Acetoxyacetylaminofluorene (BioDeep_00000175676)

   

human metabolite blood metabolite


代谢物信息卡片


Acetic acid, ester with N-(fluoren-2-yl)acetohydroxamic acid

化学式: C17H15NO3 (281.105188)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 99.4%

分子结构信息

SMILES: CC(=O)N(C1=CC2=C(C=C1)C3=CC=CC=C3C2)OC(=O)C
InChI: InChI=1S/C17H15NO3/c1-11(19)18(21-12(2)20)15-7-8-17-14(10-15)9-13-5-3-4-6-16(13)17/h3-8,10H,9H2,1-2H3

描述信息

D009676 - Noxae > D000477 - Alkylating Agents

同义名列表

23 个代谢物同义名

Acetic acid, ester with N-(fluoren-2-yl)acetohydroxamic acid; Acetate, ester with N-(fluoren-2-yl)acetohydroxamate; Acetic acid, (N-acetyl-N-(2-fluorenyl)amino) ester; Acetate, (N-acetyl-N-(2-fluorenyl)amino) ester; N-(Fluoren-2-yl)acetohydroxamic acetic acid; N-(Fluoren-2-yl)acetohydroxamic acetamide; N-(Fluoren-2-yl)acetohydroxamic acetate; N-(Acetoxy)-N-9H-fluoren-2-ylacetamide; N-(9H-fluoren-2-yl)acetamido acetate; N-Acetoxy-N-acetyl-2-aminofluorene; N Acetoxy N acetyl 2 aminofluorene; N-Acetoxy-N-2-fluorenylacetamide; N Acetoxy 2 acetylaminofluorene; N-Acetoxy-2-acetylaminofluorene; N-Acetoxy-2-fluorenylacetamide; N-Acetoxy-2-acetaminofluorene; 2-Acetoxyacetylaminofluorene; Acetoxyacetylaminofluorene; Acetoxyfluorenylacetamide; Acetoxyacetamidofluorene; Acetoxy aaf; NA-aaf; NAAAF



