9-Fluorenylmethyl chloroformate (BioDeep_00000173793)

   

human metabolite blood metabolite


代谢物信息卡片


(9H-fluoren-9-yl)methyl chloroformate

化学式: C15H11ClO2 (258.0447536)
中文名称: 芴甲氧羰酰氯(Fmoc-Cl)
谱图信息: 最多检出来源 Homo sapiens(blood) 78.95%

分子结构信息

SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)Cl
InChI: InChI=1S/C15H11ClO2/c16-15(17)18-9-14-12-7-3-1-5-10(12)11-6-2-4-8-13(11)14/h1-8,14H,9H2



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • I G Bressán, S F Llesuy, C Rodriguez, A Ferloni, A R Dawidowski, S B Figar, M I Giménez. Optimization and validation of a liquid chromatography-tandem mass spectrometry method for the determination of glyphosate in human urine after pre-column derivatization with 9-fluorenylmethoxycarbonyl chloride. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 May; 1171(?):122616. doi: 10.1016/j.jchromb.2021.122616. [PMID: 33744598]
  • Xinyu Li, Shixuan Zheng, Xuekun Ma, Kaimin Cheng, Guoyao Wu. Effects of dietary starch and lipid levels on the protein retention and growth of largemouth bass (Micropterus salmoides). Amino acids. 2020 Jul; 52(6-7):999-1016. doi: 10.1007/s00726-020-02869-6. [PMID: 32648068]
  • A Khedr, A N Khayyat, A A El-Shorbagi. Liquid chromatography-diode array-mass spectrometric analysis of amino and mercapto compounds coupled with chloroimino derivatization reagent. Journal of chromatography. A. 2020 Jun; 1621(?):461078. doi: 10.1016/j.chroma.2020.461078. [PMID: 32312546]
  • Nuraniye Eruygur, Emrah Dural. Determination of 1-Deoxynojirimycin by a developed and validated HPLC-FLD method and assessment of In-vitro antioxidant, α-Amylase and α-Glucosidase inhibitory activity in mulberry varieties from Turkey. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Feb; 53(?):234-242. doi: 10.1016/j.phymed.2018.09.016. [PMID: 30668403]
  • Yadi Wang, Siqi Du, Daniel W Armstrong. Sensitive analysis of N-blocked amino acids using high-performance liquid chromatography with paired ion electrospray ionization mass spectrometry. Analytical and bioanalytical chemistry. 2018 Jul; 410(19):4725-4735. doi: 10.1007/s00216-018-0901-5. [PMID: 29428992]
  • Dasharath P Oulkar, Sandip Hingmire, Arnab Goon, Manjusha Jadhav, Bharat Ugare, Ahammed Shabeer Thekkumpurath, Kaushik Banerjee. Optimization and Validation of a Residue Analysis Method for Glyphosate, Glufosinate, and Their Metabolites in Plant Matrixes by Liquid Chromatography with Tandem Mass Spectrometry. Journal of AOAC International. 2017 May; 100(3):631-639. doi: 10.5740/jaoacint.17-0046. [PMID: 28300023]
  • Yongtao Han, Le Song, Pengyue Zhao, Yanjie Li, Nan Zou, Yuhong Qin, Xuesheng Li, Canping Pan. Residue determination of glufosinate in plant origin foods using modified Quick Polar Pesticides (QuPPe) method and liquid chromatography coupled with tandem mass spectrometry. Food chemistry. 2016 Apr; 197(Pt A):730-6. doi: 10.1016/j.foodchem.2015.11.021. [PMID: 26617010]
  • Bin Xu, Dong-Yang Zhang, Ze-Yu Liu, Ying Zhang, Li Liu, Long Li, Charles C Liu, Guo-Hua Wu. Rapid determination of 1-deoxynojirimycin in Morus alba L. leaves by direct analysis in real time (DART) mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2015 Oct; 114(?):447-54. doi: 10.1016/j.jpba.2015.06.010. [PMID: 26133103]
  • Jörg Ziegler, Steffen Abel. Analysis of amino acids by HPLC/electrospray negative ion tandem mass spectrometry using 9-fluorenylmethoxycarbonyl chloride (Fmoc-Cl) derivatization. Amino acids. 2014 Dec; 46(12):2799-808. doi: 10.1007/s00726-014-1837-5. [PMID: 25218137]
  • Jörg Ziegler, Jakob Qwegwer, Melvin Schubert, Jessica L Erickson, Martin Schattat, Katharina Bürstenbinder, C Douglas Grubb, Steffen Abel. Simultaneous analysis of apolar phytohormones and 1-aminocyclopropan-1-carboxylic acid by high performance liquid chromatography/electrospray negative ion tandem mass spectrometry via 9-fluorenylmethoxycarbonyl chloride derivatization. Journal of chromatography. A. 2014 Oct; 1362(?):102-9. doi: 10.1016/j.chroma.2014.08.029. [PMID: 25160953]
