Indecainide (BioDeep_00000033204)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


9-{3-[(propan-2-yl)amino]propyl}-9H-fluorene-9-carboximidate

化学式: C20H24N2O (308.18885339999997)
中文名称: 英地卡胺
谱图信息: 最多检出来源 Danio rerio(blood) 69.23%

分子结构信息

SMILES: CC(C)NCCCC1(C(N)=O)C2=CC=CC=C2C2=CC=CC=C12
InChI: InChI=1S/C20H24N2O/c1-14(2)22-13-7-12-20(19(21)23)17-10-5-3-8-15(17)16-9-4-6-11-18(16)20/h3-6,8-11,14,22H,7,12-13H2,1-2H3,(H2,21,23)

描述信息

Indecainide is only found in individuals that have used or taken this drug. It is a rarely used antidysrhythmic. Indecainide has local anesthetic activity and belongs to the membrane stabilizing (Class 1) group of antiarrhythmic agents; it has electrophysiologic effects characteristic of the IC class of antiarrhythmics.Indecainide acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers.
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent

同义名列表

10 个代谢物同义名

9-{3-[(propan-2-yl)amino]propyl}-9H-fluorene-9-carboximidate; 9-(3-((1-Methylethyl)amino)propyl)-9H-fluorene-9-carboxamide; 9-{3-[(propan-2-yl)amino]propyl}-9H-fluorene-9-carboxamide; 9[3[(1methylethyl)amino]propyl]-fluorene-9-carboxamide; 9-(3-(Isopropylamino)propyl))fluorene-9-carboxamide; 9-(3-(Isopropylamino)propyl)-9-fluorenylcarboxamid; Indecainide hydrochloride; Indecainide; Ricainide; Ricainid



数据库引用编号

8 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • E V Giardina, A L Saroff, M Schneider. Effect of indecainide in patients with left ventricular dysfunction. Clinical pharmacology and therapeutics. 1990 Nov; 48(5):582-9. doi: 10.1038/clpt.1990.195. [PMID: 2225716]
  • D R Holland, W B Lacefield, C R Gonzales, S R Johnston, J A Turk. Indecainide: effects on arrhythmias, electrophysiology, and cardiovascular dynamics. Journal of cardiovascular pharmacology. 1989 Sep; 14(3):454-61. doi: NULL. [PMID: 2476626]
  • D M Salerno, J Krejci, G Granrud, M Hodges. Indecainide for treatment of ventricular ectopic depolarizations: efficacy, pharmacokinetics, hemodynamic effects and safety. Journal of the American College of Cardiology. 1988 Apr; 11(4):843-50. doi: 10.1016/0735-1097(88)90221-5. [PMID: 3351153]
  • G E Sandusky, D B Meyers. Toxicology of indecainide hydrochloride after intravenous administration to rats and dogs. Toxicology letters. 1985 Aug; 26(2-3):107-10. doi: 10.1016/0378-4274(85)90153-5. [PMID: 4035704]
  • K Z Farid, A F Fasola, J F Nash. Liquid chromatographic determination of indecainide, a new antiarrhythmic drug, and its major metabolite, desisopropyl indecainide, in biological samples. Journal of chromatography. 1985 Feb; 337(2):329-40. doi: 10.1016/0378-4347(85)80046-3. [PMID: 3988863]
  • T D Lindstrom, G W Whitaker. The pharmacokinetics of indecainide in mice, rats, dogs, and monkeys. Drug metabolism and disposition: the biological fate of chemicals. 1984 Nov; 12(6):683-90. doi: NULL. [PMID: 6150816]
  • T D Lindstrom, W B Lacefield, G W Whitaker. Metabolism of the antiarrhythmic agent, indecainide, in rats, dogs, and monkeys. Drug metabolism and disposition: the biological fate of chemicals. 1984 Nov; 12(6):691-7. doi: NULL. [PMID: 6150817]