2-Aminofluorene (BioDeep_00000173183)

   

human metabolite blood metabolite


代谢物信息卡片


9H-fluoren-2-amine

化学式: C13H11N (181.0891446)
中文名称: 2-氨基芴
谱图信息: 最多检出来源 Bos taurus(endogenous) 37.04%

分子结构信息

SMILES: C1C2=CC=CC=C2C3=C1C=C(C=C3)N
InChI: InChI=1S/C13H11N/c14-11-5-6-13-10(8-11)7-9-3-1-2-4-12(9)13/h1-6,8H,7,14H2

描述信息

D009676 - Noxae > D002273 - Carcinogens
D009676 - Noxae > D009153 - Mutagens

同义名列表

5 个代谢物同义名

9H-fluoren-2-amine; 2-Fluorenylamine; 2-aminofluorene; 2-Fluorenamine; 2-Aminoflurene



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Yasuhiro Uno, Norie Murayama, Hiroshi Yamazaki. Molecular and Functional Characterization of N-Acetyltransferases NAT1 and NAT2 in Cynomolgus Macaque. Chemical research in toxicology. 2018 11; 31(11):1269-1276. doi: 10.1021/acs.chemrestox.8b00236. [PMID: 30358977]
  • Sergey Orlov, Iryna Goncharova, Marie Urbanová. Circular dichroism study of the interaction between mutagens and bilirubin bound to different binding sites of serum albumins. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2014 May; 126(?):68-75. doi: 10.1016/j.saa.2014.01.139. [PMID: 24589992]
  • Li-Chun Wang, Ya-Qin Yu, Min Fang, Cai-Gui Zhan, Hong-Yan Pan, Yong-Ning Wu, Zhi-Yong Gong. Antioxidant and antigenotoxic activity of bioactive extracts from corn tassel. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. 2014 Feb; 34(1):131-136. doi: 10.1007/s11596-014-1244-x. [PMID: 24496692]
  • Paola Hernández, Rosario Rojas, Robert H Gilman, Michel Sauvain, Lidia M Lima, Eliezer J Barreiro, Mercedes González, Hugo Cerecetto. Hybrid furoxanyl N-acylhydrazone derivatives as hits for the development of neglected diseases drug candidates. European journal of medicinal chemistry. 2013 Jan; 59(?):64-74. doi: 10.1016/j.ejmech.2012.10.047. [PMID: 23202852]
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  • Rajbir Kaur, Upendra Sharma, Bikram Singh, Saroj Arora. Antimutagenic and antioxidant characteristics of Chukrasia tabularis A Juss extracts. International journal of toxicology. 2011 Feb; 30(1):21-34. doi: 10.1177/1091581810385362. [PMID: 20959614]
  • Natalie L Milic, Suong N T Ngo, Ceilidh L Marchant, Tamara A Height, Ross A McKinnon. Pulmonary cytochrome P450 enzymes belonging to the CYP4B subfamily from an Australian marsupial, the tammar wallaby (Macropus eugenii). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2011 Jan; 153(1):60-6. doi: 10.1016/j.cbpc.2010.08.006. [PMID: 20826229]
  • Maryam Zahin, Farrukh Aqil, Iqbal Ahmad. Broad spectrum antimutagenic activity of antioxidant active fraction of punica granatum L. peel extracts. Mutation research. 2010 Dec; 703(2):99-107. doi: 10.1016/j.mrgentox.2010.08.001. [PMID: 20708098]
  • Geetanjali Rampal, Tarunpreet Singh Thind, Adarsh Pal Vig, Saroj Arora. Antimutagenic potential of glucosinolate-rich seed extracts of broccoli (Brassica oleracea L var italica Plenck). International journal of toxicology. 2010 Dec; 29(6):616-24. doi: 10.1177/1091581810379165. [PMID: 20864623]
  • Nilusha Ragunathan, Julien Dairou, Elodie Sanfins, Florent Busi, Christophe Noll, Nathalie Janel, Jean-Marie Dupret, Fernando Rodrigues-Lima. Cadmium alters the biotransformation of carcinogenic aromatic amines by arylamine N-acetyltransferase xenobiotic-metabolizing enzymes: molecular, cellular, and in vivo studies. Environmental health perspectives. 2010 Dec; 118(12):1685-91. doi: 10.1289/ehp.1002334. [PMID: 20810355]