  • Bahareh Mohammadi, Esmail Tammari, Sajad Fakhri, Gholamreza Bahrami. Applicability of LC-MS/MS to optimize derivatization of topiramate with FMOC-Cl using reacted/intact drug ratio. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2013 Jun; 928(?):32-6. doi: 10.1016/j.jchromb.2013.02.041. [PMID: 23598049]
  • Naser Shraim, Ralph Clinckers, Sophie Sarre, Yvette Michotte, Ann Van Eeckhaut. Determination of reboxetine in rat brain microdialysates and plasma samples using liquid chromatography coupled to fluorescence detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Jun; 898(?):53-61. doi: 10.1016/j.jchromb.2012.04.016. [PMID: 22560340]
  • Er-gang Liu, Xu-chun Fu, Ying Qian, Hai-bo Bai. [Determination of hydroxyproline in rat kidney tissue by HPLC with pre-column derivatization]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. 2012 Mar; 41(2):188-91. doi: NULL. [PMID: 22499517]
  • Christin Fellenberg, Jörg Ziegler, Vinzenz Handrick, Thomas Vogt. Polyamine Homeostasis in Wild Type and Phenolamide Deficient Arabidopsis thaliana Stamens. Frontiers in plant science. 2012; 3(?):180. doi: 10.3389/fpls.2012.00180. [PMID: 22912643]
  • Xiaoying Mao, Yufei Hua. Composition, structure and functional properties of protein concentrates and isolates produced from walnut (Juglans regia L.). International journal of molecular sciences. 2012; 13(2):1561-1581. doi: 10.3390/ijms13021561. [PMID: 22408408]
  • Bahareh Mohammadi, Mohammad Bagher Majnooni, Pyman Malek Khatabi, Ronak Jalili, Gholamreza Bahrami. 9-fluorenylmethyl chloroformate as a fluorescence-labeling reagent for derivatization of carboxylic acid moiety of sodium valproate using liquid chromatography/tandem mass spectrometry for binding characterization: a human pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Jan; 880(1):12-8. doi: 10.1016/j.jchromb.2011.11.009. [PMID: 22173006]
  • Eunmi Ban, Ji-Youn Park, Hyung Tae Kim, Chong-Kook Kim. Determination of alendronate in low volumes of plasma by column-switching high-performance liquid chromatography method and its application to pharmacokinetic studies in human plasma. Archives of pharmacal research. 2011 Dec; 34(12):2079-86. doi: 10.1007/s12272-011-1211-z. [PMID: 22210034]
  • Belen Puente, Esther Hernandez, Susana Perez, Luis Pablo, Esther Prieto, Maria Angeles Garcia, Miguel Angel Bregante. Determination of memantine in plasma and vitreous humour by HPLC with precolumn derivatization and fluorescence detection. Journal of chromatographic science. 2011 Nov; 49(10):745-52. doi: 10.1093/chrsci/49.10.745. [PMID: 22080801]
  • Nahed M El-Enany, Amina Abdelal, Fathalla Belal. Spectrofluorimetric determination of sertraline in dosage forms and human plasma through derivatization with 9-fluorenylmethyl chloroformate. Chemistry Central journal. 2011 Oct; 5(?):56. doi: 10.1186/1752-153x-5-56. [PMID: 21978386]
  • Glen E Kisby, Peter S Spencer. Is neurodegenerative disease a long-latency response to early-life genotoxin exposure?. International journal of environmental research and public health. 2011 10; 8(10):3889-921. doi: 10.3390/ijerph8103889. [PMID: 22073019]
  • Mei-Fen Xie, Wei Zhou, Xin-Yi Tong, Yi-Le Chen, Yi Cai, Yan Li, Geng-Li Duan. High-performance liquid chromatographic determination of memantine hydrochloride in rat plasma using sensitive fluorometric derivatization. Journal of separation science. 2011 Feb; 34(3):241-6. doi: 10.1002/jssc.201000579. [PMID: 21268245]
  • Peng Yi, Li Liu, Huifen Mei, Fangling Zeng, Zhijian Huang, Huilin Niu. Establishment of reference range of plasma amino acids for younger Chinese children by reverse phase HPLC. Journal of pediatric endocrinology & metabolism : JPEM. 2011; 24(9-10):733-8. doi: 10.1515/jpem.2011.270. [PMID: 22145465]
