j.biopha.2018.03.141. [PMID: 29604597] - Ilavenil Soundharrajan, Da Hye Kim, Srigopalram Srisesharam, Palaniselvam Kuppusamy, Ravikumar Sivanesan, Ki Choon Choi. Limonene promotes osteoblast differentiation and 2-deoxy-d-glucose uptake through p38MAPK and Akt signaling pathways in C2C12 skeletal muscle cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 Jun; 45(?):41-48. doi:
10.1016/j.phymed.2018.03.019. [PMID: 29573911] - Sana Tariq, Ozair Alam, Mohammad Amir. Synthesis, p38α MAP kinase inhibition, anti-inflammatory activity, and molecular docking studies of 1,2,4-triazole-based benzothiazole-2-amines.
Archiv der Pharmazie.
2018 Apr; 351(3-4):e1700304. doi:
10.1002/ardp.201700304. [PMID: 29611883] - Di Zhu, Xue Deng, Xiao-Fei Han, Xiao-Xin Sun, Tao-Wen Pan, Lu-Ping Zheng, Yan-Qiu Liu. Wedelolactone Enhances Osteoblastogenesis through ERK- and JNK-mediated BMP2 Expression and Smad/1/5/8 Phosphorylation.
Molecules (Basel, Switzerland).
2018 Mar; 23(3):. doi:
10.3390/molecules23030561. [PMID: 29498687] - Xin-Hua Xiao, Xiao-Yan Qi, Ya-Di Wang, Li Ran, Jing Yang, Huan-Li Zhang, Can-Xin Xu, Ge-Bo Wen, Jiang-Hua Liu. Zinc alpha2 glycoprotein promotes browning in adipocytes.
Biochemical and biophysical research communications.
2018 02; 496(2):287-293. doi:
10.1016/j.bbrc.2018.01.039. [PMID: 29317208] - Christine Wenz, Dagmar Faust, Berenike Linz, Christian Turmann, Teodora Nikolova, John Bertin, Peter Gough, Peter Wipf, Anna Sophia Schröder, Stefan Krautwald, Cornelia Dietrich. t-BuOOH induces ferroptosis in human and murine cell lines.
Archives of toxicology.
2018 Feb; 92(2):759-775. doi:
10.1007/s00204-017-2066-y. [PMID: 28975372] - Linlin Zhang, Qinghe Meng, Natesh Yepuri, Guirong Wang, Xiuming Xi, Robert N Cooney. Surfactant Proteins-A and -D Attenuate LPS-Induced Apoptosis in Primary Intestinal Epithelial Cells (IECs).
Shock (Augusta, Ga.).
2018 Jan; 49(1):90-98. doi:
10.1097/shk.0000000000000919. [PMID: 28591009] - Elena Alcalde-Estévez, Ana I Arroba, Elena M Sánchez-Fernández, Carmen Ortiz Mellet, Jose M García Fernández, Laura Masgrau, Ángela M Valverde. The sp2-iminosugar glycolipid 1-dodecylsulfonyl-5N,6O-oxomethylidenenojirimycin (DSO2-ONJ) as selective anti-inflammatory agent by modulation of hemeoxygenase-1 in Bv.2 microglial cells and retinal explants.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2018 Jan; 111(?):454-466. doi:
10.1016/j.fct.2017.11.050. [PMID: 29191728] - Jinhua Zhang, Daqiang Zhao, Ning Na, Heng Li, Bin Miao, Liangqing Hong, Zhengyu Huang. Renoprotective effect of erythropoietin via modulation of the STAT6/MAPK/NF-κB pathway in ischemia/reperfusion injury after renal transplantation.
International journal of molecular medicine.
2018 Jan; 41(1):25-32. doi:
10.3892/ijmm.2017.3204. [PMID: 29115389] - Jie Liu, Yuzhang Zhu, Shipiao Chen, Bin Shen, Fang Yu, Yi Zhang, Ruilin Shen. Apocynin Attenuates Cobalt Chloride-Induced Pheochromocytoma Cell Apoptosis by Inhibiting P38-MAPK/Caspase-3 Pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 48(1):208-214. doi:
10.1159/000491720. [PMID: 30007963] - Ashutosh Chauhan, Rani Ojha, Deepak K Semwal, Satyendra P Mishra, Ruchi B Semwal. Combined Treatment with CCI779 and SB203580 Induces Cellular Senescence in Renal Cell Carcinoma Cell Line via p53 Pathway.
