Talarozole (BioDeep_00000184120)

   

human metabolite blood metabolite


代谢物信息卡片


N-{4-[2-ethyl-1-(1H-1,2,4-triazol-1-yl)butyl]phenyl}-1,3-benzothiazol-2-amine

化学式: C21H23N5S (377.16740780000003)
中文名称: Talarozole
谱图信息: 最多检出来源 Homo sapiens(blood) 99.24%

分子结构信息

SMILES: CCC(CC)C(C1=CC=C(C=C1)NC2=NC3=CC=CC=C3S2)N4C=NC=N4
InChI: InChI=1S/C21H23N5S/c1-3-15(4-2)20(26-14-22-13-23-26)16-9-11-17(12-10-16)24-21-25-18-7-5-6-8-19(18)27-21/h5-15,20H,3-4H2,1-2H3,(H,24,25)

描述信息

C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C274 - Antineoplastic Agent > C129818 - Antineoplastic Hormonal/Endocrine Agent > C481 - Antiestrogen
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C1740 - Aromatase Inhibitor
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist

同义名列表

5 个代谢物同义名

N-{4-[2-ethyl-1-(1H-1,2,4-triazol-1-yl)butyl]phenyl}-1,3-benzothiazol-2-amine; N-(4-(2-Ethyl-1-(1H-1,2,4-triazol-1-yl)butyl)phenyl)-2-benzothiazolamine; Talarozole; Rambazole; R115866



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Faith Stevison, Cathryn Hogarth, Sasmita Tripathy, Travis Kent, Nina Isoherranen. Inhibition of the all-trans Retinoic Acid (atRA) Hydroxylases CYP26A1 and CYP26B1 Results in Dynamic, Tissue-Specific Changes in Endogenous atRA Signaling. Drug metabolism and disposition: the biological fate of chemicals. 2017 07; 45(7):846-854. doi: 10.1124/dmd.117.075341. [PMID: 28446509]
  • Sasmita Tripathy, John D Chapman, Chang Y Han, Cathryn A Hogarth, Samuel L M Arnold, Jennifer Onken, Travis Kent, David R Goodlett, Nina Isoherranen. All-Trans-Retinoic Acid Enhances Mitochondrial Function in Models of Human Liver. Molecular pharmacology. 2016 May; 89(5):560-74. doi: 10.1124/mol.116.103697. [PMID: 26921399]
  • Britta Fritzsche, Jan-Philipp Schuchardt, Anja Schmidt, Heinz Nau, Florian J Schweigert, Ralph Rühl. CYP26A1-specific antagonist influence on embryonic implantation, gene expression and endogenous retinoid concentration in rats. Reproductive toxicology (Elmsford, N.Y.). 2010 Nov; 30(3):446-51. doi: 10.1016/j.reprotox.2010.05.005. [PMID: 20580668]
  • C J Verfaille, C A C B Thissen, H J Bovenschen, J Mertens, P M Steijlen, P C M van de Kerkhof. Oral R115866 in the treatment of moderate to severe plaque-type psoriasis. Journal of the European Academy of Dermatology and Venereology : JEADV. 2007 Sep; 21(8):1038-46. doi: 10.1111/j.1468-3083.2007.02158.x. [PMID: 17714122]
  • P Stoppie, M Borgers, P Borghgraef, L Dillen, J Goossens, G Sanz, H Szel, C Van Hove, G Van Nyen, G Nobels, H Vanden Bossche, M Venet, G Willemsens, J Van Wauwe. R115866 inhibits all-trans-retinoic acid metabolism and exerts retinoidal effects in rodents. The Journal of pharmacology and experimental therapeutics. 2000 Apr; 293(1):304-12. doi: NULL. [PMID: 10734183]