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  • Prabhjit Kaur, Madhu Chandel, Subodh Kumar, Neeraj Kumar, Bikram Singh, Satwinderjeet Kaur. Modulatory role of alizarin from Rubia cordifolia L. against genotoxicity of mutagens. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2010 Jan; 48(1):320-5. doi: 10.1016/j.fct.2009.10.019. [PMID: 19852997]
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  • Jianling Jin, Bo Liu, Hui Zhang, Xiao Tian, Yupin Cai, Peiji Gao. Mutagenicity of Chinese traditional medicine Semen Armeniacae amarum by two modified Ames tests. BMC complementary and alternative medicine. 2009 Nov; 9(?):43. doi: 10.1186/1472-6882-9-43. [PMID: 19912670]
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  • Annamaria Buschini, Lisa Ferrarini, Susanna Franzoni, Serena Galati, Mirca Lazzaretti, Francesca Mussi, Cristina Northfleet de Albuquerque, Tânia Maria Araújo Domingues Zucchi, Paola Poli. Genotoxicity revaluation of three commercial nitroheterocyclic drugs: nifurtimox, benznidazole, and metronidazole. Journal of parasitology research. 2009; 2009(?):463575. doi: 10.1155/2009/463575. [PMID: 20981287]
  • Mei-Due Yang, Shuw-Yuan Lin, Tsan-Hung Chiu, Chin-Chung Lin, Meng-Liang Lin, Shu-Chun Hsu, Chao-Lin Kuo, Ming-Jyh Sheu, Chih-Chung Wu, Song-Shei Lin, Jing-Gung Chung. Effects of luteolin on distribution and metabolism of 2-aminofluorene in male Sprague-Dawley rats. In vivo (Athens, Greece). 2008 Nov; 22(6):729-34. doi: NULL. [PMID: 19180999]
  • Rubem Cesar Horn, Vera Maria Ferrão Vargas. Mutagenicity and antimutagenicity of teas used in popular medicine in the salmonella/microsome assay. Toxicology in vitro : an international journal published in association with BIBRA. 2008 Jun; 22(4):1043-9. doi: 10.1016/j.tiv.2007.12.014. [PMID: 18281189]
  • H Zeytinoglu, Z Incesu, B Ayaz Tuylu, A O Turk, B Barutca. Determination of genotoxic, antigenotoxic and cytotoxic potential of the extract from lichen Cetraria aculeata (Schreb.) Fr. in vitro. Phytotherapy research : PTR. 2008 Jan; 22(1):118-23. doi: 10.1002/ptr.2279. [PMID: 17726729]
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  • Chin-Chung Lin, Shung-Te Kao, Chin-Chin Ho, Heng-Chien Ho, Te-Chun Hsia, Mei-Due Yang, Chin-Chung Yeh, Po-Erh Liu, Jing-Gung Chung. Effects of oral administration of berberine on distribution and metabolism of 2-aminofluorene in Sprague-Dawley rats. In vivo (Athens, Greece). 2007 Mar; 21(2):321-8. doi: . [PMID: 17436583]
  • K H Lu, K H Lue, T C Hsia, M C Chou, K L Lin, J G Chung. Oral administration of paclitaxel affects the distribution and metabolism of 2-aminofluorene in various tissues of Sprague-Dawley rats. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2005 Aug; 12(8):577-87. doi: 10.1016/j.phymed.2004.11.005. [PMID: 16121518]
  • Chin-Chin Ho, Yi-Shyong Lai, Der-Yean Wang, Yi-Shuan Chen, Jau-Hong Lee, Nou-Ing Tang, Jing-Gung Chung. Effects of ellagic acid by oral administration on distribution and metabolism of 2-aminofluorene in Sprague-Dawley rats. In vivo (Athens, Greece). 2005 Jan; 19(1):143-56. doi: . [PMID: 15796167]
  • Josefina Cortés-Eslava, Sandra Gómez-Arroyo, Rafael Villalobos-Pietrini, Jesús Javier Espinosa-Aguirre. Antimutagenicity of coriander (Coriandrum sativum) juice on the mutagenesis produced by plant metabolites of aromatic amines. Toxicology letters. 2004 Nov; 153(2):283-92. doi: 10.1016/j.toxlet.2004.05.011. [PMID: 15451560]