Anti-cancer agents in medicinal chemistry.
2017 Nov; 17(11):1545-1554. doi:
10.2174/1871520617666170213111002. [PMID: 28270077] - Chun-Sung Sung, Zhi-Hong Wen, Chien-Wei Feng, Chun-Hong Chen, Shi-Ying Huang, Nan-Fu Chen, Wu-Fu Chen, Chih-Shung Wong. Potentiation of spinal glutamatergic response in the neuron-glia interactions underlies the intrathecal IL-1β-induced thermal hyperalgesia in rats.
CNS neuroscience & therapeutics.
2017 Jul; 23(7):580-589. doi:
10.1111/cns.12705. [PMID: 28544775] - Akane Hongo, Naoki Okumura, Makiko Nakahara, EunDuck P Kay, Noriko Koizumi. The Effect of a p38 Mitogen-Activated Protein Kinase Inhibitor on Cellular Senescence of Cultivated Human Corneal Endothelial Cells.
Investigative ophthalmology & visual science.
2017 07; 58(9):3325-3334. doi:
10.1167/iovs.16-21170. [PMID: 28672399] - Yeon Jeong Jang, Bongkyun Park, Hee-Weon Lee, Hye Jin Park, Hyun Jung Koo, Byung Oh Kim, Eun-Hwa Sohn, Sung Hee Um, Suhkneung Pyo. Sinigrin attenuates the progression of atherosclerosis in ApoE-/- mice fed a high-cholesterol diet potentially by inhibiting VCAM-1 expression.
Chemico-biological interactions.
2017 Jun; 272(?):28-36. doi:
10.1016/j.cbi.2017.05.006. [PMID: 28483571] - Hsiao-Hang Chung, Mu-Kuan Chen, Yu-Chao Chang, Shun-Fa Yang, Chia-Chieh Lin, Chiao-Wen Lin. Inhibitory effects of Leucaena leucocephala on the metastasis and invasion of human oral cancer cells.
Environmental toxicology.
2017 Jun; 32(6):1765-1774. doi:
10.1002/tox.22399. [PMID: 28181379] - Hung-Chih Lin, Shih-Li Su, Chia-Yang Lu, Ai-Hsuan Lin, Wan-Chun Lin, Chin-San Liu, Ya-Chen Yang, Hsiu-Miao Wang, Chong-Kuei Lii, Haw-Wen Chen. Andrographolide inhibits hypoxia-induced HIF-1α-driven endothelin 1 secretion by activating Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells.
Environmental toxicology.
2017 Mar; 32(3):918-930. doi:
10.1002/tox.22293. [PMID: 27297870] - Kai-Li Jian, Chao Zhang, Zhi-Chun Shang, Lei Yang, Ling-Yi Kong. Eucalrobusone C suppresses cell proliferation and induces ROS-dependent mitochondrial apoptosis via the p38 MAPK pathway in hepatocellular carcinoma cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2017 Feb; 25(?):71-82. doi:
10.1016/j.phymed.2016.12.014. [PMID: 28190473] - Wei Li, Changyeol Lee, Sung Hee Bang, Jin Yeul Ma, Soonok Kim, Young-Sang Koh, Sang Hee Shim. Isochromans and Related Constituents from the Endophytic Fungus Annulohypoxylon truncatum of Zizania caduciflora and Their Anti-Inflammatory Effects.
Journal of natural products.