  • J Bernal, J L Bernal, M T Martin, M J Nozal, A Anadón, M R Martínez-Larrañaga, M A Martínez. Development and validation of a liquid chromatography-fluorescence-mass spectrometry method to measure glyphosate and aminomethylphosphonic acid in rat plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Dec; 878(31):3290-6. doi: 10.1016/j.jchromb.2010.10.013. [PMID: 21106459]
  • Taiji Kawakatsu, Sakiko Hirose, Hiroshi Yasuda, Fumio Takaiwa. Reducing rice seed storage protein accumulation leads to changes in nutrient quality and storage organelle formation. Plant physiology. 2010 Dec; 154(4):1842-54. doi: 10.1104/pp.110.164343. [PMID: 20940349]
  • Philippa B Mills, Emma J Footitt, Kevin A Mills, Karin Tuschl, Sarah Aylett, Sophia Varadkar, Cheryl Hemingway, Neil Marlow, Janet Rennie, Peter Baxter, Olivier Dulac, Rima Nabbout, William J Craigen, Bernhard Schmitt, François Feillet, Ernst Christensen, Pascale De Lonlay, Mike G Pike, M Imelda Hughes, Eduard A Struys, Cornelis Jakobs, Sameer M Zuberi, Peter T Clayton. Genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy (ALDH7A1 deficiency). Brain : a journal of neurology. 2010 Jul; 133(Pt 7):2148-59. doi: 10.1093/brain/awq143. [PMID: 20554659]
  • Patricia Almudever, José-Esteban Peris, Teresa Garrigues, Octavio Diez, Ana Melero, Manuel Alós. Quantification of nortriptyline in plasma by HPLC and fluorescence detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Mar; 878(9-10):841-4. doi: 10.1016/j.jchromb.2010.01.033. [PMID: 20172767]
  • Alyaa Ibrahim, Fakhreddin Jamali. Improved sensitive high performance liquid chromatography assay for glucosamine in human and rat biological samples with fluorescence detection. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 2010; 13(2):128-35. doi: 10.18433/j3t01s. [PMID: 20816000]
  • Xuezheng Song, Yi Lasanajak, Carlos Rivera-Marrero, Anthony Luyai, Margaret Willard, David F Smith, Richard D Cummings. Generation of a natural glycan microarray using 9-fluorenylmethyl chloroformate (FmocCl) as a cleavable fluorescent tag. Analytical biochemistry. 2009 Dec; 395(2):151-60. doi: 10.1016/j.ab.2009.08.024. [PMID: 19699706]
  • Yiqiang Chen, Qian Chen, Shusheng Tang, Xilong Xiao. LC method for the analysis of kanamycin residue in swine tissues using derivatization with 9-fluorenylmethyl chloroformate. Journal of separation science. 2009 Nov; 32(21):3620-6. doi: 10.1002/jssc.200900408. [PMID: 19842123]
  • Xiaojuan Chang, Jingdong Peng, Shaopu Liu, Limin Liu, Yongkuang Dai. [Determination of netilmicin in rat plasma by reversed-phase high performance liquid chromatography with fluorescence detection and pre-column derivatization]. Se pu = Chinese journal of chromatography. 2009 Nov; 27(6):794-8. doi: NULL. [PMID: 20352933]
  • Yusuke Kakei, Isomaro Yamaguchi, Takanori Kobayashi, Michiko Takahashi, Hiromi Nakanishi, Takashi Yamakawa, Naoko K Nishizawa. A highly sensitive, quick and simple quantification method for nicotianamine and 2'-deoxymugineic acid from minimum samples using LC/ESI-TOF-MS achieves functional analysis of these components in plants. Plant & cell physiology. 2009 Nov; 50(11):1988-93. doi: 10.1093/pcp/pcp141. [PMID: 19880395]
  • A Jámbor, I Molnár-Perl. Quantitation of amino acids in plasma by high performance liquid chromatography: simultaneous deproteinization and derivatization with 9-fluorenylmethyloxycarbonyl chloride. Journal of chromatography. A. 2009 Aug; 1216(34):6218-23. doi: 10.1016/j.chroma.2009.06.083. [PMID: 19631330]
  • Shengyuan Xiao, Peter H Yu. A fluorometric high-performance liquid chromatography procedure for simultaneous determination of methylamine and aminoacetone in blood and tissues. Analytical biochemistry. 2009 Jan; 384(1):20-6. doi: 10.1016/j.ab.2008.09.029. [PMID: 18845121]
  • Guoying Cao, Feda' Emad Atta Ali, Francis Chiu, Alexandre P Zavascki, Roger L Nation, Jian Li. Development and validation of a reversed-phase high-performance liquid chromatography assay for polymyxin B in human plasma. The Journal of antimicrobial chemotherapy. 2008 Nov; 62(5):1009-14. doi: 10.1093/jac/dkn343. [PMID: 18765414]
