Imidaprilat (BioDeep_00000014090)

 

Secondary id: BioDeep_00000624677

human metabolite Endogenous


代谢物信息卡片


(4S)-1-Methyl-3-{(2S)-2-[N-((1S)-1-carboxy-3-phenylpropyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylic acid

  化学式: C18H23N3O6 (377.1587)
中文名称: 咪达普利拉
  谱图信息: 最多检出来源 Homo sapiens(plant) 0.87%

分子结构信息

SMILES: CC(C(=O)N1C(CN(C1=O)C)C(=O)O)NC(CCC2=CC=CC=C2)C(=O)O
InChI: InChI=1S/C18H23N3O6/c1-11(15(22)21-14(17(25)26)10-20(2)18(21)27)19-13(16(23)24)9-8-12-6-4-3-5-7-12/h3-7,11,13-14,19H,8-10H2,1-2H3,(H,23,24)(H,25,26)/t11-,13-,14-/m0/s1


描述信息

Imidaprilat, is the active metabolite of Imidapril. Imidapril is a prodrug used to treat hypertension, chronic congestive heart failure (CHF), acute myocardial infarction (AMI), and diabetic nephropathy (PMID: 17547476,18192036,12177688, 17094051). Imidapril belongs to a class of long-acting, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitors (PMID: 8851752, 12177688). Imidaprilat competitively binds and inhibits the catalytic activity of ACE, which results in a reduction of peripheral resistance and a reduction in systemic blood pressure (BP) (PMID: 17547476). Imidaprilat is only found in individuals that have used or taken imidapril.
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor

同义名列表

14 个代谢物同义名

(4S)-1-Methyl-3-{(2S)-2-[N-((1S)-1-carboxy-3-phenylpropyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylic acid; (4S)-3-[(2S)-2-{[(1S)-1-carboxy-3-phenylpropyl]amino}propanoyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid; (4S)-1-Methyl-3-{(2S)-2-[N-((1S)-1-carboxy-3-phenylpropyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate; 3-(2-(N-(1-Carboxy-3-phenylpropyl)amino)propionyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid; Imidaprilat, monosodium salt, (4S-(3(r*(r*)),4R*))-isomer; Imidaprilat hydrochloride, (4S-(3(s*(r*)),4R*))-isomer; Imidaprilat hydrochloride, (4S-(3(r*(r*)),4R*)); Imidaprilat, (4S-(3(R(r*)),4R*))-isomer; Imidaprilic acid; Imidaprilatum; Imidaprilate; Imidaprilat; 120294-09-9; 6366a



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Chiari Kojima, Jun Ino, Hideto Ishii, Kosaku Nitta, Masayuki Yoshida. MMP-9 inhibition by ACE inhibitor reduces oxidized LDL-mediated foam-cell formation. Journal of atherosclerosis and thrombosis. 2010 Feb; 17(1):97-105. doi: 10.5551/jat.1685. [PMID: 20093780]
  • K Sakamoto, K Sugimoto, A Fujimura. Different inhibition of enalaprilat and imidaprilat on bradykinin metabolizing enzymes. Life sciences. 2000 Sep; 67(18):2159-65. doi: 10.1016/s0024-3205(00)00812-2. [PMID: 11045597]
  • Y Sasaki, T Noguchi, J Seki, J C Giddings, J Yamamoto. Protective effects of imidapril on He-Ne laser-induced thrombosis in cerebral blood vessels of stroke-prone spontaneously hypertensive rats. Thrombosis and haemostasis. 2000 May; 83(5):722-7. doi: 10.1055/s-0037-1613899. [PMID: 10823269]
  • M Mabuchi, Y Kano, T Fukuyama, T Kondo. Determination of imidapril and imidaprilat in human plasma by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications. 1999 Oct; 734(1):145-53. doi: 10.1016/s0378-4347(99)00346-1. [PMID: 10574200]
  • T Obata, Y Yamanaka. Protective effect of imidaprilat, an angiotensin-converting enzyme inhibitor on *OH generation in rat myocardium. Biochimica et biophysica acta. 1999 Oct; 1472(1-2):62-70. doi: 10.1016/s0304-4165(99)00104-x. [PMID: 10572926]
  • J F Hoogkamer, C H Kleinbloesem, A Nokhodian, M J Ouwerkerk, G Lankhaar, W Ungethüm, W Kirch. Pharmacokinetics of imidapril and its active metabolite imidaprilat following single dose and during steady state in patients with chronic renal failure. European journal of clinical pharmacology. 1998 Mar; 54(1):59-61. doi: 10.1007/s002280050421. [PMID: 9591932]
  • K Yamanaka, N Takehara, K Murata, K Banno, T Sato. Pharmacokinetic and pharmacodynamic study of imidaprilat, an active metabolite of imidapril, a new angiotensin-converting enzyme inhibitor, in spontaneously hypertensive rats. Journal of pharmaceutical and biomedical analysis. 1997 Aug; 15(12):1851-9. doi: 10.1016/s0731-7085(96)02015-8. [PMID: 9278890]
  • S Harder, P A Thürmann. Pharmacokinetic and pharmacodynamic interaction trial after repeated oral doses of imidapril and digoxin in healthy volunteers. British journal of clinical pharmacology. 1997 May; 43(5):475-80. doi: 10.1046/j.1365-2125.1997.00588.x. [PMID: 9159562]
  • J F Hoogkamer, C H Kleinbloesem, A Nokhodian, M J Ouwerkerk, G Lankhaar, W Ungethüm, W Kirch. Pharmacokinetics of imidapril and its active metabolite imidaprilat following single dose and during steady state in patients with impaired liver function. European journal of clinical pharmacology. 1997; 51(6):489-91. doi: 10.1007/s002280050236. [PMID: 9112065]
  • K Yamanaka, N Takehara, K Murata, K Banno, T Sato. Steady-state pharmacokinetics and pharmacodynamics of imidaprilat, an active metabolite of imidapril, a new angiotensin-converting enzyme inhibitor in spontaneously hypertensive rats. Journal of pharmaceutical sciences. 1996 Nov; 85(11):1234-7. doi: 10.1021/js9600033. [PMID: 8923331]
  • K Yamanaka, S Morikawa, K Murata, K Banno, T Sato, T Takai, T Suzuki, M Mizobe, M Ito, K Ishibashi. Radioimmunoassay for imidapril, a new angiotensin-converting enzyme inhibitor, and imidaprilat, its active metabolite, in human plasma and urine. Journal of pharmaceutical and biomedical analysis. 1996 Jan; 14(3):281-7. doi: 10.1016/0731-7085(95)01595-7. [PMID: 8851752]
  • K Tagawa, M Mizobe, K Noda. A saturable tissue-angiotensin I converting enzyme (ACE) binding model for the pharmacokinetic analysis of imidapril, a new ACE inhibitor, and its active metabolite in human. Biological & pharmaceutical bulletin. 1995 Jan; 18(1):64-9. doi: 10.1248/bpb.18.64. [PMID: 7735253]
  • N Ogiku, H Sumikawa, R Ishida. No relation of the suppressive effect on the sympathetic nervous system to the acute hypotension caused by imidapril and enalapril. Japanese journal of pharmacology. 1993 Nov; 63(3):295-303. doi: 10.1254/jjp.63.295. [PMID: 7906318]