Methyl 4-(2-(2-hydroxy-2-(3-chlorophenyl)ethylamino)propyl)phenoxyacetate (BioDeep_00000176832)

   

human metabolite blood metabolite


代谢物信息卡片


Methyl 2-[4-(2-{[2-(3-chlorophenyl)-2-hydroxyethyl]amino}propyl)phenoxy]acetic acid

化学式: C20H24ClNO4 (377.13937740000006)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CC1=CC=C(C=C1)OCC(=O)OC)NCC(C2=CC(=CC=C2)Cl)O
InChI: InChI=1S/C20H24ClNO4/c1-14(22-12-19(23)16-4-3-5-17(21)11-16)10-15-6-8-18(9-7-15)26-13-20(24)25-2/h3-9,11,14,19,22-23H,10,12-13H2,1-2H3

描述信息

D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists

同义名列表

6 个代谢物同义名

Methyl 2-[4-(2-{[2-(3-chlorophenyl)-2-hydroxyethyl]amino}propyl)phenoxy]acetic acid; methyl 2-[4-(2-{[2-(3-chlorophenyl)-2-hydroxyethyl]amino}propyl)phenoxy]acetate; Methyl 4-(2-(2-hydroxy-2-(3-chlorophenyl)ethylamino)propyl)phenoxyacetic acid; methyl 4-(2-{[2-(3-chlorophenyl)-2-hydroxyethyl]amino}propyl)phenoxyacetate; Methyl 4-(2-(2-hydroxy-2-(3-chlorophenyl)ethylamino)propyl)phenoxyacetate; BRL 35135, Hydrombromide, (r*,r*)-(+-)-isomer