  • Ernest Adeghate, Péter Sótonyi, Huba Kalász. Chronic experimental diabetes accelerates urinary elimination of deprenyl and its metabolites. The open medicinal chemistry journal. 2008 Jan; 2(?):1-5. doi: 10.2174/1874104500802010001. [PMID: 19662137]
  • Kui Yang, Zhongdan Zhao, Richard W Gross, Xianlin Han. Shotgun lipidomics identifies a paired rule for the presence of isomeric ether phospholipid molecular species. PloS one. 2007 Dec; 2(12):e1368. doi: 10.1371/journal.pone.0001368. [PMID: 18159251]
  • Valentin Lozanov, Bistra Benkova, Lyudmila Mateva, Stefan Petrov, Elenko Popov, Chavdar Slavov, Vanio Mitev. Liquid chromatography method for simultaneous analysis of amino acids and biogenic amines in biological fluids with simultaneous gradient of pH and acetonitrile. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Dec; 860(1):92-7. doi: 10.1016/j.jchromb.2007.10.020. [PMID: 17983865]
  • Alaa Khedr, Mahmoud M Sheha, Ibrahim A Darwish. Sensitive determination of trimetazidine in spiked human plasma by HPLC with fluorescence detection after pre-column derivatization with 9-fluorenylmethyl chloroformate. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Sep; 856(1-2):337-42. doi: 10.1016/j.jchromb.2007.06.036. [PMID: 17644495]
  • Hans M H van Eijk, Dennis P L Suylen, Cornelis H C Dejong, Yvette C Luiking, Nicolaas E P Deutz. Measurement of amino acid isotope enrichment by liquid chromatography mass spectroscopy after derivatization with 9-fluorenylmethylchloroformate. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Sep; 856(1-2):48-56. doi: 10.1016/j.jchromb.2007.05.020. [PMID: 17561452]
  • Franciszek K Główka, Marta Karaźniewicz-Łada. Determination of roxithromycin in human plasma by HPLC with fluorescence and UV absorbance detection: application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Jun; 852(1-2):669-73. doi: 10.1016/j.jchromb.2007.02.022. [PMID: 17329175]
  • Gholamreza Bahrami, Bahareh Mohammadi. Determination of clarithromycin in human serum by high-performance liquid chromatography after pre-column derivatization with 9-fluorenylmethyl chloroformate: application to a bioequivalence study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 May; 850(1-2):417-22. doi: 10.1016/j.jchromb.2006.12.027. [PMID: 17223392]
  • Jutima Boonleang, Kamon Panrat, Chanpa Tantana, Siriporn Krittathanmakul, Worawut Jintapakorn. Bioavailability and pharmacokinetic comparison between generic and branded azithromycin capsule: a randomized, double-blind, 2-way crossover in healthy male Thai volunteers. Clinical therapeutics. 2007 Apr; 29(4):703-10. doi: 10.1016/j.clinthera.2007.04.010. [PMID: 17617293]
  • Jing Zhu, San-kang Liu, Chun-mei Fu, Zhang-wan Li. [Analysis of dencichine by HPLC with pre-column derivatization]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2006 Nov; 31(22):1865-8. doi: ". [PMID: 17285985]
  • Yanli Han, Min Zuo, Li Qi, Kun Liu, Lanqun Mao, Yi Chen. Online acid barrage stacking anti-salt injection for capillary electrophoresis of 9-fluorenylmethylchloroformate-derivatized amino acids in high ionic strength solutions by UV detection. Electrophoresis. 2006 Nov; 27(21):4240-8. doi: 10.1002/elps.200600149. [PMID: 17022015]
  • Tao-min Huang, Chun-Hui Deng, Nian-zhu Chen, Zhen Liu, Geng-Li Duan. High performance liquid chromatography for the determination of glucosamine sulfate in human plasma after derivatization with 9-fluorenylmethyl chloroformate. Journal of separation science. 2006 Oct; 29(15):2296-302. doi: 10.1002/jssc.200600162. [PMID: 17120813]
  • Li-jun Zhang, Tao-min Huang, Xiao-ling Fang, Xue-ning Li, Qing-song Wang, Zhi-wen Zhang, Xian-yi Sha. Determination of glucosamine sulfate in human plasma by precolumn derivatization using high performance liquid chromatography with fluorescence detection: its application to a bioequivalence study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Sep; 842(1):8-12. doi: 10.1016/j.jchromb.2006.04.045. [PMID: 16740419]