2017 01; 80(1):205-209. doi:
10.1021/acs.jnatprod.6b00698. [PMID: 28009172] - Yong-Tao Xiao, Wei-Hui Yan, Yi Cao, Jun-Kai Yan, Wei Cai. P38 MAPK Pharmacological Inhibitor SB203580 Alleviates Total Parenteral Nutrition-Induced Loss of Intestinal Barrier Function but Promotes Hepatocyte Lipoapoptosis.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 41(2):623-634. doi:
10.1159/000457933. [PMID: 28214831] - Lei Tian, Xinghua Shao, Yuanyuan Xie, Qin Wang, Xiajing Che, Minfang Zhang, Weijia Xu, Yao Xu, Shan Mou, Zhaohui Ni. Kidney Injury Molecule-1 is Elevated in Nephropathy and Mediates Macrophage Activation via the Mapk Signalling Pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 41(2):769-783. doi:
10.1159/000458737. [PMID: 28214834] - Man Yang, Ling Wang, Li-Jie Gu, Wei-Jie Yuan. Helicobacter pylori cytotoxin-associated gene A impairs the filtration barrier function of podocytes via p38 MAPK signaling pathway.
Acta biochimica Polonica.
2017; 64(3):471-475. doi:
10.18388/abp.2016_1322. [PMID: 28803254] - Xincai Zhang, Jinqin Chen, Shixun Wang. Serum Amyloid A Induces a Vascular Smooth Muscle Cell Phenotype Switch through the p38 MAPK Signaling Pathway.
BioMed research international.
2017; 2017(?):4941379. doi:
10.1155/2017/4941379. [PMID: 28642873] - Jing-Yi Zhang, Gui-Bo Sun, Yun Luo, Min Wang, Wei Wang, Yu-Yang Du, Ying-Li Yu, Xiao-Bo Sun. Salvianolic Acid A Protects H9c2 Cells from Arsenic Trioxide-Induced Injury via Inhibition of the MAPK Signaling Pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 41(5):1957-1969. doi:
10.1159/000472409. [PMID: 28391263] - Yuanyuan Wang, Juan Zhang, Lian Zhang, Ping Gao, Xiaoyan Wu. Adiponectin attenuates high glucose-induced apoptosis through the AMPK/p38 MAPK signaling pathway in NRK-52E cells.
PloS one.
2017; 12(5):e0178215. doi:
10.1371/journal.pone.0178215. [PMID: 28542560] - Ilona Schelle, Janina Bruening, Mareike Buetepage, Harald Genth. Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B.
Toxins.
2016 12; 9(1):. doi:
10.3390/toxins9010002. [PMID: 28025502] - Fang Gao, Yanping Wang, Shulin Li, Zhuojun Wang, Caixia Liu, Dong Sun. Inhibition of p38 mitogen-activated protein kinases attenuates renal interstitial fibrosis in a murine unilateral ureteral occlusion model.
Life sciences.
2016 Dec; 167(?):78-84. doi:
10.1016/j.lfs.2016.10.022. [PMID: 27773718] - Lin Wang, Xiaofan Hu, Xiangyu Ma, Zhensheng Ma, Yang Zhang, Yizhao Lu, Xiang Li, Wei Lei, Yafei Feng. Promotion of osteointegration under diabetic conditions by tantalum coating-based surface modification on 3-dimensional printed porous titanium implants.
Colloids and surfaces. B, Biointerfaces.
2016 Dec; 148(?):440-452. doi:
10.1016/j.colsurfb.2016.09.018. [PMID: 27648775] - Ya-Jing Feng, Yong-Yu Li, Xu-Hong Lin, Kun Li, Ming-Hua Cao. Anti-inflammatory effect of cannabinoid agonist WIN55, 212 on mouse experimental colitis is related to inhibition of p38MAPK.
World journal of gastroenterology.
2016 Nov; 22(43):9515-9524. doi:
10.3748/wjg.v22.i43.9515. [PMID: 27920472] - Bo Gao, Wang Sun, Xianzhi Meng, Dongbo Xue, Weihui Zhang. Screening of differentially expressed protein kinases in bone marrow endothelial cells and the protective effects of the p38a inhibitor SB203580 on bone marrow in liver fibrosis.
Molecular medicine reports.