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Noah M Walton, Rick Shin, Katsunori Tajinda, Carrie L Heusner, Jeffrey H Kogan, Shinichi Miyake, Qian Chen, Kouichi Tamura, Mitsuyuki Matsumoto. Adult neurogenesis transiently generates oxidative stress. PloS one. 2012; 7(4):e35264. doi: 10.1371/journal.pone.0035264. [PMID: 22558133]
  • Monika Pietrowska, Piotr Widłak. Characterization of a novel protein that specifically binds to DNA modified by N-acetoxy-acetylaminofluorene and cis-diamminedichloroplatinum. Acta biochimica Polonica. 2005; 52(4):867-74. doi: 10.18388/abp.2005_3400. [PMID: 15940347]
  • E D Wagner, K Repetny, J S Tan, T Gichner, M J Plewa. Mutagenic synergy between paraoxon and mammalian or plant-activated aromatic amines. Environmental and molecular mutagenesis. 1997; 30(3):312-20. doi: 10.1002/(sici)1098-2280(1997)30:3<312::aid-em10>3.0.co;2-g. [PMID: 9366910]
  • T Gichner, J Veleminský, E D Wagner, M J Plewa. Mutagenic synergy between paraoxon and plant-activated m-phenylenediamine or 2-acetoxyacetylaminofluorene. Environmental and molecular mutagenesis. 1996; 27(1):59-66. doi: 10.1002/(sici)1098-2280(1996)27:1<59::aid-em8>3.0.co;2-9. [PMID: 8625949]
  • T Gichner, G Voutsinas, A Patrineli, A Kappas, M J Plewa. Antimutagenicity of three isomers of aminobenzoic acid in Salmonella typhimurium. Mutation research. 1994 Sep; 309(2):201-10. doi: 10.1016/0027-5107(94)90093-0. [PMID: 7520977]
  • L E Knudsen, T Boisen, J M Christensen, J E Jelnes, G E Jensen, J C Jensen, K Lundgren, C Lundsteen, B Pedersen, K Wassermann. Biomonitoring of genotoxic exposure among stainless steel welders. Mutation research. 1992 May; 279(2):129-43. doi: 10.1016/0165-1218(92)90255-x. [PMID: 1375338]
  • D D Brenner, A M Jeffrey, L Latriano, L Wazneh, D Warburton, M Toor, R W Pero, L R Andrews, S Walles, F P Perera. Biomarkers in styrene-exposed boatbuilders. Mutation research. 1991 Nov; 261(3):225-36. doi: 10.1016/0165-1218(91)90071-s. [PMID: 1719415]
  • O A Olivero, C Semino, M C Poirier. Localization of DNA adducts induced by N-acetoxy-N-2-acetylaminofluorene in Chinese hamster ovary cells using electron microscopy and colloidal gold. Genes, chromosomes & cancer. 1990 Jul; 2(2):130-6. doi: 10.1002/gcc.2870020209. [PMID: 1703779]
  • M C Mah, V M Maher, H Thomas, T M Reid, C M King, J J McCormick. Mutations induced by aminofluorene-DNA adducts during replication in human cells. Carcinogenesis. 1989 Dec; 10(12):2321-8. doi: 10.1093/carcin/10.12.2321. [PMID: 2591021]
  • V M Maher, J L Yang, M C Mah, J J McCormick. Comparing the frequency and spectra of mutations induced when an SV-40 based shuttle vector containing covalently bound residues of structurally-related carcinogens replicates in human cells. Mutation research. 1989 Mar; 220(2-3):83-92. doi: 10.1016/0165-1110(89)90013-4. [PMID: 2538743]
  • R Pero, L Hagmar, J Seidegård, T Bellander, R Attewell, S Skerfving. Biological effects in a chemical factory with mutagenic exposure. II. Analysis of unscheduled DNA synthesis and adenosine diphosphate ribosyl transferase, epoxide hydrolase, and glutathione transferase in resting mononuclear leukocytes. International archives of occupational and environmental health. 1988; 60(6):445-51. doi: 10.1007/bf00381393. [PMID: 3137175]
  • L Möller, J Rafter, J A Gustafsson. Metabolism of the carcinogenic air pollutant 2-nitrofluorene in the rat. Carcinogenesis. 1987 May; 8(5):637-45. doi: 10.1093/carcin/8.5.637. [PMID: 3581422]
  • A Gentil, A Margot, A Sarasin. 2-(N-acetoxy-N-acetylamino)fluorene mutagenesis in mammalian cells: sequence-specific hot spot. Proceedings of the National Academy of Sciences of the United States of America. 1986 Dec; 83(24):9556-60. doi: 10.1073/pnas.83.24.9556. [PMID: 3025845]
  • R W Pero, S Heim, C Bryngelsson. Lower rates of thymidine incorporation into DNA of skin fibroblasts from patients with adenomatosis of the colon and rectum. Carcinogenesis. 1986 Apr; 7(4):541-5. doi: 10.1093/carcin/7.4.541. [PMID: 2870819]
  • V T Vu, P H Grantham, P P Roller, W D Hankins, P J Wirth, S S Thorgeirsson. Formation of DNA adducts from N-acetoxy-2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene in rat hemopoietic tissues in vivo. Cancer research. 1986 Jan; 46(1):233-8. doi: . [PMID: 3940194]
  • M A Muysken-Schoen, R A Baan, P H Lohman. Detection of DNA adducts in N-acetoxy-2-acetylaminofluorene-treated human fibroblasts by means of immunofluorescence microscopy and quantitative immunoautoradiography. Carcinogenesis. 1985 Jul; 6(7):999-1004. doi: 10.1093/carcin/6.7.999. [PMID: 3893785]
  • R W Pero, A Olsson, D Johnson. Regulation of extracellular thymidine pools in human blood samples. Basic life sciences. 1985; 31(?):481-6. doi: 10.1007/978-1-4613-2449-2_31. [PMID: 3994631]
  • E Trell, L Janzon, R W Pero, C Bryngelsson, T Bryngelsson, R Korsgaard. Mutagen sensitivity, smoking habits and enzyme induction in healthy middle-aged men. Environmental research. 1984 Dec; 35(2):421-9. doi: 10.1016/0013-9351(84)90149-x. [PMID: 6150846]
  • J A Maga, K Dixon. Enhanced replication of damaged SV40 DNA in carcinogen-treated monkey cells. Photochemistry and photobiology. 1984 Oct; 40(4):473-8. doi: 10.1111/j.1751-1097.1984.tb04620.x. [PMID: 6095339]
  • S M Cohn, B R Krawisz, S L Dresler, M W Lieberman. Induction of replicative DNA synthesis in quiescent human fibroblasts by DNA damaging agents. Proceedings of the National Academy of Sciences of the United States of America. 1984 Aug; 81(15):4828-32. doi: 10.1073/pnas.81.15.4828. [PMID: 6589629]
  • R J Zimmerman, J B Little. Characteristics of human diploid fibroblasts transformed in vitro by chemical carcinogens. Cancer research. 1983 May; 43(5):2183-9. doi: NULL. [PMID: 6831442]
  • M C Poirier, S H Yuspa, B True, B A Laishes. DNA adduct formation and removal in N-acetoxy-2-acetylaminofluorene-exposed cultured cells and in organs from rats fed 2-acetylaminofluorene. Basic life sciences. 1983; 24(?):619-35. doi: 10.1007/978-1-4684-4400-1_33. [PMID: 6860277]
  • M E Zolan, G A Cortopassi, C A Smith, P C Hanawalt. Deficient repair of chemical adducts in alpha DNA of monkey cells. Cell. 1982 Mar; 28(3):613-9. doi: 10.1016/0092-8674(82)90216-1. [PMID: 7074686]
  • M A Babich, T P Coohill, W Snipes, W D Taylor. The effect of metabolic inhibitors on the large plaque effect with Herpes simplex virus. Photochemistry and photobiology. 1981 Aug; 34(2):197-201. doi: NULL. [PMID: 6267622]
  • R J Zimmerman, J B Little. Starvation for arginine and glutamine sensitizes human diploid cells to the transforming effects of N-acetoxy-2-acetylaminofluorene. Carcinogenesis. 1981; 2(12):1303-10. doi: 10.1093/carcin/2.12.1303. [PMID: 7326831]
  • M Spodheim-Maurizot, G Saint-Ruf, M Leng. Antibodies to N-hydroxy-2-aminofluorene modified DNA as probes in the study of DNA reacted with derivatives of 2-acetylaminofluorene. Carcinogenesis. 1980; 1(10):807-12. doi: 10.1093/carcin/1.10.807. [PMID: 11219851]
  • M Guigues, M Leng. Reactivity of antibodies to guanosine modified by the carcinogen N-acetoxy-N-2-acetylaminofluorene. Nucleic acids research. 1979 Feb; 6(2):733-44. doi: 10.1093/nar/6.2.733. [PMID: 570700]
  • B C Myhr, J A Dipaolo. Mutagenesis by N-acetoxy-2-acetyl aminofluorene of chinese hamster V79 cells is unaffected by caffeine. Chemico-biological interactions. 1978 Apr; 21(1):1-18. doi: 10.1016/0009-2797(78)90064-9. [PMID: 566636]