  • Gholamreza Bahrami, Amir Kiani. Sensitive high-performance liquid chromatographic quantitation of gabapentin in human serum using liquid-liquid extraction and pre-column derivatization with 9-fluorenylmethyl chloroformate. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 May; 835(1-2):123-6. doi: 10.1016/j.jchromb.2006.03.011. [PMID: 16574508]
  • Fengguo Xu, Zunjian Zhang, Haoyan Jiao, Yuan Tian, Beibei Zhang, Yun Chen. Quantification of fudosteine in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry employing precolumn derivatization with 9-fluorenylmethyl chloroformate. Journal of mass spectrometry : JMS. 2006 May; 41(5):685-92. doi: 10.1002/jms.1028. [PMID: 16598709]
  • H Y Jiao, Z J Zhang, F G Xu, Y Tian, B B Zhang, Y Chen. The pharmacokinetics of orally administered fudosteine in healthy Chinese volunteers. European journal of drug metabolism and pharmacokinetics. 2006 Apr; 31(2):65-71. doi: 10.1007/bf03191121. [PMID: 16898073]
  • Evangelos J Giamarellos-Bourboulis, Anastasia Antonopoulou, Maria Raftogiannis, Pantelis Koutoukas, Thomas Tsaganos, Vassiliki Tziortzioti, Charalambos Panagou, Theodoros Adamis, Helen Giamarellou. Clarithromycin is an effective immunomodulator when administered late in experimental pyelonephritis by multidrug-resistant Pseudomonas aeruginosa. BMC infectious diseases. 2006 Feb; 6(?):31. doi: 10.1186/1471-2334-6-31. [PMID: 16504031]
  • Min-Hyuk Yun, Kwang-il Kwon. High-performance liquid chromatography method for determining alendronate sodium in human plasma by detecting fluorescence: application to a pharmacokinetic study in humans. Journal of pharmaceutical and biomedical analysis. 2006 Jan; 40(1):168-72. doi: 10.1016/j.jpba.2005.06.025. [PMID: 16095861]
  • Gholamreza Bahrami, Bahareh Mohammadi. A new on-line, in-tube pre-column derivatization technique for high performance liquid chromatographic determination of azithromycin in human serum. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Jan; 830(2):355-8. doi: 10.1016/j.jchromb.2005.10.044. [PMID: 16310417]
  • Zhen Liu, Yunfei Sha, Taomin Huang, Bei Yang, Geng-Li Duan. High-performance liquid chromatographic determination of vertilmicin in rat plasma using sensitive fluorometric derivatization. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 Dec; 828(1-2):2-8. doi: 10.1016/j.jchromb.2005.06.045. [PMID: 16253575]
  • Gholamreza Bahrami, Shahla Mirzaeei, Bahareh Mohammadi, Amir Kiani. High performance liquid chromatographic determination of topiramate in human serum using UV detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 Aug; 822(1-2):322-5. doi: 10.1016/j.jchromb.2005.05.032. [PMID: 15996538]
  • Xianlin Han, Kui Yang, Hua Cheng, Kora N Fikes, Richard W Gross. Shotgun lipidomics of phosphoethanolamine-containing lipids in biological samples after one-step in situ derivatization. Journal of lipid research. 2005 Jul; 46(7):1548-60. doi: 10.1194/jlr.d500007-jlr200. [PMID: 15834120]
  • Gholamreza Bahrami, Shahla Mirzaeei, Amir Kiani. High performance liquid chromatographic determination of azithromycin in serum using fluorescence detection and its application in human pharmacokinetic studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 Jun; 820(2):277-81. doi: 10.1016/j.jchromb.2005.03.042. [PMID: 15876560]
  • H Kalász, Z Szücs, M Tihanyi, A Szilágyi, J Lengyel. Detection of Nepsilon-monomethyllysine using high-performance liquid chromatography and high-performance liquid chromatography-mass spectrometry. Journal of chromatography. A. 2005 Jun; 1079(1-2):208-12. doi: 10.1016/j.chroma.2005.03.079. [PMID: 16038306]
  • Huba Kalász, Imre Klebovich, Katalin Balogh-Nemes, Agnes Szilágyi, Mária Tihanyi, Tibor Szarvas, József Lengyel. Detection of N-monomethyl-lysine generated by metabolic transmethylation. Analytical and bioanalytical chemistry. 2005 Jun; 382(3):760-4. doi: 10.1007/s00216-005-3089-4. [PMID: 15756599]