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Edward T Wargent, Jacqueline F O'Dowd, Mohamed S Zaibi, Dan Gao, Chen Bing, Paul Trayhurn, Michael A Cawthorne, Jonathan R S Arch, Claire J Stocker. Contrasts between the effects of zinc-α2-glycoprotein, a putative β3/2-adrenoceptor agonist and the β3/2-adrenoceptor agonist BRL35135 in C57Bl/6 (ob/ob) mice. The Journal of endocrinology. 2013 Feb; 216(2):157-68. doi: 10.1530/joe-12-0402. [PMID: 23151357]
  • Gerjanne J Vianen, Peter P Obels, Guido E E J M van den Thillart, Johan Zaagsma. Beta-adrenoceptors mediate inhibition of lipolysis in adipocytes of tilapia (Oreochromis mossambicus). American journal of physiology. Endocrinology and metabolism. 2002 Feb; 282(2):E318-25. doi: 10.1152/ajpendo.00187.2001. [PMID: 11788363]
  • D S Fletcher, M R Candelore, D Grujic, B B Lowell, S Luell, V S Susulic, D E Macintyre. Beta-3 adrenergic receptor agonists cause an increase in gastrointestinal transit time in wild-type mice, but not in mice lacking the beta-3 adrenergic receptor. The Journal of pharmacology and experimental therapeutics. 1998 Nov; 287(2):720-4. doi: NULL. [PMID: 9808702]
  • E Savontaus, J Rouru, O Boss, R Huupponen, M Koulu. Differential regulation of uncoupling proteins by chronic treatments with beta 3-adrenergic agonist BRL 35135 and metformin in obese fa/fa Zucker rats. Biochemical and biophysical research communications. 1998 May; 246(3):899-904. doi: 10.1006/bbrc.1998.8721. [PMID: 9618309]
  • P P Vicario, M R Candelore, M T Schaeffer, L Kelly, G M Thompson, E J Brady, R Saperstein, D E MacIntyre, L M Tota, M A Cascieri. Desensitization of beta3-adrenergic receptor-stimulated adenylyl cyclase activity and lipolysis in rats. Life sciences. 1998; 62(7):627-38. doi: 10.1016/s0024-3205(97)01158-2. [PMID: 9472722]
  • K A Virtanen, J Rouru, V Hänninen, E Savontaus, T Rouvari, T Teirmaa, M Koulu, R Huupponen. Chronic treatment with BRL 35135 potentiates the action of insulin on lipid metabolism. European journal of pharmacology. 1997 Aug; 332(2):215-8. doi: 10.1016/s0014-2999(97)01104-7. [PMID: 9286624]
  • K Hashimoto, Y Nagao, K Ida, M Takeda, N Murakami, K Kato, M Mizota. Improvement of metabolic disorders and visceral fat obesity by the beta 3-adrenoceptor agonist (R*,R*)-(+/-)-methyl-4-[2-[2-hydroxy-2 -(3-chlorophenyl)ethylamino]propyl]-phenoxyacetate hydrobromide (BRL35135A) in genetically obese rodents. Biochemical pharmacology. 1996 Nov; 52(10):1529-35. doi: 10.1016/s0006-2952(96)00552-7. [PMID: 8937467]
  • P Trayhurn, J S Duncan, D V Rayner, L J Hardie. Rapid inhibition of ob gene expression and circulating leptin levels in lean mice by the beta 3-adrenoceptor agonists BRL 35135A and ZD2079. Biochemical and biophysical research communications. 1996 Nov; 228(2):605-10. doi: 10.1006/bbrc.1996.1704. [PMID: 8920957]
  • C Charon, F Dupuy, V Marie, R Bazin. Effect of the beta-adrenoceptor agonist BRL-35135 on development of obesity in suckling Zucker (fa/fa) rats. The American journal of physiology. 1995 Jun; 268(6 Pt 1):E1039-45. doi: 10.1152/ajpendo.1995.268.6.e1039. [PMID: 7611376]
  • Y L Liu, M J Stock. Acute effects of the beta 3-adrenoceptor agonist, BRL 35135, on tissue glucose utilisation. British journal of pharmacology. 1995 Feb; 114(4):888-94. doi: 10.1111/j.1476-5381.1995.tb13287.x. [PMID: 7773551]
  • E Santti, R Huupponen, J Rouru, V Hänninen, U Pesonen, M Jhanwar-Uniyal, M Koulu. Potentiation of the anti-obesity effect of the selective beta 3-adrenoceptor agonist BRL 35135 in obese Zucker rats by exercise. British journal of pharmacology. 1994 Dec; 113(4):1231-6. doi: 10.1111/j.1476-5381.1994.tb17129.x. [PMID: 7889277]
  • V Marie, F Dupuy, R Bazin. Acute injection of beta-adrenoceptor agonist BRL 35135 corrects both impaired uncoupling protein and lipoprotein lipase gene expression but not hypercapacity of lipogenesis in brown adipose tissue of suckling fa/fa rats. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 1994 May; 18(5):273-9. doi: ". [PMID: 7914794]
  • N M Wheeldon, D G McDevitt, L C McFarlane, B J Lipworth. Beta-adrenoceptor subtypes mediating the metabolic effects of BRL 35135 in man. Clinical science (London, England : 1979). 1994 Mar; 86(3):331-7. doi: 10.1042/cs0860331. [PMID: 7908864]
  • H Abe, Y Minokoshi, T Shimazu. Effect of a beta 3-adrenergic agonist, BRL35135A, on glucose uptake in rat skeletal muscle in vivo and in vitro. The Journal of endocrinology. 1993 Dec; 139(3):479-86. doi: 10.1677/joe.0.1390479. [PMID: 7907647]
  • D M Newnham, C G Ingram, A Mackie, B J Lipworth. Beta-adrenoceptor subtypes mediating the airways response to BRL 35135 in man. British journal of clinical pharmacology. 1993 Dec; 36(6):567-71. doi: 10.1111/j.1365-2125.1993.tb00416.x. [PMID: 12959274]
  • T H Mitchell, R D Ellis, S A Smith, G Robb, M A Cawthorne. Effects of BRL 35135, a beta-adrenoceptor agonist with novel selectivity, on glucose tolerance and insulin sensitivity in obese subjects. International journal of obesity. 1989; 13(6):757-66. doi: NULL. [PMID: 2695481]