Phentolamine mesylate (BioDeep_00000858532)
代谢物信息卡片
Phentolamine mesylate
化学式: C18H23N3O4S (377.14091980000006)
中文名称: 甲磺酸酚妥拉明
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC=C(C=C1)N(CC2=NCCN2)C3=CC(=CC=C3)O.CS(=O)(=O)O
InChI: 1H3,(H,2,3,4)
描述信息
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Phentolamine mesylate (Phentolamine methanesulfonate) is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine mesylate can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction[1][2][3].
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D00509
- PubChem: 91430
- ChEMBL: CHEMBL1200873
- MeSH: Phentolamine
- CAS: 65-28-1
- medchemexpress: HY-B0362A
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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文献列表
- Qian Liu, Shengwei Wu, Zhenlin Chen, Jin Cai. Phentolamine Protects against Apoptosis and Inflammation in a Neonatal Pneumonia Cell Model Induced by LPS by Regulating the TrkA/Akt Signaling Pathways.
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World journal of gastroenterology.
2005 Feb; 11(6):863-6. doi:
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Circulation research.
2005 Feb; 96(2):189-96. doi:
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Journal of neuroimmunology.
2005 Jan; 158(1-2):120-7. doi:
10.1016/j.jneuroim.2004.08.017. [PMID: 15589045] - Frederique M Poulet, Mark R Berardi, William Halliwell, Barbara Hartman, Carol Auletta, Henry Bolte. Development of hibernomas in rats dosed with phentolamine mesylate during the 24-month carcinogenicity study.
Toxicologic pathology.
2004 Sep; 32(5):558-66. doi:
10.1080/01926230490505086. [PMID: 15603540] - Dana P Damron, Ira M Bernstein, Robert E Shapiro, Adrienne Schonberg. Uterine blood flow response to alpha-adrenergic blockade in nulligravid women of reproductive age.
Journal of the Society for Gynecologic Investigation.
2004 Sep; 11(6):388-92. doi:
10.1016/j.jsgi.2004.02.009. [PMID: 15350252] - Veronika Gresz, Tae-Hwan Kwon, Hong Gong, Peter Agre, Martin C Steward, Landon S King, Søren Nielsen. Immunolocalization of AQP-5 in rat parotid and submandibular salivary glands after stimulation or inhibition of secretion in vivo.
American journal of physiology. Gastrointestinal and liver physiology.
2004 Jul; 287(1):G151-61. doi:
10.1152/ajpgi.00480.2003. [PMID: 14988067] - Srinath Setty, Wei Sun, Rodolfo Martinez, H Fred Downey, Johnathan D Tune. Alpha-adrenoceptor-mediated coronary vasoconstriction is augmented during exercise in experimental diabetes mellitus.
Journal of applied physiology (Bethesda, Md. : 1985).
2004 Jul; 97(1):431-8. doi:
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Canadian journal of physiology and pharmacology.
2004 Jul; 82(7):465-73. doi:
10.1139/y04-072. [PMID: 15389293] - Raffaele Capasso, Francesca Borrelli, Francesco Capasso, Nicola Mascolo, Angelo A Izzo. Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro.
Urology.
2004 Jul; 64(1):168-72. doi:
10.1016/j.urology.2004.02.021. [PMID: 15245964] - Cedric Moro, Francois Crampes, Coralie Sengenes, Isabelle De Glisezinski, Jean Galitzky, Claire Thalamas, Max Lafontan, Michel Berlan. Atrial natriuretic peptide contributes to physiological control of lipid mobilization in humans.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2004 May; 18(7):908-10. doi:
10.1096/fj.03-1086fje. [PMID: 15033935] - Yutaka Oda, Tomoharu Funao, Katsuaki Tanaka, Akira Asada. Vasodilation increases the threshold for bupivacaine-induced convulsions in rats.
Anesthesia and analgesia.
2004 Mar; 98(3):677-82, table of contents. doi:
10.1213/01.ane.0000101984.50597.e9. [PMID: 14980918] - Duane J Myklejord. Undiagnosed pheochromocytoma: the anesthesiologist nightmare.
Clinical medicine & research.
2004 Feb; 2(1):59-62. doi:
10.3121/cmr.2.1.59. [PMID: 15931336] - Eun Jung Kim, Yun Jung Lee, Jang Hern Lee, Ho Jae Han. Effect of epinephrine on alpha-methyl-D-glucopyranoside uptake in renal proximal tubule cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2004; 14(4-6):395-406. doi:
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International journal of clinical pharmacology and therapeutics.
2004 Jan; 42(1):43-9. doi:
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Experimental neurology.
2003 Dec; 184(2):1027-33. doi:
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Journal of alternative and complementary medicine (New York, N.Y.).
2003 Oct; 9(5):727-33. doi:
10.1089/107555303322524571. [PMID: 14629850] - Frederick Jia-Pei Miao, Paul Green, Neal Benowitz, Jon D Levine. Vagal modulation of spinal nicotine-induced inhibition of the inflammatory response mediated by descending antinociceptive controls.
Neuropharmacology.
2003 Oct; 45(5):605-11. doi:
10.1016/s0028-3908(03)00224-7. [PMID: 12941374] - Raghvendra K Dubey, Lefteris C Zacharia, Delbert G Gillespie, Bruno Imthurn, Edwin K Jackson. Catecholamines block the antimitogenic effect of estradiol on human glomerular mesangial cells.
Hypertension (Dallas, Tex. : 1979).
2003 Sep; 42(3):349-55. doi:
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International journal of impotence research.
2003 Aug; 15(4):282-6. doi:
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American journal of physiology. Heart and circulatory physiology.
2003 Jun; 284(6):H2412-8. doi:
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Toxicology.
2003 Apr; 186(3):181-9. doi:
10.1016/s0300-483x(02)00747-3. [PMID: 12628311] - Steven L Bealer, William R Crowley. Angiotensin II-induced release of oxytocin: interaction with norepinephrine and role in lactation.
Regulatory peptides.
2003 Mar; 111(1-3):41-6. doi:
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American journal of physiology. Renal physiology.
2002 Sep; 283(3):F583-7. doi:
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2002 Aug; 103 Suppl 48(?):430S-433S. doi:
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Acta physiologica Scandinavica.
2002 Jul; 175(3):245-51. doi:
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Brain research.
2002 Jun; 939(1-2):26-33. doi:
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European journal of pharmacology.
2002 Mar; 438(3):197-205. doi:
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American journal of physiology. Endocrinology and metabolism.
2002 Feb; 282(2):E318-25. doi:
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Nature.
2002 Jan; 415(6869):339-43. doi:
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Urology.
2002 Jan; 59(1):155-8. doi:
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Biochemical pharmacology.
2001 Dec; 62(12):1685-94. doi:
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Biochemical pharmacology.
2001 Dec; 62(12):1695-703. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
2001 Dec; 98(25):14720-5. doi:
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