  • Tsan-Hung Chiu, Jung-Chou Chen, Lieh-Der Chen, Jau-Hong Lee, Jing-Gung Chung. Gypenosides inhibited N-acetylation of 2-aminofluorene, N-acetyltransferase gene expression and DNA adduct formation in human cervix epithelioid carcinoma cells (HeLa). Research communications in molecular pathology and pharmacology. 2004; 115-116(?):157-74. doi: ". [PMID: 17564315]
  • Jing-Pin Lin, Kwork-Chui Cheng, Guang-Wei Chen, Mei-Due Yang, Tsan-Hung Chiu, Jing-Gung Chung. Effects of (-)-menthol on the distribution and metabolism of 2-aminofluorene in various tissues of Sprague-Dawley rats. In vivo (Athens, Greece). 2003 Sep; 17(5):441-55. doi: NULL. [PMID: 14598608]
  • Tsan-Hung Chiu, Jung-Chou Chen, Jing-Gung Chung. N-acetyltransferase is involved in gypenosides-induced N-acetylation of 2-aminofluorene and DNA adduct formation in human cervix epidermoid carcinoma cells (Ca Ski). In vivo (Athens, Greece). 2003 May; 17(3):281-8. doi: ". [PMID: 12929581]
  • J B F Fernandes, V M F Vargas. Mutagenic and antimutagenic potential of the medicinal plants M. laevigata and C. xanthocarpa. Phytotherapy research : PTR. 2003 Mar; 17(3):269-73. doi: 10.1002/ptr.1058. [PMID: 12672159]
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  • Swayamjot Kaur, Saroj Arora, Satwinderjeet Kaur, Subodh Kumar. Bioassay-guided isolation of antimutagenic factors from fruits of Terminalia bellerica. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 2003; 22(1):69-76. doi: ". [PMID: 12678407]
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  • Yi-Min Lee, Shan-Fu Chen, Yu-Ching Li, Song-Shei Lin, Jing-Gung Chung. Oral administration of 5-methoxypsoralen affects the distribution and metabolism of 2-aminofluorene in Sprague-Dawley rats. In vivo (Athens, Greece). 2002 May; 16(3):201-13. doi: . [PMID: 12182117]
  • Kamaljit Kaur, Saroj Arora, Michael E Hawthorne, Swayamjot Kaur, Subodh Kumar, Rajendra G Mehta. A correlative study on antimutagenic and chemopreventive activity of Acacia auriculiformis A. Cunn. and Acacia nilotica (L.) Willd. Ex Del. Drug and chemical toxicology. 2002 Feb; 25(1):39-64. doi: 10.1081/dct-100108471. [PMID: 11850969]
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  • Kamaljit Kaur, Saroj Arora, Subodh Kumar, Avinash Nagpal. Modulatory effect of phenolic fractions of Terminalia arjuna on the mutagenicity in Ames assay. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 2002; 21(1):45-56. doi: ". [PMID: 11934012]
  • Hiroshi Yamazaki, Hitomi Iketaki, Ayaka Shibata, Miki Nakajima, Tsuyoshi Yokoi. Activities of cytochrome p450 enzymes in liver and kidney microsomes from systemic carnitine deficiency mice with a gene mutation of carnitine/organic cation transporter. Drug metabolism and pharmacokinetics. 2002; 17(1):47-53. doi: 10.2133/dmpk.17.47. [PMID: 15618652]
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  • J Cortés-Eslava, S Gómez-Arroyo, R Villalobos-Pietrini, J J Espinosa-Aguirre. Metabolic activation of three arylamines and two organophosphorus insecticides by coriander (Coriandrum sativum) a common edible vegetable. Toxicology letters. 2001 Dec; 125(1-3):39-49. doi: 10.1016/s0378-4274(01)00414-3. [PMID: 11701221]
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  • J G Chung, H L Chang, C C Yeh, H F Lu, C C Chang, H D Tsai. Effects of the immunomodulator tilorone on the acetylation of 2-aminofluorene and DNA-2-aminofluorene adducts in the rats. Anticancer research. 2000 Jan; 20(1A):467-73. doi: NULL. [PMID: 10769698]
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