2016 Nov; 14(5):4629-4637. doi:
10.3892/mmr.2016.5837. [PMID: 27748901] - Jun-Yu Ke, Wu Zhang, Rui-Song Gong, Wan-Jing Cen, Hui-Qun Huang, Ye-Rong Li, Wei-Dong Kong, Jian-Wei Jiang. A monomer purified from Paris polyphylla (PP-22) triggers S and G2/M phase arrest and apoptosis in human tongue squamous cell carcinoma SCC-15 by activating the p38/cdc25/cdc2 and caspase 8/caspase 3 pathways.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.
2016 Nov; 37(11):14863-14872. doi:
10.1007/s13277-016-5376-4. [PMID: 27644244] - Michael M Chen, Eileen B O'Halloran, Jill A Shults, Elizabeth J Kovacs. Kupffer Cell p38 Mitogen-Activated Protein Kinase Signaling Drives Postburn Hepatic Damage and Pulmonary Inflammation When Alcohol Intoxication Precedes Burn Injury.
Critical care medicine.
2016 10; 44(10):e973-9. doi:
10.1097/ccm.0000000000001817. [PMID: 27322363] - Gregory W Thomas, Leonard T Rael, Melissa Hausburg, Elizabeth D Frederick, Edward Brody, David Bar-Or. The low molecular weight fraction of commercial human serum albumin induces acetylation of α-tubulin and reduces transcytosis in retinal endothelial cells.
Biochemical and biophysical research communications.
2016 09; 478(4):1780-5. doi:
10.1016/j.bbrc.2016.09.026. [PMID: 27613088] - Naoyuki Kawao, Masato Yano, Yukinori Tamura, Katsumi Okumoto, Kiyotaka Okada, Hiroshi Kaji. Role of osteoclasts in heterotopic ossification enhanced by fibrodysplasia ossificans progressiva-related activin-like kinase 2 mutation in mice.
Journal of bone and mineral metabolism.
2016 Sep; 34(5):517-25. doi:
10.1007/s00774-015-0701-3. [PMID: 26204847] - Xuezhong Gong, Vladimir N Ivanov, Tom K Hei. 2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells.
Archives of toxicology.
2016 Sep; 90(9):2187-2200. doi:
10.1007/s00204-015-1600-z. [PMID: 26404762] - Jeffrey M Wilde, Jonathan P Gumucio, Jeremy A Grekin, Dylan C Sarver, Andrew C Noah, David G Ruehlmann, Max E Davis, Asheesh Bedi, Christopher L Mendias. Inhibition of p38 mitogen-activated protein kinase signaling reduces fibrosis and lipid accumulation after rotator cuff repair.
Journal of shoulder and elbow surgery.
2016 Sep; 25(9):1501-8. doi:
10.1016/j.jse.2016.01.035. [PMID: 27068389] - Li-Li Huang, Xiao-Lin Zhu, Wei-Qian Deng, Na Duan, Xiu-Jie Liang, Yue Wang, Ting-Ting Guo, Shuang-Shuang Shu, Xiao-Hong Xiang, Ting-Ting Jiang, Xun Tang, Jun Zhang. [P38 MAPK signaling pathway mediates advanced oxidation protein product-induced epithelial-to-mesenchymal transition in tubular cells].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2016 Aug; 36(9):1209-1214. doi:
NULL. [PMID: 27687652] - Eun-Yeong Kim, Hee-Jung Choi, Tae-Wook Chung, Jun-Yong Choi, Hyung Sik Kim, Yeon-Seop Jung, Syng-Ook Lee, Ki-Tae Ha. Water-extracted Perilla frutescens increases endometrial receptivity though leukemia inhibitory factor-dependent expression of integrins.
Journal of pharmacological sciences.
2016 Aug; 131(4):259-66. doi:
10.1016/j.jphs.2016.07.004. [PMID: 27562703] - Mingtao Chang, Yang Li, Dong Liu, Lianyang Zhang, Hongguang Zhang, Hao Tang, Huayu Zhang. Melatonin prevents secondary intra-abdominal hypertension in rats possibly through inhibition of the p38 MAPK pathway.
Free radical biology & medicine.