  • Elisabeth L Schwarz, William L Roberts, Marzia Pasquali. Analysis of plasma amino acids by HPLC with photodiode array and fluorescence detection. Clinica chimica acta; international journal of clinical chemistry. 2005 Apr; 354(1-2):83-90. doi: 10.1016/j.cccn.2004.11.016. [PMID: 15748603]
  • Erik Wilms, Henk Trumpie, Wim Veenendaal, Daan Touw. Quantitative determination of azithromycin in plasma, blood and isolated neutrophils by liquid chromatography using pre-column derivatization with 9-fluorenylmethyloxycarbonyl-chloride and fluorescence detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 Jan; 814(1):37-42. doi: 10.1016/j.jchromb.2004.09.058. [PMID: 15607705]
  • Gh Bahrami, Sh Mirzaeei, A Kiani. Sensitive analytical method for Topiramate in human serum by HPLC with pre-column fluorescent derivatization and its application in human pharmacokinetic studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Dec; 813(1-2):175-80. doi: 10.1016/j.jchromb.2004.09.054. [PMID: 15556531]
  • C Cháfer-Pericás, P Campíns-Falcó, R Herráez-Hernández. Application of solid-phase microextraction combined with derivatization to the determination of amphetamines by liquid chromatography. Analytical biochemistry. 2004 Oct; 333(2):328-35. doi: 10.1016/j.ab.2004.05.056. [PMID: 15450809]
  • Jin-Won Kim, Soo-Un Kim, Heui Sam Lee, Iksoo Kim, Mi Young Ahn, Kang Sun Ryu. Determination of 1-deoxynojirimycin in Morus alba L. leaves by derivatization with 9-fluorenylmethyl chloroformate followed by reversed-phase high-performance liquid chromatography. Journal of chromatography. A. 2003 Jun; 1002(1-2):93-9. doi: 10.1016/s0021-9673(03)00728-3. [PMID: 12885082]
  • M Buratti, C Valla, D Xaiz, G Brambilla, A Colombi. Determination of hexafluoroisopropanol, a sevoflurane urinary metabolite, by 9-fluorenylmethyl chloroformate derivatization. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2002 Sep; 776(2):237-43. doi: 10.1016/s1570-0232(02)00310-0. [PMID: 12138006]
  • Maria Augusta Ragg, Roberto Mandrioli, Giovanna Casamenti, Vittorio Volterra, Sergio Pinzauti. Determination of reboxetine, a recent antidepressant drug, in human plasma by means of two high-performance liquid chromatography methods. Journal of chromatography. A. 2002 Mar; 949(1-2):23-33. doi: 10.1016/s0021-9673(01)01438-8. [PMID: 11999739]
  • P Ptácek, J Klíma, J Macek. Determination of alendronate in human urine as 9-fluorenylmethyl derivative by high-performance liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2002 Feb; 767(1):111-6. doi: 10.1016/s0378-4347(01)00551-5. [PMID: 11863282]
  • Matthew S Wheal, Laurence I Heller, Wendell A Norvell, Ross M Welch. Reversed-phase liquid chromatographic determination of phytometallophores from Strategy II Fe-uptake species by 9-fluorenylmethyl chloroformate fluorescence. Journal of chromatography. A. 2002 Jan; 942(1-2):177-83. doi: 10.1016/s0021-9673(01)01375-9. [PMID: 11822383]
  • J Li, R W Milne, R L Nation, J D Turnidge, K Coulthard, D W Johnson. A simple method for the assay of colistin in human plasma, using pre-column derivatization with 9-fluorenylmethyl chloroformate in solid-phase extraction cartridges and reversed-phase high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications. 2001 Sep; 761(2):167-75. doi: 10.1016/s0378-4347(01)00326-7. [PMID: 11587346]
  • R Herráez-Hernández, P Campíns-Falcó, J Verdú-Andrés. Sensitive determination of methylenedioxylated amphetamines by liquid chromatography. The Analyst. 2001 May; 126(5):581-6. doi: 10.1039/b010035h. [PMID: 11394297]
  • A Posyniak, J Zmudzki, J Niedzielska. Sample preparation for residue determination of gentamicin and neomycin by liquid chromatography. Journal of chromatography. A. 2001 Apr; 914(1-2):59-66. doi: 10.1016/s0021-9673(00)00980-8. [PMID: 11358232]