2016 08; 97(?):192-203. doi:
10.1016/j.freeradbiomed.2016.06.001. [PMID: 27264238] - Jia-Wen Zhai, Chang Gao, Wei-Dong Ma, Wei Wang, Li-Ping Yao, Xin-Xin Xia, Meng Luo, Yuan-Gang Zu, Yu-Jie Fu. Geraniin induces apoptosis of human breast cancer cells MCF-7 via ROS-mediated stimulation of p38 MAPK.
Toxicology mechanisms and methods.
2016 Jun; 26(5):311-8. doi:
10.3109/15376516.2016.1139025. [PMID: 27097871] - Yu Zhu, Jin-Tao Liu, Li-Yan Yang, Wen-Pei Du, Xiao-Chun Li, Xiang Qian, Peng-Fei Yu, Jian-Wen Liu, Hong Jiang. p38 mitogen-activated protein kinase inhibition modulates nucleus pulposus cell apoptosis in spontaneous resorption of herniated intervertebral discs: An experimental study in rats.
Molecular medicine reports.
2016 May; 13(5):4001-6. doi:
10.3892/mmr.2016.5039. [PMID: 27035219] - Makoto Shirai, Shingo Arakawa, Munehiro Teranishi, Kiyonori Kai. Decreased hepatic phosphorylated p38 mitogen-activated protein kinase contributes to attenuation of thioacetamide-induced hepatic necrosis in diet-induced obese mice.
The Journal of toxicological sciences.
2016 Apr; 41(2):245-53. doi:
10.2131/jts.41.245. [PMID: 26961609] - Wei Zhang, Yongjun Xie, Weihua Liu, Xuefeng Xu, Xuelian Chen, Hairong Liu, Yueming Liu. Role of Metallothionein in Post-Burn Inflammation.
Inflammation.
2016 Apr; 39(2):768-74. doi:
10.1007/s10753-016-0305-7. [PMID: 26833479] - Sheng-Hua Wu, Xiao-Qing Chen, Jing Lü, Ming-Jie Wang. BML-111 Attenuates Renal Ischemia/Reperfusion Injury Via Peroxisome Proliferator-Activated Receptor-α-Regulated Heme Oxygenase-1.
Inflammation.
2016 Apr; 39(2):611-24. doi:
10.1007/s10753-015-0286-y. [PMID: 26597893] - Nicole A Crowley, Daniel W Bloodgood, J Andrew Hardaway, Alexis M Kendra, Jordan G McCall, Ream Al-Hasani, Nora M McCall, Waylin Yu, Zachary L Schools, Michael J Krashes, Bradford B Lowell, Jennifer L Whistler, Michael R Bruchas, Thomas L Kash. Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit.
Cell reports.
2016 Mar; 14(12):2774-83. doi:
10.1016/j.celrep.2016.02.069. [PMID: 26997280] - Mi-Hee Yu, Syng-Ook Lee. Hydroquinone stimulates cell invasion through activator protein-1-dependent induction of MMP-9 in HepG2 human hepatoma cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2016 Mar; 89(?):120-5. doi:
10.1016/j.fct.2016.01.015. [PMID: 26807887] - Yunpeng Fan, Yuede Jiang, Jianjun Liu, Yongxiang Kang, Ruiqiao Li, Jingyu Wang. The anti-tumor activity and mechanism of alkaloids from Aconitum szechenyianum Gay.
Bioorganic & medicinal chemistry letters.
2016 Jan; 26(2):380-387. doi:
10.1016/j.bmcl.2015.12.006. [PMID: 26711147] - Hee-Jung Choi, Tae-Wook Chung, Mi-Ju Park, Kyu Sup Lee, Youngjin Yoon, Hyung Sik Kim, Jun Hee Lee, Sang-Mo Kwon, Syng-Ook Lee, Keuk-Jun Kim, Jin-Ho Baek, Ki-Tae Ha. Paeonia lactiflora Enhances the Adhesion of Trophoblast to the Endometrium via Induction of Leukemia Inhibitory Factor Expression.
PloS one.
2016; 11(2):e0148232. doi:
10.1371/journal.pone.0148232. [PMID: 26839969]