  • E C Chan, P Y Wee, P Y Ho, P C Ho. High-performance liquid chromatographic assay for catecholamines and metanephrines using fluorimetric detection with pre-column 9-fluorenylmethyloxycarbonyl chloride derivatization. Journal of chromatography. B, Biomedical sciences and applications. 2000 Dec; 749(2):179-89. doi: 10.1016/s0378-4347(00)00423-0. [PMID: 11145055]
  • S Kimura, M Numaguchi, T Kaizu, D Kim, Y Takagi, K Gomi. High galactosylation of oligosaccharides in umbilical cord blood IgG, and its relationship to placental function. Clinica chimica acta; international journal of clinical chemistry. 2000 Sep; 299(1-2):169-77. doi: 10.1016/s0009-8981(00)00289-8. [PMID: 10900302]
  • G Aymard, B Labarthe, D Warot, I Berlin, B Diquet. Sensitive determination of ephedrine and norephedrine in human plasma samples using derivatization with 9-fluorenylmethyl chloroformate and liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications. 2000 Jul; 744(1):25-31. doi: 10.1016/s0378-4347(00)00217-6. [PMID: 10985563]
  • R Herráez-Hernández, P Campíns-Falcó. Derivatization of tertiary amphetamines with 9-fluorenylmethyl chloroformate for liquid chromatography: determination of N-methylephedrine. The Analyst. 2000 Jun; 125(6):1071-6. doi: 10.1039/b002138p. [PMID: 10932852]
  • R W Sparidans, J den Hartig, S Cremers, J H Beijnen, P Vermeij. Semi-automatic liquid chromatographic analysis of olpadronate in urine and serum using derivatization with (9-fluorenylmethyl)chloroformate. Journal of chromatography. B, Biomedical sciences and applications. 2000 Feb; 738(2):331-41. doi: 10.1016/s0378-4347(99)00532-0. [PMID: 10718651]
  • A Yusuf, S Al-Rawithi, D Raines, H Frayha, T A Toonsi, I Al-Mohsen, A E1-Yazigi. Simplified high-performance liquid chromatographic method for the determination of gentamicin sulfate in a microsample of plasma: comparison with fluorescence polarization immunoassay. Therapeutic drug monitoring. 1999 Dec; 21(6):647-52. doi: 10.1097/00007691-199912000-00012. [PMID: 10604827]
  • M M Or-Rashid, R Onodera, S Wadud, M E Nasser, M R Amin. Rapid determination of lysine in biological samples by isocratic liquid chromatography. Journal of AOAC International. 1999 Jul; 82(4):809-14. doi: 10.1093/jaoac/82.4.809. [PMID: 10444822]
  • J Sastre Toraño, H J Guchelaar. Quantitative determination of the macrolide antibiotics erythromycin, roxithromycin, azithromycin and clarithromycin in human serum by high-performance liquid chromatography using pre-column derivatization with 9-fluorenylmethyloxycarbonyl chloride and fluorescence detection. Journal of chromatography. B, Biomedical sciences and applications. 1998 Dec; 720(1-2):89-97. doi: 10.1016/s0378-4347(98)00456-3. [PMID: 9892071]
  • B Morin, W A Bubb, M J Davies, R T Dean, S Fu. 3-Hydroxylysine, a potential marker for studying radical-induced protein oxidation. Chemical research in toxicology. 1998 Nov; 11(11):1265-73. doi: 10.1021/tx980118h. [PMID: 9815186]
  • B Knoche, S Milosavljev, S Gropper, L A Brunner, M L Powell. Enantioselective determination of selfotel in human urine by high-performance liquid chromatography on a chiral stationary phase after derivatization with 9-fluorenylmethyl chloroformate. Journal of chromatography. B, Biomedical sciences and applications. 1997 Aug; 695(2):355-63. doi: 10.1016/s0378-4347(97)00196-5. [PMID: 9300872]
  • H M van Eijk, D R Rooyakkers, A J Wagenmakers, P B Soeters, N E Deutz. Isolation and quantitation of isotopically labeled amino acids from biological samples. Journal of chromatography. B, Biomedical sciences and applications. 1997 Apr; 691(2):287-96. doi: 10.1016/s0378-4347(96)00475-6. [PMID: 9174264]
  • T Teerlink, M W Hennekes, C Mulder, H F Brulez. Determination of dimethylamine in biological samples by high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications. 1997 Apr; 691(2):269-76. doi: 10.1016/s0378-4347(96)00476-8. [PMID: 9174262]
  • R Herráez-Hernández, P Campíns-Falcó, A Sevillano-Cabeza. Determination of amphetamine and related compounds in urine using on-line derivatization in octadecyl silica columns with 9-fluorenylmethyl chloroformate and liquid chromatography. Journal of chromatography. B, Biomedical applications. 1996 Apr; 679(1-2):69-78. doi: 10.1016/0378-4347(95)00581-1. [PMID: 8998571]
  • D A Stead, R M Richards. Sensitive fluorimetric determination of gentamicin sulfate in biological matrices using solid-phase extraction, pre-column derivatization with 9-fluorenylmethyl chloroformate and reversed-phase high-performance liquid chromatography. Journal of chromatography. B, Biomedical applications. 1996 Jan; 675(2):295-302. doi: 10.1016/0378-4347(95)00355-x. [PMID: 8852718]
  • S Castelain, S Kamel, C Picard, G Desmet, J L Sebert, M Brazier. A simple and automated HPLC method for determination of total hydroxyproline in urine. Comparison with excretion of pyridinolines. Clinica chimica acta; international journal of clinical chemistry. 1995 Feb; 235(1):81-90. doi: 10.1016/0009-8981(95)06003-7. [PMID: 7634493]
  • H Nattouf, C Davrinche, M Sinet, R Farinotti. High-performance liquid chromatographic assay for 3'-amino-3'-deoxythymidine in plasma, with 9-fluorenyl methyl chloroformate as the derivatization agent. Journal of chromatography. B, Biomedical applications. 1995 Feb; 664(2):365-71. doi: 10.1016/0378-4347(94)00499-u. [PMID: 7780589]
  • R La Croix, E Pianezzola, M Strolin Benedetti. Sensitive high-performance liquid chromatographic method for the determination of the three main metabolites of selegiline (L-deprenyl) in human plasma. Journal of chromatography. B, Biomedical applications. 1994 Jun; 656(1):251-8. doi: 10.1016/0378-4347(94)00039-5. [PMID: 7952037]
  • G Zierfels, M Petz. [Fluorimetric determination of erythromycin residues in foods of animal origin after derivatization with FMOC and HPLC separation]. Zeitschrift fur Lebensmittel-Untersuchung und -Forschung. 1994 Apr; 198(4):307-12. doi: 10.1007/bf01193180. [PMID: 8197827]
  • K C Chan, G M Janini, G M Muschik, H J Issaq. Micellar electrokinetic chromatography of hydroxyproline and other secondary amino acids in biological samples with laser-induced fluorescence detection. Journal of chromatography. 1993 Dec; 622(2):269-73. doi: 10.1016/0378-4347(93)80276-a. [PMID: 8150876]
  • D L Mount, F C Churchill, Y Bergqvist. Determination of mefloquine in blood, filter paper-absorbed blood and urine by 9-fluorenylmethyl chloroformate derivatization followed by liquid chromatography with fluorescence detection. Journal of chromatography. 1991 Mar; 564(1):181-93. doi: 10.1016/0378-4347(91)80080-v. [PMID: 1860912]
  • A Sintov, R Siden, R J Levy. Sensitive high-performance liquid chromatographic assay using 9-fluorenylmethylchloroformate for monitoring controlled-release lidocaine in plasma. Journal of chromatography. 1989 Nov; 496(2):335-44. doi: 10.1016/s0378-4347(00)82581-5. [PMID: 2613837]
  • T Teerlink, E de Boer. Determination of 3-methylhistidine in urine by high-performance liquid chromatography using pre-column derivatization with 9-fluorenylmethyl chloroformate. Journal of chromatography. 1989 Jul; 491(2):418-23. doi: 10.1016/s0378-4347(00)82860-1. [PMID: 2808627]
  • G E Kisby, D N Roy, P S Spencer. Determination of beta-N-methylamino-L-alanine (BMAA) in plant (Cycas circinalis L.) and animal tissue by precolumn derivatization with 9-fluorenylmethyl chloroformate (FMOC) and reversed-phase high-performance liquid chromatography. Journal of neuroscience methods. 1988 Nov; 26(1):45-54. doi: 10.1016/0165-0270(88)90128-8. [PMID: 3199847]
  • W Vogt, E Egeler, W Sommer, F Eisenbeiss, H D Meyer. High-performance liquid chromatographic determination of hormonal peptides and their fluorenylmethoxycarbonyl derivatives. Journal of chromatography. 1987 Jul; 400(?):83-9. doi: 10.1016/s0021-9673(01)81601-0. [PMID: 3667762]